Article
Oncology
Austin L. Brown, Kimberly P. Raghubar, Olga A. Taylor, Melanie Brooke Bernhardt, Lisa S. Kahalley, Wei Pan, Philip J. Lupo, Marilyn J. Hockenberry, Michael E. Scheurer
Summary: Research on pediatric acute lymphoblastic leukemia (ALL) patients found that symptoms such as fatigue, pain, nausea, and sleep disturbances at specific treatment stages were associated with subsequent relapse. This suggests that patient-reported symptoms could serve as prognostic indicators for identifying high-risk pediatric ALL patients.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Kimberly P. Raghubar, Tiffany Chambers, Ryan M. Hill, Olga Taylor, Marilyn Hockenberry, M. Casey Hooke, Pauline Mitby, Ida Ki Moore, Austin L. Brown, Michael E. Scheurer
Summary: This study found that suicidal ideation during childhood ALL treatment was more common in children under 12 years old, especially in ethnic groups not typically associated with increased risk, and was associated with increasing physical and depressive symptoms.
Review
Oncology
Marina Oldenburg, Nadine Ruechel, Stefan Janssen, Arndt Borkhardt, Katharina L. Goessling
Summary: The concept of holobionts emphasizes the complex interactions between a host and other species, which, if disturbed may lead to disease and premature aging. The impact of chemotherapy on the microbiome and long-term dysbiosis in survivors of acute lymphoblastic leukemia requires further research.
Article
Medicine, Research & Experimental
Yizhen Li, Wentao Yang, Meenakshi Devidas, Stuart S. Winter, Chimene Kesserwan, Wenjian Yang, Kimberly P. Dunsmore, Colton Smith, Maoxiang Qian, Xujie Zhao, Ranran Zhang, Julie M. Gastier-Foster, Elizabeth A. Raetz, William L. Carroll, Chunliang Li, Paul P. Liu, Karen R. Rabin, Takaomi Sanda, Charles G. Mullighan, Kim E. Nichols, William E. Evans, Ching-Hon Pui, Stephen P. Hunger, David T. Teachey, Mary Relling, Mignon L. Loh, Jun J. Yang
Summary: Genetic alterations in the RUNX1 gene are associated with various blood disorders, especially those of the megakaryocyte and myeloid lineages. Germline RUNX1 variants have different effects on B-ALL and T-ALL, with the latter showing severe damaging effects. Additionally, JAK3 mutation is a common somatic genomic abnormality in T-ALL with germline RUNX1 variants.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Yuting Zhu, Xiaopeng Ma, Heng Zhang, Yijun Wu, Meiyun Kang, Yongjun Fang, Yao Xue
Summary: The study revealed that circADD2 is down-regulated in ALL, and its overexpression inhibits cell proliferation while promoting apoptosis. circADD2 functions by directly sponging miR-149-5p.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Maria Kourti, Michalis Aivaliotis, Emmanouel Hatzipantelis
Summary: Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and risk-directed therapy based on clinical, biologic and genetic features has played a significant role in its treatment. Despite improvement in survival rates, ALL remains a leading cause of cancer-related deaths. Proteomics is a cutting-edge technology that aims to understand the impact of the proteome on leukemia subtypes and identify new biomarkers and targets for therapy.
Article
Oncology
Marco Severgnini, Mariella D'Angio, Silvia Bungaro, Giovanni Cazzaniga, Ingrid Cifola, Grazia Fazio
Summary: In this study, RNA-seq technology was used to comprehensively profile the transcriptional landscape of childhood BCP-ALL cases. The analysis revealed a subset of conjoined genes (CGs) that were exclusively expressed in leukemic cases, suggesting a potential novel mechanism of transcriptional regulation in childhood leukemia and potential leukemia-specific biomarkers.
Article
Clinical Neurology
Rui Li, Ji-Hong Tang, Bing-Bing Zhang, Xiao-Yan Shi, Yuan-Yuan Dai, Rui Qu
Summary: The clinical characteristics of epileptic seizures in children with acute lymphoblastic leukemia (ALL) during treatment were analyzed. Epileptic seizures mainly occurred in the induction remission period, maintenance treatment period, and after bone marrow transplantation. The common causes were MTX-related demyelinating encephalopathy and reversible posterior encephalopathy syndrome (PRES). Convulsion was the first symptom. Early neuroimaging and EEG examination are important for early diagnosis and treatment.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Yao Xue, Jing Chen, Siyuan Gao, Xiaowen Zhai, Ningling Wang, Ju Gao, Yu Lv, Mengmeng Yin, Yong Zhuang, Hui Zhang, Xiaofan Zhu, Xuedong Wu, Chi Kong Li, Shaoyan Hu, Changda Liang, Runming Jin, Hui Jiang, Minghua Yang, Lirong Sun, Kaili Pan, Jiaoyang Cai, Jingyan Tang, Xianmin Guan, Yongjun Fang
Summary: Tumor lysis syndrome (TLS) is a common and fatal complication of childhood hematologic malignancies, with age, white blood cell count, and tumor type being risk factors for TLS occurrence. Hyperphosphatemia and hypocalcemia are common in TLS children with hyperleukocytosis, and significant differences in levels of potassium, calcium, phosphorus, and uric acid were observed in different groups of TLS patients. Older age, infant, a higher level of white blood cells, and T-ALL were identified as risk factors for TLS occurrence.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Sofie Gottschalk Hojfeldt, Kathrine Grell, Jonas Abrahamsson, Bendik Lund, Kim Vettenranta, Olafur G. Jonsson, Thomas L. Frandsen, Benjamin O. Wolthers, Hanne Vibeke Marquart, Goda Vaitkeviciene, Kristi Lepik, Mats Heyman, Kjeld Schmiegelow, Birgitte Klug Albertsen
Summary: Truncation of asparaginase treatment due to toxicity or silent inactivation may increase relapse risk in children with acute lymphoblastic leukemia, highlighting the importance of therapeutic drug monitoring and appropriate adjustment of therapy.
Review
Oncology
Lilly Velentza, Farasat Zaman, Lars Savendahl
Summary: GCs are widely used in the treatment of childhood ALL but their long-term use is associated with bone-related morbidities. Unfortunately, there is currently no efficient treatment for bone health impairment in patients and survivors. The review aims to discuss how GCs impact bone health in pediatric ALL and efforts made to minimize these side effects.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Unai Illarregi, Jaione Telleria, Nerea Bilbao-Aldaiturriaga, Elixabet Lopez-Lopez, Javier Ballesteros, Idoia Martin-Guerrero, Angela Gutierrez-Camino
Summary: Childhood acute lymphoblastic leukemia is a heterogeneous disease with multiple molecular subtypes, and long non-coding RNAs (lncRNAs) have the potential to serve as novel diagnostic, classification, and treatment response markers to improve survival rates and refine patient classification.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kinga Panuciak, Emilia Nowicka, Angelika Mastalerczyk, Joanna Zawitkowska, Maciej Niedzwiecki, Monika Lejman
Summary: Recent years have seen significant progress in the treatment of B-cell acute lymphoblastic leukemia (ALL), with improved conventional therapy schemes and the development of new treatment forms. The 5-year survival rates now exceed 90% in pediatric patients. However, at the molecular level, there are still many variations that need to be analyzed in more detail, including aneuploidy, which is among the most common genetic changes in B-cell ALL. Our work will focus on summarizing the current state of knowledge on aneuploidy and its correlates with the treatment of B-cell ALL patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Mary H. Ward, Jessica M. Madrigal, Rena R. Jones, Melissa C. Friesen, Roni T. Falk, David Koebel, Catherine Metayer
Summary: Based on the California Childhood Leukemia Study, this research evaluated the relationship between residential pesticide use and the risk of childhood acute lymphoblastic leukemia (ALL). The study found that glyphosate concentrations in house dust were associated with occupational pesticide exposure, nearby agricultural use, treatment for lawn weeds and bees/wasps, and sampling season. However, increasing glyphosate concentrations were not associated with an increased ALL risk. This study highlights the potential risk of young children being exposed to pesticides in residential settings and the need for further research.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Shamil Urazbakhtin, Anastasia Smirnova, Anastasiya Volakhava, Elena Zerkalenkova, Maria Salyutina, Michael Doubek, Hana Jelinkova, Nelly Khudainazarova, Egor Volchkov, Laima Belyaeva, Ekaterina Komech, Sarka Pavlova, Yuri Lebedev, Karla Plevova, Yulia Olshanskaya, Alexander Komkov, Ilgar Mamedov
Summary: Retroelements have been proposed to play a role in cancerogenesis and different cancer types are characterized by varying levels of tumor-specific RE insertions. Recent study found that acute lymphoblastic leukemia and childhood acute leukemias have low levels of RE insertional activity, and no new tumor-specific RE insertions were identified in the acute leukemia samples tested. Additionally, increased transcription levels of active L1 copies were found, but this was not sufficient for a significant elevation of L1 retrotranspositional activity in leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Nina S. Kadan-Lottick, Daniel J. Zheng, Mingjuan Wang, Michael W. Bishop, Deo Kumar Srivastava, Wilhelmenia L. Ross, Rozalyn L. Rodwin, Kirsten K. Ness, Todd M. Gibson, Sheri L. Spunt, Mehmet Fatih Okcu, Wendy M. Leisenring, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Krull
Summary: This study examined the long-term neurocognitive outcomes of survivors of childhood osteosarcoma and Ewing sarcoma. The results showed that these survivors are more likely to report neurocognitive difficulties, which are related to employment status and chronic health conditions. Therefore, early screening, prevention, and treatment of chronic health conditions may be important for improving/preventing long-term neurocognitive outcomes.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Maryann Calligan, Lauren Chakkalackal, Grace Dadzie, Cassandra Tardif-Theriault, Sadie Cook, Emily Vettese, Dilip Soman, Susan Kuczynski, Tal Schechter, L. Lee Dupuis, Lillian Sung
Summary: The objective of this study was to determine the feasibility of three times weekly symptom reporting by pediatric cancer patients for eight weeks. English-speaking patients aged 8-18 with cancer were included in the study. The results showed that three times weekly symptom reporting was feasible for pediatric cancer patients and mechanisms to enhance symptom reporting were identified.
Article
Oncology
Thomas Lehrnbecher, Paula D. Robinson, Roland A. Ammann, Brian Fisher, Priya Patel, Robert Phillips, Melissa P. Beauchemin, Fabianne Carlesse, Elio Castagnola, Bonnie L. Davis, Caitlin W. Elgarten, Andreas H. Groll, Gabrielle M. Haeusler, Christa Koenig, Maria E. Santolaya, Wim J. E. Tissing, Joshua Wolf, Sarah Alexander, Helen Hu, L. Lee Dupuis, Lillian Sung
Summary: This article aims to update a clinical practice guideline for the management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients. The guideline panel reviewed new randomized controlled trials and classified the evidence quality. Changes were made based on the latest evidence.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Hematology
Carolin Escherich, Wenan Chen, Satoshi Miyamoto, Yui Namikawa, Wenjian Yang, David T. Teachey, Zhenhua Li, Elizabeth A. Raetz, Eric Larsen, Meenakshi Devidas, Paul L. Martin, Gang Wu, Ching-Hon Pui, Stephen P. Hunger, Mignon L. Loh, Masatoshi Takagi, Jun J. Yang
Article
Hematology
Zhenhua Li, Ti-Cheng Chang, Jacob J. Junco, Meenakshi Devidas, Yizhen Li, Wenjian Yang, Xin Huang, Dale J. Hedges, Zhongshan Cheng, Mary Shago, Andrew J. Carroll, Nyla A. Heerema, Julie Gastier-Foster, Brent L. Wood, Michael J. Borowitz, Lauren Sanclemente, Elizabeth A. Raetz, Stephen P. Hunger, Eleanor Feingold, Tracie C. Rosser, Stephanie L. Sherman, Mignon L. Loh, Charles G. Mullighan, Jiyang Yu, Gang Wu, Philip J. Lupo, Karen R. Rabin, Jun J. Yang
Summary: This study investigates the genomics of Down syndrome-related acute lymphoblastic leukemia (DS-ALL) and identifies 15 molecular subtypes, as well as abnormal activation of key genes. It also reveals the common occurrence of somatic genomic abnormalities mediated by gene rearrangements in DS-ALL and the association between subtype heterogeneity and prognosis. These findings provide important insights into the biology of DS-ALL and offer opportunities for individualized treatment.
Article
Oncology
Emily Vettese, Farha Sherani, Allison A. King, Lolie Yu, Catherine Aftandilian, Christina Baggott, Vibhuti Agarwal, Ramamoorthy Nagasubramanian, Kara M. Kelly, David R. Freyer, Etan Orgel, Scott M. Bradfield, Wade Kyono, Michael Roth, Lisa M. Klesges, Melissa Beauchemin, Allison Grimes, George Tomlinson, L. Lee Dupuis, Lillian Sung
Summary: The study aimed to describe the adaptation process and specific adaptation decisions related to symptom management care pathways based on clinical practice guidelines. The findings showed that most care pathways were adopted or adapted. The adaptation process was accomplished over a relatively short timeframe. Future research should focus on evaluating care pathway compliance and determining the impact of care pathway-consistent care on patient outcomes.
Article
Pediatrics
Azgar Abdul Rasheed, Shuvadeep Ganguly, Deepam Pushpam, Ashwati S. Pillai, Anu Theresa Joison, Priya Sharma, Swetambri Sharma, L. Lee Dupuis, Sameer Bakhshi
Summary: The Pediatric Nausea Assessment Tool (PeNAT) was translated into Hindi and validated in Indian pediatric cancer patients and survivors. The PeNAT-Hindi showed good reliability and acceptable validity, making it suitable for measuring nausea among Hindi-speaking children. Further evaluation is needed to assess the responsiveness of PeNAT-Hindi to changes in nausea severity.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Oncology
Priya Patel, Paula D. Robinson, Robert Phillips, Christina Baggott, Katie Devine, Paul Gibson, Gregory M. T. Guilcher, Mark T. Holdsworth, Eloise Neumann, Andrea D. Orsey, Daniela Spinelli, Jennifer Thackray, Marianne van de Wetering, Sandra Cabral, Lillian Sung, L. Lee Dupuis
Summary: This clinical practice guideline update provides recommendations for treating breakthrough chemotherapy-induced nausea and vomiting (CINV) and preventing refractory CINV in pediatric patients. Two systematic reviews of randomized controlled trials in adult and pediatric patients informed the recommendations. In patients with breakthrough CINV, escalation of antiemetic agents to those recommended for chemotherapy of the next higher level of emetogenic risk is strongly recommended. A similar recommendation to escalate therapy is made to prevent refractory CINV in patients who did not experience complete breakthrough CINV control and are receiving minimally or low emetogenic chemotherapy. A strong recommendation to use antiemetic agents that controlled breakthrough CINV for the prevention of refractory CINV is also made.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Multidisciplinary Sciences
Nancy Santesso, Melissa Beauchemin, Paula D. Robinson, Alexandra M. Walsh, Aaron J. Sugalski, Tammy Lo, Ha Dang, Brian T. Fisher, Allison C. Grimes, Andrea Rothfus Wrightson, Lolie C. Yu, Lillian Sung, L. Lee Dupuis
Summary: This study aimed to develop a summary format of clinical practice guideline recommendations to improve understandability among healthcare professionals. Through iterative interviews, a straightforward format with clear headings, rationale, supporting evidence, and related factors was created.
Article
Health Care Sciences & Services
Deborah Tomlinson, Lauren Chakkalackal, Maryann Calligan, Cassandra Tardif-Theriault, Susan Kuczynski, Tal Schechter, Emily Vettese, George A. Tomlinson, L. Lee Dupuis, Lillian Sung
Summary: This study aimed to determine the relationship between prevalence of symptom documentation and intervention provision, and increasing severity of bothersome symptoms, as identified by guardians using guardian-reported proxy-SSPedi. The results showed that documentation and intervention were more common for some symptoms with increasing severity of bother, but intervention was not more common with increasing severity of bother for fatigue, changes in hunger, and anger.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Oncology
Susan K. P. Parsons, Melissa P. Beauchemin, Lee Dupuis, Aaron Sugalski, Julie Anna J. Wolfson, Sheila J. G. Santacroce, Jordan G. Marchak, Lillian E. Sung, Michael E. Roth, COG Canc Care Delivery Res Comm
Summary: The National Cancer Institute (NCI) has a long history of promoting community oncology sites' participation in clinical trials research and clinical care. In 2014, the NCI re-organized to establish the NCI Community Oncology Research Program (NCORP) network, which includes various research bases and community sites. The COG portfolio for Cancer Care Delivery Research (CCDR) focuses on guideline congruence and financial toxicity, aiming to improve the quality and affordability of cancer care. To ensure the success of the program, interdisciplinary investigators and clinicians dedicated to community oncology and the populations they serve will be engaged.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Andrew R. Ostrenga, Jennifer Thackray, Ha-Mill H. M. McLearan, Kevin M. Mulieri, Elizabeth Bisaccia, Olga Militano, L. Lee Dupuis, M. Brooke Bernhardt
Summary: The COG Pharmacy Discipline consists of pharmacists and pharmacy technicians from over 200 COG-member institutions. They play an essential role in designing and carrying out COG clinical trials, including study drug management, access, and direct patient care. The discipline is actively involved in continuing education, research, and growth in areas such as pharmacogenomics and implementation science.
PEDIATRIC BLOOD & CANCER
(2023)
Review
Oncology
Maxime Caru, Amanda Wurz, Jennifer Brunet, Emily D. Barb, Scott C. Adams, Michael E. Roth, Kerri Winters-Stone, Miranda M. Fidler-Benaoudia, Smita Dandekar, Kirsten K. Ness, S. Nicole Culos-Reed, Fiona Schulte, Pooja Rao, David Mizrahi, Maria Chang Swartz, Marlie Smith, Carmina G. Valle, Nina S. Kadan-Lottick, Christina M. Dieli-Conwright, Kathryn H. Schmitz
Summary: This scoping review examined the assessment methodologies for physical activity and physical fitness in studies focusing on adolescents and young adults diagnosed with cancer. Self-reported questionnaires were primarily used for assessing physical activity, while a few studies also conducted physical fitness assessments. The considerable heterogeneity across studies limits the creation of formal recommendations or guidelines for researchers, healthcare providers, and policy makers.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Hematology
Nathan P. Gossai, Meenakshi Devidas, Zhiguo Chen, Brent L. Wood, Patrick A. Zweidler-McKay, Karen R. Rabin, Mignon L. Loh, Elizabeth A. Raetz, Naomi J. Winick, Michael J. Burke, Andrew J. Carroll, Natia Esiashvili, Nyla A. Heerema, William L. Carroll, Stephen P. Hunger, Kimberly P. Dunsmore, Stuart S. Winter, David T. Teachey
Summary: The prognostic significance of CNS leukemic involvement in newly diagnosed T-ALL is not optimistic, and the outcomes are not affected by therapeutic differences or some treatment methods. Further research is needed to improve treatment methods.
Article
Health Care Sciences & Services
Ida Mehrdadi, Neeraj Dhaliwal, Lauren Chakkalackal, Gloria Green, Tal Schechter, Sue Zupanec, L. Lee Dupuis, Lillian Sung
Summary: This study aimed to describe the prevalence of taste changes among newly diagnosed pediatric cancer patients over a 6-month period and identify factors associated with taste changes. The results showed that taste changes were common within 8 weeks of cancer diagnosis but significantly declined over time. Nausea, dry mouth, and recent vincristine were identified as independent risk factors for taste changes.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
