Article
Chemistry, Analytical
Amir Reza Ameri, Armin Imanparast, Mohammad Passandideh-Fard, Seyed Ali Mousavi Shaegh
Summary: Microfluidics has been used to create a whole-thermoplastic microfluidic chip for on-chip cell culture. The chip was made of polymethyl methacrylate (PMMA) and thermoplastic polyurethane (TPU) using high precision micromilling and laser micromachining. A pneumatic solo diffuser-nozzle micropump was integrated with the chip for on-chip pumping. The chip also included an oxygenator for sufficient oxygen delivery. The proposed chip showed promising potential for various cell culture studies.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Korakot Boonyaphon, Zhenglin Li, Sung-Jin Kim
Summary: In this study, a microfluidic recirculation system driven by water-head pressures was developed, which enables media recirculation in parallel channels with pulsatile and constant flows. The system allows control of flow rates and shear stress, and can be used for systematic and parallel analysis of cell response to fluidic shearing patterns.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Environmental
Changmin Shao, Yunru Yu, Xin Lei, Jie Cao, Yuanjin Zhao, Fangfu Ye
Summary: Drug resistance is a major obstacle in cancer treatment. A novel organ-on-a-chip platform based on an inverse opal scaffold was developed to generate tumor cell spheroids and study resistance. The platform allowed for the formation of homogeneous hepatoma cell spheroids and the establishment of liver tumor models with varying levels of drug-resistant phenotypes. The platform provided valuable preclinical data on dynamic drug resistance in different tumor stages and medication periods.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biology
Pragya Prasanna, Shweta Rathee, Vedanabhatla Rahul, Debabrata Mandal, Macherla Sharath Chandra Goud, Pardeep Yadav, Susan Hawthorne, Ankur Sharma, Piyush Kumar Gupta, Shreesh Ojha, Niraj Kumar Jha, Chiara Villa, Saurabh Kumar Jha
Summary: Alzheimer's disease is a significant global health concern with limited therapeutic options and poor understanding of its pathophysiology. Microfluidics offers new possibilities in AD research by providing insights into disease pathways and mechanisms.
Review
Chemistry, Analytical
Qianbin Zhao, Tim Cole, Yuxin Zhang, Shi-Yang Tang
Summary: Organ-on-a-chip (OOC) technology replicates organ- or tissue-level functionality at a small scale using microfluidic 3D cell culture principle. It offers an alternative to animal models for drug development and environmental toxicology screening, by mimicking cell-cell interactions and mechanical stimuli that influence cell behavior. OOC prototypes leverage microfluidic technology to reproduce mechanically dynamic microenvironments on-chip for enhanced in vitro functional organ models.
Review
Medicine, General & Internal
Job Komen, Sanne M. van Neerven, Albert van den Berg, Louis Vermeulen, Andries D. van der Meer
Summary: This study explores the potential of using organ-on-chip technology to mimic cancer xenograft models for validating cancer-on-chip models. By reviewing the biological characteristics and comparing the growth of on-chip tumors with xenografts, it shows that organ-on-chip technology is capable of mimicking many aspects of xenograft tumors, yet further development and validation is needed.
Article
Engineering, Electrical & Electronic
Valeria Nico, Eric Dalton
Summary: Microfluidic technology has grown rapidly in recent years, with limitations in pumps for high-end electronics and biomedical devices. A novel magnetic shuttle pump technology and numerical model were proposed to address this issue, showing promising results in achieving required pressure and flow characteristics through simulations and experiments.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Review
Engineering, Electrical & Electronic
Farzad Forouzandeh, Arpys Arevalo, Ahmed Alfadhel, David A. Borkholder
Summary: This report reviews the progress on peristaltic micropumps and discusses various techniques and important parameters involved in mimicking the physiological transport mechanism. It also evaluates research efforts over the past 30 years and provides suggestions for future development.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Biophysics
Shan Liu, Shikha Kumari, Hongyi He, Parichita Mishra, Bhisham Narayan Singh, Divakar Singh, Sutong Liu, Pradeep Srivastava, Chenzhong Li
Summary: As a simulation of human cells, tissues, organs, and systems, Organ-on-a-Chip (OOC) has ethical advantages and development potential over animal experiments. Advancements in 3D cell biology and engineering, chip materials, and 3D printing have facilitated the connection of multi-organs-on-chips for simulation and the development of new drug screening platforms. The success of organ model modeling is crucial, and this paper provides a comprehensive review and discussion of detection and evaluation technologies in organ-on-a-chip research.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Pharmacology & Pharmacy
Jingyu Fu, Hailong Qiu, Cherie S. Tan
Summary: Drug discovery is a costly and complex process, and efficient methods are needed to screen potential compounds and remove toxic substances. The liver plays a crucial role in determining drug efficacy and potential side effects. The liver-on-a-chip platform based on microfluidic technology has gained attention for its ability to predict drug metabolism and hepatotoxicity, as well as study pharmacokinetics and pharmacodynamics when combined with other organ-on-chip systems.
Article
Chemistry, Analytical
Yi-bo Zheng, Li-dong Ma, Jian-lin Wu, Yi-ming Wang, Xian-sheng Meng, Ping Hu, Qiong-lin Liang, Yuan-yuan Xie, Guo-an Luo
Summary: A three-dimensional dynamic multi-cellular liver-on-a-chip device was developed to mimic the microenvironment of in vivo liver tissue, showing improved liver function and drug toxicity detection capabilities compared to traditional static cultures, by co-culturing hepatocytes and endothelial cells in the chip.
Article
Engineering, Biomedical
Leyla Amirifar, Amir Shamloo, Rohollah Nasiri, Natan Roberto de Barros, Ze Zhong Wang, Bige Deniz Unluturk, Alberto Libanori, Oleksandr Ievglevskyi, Sibel Emir Diltemiz, Samuel Sances, Ilangko Balasingham, Stephanie K. Seidlits, Nureddin Ashammakhi
Summary: Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to the development of organ-on-a-chip devices that can replicate key functions of various organs. These platforms promise to provide novel insights into physiological events, including disease mechanisms, and evaluate the impact of external interventions such as drug administration. Therefore, the neuroscience field is expected to benefit greatly from these innovative tools.
Article
Chemistry, Multidisciplinary
Haiqing Bai, Kristen N. Peters Olson, Ming Pan, Thomas Marshall, Hardeep Singh, Jingzhe Ma, Paige Gilbride, Yu-Chieh Yuan, Jenna McCormack, Longlong Si, Sushila Maharjan, Di Huang, Xiaohua Qian, Carol Livermore, Yu Shrike Zhang, Xin Xie
Summary: This study introduces an approach to pattern fluid guides inside microchannels by establishing differential hydrophilicity using pressure-sensitive adhesives as masks and a subsequent selective coating with a biocompatible polymer. The method achieves rapid and consistent hydrogel flow and is suitable for dynamic 3D cell culture. Additionally, the device shows potential for pharmaceutical high-throughput screening applications.
Review
Nanoscience & Nanotechnology
Daniel Vera, Maria Garcia-Diaz, Nuria Torras, Mar Alvarez, Rosa Villa, Elena Martinez
Summary: Researchers have integrated hydrogels into microfluidic setups to develop tissue barrier-on-chips that accurately account for different cellular and acellular compartments, including the cellular components and functionality of in vivo tissues. These platforms have the potential to greatly improve the predictive capacities of in vitro systems in applications such as drug development or disease modeling, but face challenges in microfabrication.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Daniel A. Ferreira, Mario Rothbauer, Joao P. Conde, Peter Ertl, Carla Oliveira, Pedro L. Granja
Summary: A streamlined approach for fabricating organ-on-a-chip devices using an adaptation of xurography is proposed, allowing rapid and low-cost generation of multilayered, membrane-integrated biochips suitable for organ-on-a-chip applications without cytotoxic effects on cells.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rong Xia, Wei Sun, Joseph Yee, Sheila Sheth, Chrystia Slywotzky, Steven Hodak, Tamar C. Brandler
Summary: This study aimed to explore the molecular profiles of cytologically indeterminate thyroid nodules stratified by TI-RADS categories. RAS mutations were the most common alteration, while aggressive mutations like BRAF(V600E) and TERT were mainly found in TR4 and TR5 categories. ThyroSeq results were positively correlated with thyroid malignancy, particularly when NIFTP was categorized as malignant. Echogenicity scores were negatively correlated with ThyroSeq results in thyroid nodules.
Editorial Material
Multidisciplinary Sciences
Zhenzhen Zhou, Yuan Pang, Wei Sun
CHINESE SCIENCE BULLETIN-CHINESE
(2022)
Article
Engineering, Biomedical
Anyang Wang, Lina Dong, Zhongwei Guo, Wei Sun, Shengli Mi
Summary: In this study, a novel thermoresponsive gel was developed for sustained drug delivery in the treatment of bacterial keratitis. The gel exhibited improved antibacterial ability and low cytotoxicity to human corneal cells.
BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Environmental
Zhongwei Guo, Yuanyuan Xu, Lina Dong, Malav S. Desai, Jingjing Xia, Mujiao Liang, Seung-Wuk Lee, Shengli Mi, Wei Sun
Summary: In this study, we designed and synthesized genetically encoded materials called elastin-like polypeptides (ELPs) that can undergo temperature-induced phase transition and photo-crosslinking due to modification with methacrylate groups. The degree of methacrylate functionalization can be controlled by adjusting the reactant ratio. By combining hydrogel fabrication strategy, the methacrylated ELPs (ELP-MA) can be engineered into different physical forms such as coacervates and hydrogels, functioning as light transmittance regulators and elastic adhesives. The physical properties of the hydrogels can be controlled by the degree of methacrylation and ELP-MA concentration. The resulting ELP-MA hydrogels showed good biocompatibility when implanted subcutaneously in mice.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Chengjin Wang, Yang Yang, Jingyuan Ji, Yongcong Fang, Liliang Ouyang, Lei Zhang, Wei Sun
Summary: The study proposed an integrated bioresorbable stent coated with dipyridamole-loaded nanofibers, which effectively prevents the proliferation of smooth muscle cells without adverse effects on endothelial cells, and exhibits excellent hemocompatibility. The in vivo implantation of the stent showed initial patency and continuous endothelialization, alleviating neointimal formation, indicating its potential for restenosis prevention and endothelialization.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Editorial Material
Multidisciplinary Sciences
Zhenzhen Zhou, Yuan Pang, Wei Sun
CHINESE SCIENCE BULLETIN-CHINESE
(2022)
Editorial Material
Multidisciplinary Sciences
Zhenzhen Zhou, Yuan Pang, Wei Sun
CHINESE SCIENCE BULLETIN-CHINESE
(2022)
Article
Engineering, Biomedical
Lina Dong, Mujiao Liang, Zhongwei Guo, Anyang Wang, Gangpei Cai, Tianying Yuan, Shengli Mi, Wei Sun
Summary: This study successfully synthesized hydrogels with oriented structures and dual responsiveness through a new fabrication process, providing potential applications for ordered biological soft tissue repair.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Materials Science, Multidisciplinary
Jingyuan Ji, Chengjin Wang, Zhuo Xiong, Yuan Pang, Wei Sun
Summary: Bone repair is a complex process that involves angiogenesis and osteogenesis, controlled by various factors. This study proposes a 3D-printed scaffold with a sequential delivery platform to promote the coupling regeneration of blood vessels and bones. The scaffold showed enhanced proliferation and differentiation of BMSCs and HUVECs in vitro, and better angiogenesis and osteoinductive effects in vivo.
MATERIALS TODAY ADVANCES
(2022)
Article
Engineering, Biomedical
Jingjing Xia, Zhuo Xiong, Jiaxuan Guo, Yongan Wang, Yuan Luo, Yangyang Sun, Zhongwei Guo, Bingchuan Lu, Ting Zhang, Wei Sun
Summary: Researchers designed a biomimetic multichannel micro-lung chip to mimic the interface between lung epithelium and interstitium for studying pulmonary fibrosis induced by PQ poisoning. The chip-based model showed decreased cell viability and significant changes in fibrosis-related proteins. Co-culturing A549 and MRC-5 cells in the chip induced severe epithelial-mesenchymal transition compared to the non-contact model. This novel co-culture micro-lung chip provides a new approach for studying lung fibrosis and drug development.
Article
Materials Science, Multidisciplinary
Zhichang Du, Gangnan Zhao, Anyang Wang, Wei Sun, Shengli Mi
Summary: The paper introduces a microfluidic contact lens that integrates a microchannel and a micropump to achieve drug release through the mechanical action of blinking. Experimental results demonstrate the controllability of liquid release and the good flexibility, light transmittance, and biocompatibility of the microfluidic contact lens. The liquid exchange between the eye and the contact lens provides potential for personalized medicine.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Engineering, Biomedical
Yuanyuan Xu, Chengjin Wang, Yang Yang, Hui Liu, Zhuo Xiong, Ting Zhang, Wei Sun
Summary: Three-dimensional bioprinting has the potential to reverse engineer human pathophysiology and develop biomimetic experimental systems. This study presents a portable, modular, low-cost, and easy-to-use multifunctional 3D bioprinting system that can successfully print constructs with detailed surface structures, hollow structures, and multiscale complex tissue analogs.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Engineering, Biomedical
Yang Yang, Runze Xu, Chengjin Wang, Yuzhi Guo, Wei Sun, Liliang Ouyang
Summary: In this study, recombinant human type III collagen (rhCol3) was introduced as a bioink component to enhance human skin tissue engineering. The results show that rhCol3 promotes cell growth, increases the spreading of epidermal keratinocytes at an early stage, and contributes to skin wound healing.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Engineering, Biomedical
Zhongwei Guo, Zunghang Wei, Wei Sun
Summary: Adhesive hydrogels with rapid and controllable properties have been developed using polyphenol chemistry. These hydrogels show excellent mechanical and adhesion performance on wet and dynamic biological tissues. The results demonstrate the promising potential of these hydrogels as surgical sealants.
Article
Chemistry, Multidisciplinary
Yongcong Fang, Chengjin Wang, Zibo Liu, Jeonghoon Ko, Li Chen, Ting Zhang, Zhuo Xiong, Lei Zhang, Wei Sun
Summary: In this study, a conductive multiscale filled NGC (MF-NGC) is developed, which significantly enhances peripheral nerve regeneration. The printed MF-NGCs possess good permeability, mechanical stability, and electrical conductivity, promoting the elongation and growth of Schwann cells and neurite outgrowth. Animal studies demonstrate that the MF-NGCs promote neovascularization and M2 transition, leading to improved peripheral nerve regeneration. This study demonstrates the feasibility of using 3D-printed conductive MF-NGCs with hierarchically oriented fibers as functional conduits.
Article
Engineering, Electrical & Electronic
Kehao Feng, Zhenghua Zhang, Guohua Bai, Xiuyuan Fan, Rongzhi Zhao, Xuefeng Zhang
Summary: This paper proposes a new method to accurately evaluate the high-frequency power loss of soft magnetic materials. Through a two-step calibration, the system is able to compensate for the phase angle discrepancy between the exciting current and induced voltage, enabling a higher power loss measurement frequency.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Mingfang Kang, Tong Liu, Hongmei Sun, Lin Li, Keliang Wang
Summary: In this study, the absorption performance of ambient nitrogenous toxic gases on a monolayer of blue phosphorus phase germanium selenide (GeSe) was investigated using density-functional theory calculations. The results showed that GeSe monolayer exhibits higher sensitivity and selectivity for the hazardous gas NO.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Yaqiong Niu, Zhicheng Zou, Longsheng Cheng, Chaofeng Ye
Summary: This paper proposes a novel method to stabilize the laser diode output using a close-loop control with two feedbacks. The proposed method performs better for long-time operations.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Jiajie Li, Ying Liu, Zhen Chai, Qian Cao, Renjie Li, Yueyang Zhai
Summary: This study proposed an efficient and high-quality beam-splitting method based on a diffractive optical element, enabling multichannel SERF atomic magnetometers to achieve ultra-high consistency and sensitivity. It has significant applications in array biomagnetic measurement systems.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
E. Oliveira, C. Doering, H. Fouckhardt
Summary: With the development of Lab on a chip technology, fluid management using dispersed droplets has become an important approach. Electrowetting on dielectric (EWOD) is one method for droplet actuation, but it requires prior definition of droplet positions. Optoelectrowetting (OEW) goes further by allowing changes in electrical parameters through impinging light spots, without the need for predefined droplet positions. This study re-evaluates the key parameters of OEW and explores their effects on droplet actuation using numerical optimization methods.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Haipeng Wang, Zhiguo Wang, Gancheng Zhu, Shuai Zhang
Summary: A novel capacitive proximity skin was developed to improve the performance of robotics in handling liquid-filled containers. This skin features a flexible structure that can adapt to different grippers and seamlessly integrate with Robot Operating System. Experimental results demonstrated that this proximity skin achieved data-lossless detection and contactless measurement of liquid level, making it suitable for grasping operations.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Tsenguun Byambadorj, Xiangyu Zhao, Yutao Qin, Yogesh B. Gianchandani
Summary: In this research, a monolithically microfabricated Knudsen pump (KP) without suspended membranes was presented. These pumps offer improved mechanical robustness, wider process window, and simplified microfabrication process compared to previous designs. The experimental results matched the modeling results well, indicating the potential for monolithic integration onto complex lab-on-a-chip systems.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Hamed Karami, Saeed Karami Chemeh, Vahid Azizi, Hooman Sharifnasab, Jose Ramos, Mohammed Kamruzzaman
Summary: Aroma is a significant quality trait for pharmaceutical plants and their products, indicating the quality of the raw material. An electronic nose is an efficient approach for identifying and evaluating the aroma of essential oils. In this study, tarragon was dried at different temperatures and air velocities, and the purity of tarragon essential oil was evaluated using an electronic nose. Multivariate data analysis and artificial neural networks modeling were employed to quantify and classify the obtained essential oils.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Xiaoyang Duan, Dan Xu, Wenjun Jia, Ran Li, Bohao Sun, Ruitian Yan, Wenjie Zhao
Summary: Flower-like WO3/WS2 heterojunction materials constructed via a low-temperature in-situ oxidation method exhibit significant improvements in the detection of NO2 gas in gas sensors, along with good selectivity and reproducibility.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Peng Yu, Mengyang Zhang, Manqi You, Yuxi Gao, Landong Xiao, Yan Peng, Jingxia Lai, Zhouzhao Shi, Siwei Luo, Gencai Guo, Gang Guo
Summary: Recent studies have shown that two-dimensional Janus transition metal dichalcogenides (TMDs) have great potential for applications in gas sensors. By conducting first principles calculations, this study explores the potential application of Pd-doped monolayer HfSeS as gas sensor materials for detecting CO, CO2, NH3, and NO. The results demonstrate the good thermodynamical stability and reversible adsorption of these molecules on both pristine and Pd-doped HfSeS, with Pd-doped HfSeS showing higher sensitivity towards NO due to its metallic behavior upon NO adsorption.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Jinlan Yang, Linjiao Li, Jun Huang, Quan Zhang, Hiba Affane
Summary: This study proposes a method for large-scale aggregation of micro-particles by creating a vortex region using low-frequency oscillation. Experimental results show that this method can achieve a large aggregation area and has the advantages of low cost and low power consumption.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Jitendra Singh, Saurabh Kumar Gupta, Vinita
Summary: In this investigation, a Surface Acoustic Wave (SAW) formalin gas sensor was explored for low-level formalin gas sensing applications. The sensor showed stable response and high sensitivity to formalin gas concentration, making it a reliable and useful sensor for room temperature operations.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Junyao Wang, Yahao Liu, Huan Liu, Qi Hou, Jianxin Xu, Hongxu Pan, Jingran Quan, Yansong Chen, Hanbo Yang, Lixiang Li
Summary: A flexible electrode with a serpentine-shaped tetra-chiral structure was designed to improve the mechanical properties and prevent mechanical fracture of flexible electrodes. The research demonstrated that this structure reduced the maximum tensile stress by 87.19% compared to the existing tetra-chiral structure. The flexible electrode remained conductive even at a strain of 70% and showed resistance values of 5 ohm and 4.4 ohm at a bending angle of 180 degrees and after 1000 fold cycles. Furthermore, the flexible electrodes showed great potential in biological signal monitoring, particularly in collecting ECG and pulse signals.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
Taihao Chen, Yong Fang, Mengru Zhu, Zhiwei Zhao, Wei Lei, Zhuoya Zhu, Helong Jiang
Summary: Flexible dual-spectral carbon nanodots/flexible n-silicon heterojunction photodetectors with high responsivity and detectivity are reported. These detectors show photo response in UV illumination and only in forward bias under visible illumination. The photocurrent of the device remains high even under bending strain.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
Article
Engineering, Electrical & Electronic
M. S. Sikandar Bathusha, Israr Ud Din, Rehan Umer, Kamran A. Khan
Summary: Graphene-based nanomaterials are used as embedded sensors to monitor fracture behavior in composite structures. This study investigates the in-situ crack propagation and fracture behavior in a glass fiber reinforced polymer composite using embedded reduced graphene oxide coated fabrics and highly conductive graphene nanoplatelet paper.
SENSORS AND ACTUATORS A-PHYSICAL
(2024)
