Article
Biology
Yuan Liang, Wenzhen Yin, Chao Luo, Lijun Sun, Tiange Feng, Yunhua Zhang, Yue Yin, Weizhen Zhang
Summary: Long-term intermittent fasting before pregnancy disrupts intestinal homeostasis of offspring, leading to disorders in glucose and lipid metabolism.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jorge Lopez-Tello, Zoe Schofield, Raymond Kiu, Matthew J. Dalby, Douwe van Sinderen, Gwenaelle Le Gall, Amanda N. Sferruzzi-Perri, Lindsay J. Hall
Summary: This study demonstrates that the bacterium Bifidobacterium breve UCC2003, a key member of the maternal gut microbiota, modulates maternal body adaptations, placental structure, and nutrient transporter capacity, with implications for fetal metabolism and growth.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Nutrition & Dietetics
Liuqiao Sun, Xuying Tan, Xiaoping Liang, Hangjun Chen, Qian Ou, Qiongmei Wu, Xinxue Yu, Hanqing Zhao, Qiaoli Huang, Zehua Yi, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang
Summary: Maternal betaine supplementation alleviates NAFLD in offspring through regulating gut microbiota and SCFAs.
Article
Veterinary Sciences
Ruyue Cheng, Jiawen Guo, Yujie Zhang, Guo Cheng, Wei Qian, ChaoMin Wan, Ming Li, Francesco Marotta, Xi Shen, Fang He
Summary: This study found that ceftriaxone exposure during pregnancy significantly altered the maternal gut microbiota, leading to decreased immunity in mothers. However, the placenta microbiota was mainly dominated by Proteobacteria, especially Ralstonia, regardless of ceftriaxone treatment.
EXPERIMENTAL ANIMALS
(2021)
Article
Food Science & Technology
Qian Liu, Xin An, Yuan Chen, Yuxuan Deng, Haili Niu, Ruisen Ma, Haoan Zhao, Wei Cao, Xiaoru Wang, Meng Wang
Summary: Personalized diets can change the internal metabolism of organisms and affect overall health. This study found that polysaccharides extracted from Auricularia auricula have regulatory effects on metabolism and gut microbiota in mice. The supplementation of these polysaccharides altered the composition of the mice intestinal flora and regulated various metabolic pathways.
Article
Nutrition & Dietetics
Marijke M. Faas, Yuanrui Liu, Lieske Wekema, Gisela A. Weiss, Carolien A. van Loo-Bouwman, Luis Silva Lagos
Summary: This study found that inducing gut dysbiosis during pregnancy by antibiotic treatment alters the maternal immune response, which may affect fetal and placental weight.
Article
Microbiology
Cunxi Xue, Qinyuan Xie, Chenhong Zhang, Yimeng Hu, Xiaoting Song, Yifan Jia, Xiaoyang Shi, Yiqi Chen, Yalei Liu, Lingyun Zhao, Fenglian Huang, Huijuan Yuan
Summary: The study demonstrates that the gut microbiota transmitted via birth and nursing are important contributors to the glucose metabolism phenotype in offspring. Blocking vertical transmission of microbiota improves insulin sensitivity and islet function in the offspring of mothers with hyperglycaemia in pregnancy.
Article
Nutrition & Dietetics
Lin Song, Jiaqi Cui, Shuyuan Hu, Rui Wang, Hongbao Li, Bo Sun
Summary: A maternal high-fat diet has long-term adverse effects on offspring, but these effects can be ameliorated by maternal metformin treatment. This study found that maternal high-fat diet caused dysbiosis of gut microbiota, leading to colonic inflammation and gut barrier disruption. However, maternal metformin treatment reversed this dysbiosis and improved the metabolic phenotype of the offspring.
Article
Microbiology
Shengtang Qin, Yutong Wang, Shuxian Wang, Bohan Ning, Jing Huai, Huixia Yang
Summary: Studies have shown a connection between gestational diabetes mellitus (GDM) and abnormalities in the gut microbiota, with offspring of affected women having an increased risk of diabetes. This study using a pregnant mouse model found that fecal microbiota transplantation (FMT) resulted in different colonization patterns of gut microbiota and phenotype in the offspring. Additionally, the offspring of GDM-FMT mice exhibited differences in gut microbiota and higher body weight and blood glucose levels compared to control offspring.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anais Mazenc, Loic Mervant, Claire Maslo, Corinne Lencina, Valerie Bezirard, Mathilde Leveque, Ingrid Ahn, Valerie Alquier-Bacquie, Nathalie Naud, Cecile Helies-Toussaint, Laurent Debrauwer, Sylvie Chevolleau, Francoise Gueraud, Fabrice H. F. Pierre, Vassilia Theodorou, Maiwenn Olier
Summary: Maternal environment, including nutrition and microbiota, plays a critical role in determining the offspring's risk of chronic diseases such as diabetes. The form of iron added to the maternal diet can influence the establishment of offspring's gut microbiota. Male offspring from heme-enriched-fed mothers showed higher oxidative stress markers, impaired insulin secretion, and gut barrier defects, which may be predictive of diabetes development.
Article
Agriculture, Multidisciplinary
Jiamao Yan, Li Kong, Xiaoyuan Zhang, Mubin Yu, Kexin Zhu, Aihong Zhao, Dachuan Shi, Yonghong Sun, Junjie Wang, Wei Shen, Lan Li
Summary: This study found that maternal exposure to ZEN can impact ovarian development and gut microbiota in offspring, leading to reproductive disorders. These findings provide new insights for therapeutic strategies to address reproductive disorders caused by ZEN exposure.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Neurosciences
Cassandre Morel, Ines Martinez Sanchez, Yamina Cherifi, Nicolas Chartrel, Rochellys Diaz Heijtz
Summary: This study investigated the effects of maternal gut microbiota perturbations on neurobehavioral outcomes in offspring. The results showed that antibiotic exposure during a critical perinatal window altered ultrasonic communication patterns in male neonatal offspring. It also resulted in reduced social motivation, social interaction, and increased anxiety-like behavior in juvenile male offspring.
Article
Medicine, General & Internal
Samantha L. Dawson, Martin O'Hely, Felice N. Jacka, Anne-Louise Ponsonby, Christos Symeonides, Amy Loughman, Fiona Collier, Margarita Moreno-Betancur, Peter Sly, David Burgner, Mimi L. K. Tang, Richard Saffery, Sarath Ranganathan, Michael A. Conlon, Leonard C. Harrison, Susanne Brix, Karsten Kristiansen, Peter Vuillermin
Summary: The diversity of maternal prenatal gut microbiota and taxa from butyrate-producing families were found to be associated with child internalizing behavior at two years old. A healthy prenatal diet indirectly reduced child internalizing behaviors through higher alpha diversity of maternal fecal microbiota. These findings support animal studies in showing the impact of maternal prenatal gut microbiota on offspring brain development and behavior.
Article
Microbiology
Zihan Zhang, Chao Xue, Mengyao Ju, Jiawei Guo, Minghui Wang, Sijie Yi, Xianfeng Yi
Summary: The study suggests that maternal gut dysbiosis may contribute to neurodevelopmental disorders and behavioral defects in offspring, with maternal antibiotic treatment leading to significant changes in offspring gut microbiota and social interactions. This highlights the potential role of maternal gut microbiota as a mediator between offspring microbiota and behaviors in animal models.
Article
Nutrition & Dietetics
Amelie Le, Amandine Selle, Philippe Aubert, Tony Durand, Carole Brosseau, Philippe Bordron, Erwan Delage, Samuel Chaffron, Camille Petitfils, Nicolas Cenac, Michel Neunlist, Marie Bodinier, Malvyne Rolli-Derkinderen
Summary: Maternal diet plays a crucial role in preventing or contributing to the development of chronic diseases. Supplementation of maternal diet with prebiotics has been shown to reduce the risk of food allergies and affect intestinal permeability in offspring. However, the role of prebiotics in modulating the development of colitis remains unknown.
FRONTIERS IN NUTRITION
(2023)
Article
Urology & Nephrology
Ayumi Matsui, Ayumi Yoshifuji, Junichiro Irie, Takaya Tajima, Kiyotaka Uchiyama, Tomoaki Itoh, Shu Wakino, Hiroshi Itoh
Summary: This study found that canagliflozin can increase colonic glucose concentration and the number of Lactobacillus bacteria, restore the expression of tight junction proteins in the colon, decrease serum uremic toxin concentrations, and ameliorate cardiac interstitial fibrosis in nephrectomized rats. These effects may be attributed to the inhibition of SGLT1 by canagliflozin, as similar effects were not observed in tofogliflozin-treated rats.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Article
Toxicology
Susumu Kodama, Shuzo Matsumoto, Yuta Takamura, Michiko Fujihara, Masaki Watanabe, Atsushi Ono, Hiroki Kakuta
Summary: This study explored the structure-activity relationship of 1,3-bis-tert-butyl monocyclic benzene derivatives for RXR alpha activation and found that a bulky substituent at the 5-position is favorable for agonistic activity towards human RXR alpha.
TOXICOLOGY LETTERS
(2023)
Article
Endocrinology & Metabolism
Miki Igarashi, Kensuke Iwasa, Tetsuhiko Hayakawa, Tsuyoshi Tsuduki, Ikuo Kimura, Kei Maruyama, Keisuke Yoshikawa
Summary: In this study, it was found that dietary oleic acid (OA) is an important molecule in inducing satiety by reducing food intake. This effect is mediated through the signaling of oleoylethanolamide (OEA).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Junki Miyamoto, Hidenori Shimizu, Keiko Hisa, Chiaki Matsuzaki, Shinsuke Inuki, Yuna Ando, Akari Nishida, Ayano Izumi, Mayu Yamano, Chihiro Ushiroda, Junichiro Irie, Takane Katayama, Hiroaki Ohno, Hiroshi Itoh, Kenji Yamamoto, Ikuo Kimura
Summary: Fermented foods have health benefits due to probiotic bacteria or microproducts produced by bacterial fermentation. Prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) show significant metabolic benefits. EPS-derived gut microbial short-chain fatty acids improve glucose metabolism and energy homeostasis, and alter gut microbial composition.
Article
Chemistry, Medicinal
Kizuku Miura, Michiko Fujihara, Masaki Watanabe, Yuta Takamura, Mayu Kawasaki, Shogo Nakano, Hiroki Kakuta
Summary: This study measured the internal polarity of the RXR alpha-ligand binding pocket (LBP) by measuring fluorescence solvatochromism. The findings are expected to aid in the design of selective ligands for the RXR receptor. This method could also be applicable for evaluating the internal polarity of LBPs in other receptors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Multidisciplinary Sciences
Kazuhiro Kashiwagi, Jun Inaishi, Shotaro Kinoshita, Yasuyo Wada, Sayaka Hanashiro, Kiko Shiga, Momoko Kitazawa, Shiori Tsutsumi, Hiroyuki Yamakawa, Junichiro Irie, Taishiro Kishimoto
Summary: This study found a correlation between body mass index (BMI), glycemic variability (GV), and life-related factors in healthy nondiabetic adults. Prediabetes and underweight individuals had higher GV, possibly due to irregular eating habits and low activity levels. On the other hand, overweight individuals had longer periods of elevated blood sugar, potentially due to dietary habits and lack of exercise.
Article
Chemistry, Medicinal
Yuta Takamura, Shota Kikuzawa, Michiko Fujihara, Yukinari Sunatsuki, Kazutaka Higaki, Hiroki Kakuta
Summary: In this study, two crystal forms of the RXR agonist NEt-3IB were characterized and investigated through thermogravimetry, powder X-ray diffraction, and single crystal X-ray diffraction. The crystal forms were identified as monohydrate form I and anhydrate form II, which could be reversibly interconverted. The solubility of form I was found to be lower than form II. Thus, form I may be more suitable for targeting IBD due to higher delivery to the lower gastrointestinal tract and reduced systemic side effects associated with lower water solubility.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Endocrinology & Metabolism
Miki Igarashi, Tetsuhiko Hayakawa, Haruka Tanabe, Keita Watanabe, Akari Nishida, Ikuo Kimura
Summary: In this study, Gpr119 knockout mice were generated using CRISPR-Cas9 gene-editing technology. The results showed that Gpr119-deficient mice exhibited lower blood glucose levels and greater weight loss under food deprivation conditions. Further experiments revealed that elevated levels of OEA in the cecum were associated with satiety control and energy metabolism.
MOLECULAR METABOLISM
(2023)
Meeting Abstract
Peripheral Vascular Disease
Shunta Takebayashi, Junichiro Irie, Isao Kurihara, Sakiko Kobayashi, Kazutoshi Miyashita, Kenichiro Kinouchi, Toshifumi Nakamura, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Shintaro Yamaguchi, Taichi Nagahisa, Shotaro Kosugi, Ken Nishioka, Yasuhiro Watanabe, Koichiro Homma, Kazutoshi Miyashita, Junichiro Irie, Jun Yoshino, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Nobuko Goto, Motoko Kita, Junichiro Irie, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Arata Itoh, Kazunari Yuki, Junichiro Irie, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)