标题
Single-cell transcriptional diversity is a hallmark of developmental potential
作者
关键词
-
出版物
SCIENCE
Volume 367, Issue 6476, Pages 405-411
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2020-01-24
DOI
10.1126/science.aax0249
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The single-cell transcriptional landscape of mammalian organogenesis
- (2019) Junyue Cao et al. NATURE
- A comparison of single-cell trajectory inference methods
- (2019) Wouter Saelens et al. NATURE BIOTECHNOLOGY
- Efficient integration of heterogeneous single-cell transcriptomes using Scanorama
- (2019) Brian Hie et al. NATURE BIOTECHNOLOGY
- Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data
- (2019) Samuel L. Wolock et al. Cell Systems
- Concepts and limitations for learning developmental trajectories from single cell genomics
- (2019) Sophie Tritschler et al. DEVELOPMENT
- Clinical and Therapeutic Implications of Cancer Stem Cells
- (2019) Michael F. Clarke NEW ENGLAND JOURNAL OF MEDICINE
- Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
- (2019) Huidong Chen et al. Nature Communications
- A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution
- (2019) Jonathan S. Packer et al. SCIENCE
- Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
- (2018) Kelly Street et al. BMC GENOMICS
- Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
- (2018) Tathiane M. Malta et al. CELL
- Single-Cell Transcriptomics Meets Lineage Tracing
- (2018) Lennart Kester et al. Cell Stem Cell
- A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation
- (2018) Eric M. Kernfeld et al. IMMUNITY
- Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing
- (2018) Hannah Hochgerner et al. NATURE NEUROSCIENCE
- Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics
- (2018) Mireya Plass et al. SCIENCE
- Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis
- (2018) Jeffrey A. Farrell et al. SCIENCE
- The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution
- (2018) James A. Briggs et al. SCIENCE
- Single-cell full-length total RNA sequencing uncovers dynamics of recursive splicing and enhancer RNAs
- (2018) Tetsutaro Hayashi et al. Nature Communications
- CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo
- (2018) Gabriel N Aughey et al. eLife
- Identification of the Human Skeletal Stem Cell
- (2018) Charles K.F. Chan et al. CELL
- RNA velocity of single cells
- (2018) Gioele La Manno et al. NATURE
- Joint profiling of chromatin accessibility and gene expression in thousands of single cells
- (2018) Junyue Cao et al. SCIENCE
- Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
- (2018) et al. NATURE
- Gain of CTCF-Anchored Chromatin Loops Marks the Exit from Naive Pluripotency
- (2018) Aleksandra Pękowska et al. Cell Systems
- Single-cell gene expression analysis reveals regulators of distinct cell subpopulations among developing human neurons
- (2017) Jiaxu Wang et al. GENOME RESEARCH
- A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation
- (2017) Li Yang et al. HEPATOLOGY
- Comparative Analysis of Single-Cell RNA Sequencing Methods
- (2017) Christoph Ziegenhain et al. MOLECULAR CELL
- A single-cell survey of the small intestinal epithelium
- (2017) Adam L. Haber et al. NATURE
- Single-cell mRNA quantification and differential analysis with Census
- (2017) Xiaojie Qiu et al. NATURE METHODS
- Salmon provides fast and bias-aware quantification of transcript expression
- (2017) Rob Patro et al. NATURE METHODS
- Reversed graph embedding resolves complex single-cell trajectories
- (2017) Xiaojie Qiu et al. NATURE METHODS
- Transcriptional landscape of the human cell cycle
- (2017) Yin Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
- (2017) Alessandro Furlan et al. SCIENCE
- Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling
- (2017) Bhupinder Pal et al. Nature Communications
- Transcriptomic and anatomic parcellation of 5-HT3AR expressing cortical interneuron subtypes revealed by single-cell RNA sequencing
- (2017) Sarah Frazer et al. Nature Communications
- Single-cell entropy for accurate estimation of differentiation potency from a cell’s transcriptome
- (2017) Andrew E. Teschendorff et al. Nature Communications
- Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
- (2017) Shaheen S. Sikandar et al. Nature Communications
- Massively parallel digital transcriptional profiling of single cells
- (2017) Grace X. Y. Zheng et al. Nature Communications
- Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types
- (2017) Ying-Jiun J. Chen et al. Scientific Reports
- Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling
- (2017) Scott A. Yuzwa et al. Cell Reports
- Mouse embryonic stem cells can differentiate via multiple paths to the same state
- (2017) James Alexander Briggs et al. eLife
- Reconstructing Lineage Hierarchies of Mouse Uterus Epithelial Development Using Single-Cell Analysis
- (2017) Bingbing Wu et al. Stem Cell Reports
- Complex heatmaps reveal patterns and correlations in multidimensional genomic data
- (2016) Zuguang Gu et al. BIOINFORMATICS
- Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types
- (2016) Kyle M. Loh et al. CELL
- De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
- (2016) Dominic Grün et al. Cell Stem Cell
- Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
- (2016) Andre Olsson et al. NATURE
- Tracing haematopoietic stem cell formation at single-cell resolution
- (2016) Fan Zhou et al. NATURE
- Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche
- (2016) James Y. Chen et al. NATURE
- A developmental coordinate of pluripotency among mice, monkeys and humans
- (2016) Tomonori Nakamura et al. NATURE
- Tissue-specific designs of stem cell hierarchies
- (2016) Jane E. Visvader et al. NATURE CELL BIOLOGY
- Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution
- (2016) M Ryan Corces et al. NATURE GENETICS
- SLICE: determining cell differentiation and lineage based on single cell entropy
- (2016) Minzhe Guo et al. NUCLEIC ACIDS RESEARCH
- TSCAN: Pseudo-time reconstruction and evaluation in single-cell RNA-seq analysis
- (2016) Zhicheng Ji et al. NUCLEIC ACIDS RESEARCH
- Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
- (2016) S. Marques et al. SCIENCE
- Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability
- (2016) D. R. Pattabiraman et al. SCIENCE
- Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5 + Intestinal Stem Cells
- (2016) Tae-Hee Kim et al. Cell Reports
- Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer
- (2016) Nicholas C. Gomez et al. Cell Reports
- Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells
- (2016) Iain C. Macaulay et al. Cell Reports
- Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity
- (2016) Simon Joost et al. Cell Systems
- Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers
- (2015) Jian Shu et al. CELL
- Identification and Specification of the Mouse Skeletal Stem Cell
- (2015) Charles K.F. Chan et al. CELL
- A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development
- (2015) Walfred W.C. Tang et al. CELL
- Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis
- (2015) Jaehoon Shin et al. Cell Stem Cell
- Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells
- (2015) Monika S. Kowalczyk et al. GENOME RESEARCH
- Spatial reconstruction of single-cell gene expression data
- (2015) Rahul Satija et al. NATURE BIOTECHNOLOGY
- Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow
- (2015) Andreas Schlitzer et al. NATURE IMMUNOLOGY
- Direct Detection of Transcription Factors in Cotyledons during Seedling Development Using Sensitive Silicon-Substrate Photonic Crystal Protein Arrays
- (2015) Sarah I. Jones et al. PLANT PHYSIOLOGY
- ‘LungGENS’: a web-based tool for mapping single-cell gene expression in the developing lung: Figure 1
- (2015) Yina Du et al. THORAX
- Primed and ready: understanding lineage commitment through single cell analysis
- (2015) Rachael A. Nimmo et al. TRENDS IN CELL BIOLOGY
- The Molecular Signatures Database Hallmark Gene Set Collection
- (2015) Arthur Liberzon et al. Cell Systems
- Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads
- (2014) Hongshan Jiang et al. BMC BIOINFORMATICS
- Fgd5identifies hematopoietic stem cells in the murine bone marrow
- (2014) Roi Gazit et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
- (2014) Barbara Treutlein et al. NATURE
- The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
- (2014) Cole Trapnell et al. NATURE BIOTECHNOLOGY
- Validation of noise models for single-cell transcriptomics
- (2014) Dominic Grün et al. NATURE METHODS
- Full-length RNA-seq from single cells using Smart-seq2
- (2014) Simone Picelli et al. Nature Protocols
- Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells
- (2014) Q. Deng et al. SCIENCE
- GSVA: gene set variation analysis for microarray and RNA-Seq data
- (2013) Sonja Hänzelmann et al. BMC BIOINFORMATICS
- From single-cell to cell-pool transcriptomes: Stochasticity in gene expression and RNA splicing
- (2013) G. K. Marinov et al. GENOME RESEARCH
- Type 2 alveolar cells are stem cells in adult lung
- (2013) Christina E. Barkauskas et al. JOURNAL OF CLINICAL INVESTIGATION
- Gene-pair expression signatures reveal lineage control
- (2013) Merja Heinäniemi et al. NATURE METHODS
- Molecular regulation of stem cell quiescence
- (2013) Tom H. Cheung et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells
- (2013) Liying Yan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- MET: A Critical Player in Tumorigenesis and Therapeutic Target
- (2013) C. R. Graveel et al. Cold Spring Harbor Perspectives in Biology
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Lineage Tracing
- (2012) Kai Kretzschmar et al. CELL
- Architecture of the human regulatory network derived from ENCODE data
- (2012) Mark B. Gerstein et al. NATURE
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Gene Expression Commons: An Open Platform for Absolute Gene Expression Profiling
- (2012) Jun Seita et al. PLoS One
- Molecular signatures database (MSigDB) 3.0
- (2011) A. Liberzon et al. BIOINFORMATICS
- ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments
- (2010) Alexander Lachmann et al. BIOINFORMATICS
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- Chromatin plasticity in pluripotent cells
- (2010) Shai Melcer et al. Essays in Biochemistry
- Hematopoietic stem cell: self-renewal versus differentiation
- (2010) Jun Seita et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- The Glial Nature of Embryonic and Adult Neural Stem Cells
- (2009) Arnold Kriegstein et al. Annual Review of Neuroscience
- Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
- (2009) Elgene Lim et al. NATURE MEDICINE
- Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
- (2008) Anne Wilson et al. CELL
- Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
- (2008) Rudolf Jaenisch et al. CELL
- Transcriptome Analysis of the Normal Human Mammary Cell Commitment and Differentiation Process
- (2008) Afshin Raouf et al. Cell Stem Cell
- Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells
- (2008) L. V. Sharova et al. DNA RESEARCH
- Regulatory networks define phenotypic classes of human stem cell lines
- (2008) Franz-Josef Müller et al. NATURE
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
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