Article
Materials Science, Multidisciplinary
Bulent Caglar, Fatih Icer, Kemal Volkan Ozdokur, Sema Caglar, Agah Oktay Ozdemir, Eda Keles Guner, Burcu Meryem Beser, Ahmet Altay, Cagri Cirak, Bilge Dogan, Ahmet Tabak
Summary: Ferromagnetic BiFeO3 nanoparticles were synthesized with a rhombohedral distorted perovskite structure, characterized comprehensively, and used to develop a novel H2O2 biosensor with excellent linear response, detection and quantification limits, reproducibility, and stability. The biosensor was successfully applied for the analysis of H2O2 in milk samples with satisfactory recovery rates.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Siham Atifi, Mehr-Negar Mirvakili, Cyan A. Williams, Melanie M. Bay, Silvia Vignolini, Wadood Y. Hamad
Summary: Cellulose nanocrystals (CNCs) are functional materials with distinct properties that can be used in the fabrication of photonic, optoelectronic, and functional hybrid materials. By using electrophoretic deposition (EPD)-induced self-assembly, photonic films with long-range chirality can be produced on conductive, rigid, or flexible substrates within a few minutes.
ADVANCED MATERIALS
(2022)
Article
Polymer Science
Akhilan Elangovan, Dhananjay Suresh, Andrew O. Tarim, Anandhi Upendran, Raghuraman Kannan
Summary: The study reports a synthetic process that can be used to develop MNP, where each NP potentially carries a drug or reporter to combat diseases. Using this method, hybrid MNP composed of HSA-NP and AuNP were synthesized, with the MNP internalizing within cancer cells while aggregated nonspecific assembly failing to enter.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Chemistry, Analytical
Yu Zhong, Xiang-Guang Hu, Ai-Lin Liu, Yun Lei
Summary: Due to its fast mass transfer, high current density and rapid response, micro-scale electrochemical DNA biosensors have become a promising area of research in the widespread use of point-of-care testing for diagnosis of disease. In this study, a gold nanoparticles modified gold microelectrode (AuNPs/ Au-Me) was developed to detect the hand, foot and mouth disease (HFMD)-related gene. The modification with noble metal nanoparticles significantly increased the electroactive surface area of the microelectrode and magnified the signal for HFMD-related gene. Under optimal conditions, the biosensor showed excellent selectivity and sensitivity with a low detection limit of 0.3 fM (S/N = 3), which is sufficient for clinical diagnosis of HFMD. Additionally, the developed AuNPs/Au-Me successfully detected the polymerase chain reaction (PCR) amplified products of the target gene. Therefore, the electrochemical DNA biosensor has great potential in early-stage diagnosis and long-term monitoring of various diseases.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
M. Monti, E. Scarel, A. Hassanali, M. Stener, S. Marchesan
Summary: This study uncovers the conformational differences that drive self-assembly of dipeptides into distinct outcomes. Through in silico and experimental data, the electronic circular dichroism (ECD) spectra of self-assembling dipeptides were analyzed, revealing the importance of folded or extended conformers in the self-assembly process.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jesus G. Ovejero, Miguel A. Garcia, Pilar Herrasti
Summary: The Pechini method was evaluated for obtaining self-assembling magnetic and plasmonic nanoparticles, with the best conditions involving slightly alkaline media, ultrasound activation of silica condensation, and reaction times of around 2 hours for core-satellite nanostructures with controlled sizes.
Article
Chemistry, Analytical
Jyoti Ahlawat, Minakshi Sharma, Chandra Shekhar Pundir
Summary: An electrochemical biosensor was developed using a composite of acetylcholinesterase (AChE) and choline oxidase (ChO)/Pt nanoparticles (PtNPs)/porous graphene oxide nanosheet (GONS). Characterization techniques such as SEM, TEM, XRD, FTIR spectra, and CV were employed. The biosensor demonstrated fast response, low detection limit, good linearity, long storage stability, and high reproducibility. Furthermore, it exhibited high analytical recoveries and low coefficients of variation when measuring acetylcholine in serum samples.
Article
Chemistry, Analytical
Sinuo Feng, Yu Xue, Jianshe Huang, Xiurong Yang
Summary: In this study, an electrochemical biosensor was successfully developed for the sensitive and specific determination of miR-21. The biosensor utilized COFs and DTN as the biosensing interface and employed a CHA strategy. The biosensor showed a low detection limit of 0.33 fM and a wide linear response ranging from 1 fM to 10 nM miR-21.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Weizhen Xu, Min Ouyang, Hongmei Luo, Dong Xu, Qinlu Lin
Summary: A dark-field microscopy-based single nanoparticle color imaging method has been developed for the quantitation of glucose. The method relies on enzymatic reaction and chemical reaction between oxygen and the nanoparticles to measure glucose concentration. The method has high spatial and temporal resolution and has been successfully applied to measure glucose in human samples and cells.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Nilem Khaliq, Muhammad Asim Rasheed, Maaz Khan, Muhammad Maqbool, Mashkoor Ahmad, Shafqat Karim, Amjad Nisar, Patrik Schmuki, Sung Oh Cho, Ghafar Ali
Summary: A hybrid nanostructure electrode based on Au/CdS QDs/TNTs was fabricated for nonenzymatic detection of cholesterol and hydrogen peroxide, showing enhanced sensitivity and selectivity. The biosensor demonstrated good reproducibility and thermal stability, with promising potential for enzyme-free biosensing applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Ryo Yonenuma, Hideharu Mori
Summary: A hybrid monomer consisting of diphenylalanine and tetraphenylethylene (TPE) was synthesized and used for polymerization. The monomer formed self-assembled structures and exhibited aggregation-induced emission (AIE) properties. The resulting polymers showed stable assembled structures with characteristic emissions and AIE properties. This study demonstrated the potential of the diphenylalanine-TPE hybrid monomer for the development of chiral AIE hybrid polymers.
Review
Chemistry, Multidisciplinary
Liangchun Li, Li Xie, Renlin Zheng, Rongqin Sun
Summary: This review discusses the design and structures of self-assembly linear dipeptide hydrogels, as well as the strategies for preparing the new generation of hydrogels. With a deeper understanding of the relationship between the structures and properties of dipeptides, it is believed that dipeptide hydrogels have great potential in preparing minimal biocompatible materials.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Analytical
Li Ruiyi, Jia Hui, Li Nana, Xu Dan, Li Zaijun
Summary: The paper describes the synthesis of gold-graphene hybrid using histidine-functionalized graphene quantum dot as the linker between gold and graphene. The hybrid exhibits good dispersion and catalytic activity. By coupling with DNA cycling signal amplification, the hybrid is able to detect chlorpyrifos in fruits with high sensitivity and selectivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Olha Demkiv, Galina Gayda, Nataliya Stasyuk, Olena Brahinetz, Mykhailo Gonchar, Marina Nisnevitch
Summary: This article describes the development of amperometric biosensors based on laccase and redox-active micro/nanoparticles. It was found that laccase/CuCo/GE exhibited the highest sensitivity to catechol, suggesting potential applications of these sensors for the analysis of phenolic derivatives.
Article
Chemistry, Multidisciplinary
Zedong Li, Shuang Wu, Jingcheng Ji, Yuemeng Bai, Pengpeng Jia, Yan Gong, Shangsheng Feng, Fei Li
Summary: Lateral flow assays (LFAs), a popular point-of-care testing platform, have limited detection sensitivity. This study developed a ball pen writing-without-ink method to amplify the detection signal, resulting in improved sensitivity.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)