期刊
CANCER
卷 122, 期 24, 页码 3765-3775出版社
WILEY
DOI: 10.1002/cncr.30342
关键词
chemotherapy; metastatic; pancreatic cancer; targets; treatment standards
类别
资金
- Andrea J. Will Foundation
- Davidson Family
Of the anticipated 50,000 individuals expected to be diagnosed with pancreatic cancer in 2016, the majority will have metastatic disease. Given the noncurative nature of advanced pancreatic adenocarcinoma, treatment is aimed at inducing disease regression, controlling symptom, and extending life. The last 5 years have been marked by advances in the treatment of metastatic pancreatic cancer, specifically the approval by the US Food and Drug Administration of 2 combination chemotherapy regimens and the widespread use of a third, which have reproducibly been shown to improve survival. Ongoing studies are building on these regimens along with targeted and immunotherapeutic agents. This article will review the current treatment standards and emerging targets for metastatic pancreatic cancer. (C) 2016 American Cancer Society.
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