Article
Reproductive Biology
Maho Shimizu, Keitaro Yamanaka, Maho Azumi, Masako Tomimoto, Keiichi Washio, Ryosuke Takahashi, Satoshi Nagamata, Yuka Murata, Yui Yamasaki, Yoshito Terai
Summary: The case presented a patient with SEIC accompanied by serous ovarian carcinoma and lymph node metastasis. The difficulty in identifying the primary lesion was highlighted as both tumors were serous carcinomas. Further development of methods for differentiation between the diseases is needed due to controversial histological diagnostic criteria.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Pathology
Natalie Banet, Maryam Shahi, Denise Batista, Raluca Yonescu, Edward J. Tanner, Amanda N. Fader, Ashley Cimino-Mathews
Summary: HER-2 targeted therapy shows promising results in HER-2-positive uterine serous carcinoma, but evaluating HER-2 status can be challenging due to intratumoral heterogeneity and discordance between IHC and FISH results, highlighting the need for further research and caution in clinical practice.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Basem Fares, Liron Berger, Einav Bangiev-Girsh, Reli Rachel Kakun, Dima Ghannam-Shahbari, Yuval Tabach, Yaniv Zohar, Eyal Gottlieb, Ruth Perets
Summary: PAX8 plays a critical antiapoptotic role in uterine serous papillary carcinoma (USPC) by regulating mutated p53 and p21 expression to promote tumor proliferation. Additionally, a genome-wide transcriptome analysis suggests that metabolism and HIF-1alpha-related pathways may mediate the role of PAX8 in USPC.
Article
Chemistry, Multidisciplinary
Ruth Rodriguez-Barrueco, Jessica Latorre, Laura Devis-Jauregui, Aina Lluch, Nuria Bonifaci, Francisco J. Llobet, Mireia Olivan, Laura Coll-Iglesias, Katja Gassner, Meredith L. Davis, Jose M. Moreno-Navarrete, Anna Castells-Nobau, Laura Plata-Pena, Miki Dalmau-Pastor, Marcus Horing, Gerhard Liebisch, Vesa M. Olkkonen, Maria Arnoriaga-Rodriguez, Wifredo Ricart, Jose M. Fernandez-Real, Jose M. Silva, Francisco J. Ortega, David Llobet-Navas
Summary: The miR-424(322)/503 cluster encoded by H19X regulates multiple cellular functions and is crucial for fat mass expansion. By targeting SNCG, it controls a conserved genetic program involved in white adipocyte differentiation and commitment, allowing adipose tissue enlargement under tight regulation. Decreased miR-424(322) levels in obese individuals lead to increased SNCG expression, a mechanism normalized upon weight loss.
Article
Pathology
Hisham Assem, Douglas Rottmann, Alexander Finkelstein, Minhua Wang, Elena Ratner, Alessandro D. Santin, Natalia Buza, Pei Hui
Summary: This study found that MUSCs confined to endometrial polyps have lower rates of extrauterine disease, lymphovascular invasion, and lymph node metastasis compared to nonpolyp confined tumors. Patients with MUSC confined to polyps also have a better prognosis and lower risk of high-stage disease at presentation.
Article
Oncology
Giorgia Dinoi, Andrea Mariani, Enrica Martinelli, Alessandra Ciucci, Gian Franco Zannoni, Amy L. Weaver, Gary L. Keeney, George Vasmatzis, Panos Z. Anastasiadis, Francesco Fanfani, Giovanni Scambia, Daniela Gallo
Summary: By analyzing protein levels in 36 hysterectomy samples, it was found that CHK1, FBXW7, and PPP2R1B were associated with disease progression and death risk in uterine serous endometrial cancer patients. These findings help identify new clinically relevant biomarkers and potential drug targets.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Igor Govorov, Sanaz Attarha, Larysa Kovalevska, Emil Andersson, Elena Kashuba, Miriam Mints
Summary: The expression of STK4 in endometrial cancer (EC) is associated with patient prognosis, particularly in serous tumors where higher expression is correlated with worse prognosis. The determination of STK4 expression pattern could serve as a potential prognostic marker for serous EC.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Angela C. Nolin, Chunqiao Tian, Chad A. Hamilton, Yovanni Casablanca, Nicholas W. Bateman, John K. Chan, Michele L. Cote, Craig D. Shriver, Matthew A. Powell, Neil T. Phippen, Thomas P. Conrads, G. Larry Maxwell, Kathleen M. Darcy
Summary: This study aims to develop conditional survival and risk-assessment estimates for uterine serous carcinoma (USC) to provide tools for annual survivorship counseling and care planning. The results showed that five-year survival rates increased with higher stages and longer follow-up, while the standardized mortality ratio decreased. Differences in the risk of death were observed between diagnosis and after surviving 5 years.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Biology
Carlo Ronsini, Antonella Reino, Rossella Molitierno, Maria Giovanna Vastarella, Elvira La Mantia, Pasquale De Franciscis
Summary: SEIC is a non-invasive lesion of the endometrial epithelium that is considered a precursor to uterine serous carcinoma (USC). It is aggressive and there is limited understanding of its behavior and prognosis.
Article
Oncology
Chunyan Gu, Chen Lin, Zheng Zhu, Li Hu, Fengxu Wang, Xuehai Wang, Junpu Ruan, Xinyuan Zhao, Sen Huang
Summary: This study explored the role of IFN-gamma-related genes and long non-coding RNAs in endometrial carcinoma, identifying a prognostic signature and demonstrating significant differences in outcomes and immune microenvironment between high-risk and low-risk groups.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Blair Mcnamara, Levent Mutlu, Michelle Greenman, Justin Harold, Alessandro Santin
Summary: Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) are rare and aggressive forms of uterine cancer, with specific mutations that can be targeted by HER2-targeting therapies. This article summarizes the evidence and ongoing clinical trials for these targeted therapies.
Article
Oncology
Jenny-Maria Jonsson, Maria Baath, Ida Bjornheden, Irem Durmaz Sahin, Anna Masback, Ingrid Hedenfalk
Summary: Serous endometrial cancer (SEC) is an aggressive subtype with similarities to high-grade serous ovarian cancer (HGSOC), potentially benefiting from targeted treatments like PARP inhibitors. A study revealed that some SEC patients have homologous recombination repair deficiency, indicating a possible targeted therapy approach.
Article
Radiology, Nuclear Medicine & Medical Imaging
Takayuki Mori, Hiroki Kato, Masaya Kawaguchi, Yuichiro Hatano, Takuma Ishihara, Yoshifumi Noda, Fuminori Hyodo, Masayuki Matsuo, Tatsuro Furui, Ken-ichirou Morishige
Summary: This study aimed to evaluate the MRI findings of different types of endometrial cancer. Serous carcinoma (SC) showed heterogeneous signal with peritoneal dissemination and abnormal ascites, while clear cell carcinoma (CCC) exhibited larger tumor size, higher ADC values, infiltrative growth pattern, heterogeneous signal, and abnormal ascites.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Hui Chen, Lingjun Li, Ping Qin, Hanzhen Xiong, Ruichao Chen, Minfen Zhang, Qingping Jiang
Summary: The study identified a 4-gene signature including KRT23, CXCL1, SOX9, and ABCA10 as a potential prognostic indicator for uterine serous carcinoma, showing superior predictive performance for overall survival and recurrence-free survival.
Article
Oncology
Jaime M. Kiff, Mercedes Williams-Weisenberger, Danielle Spellacy, Bharti Garg, Elizabeth G. Munro, Amanda S. Bruegl
Summary: This study investigated the endometrial stripe thickness in patients with uterine serous carcinoma (USC) and evaluated the current guidelines for postmenopausal bleeding in this type of cancer. The study found that nearly 25% of USC patients had an endometrial stripe thickness less than 4 mm on transvaginal ultrasound, suggesting that using transvaginal ultrasound alone to triage these patients may result in a delay in diagnosis that can impact prognosis.
CANCER CAUSES & CONTROL
(2023)
Review
Oncology
Julian C. Schink, Virginia Filiaci, Helen Q. Huang, John Tidy, Matthew Winter, Jeanne Carter, Nancy Anderson, Katherine Moxley, Akira Yabuno, Sarah E. Taylor, Christina Kushnir, Neil Horowitz, David S. Miller
GYNECOLOGIC ONCOLOGY
(2020)
Article
Oncology
Yanli Ban, Jean V. Fischer, Kruti P. Maniar, Haiyang Guo, Chang Zeng, Yinuo Li, Qing Zhang, Xinkun Wang, Wei Zhang, Serdar E. Bulun, Jian-Jun Wei
FRONTIERS IN ONCOLOGY
(2020)
Letter
Obstetrics & Gynecology
Tia Jackson-Bey, Jose Prime Colina, Brett C. Isenberg, Jonathan Coppeta, Margrit Urbanek, J. Julie Kim, Teresa K. Woodruff, Joanna E. Burdette, Angela Russo
HUMAN REPRODUCTION
(2021)
Article
Oncology
Linda R. Duska, Virginia L. Filiaci, Joan L. Walker, Laura L. Holman, Emily K. Hill, Richard G. Moore, Kari L. Ring, Michael L. Pearl, Carolyn Y. Muller, Christina L. Kushnir, Heather A. Lankes, Megan Samuelson, Kelley S. Carrick, Anand Rajan, William H. Rodgers, Elise C. Kohn, Richard Piekarz, Kimberly K. Leslie
Summary: This study evaluated the short-term effects of MPA alone versus MPA plus entinostat on regulating progesterone receptor in women with newly diagnosed endometrioid endometrial adenocarcinoma. Although no immediate impact on PR was observed with entinostat in this short-term study, combination therapy showed better results in reducing Ki-67 levels. Lessons learned from this trial can help guide future treatment studies.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Oukseub Lee, Maarten C. Bosland, Minhua Wang, Ali Shidfar, Omid Hosseini, Xiaoling Xuei, Priyam Patel, Matthew J. Schipma, Irene Helenowski, J. Julie Kim, Susan E. Clare, Seema A. Khan
Summary: Results show that ulipristal acetate is the most effective among the selective progesterone receptor modulators studied, while mifepristone is ineffective and telapristone acetate is less effective. Ulipristal acetate reduces tumor incidence and delays tumor onset, and also affects gene expression in benign mammary glands.
Article
Oncology
Matthew A. Powell, Virginia L. Filiaci, Martee L. Hensley, Helen Q. Huang, Kathleen N. Moore, Krishnansu S. Tewari, Larry J. Copeland, Angeles A. Secord, David G. Mutch, Alessandro Santin, David P. Warshal, Nick M. Spirtos, Paul A. DiSilvestro, Olga B. Ioffe, David S. Miller
Summary: This phase III randomized trial compared the efficacy of paclitaxel and carboplatin (PC) with paclitaxel and ifosfamide (PI) in the treatment of uterine carcinosarcoma. The results showed that PC was not inferior to PI and should be considered as the standard treatment for uterine carcinosarcoma.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Editorial Material
Biology
J. Julie Kim
Summary: A new laboratory model helps to study the role of senescent cells in fostering a uterine environment that can support an embryo.
Review
Oncology
Mary Towner, J. Julie Kim, Melissa A. Simon, Daniela Matei, Dario Roque
Summary: This review explores the survival rate disparities between black and white women in ovarian, uterine, and cervical cancers, and proposes a theoretical framework to explain how racial differences in experience of preventive strategies, implementation of screening efforts, early detection of symptomatic disease, and appropriate treatment contribute to these disparities.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Kristina W. Thiel, Eric J. Devor, Virginia L. Filiaci, David Mutch, Katherine Moxley, Angeles Alvarez Secord, Krishnansu S. Tewari, Megan E. McDonald, Cara Mathews, Casey Cosgrove, Summer Dewdney, Carol Aghajanian, Megan Samuelson, Heather A. Lankes, Robert A. Soslow, Kimberly K. Leslie
Summary: This study examined the association between p53 immunohistochemistry (IHC) and sequencing, and found that p53 IHC alone or integrated with TP53 sequencing can predict treatment outcomes. It was discovered that bevacizumab combined with chemotherapy is particularly beneficial for improving outcomes in a specific high-risk tumor genotype/phenotype identified by p53 IHC and TP53 sequencing.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Dana B. McQueen, Kruti P. Maniar, Anne Hutchinson, Rafael Confino, Lia Bernardi, Mary Ellen Pavone
Summary: The study aimed to evaluate the prevalence of chronic endometritis in patients with retained pregnancy tissue (RPT) following miscarriage. The results showed a significantly higher prevalence of chronic endometritis in patients with RPT, suggesting that RPT could be a risk factor for this disorder.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Amanda L. Strickland, Kruti P. Maniar, Edward Tanner, Elisheva Shanes, Lawrence Jennings, Jian-Jun Wei
Summary: The pathogenesis and behavior of serous ovarian tumors vary depending on their classification. Low-grade serous carcinoma is associated with borderline tumors, less atypical cytology, and molecular aberrations in the MAPK pathway, while high-grade serous carcinoma is characterized by aggressive behavior, TP53 mutations, and chromosomal instability. We present a case of low-grade serous carcinoma with aggressive behavior and mutations in MAPK genes and SMARCA4 gene, challenging our current understanding of this tumor type and highlighting the need for further research.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Elena Hogenesch, Ronus Hojjati, Jennifer B. Bakkensen, Allison S. Komorowski, Mary Ellen Pavone, Lia A. Bernardi, Kruti P. Maniar
FERTILITY AND STERILITY
(2022)
Article
Oncology
Manish Ranjan, Oukseub Lee, Gannon Cottone, Elnaz Mirzaei Mehrabad, Benjamin T. Spike, Zexian Zeng, Shivangi Yadav, Robert Chatterton, J. Julie Kim, Susan E. Clare, Seema A. Khan
Summary: Research in mouse model shows that exposure to progesterone leads to an increase in mammary stem cells and luminal mature cells, while reducing luminal progenitor cells. However, these effects can be reversed by progesterone receptor antagonists.
BREAST CANCER RESEARCH
(2021)
Meeting Abstract
Medicine, Research & Experimental
David Escobar, Sharlene See, Raven Rodriguez, Jennifer Pincus, Kruti Maniar, Luis Blanco
LABORATORY INVESTIGATION
(2021)