期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 303, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.127106
关键词
Cobalt oxide; beta-cyclodextrin; Nanoparticle; Peroxidase-mimicking; Colorimetric sensor; Ascorbic acid
资金
- Natural Science Foundation of China [21876099, 21750110438, 21575077]
- Science and Technology Development Plans of Shandong Province [ZR2017ZCO227]
- Fundamental Research Funds of Shandong University [2016JC030]
- Shandong Provincial Natural Science Foundation [ZR2017PB007]
- Shandong Provincial Key Laboratory Project of Test Technology for Material Chemical Safety [2018SDCLHX005]
Transition metal oxides nanoparticles have shown enzyme-mimetic performance. It was demonstrated that the Co3O4@beta-cyclodextrin nanoparticles (Co3O4@beta-CD NPs) showed a higher peroxidase-mimicking catalytic activity than pure Co3O4 NPs. beta-CD molecules were coated onto the surface of Co3O4 NPs via a one-pot synthesis method. Co3O4@beta-CD NPs displayed higher affinity to 3,3',5,5'-tetramethylbenzidine (TMB) through Michaelis-Menten mechanism after modification with beta-CD. The catalytic efficiency of Co3O4@beta-CD NPs for TMB oxidation was 9.5-fold higher than that of the pure Co3O4 NPs because of the effective host-guest interactions between Co3O4@beta-CD NPs and TMB. Further, the hydrophobic cavity of beta-CD while hosting TMB could reduce the transfer distance of electrons between TMB and Co3O4 catalyst, which could lead to faster oxidation of TMB. The synergistic effects between Co3O4 and beta-CD enhanced the peroxidase-mimicking property. The efficient and visual colorimetric determination of Ascorbic Acid (AA) assay was achieved. The limit of detection was 1.09 mu M (S/N = 3) and the linear range was 10-60 mu M based on the Co3O4@beta-CD NPs peroxidase-mimicking-mediated 3.0-fold signal magnification strategy. Moreover, the outstanding selectivity toward the detection of AA was achieved, which could exhibit prospects in biomedical analysis.
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