Article
Psychiatry
Melina Wiedmann, Soeren Kuitunen-Paul, Lukas A. Basedow, Veit Roessner, Yulia Golub
Summary: Among adolescent SUD patients, MDMA use in addition to cannabis use is associated with APS, while cannabis use is not related to APS. Cannabis may increase the risk for psychosis after a longer period of use and in combination with other risk factors, such as trauma history. Clinicians should screen for APS among SUD patients using MDMA and cannabis in order to adapt treatment plans of SUDs.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Natalia Jimeno, Javier Gomez-Pilar, Jesus Poza, Roberto Hornero, Kai Vogeley, Eva Meisenzahl, Theresa K. Lichtenstein, Marlene Rosen, Joseph Kambeitz, Joachim Klosterkoetter, Frauke Schultze-Lutter
Summary: Hallucinations are characteristic symptoms of psychosis, but it is important to distinguish true psychotic hallucinations from other hallucinatory experiences. Network analysis of different symptoms revealed three clusters, and it was concluded that attenuated hallucinations should not be used to diagnose psychosis.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychology, Clinical
Lukas Andreas Basedow, Melina Felicitas Wiedmann, Soeren Kuitunen-Paul, Veit Roessner, Yulia Golub
Summary: This study explores the difference in the prevalence of attenuated psychotic symptoms (APS) between adolescent patients with only substance use disorders (SUD), SUD with a history of traumatic experiences (TEs), and SUD with self-reported post-traumatic stress disorder (PTSD). The study found that adolescents with SUD and self-reported PTSD had higher APS prevalence rates compared to those with only SUD or a history of trauma.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)
Article
Geriatrics & Gerontology
Caroline Demro, Chen Shen, Timothy J. Hendrickson, Jessica L. Arend, Seth G. Disner, Scott R. Sponheim
Summary: Schizophrenia and other psychotic disorders are associated with advanced brain-age, indicating non-progressive structural brain abnormalities. These findings suggest a transdiagnostic and neurodevelopmental formulation of psychotic psychopathology.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Clinical Neurology
Marc J. Weintraub, Megan C. Ichinose, Jamie Zinberg, Monica Done, Georga M. Morgan-Fleming, Catherine A. Wilkerson, Robin D. Brown, Carrie E. Bearden, David J. Miklowitz
Summary: This study examined the acceptability and initial efficacy of an app-enhanced Unified Protocol for Adolescents [UP-A] in treating more severe mood disorders or psychotic spectrum disorders in adolescents. The results showed that the app was acceptable and useful for participants and their parents, and the treatment led to significant improvements in symptoms and functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Dorte Nordholm, Marie Aarrebo Jensen, Louise Birkedal Glenthoj, Tina Dam Kristensen, Christina Wenneberg, Anne Helene Garde, Merete Nordentoft
Summary: Sleep disturbances are common in individuals at ultra high-risk of psychosis and have been found to play a causal role in the occurrence of psychotic symptoms. Few studies have systematically investigated sleep disturbances in this population. The results suggest that high-risk individuals have difficulties waking up and feel exhausted upon awakening, indicating a delayed sleep phase.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Ulrike Nowak, Katarina Krkovic, Mathias K. Kammerer, Tania M. Lincoln
Summary: This study focused on exploring the temporal affect dynamics in psychosis and found that individuals with psychotic disorders have increased affective instability. There were no significant differences in variability and inertia. These findings have important implications for emotion-focused interventions for psychosis.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Danielle N. Pratt, Miranda Bridgwater, Jason Schiffman, Lauren M. Ellman, Vijay A. Mittal
Summary: Psychosis-risk inventories, like the SIPS, use symptom components to create a single-severity rating, potentially masking important clinical details.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychology, Multidisciplinary
Petr Bob, Tereza Petraskova Touskova, Ondrej Pec, Jiri Raboch, Nash Boutros, Paul Lysaker
Summary: This study found a significant correlation between hair cortisol levels and stress symptoms as well as complex partial seizure-like symptoms in patients experiencing their initial episode of psychosis. However, there was no significant correlation between hair cortisol levels and symptoms of anxiety and depression. These findings suggest a potential relationship between epileptic-like symptoms and stress responses in patients during their first psychotic episode.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Maya Kuperberg, Douglas Katz, Sophie L. A. Greenebaum, Nevita George, Louisa G. Sylvia, Gustavo Kinrys, Astrid Desrosiers, Andrew A. Nierenberg
Summary: This study examined the relationship between psychotic symptoms during bipolar depressive episodes and suicidal ideation among outpatients with bipolar disorder. The results indicated that patients with psychotic symptoms were more likely to report active suicidal thoughts, including specific plans and methods.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
M. J. Bosma, S. R. Cox, T. Ziermans, C. R. Buchanan, X. Shen, E. M. Tucker-Drob, M. J. Adams, H. C. Whalley, S. M. Lawrie
Summary: This study reveals that lower global white matter microstructure is associated with having PLEs in combination with distress, suggesting a direction of future research. Additionally, it replicates the finding that processing speed mediates the relationship between white matter microstructure and g-factor.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
LiHua Xu, Mei Zhang, ShuQin Wang, YanYan Wei, HuiRu Cui, ZhenYing Qian, YingChan Wang, XiaoChen Tang, YeGang Hu, YingYing Tang, TianHong Zhang, JiJun Wang
Summary: This study found that high-risk individuals with attenuated psychotic symptoms may have impaired cognitive insight, characterized by poorer self-reflectiveness. The correlation between cognitive and clinical insight is associated with the duration of untreated attenuated psychotic symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Christian Theisen, Marlene Rosen, Eva Meisenzahl, Nikolaos Koutsouleris, Theresa Lichtenstein, Stephan Ruhrmann, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Anita Riecher-Roessler, Katharine Chisholm, Rachel Upthegrove, Linda A. A. Antonucci, Alessandro Bertolino, Alessandro Pigoni, Raimo K. R. Salokangas, Christos Pantelis, Stephen J. J. Wood, Rebekka Lencer, Peter Falkai, Jarmo Hietala, Paolo Brambilla, Andre Schmidt, Christina Andreou, Stefan Borgwardt, Naweed Osman, Frauke Schultze-Lutter, PRONIA Consortium
Summary: The study investigated the thematic contents of Attenuated Psychosis Symptoms (APS) and their association with demographic and clinical factors. The results showed a wide range of different contents reported by APS patients, highlighting the psychopathological heterogeneity of this group. The prevalence rates of contents were lower compared to North-American samples, likely due to stricter rating of APS and cultural influences.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Gonzalo Salazar de Pablo, Filippo Besana, Vincenzo Arienti, Ana Catalan, Julio Vaquerizo-Serrano, Anna Cabras, Joana Pereira, Livia Soardo, Francesco Coronelli, Simi Kaur, Josette da Silva, Dominic Oliver, Natalia Petros, Carmen Moreno, Ana Gonzalez-Pinto, Covadonga M. Diaz-Caneja, Jae Il Shin, Pierluigi Politi, Marco Solmi, Renato Borgatti, Martina Maria Mensi, Celso Arango, Christoph U. Correll, Philip McGuire, Paolo Fusar-Poli
Summary: The meta-analysis study revealed that CHR-P individuals show improvements in symptoms and functional outcomes over time, but sustaining these improvements in the long term is challenging, with less than half of patients achieving full remission.