Article
Multidisciplinary Sciences
Saori Tatsuno, Hiroshi Doi, Wataru Okada, Eri Inoue, Kiyoshi Nakamatsu, Masao Tanooka, Masahiro Tanaka, Yasumasa Nishimura
Summary: The risk factors for severe radiation pneumonitis (RP) in patients with lung cancer who undergo rotating gantry intensity-modulated radiation therapy (IMRT) using volumetric modulated arc therapy (VMAT) or helical tomotherapy (HT) are poorly understood. This retrospective study included 52 patients who received rotating gantry IMRT for locally advanced lung cancer. In multivariate analysis, lung V5 >= 40% was associated with grade >= 2 RP, and past medical history of pneumonectomy and total lung volume <= 3260 cc were independently associated with grade >= 3 RP.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Tzu-Hui Pao, Ying-Yuan Chen, Wei-Lun Chang, Jeffrey Shu-Ming Chang, Nai-Jung Chiang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen, Ta-Jung Chung, Forn-Chia Lin
Summary: The study found that T4 and esophageal stenosis at baseline were independent risk factors for esophageal fistula in ESCC patients treated with definitive CCRT with IMRT. Patients who received repair or stenting for esophageal perforation appeared to have a trend towards improved survival.
Article
Oncology
Jing You, Shuchai Zhu, Jiancheng Li, Jie Li, Junyue Shen, Yidian Zhao, Xiaomin Li, Lin Jia, Qingshan Li, Jun Yang, Yiqun Wu, Wenbin Shen, Haishan Wu, Xueqin Wu, Xiaomin Wang, Yaqiong Ren, Jun He, Pingping Lin, Guangying Zhu, Anhui Shi
Summary: This study aimed to investigate whether a high dose of 59.4 Gy using intensity-modulated radiation therapy (IMRT) would improve survival without increasing toxicities in patients with esophageal cancer. The results showed that a high dose of radiation did not improve survival compared to the standard dose in patients with inoperable thoracic esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Hiroyasu Tamamura, Kenkei Hasatani, Sae Matsumoto, Satoko Asahi, Hitoshi Tatebe, Yoshitaka Sato, Keiichiro Matsusita, Yuji Tameshige, Yoshikazu Maeda, Makoto Sasaki, Shigeyuki Takamatsu, Kazutaka Yamamoto
Summary: Early-stage esophageal cancer with extensive lymph node metastasis requires elective nodal irradiation for chemoradiotherapy. Determining the appropriate dose for prophylactic irradiation is important. This study found that a dose of 36 Gy was effective in preventing lymph node metastasis and reducing adverse events.
Article
Oncology
Christopher Nutting, Laura Finneran, Justin Roe, Mark A. Sydenham, Matthew Beasley, Shree Bhide, Cheng Boon, Audrey Cook, Emma De Winton, Marie Emson, Bernadette Foran, Robert Frogley, Imran Petkar, Laura Pettit, Keith Rooney, Tom Roques, Devraj Srinivasan, Justine Tyler, DARS Trialist Grp
Summary: The study found that dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) improved swallowing function and reduced radiation dose-related damage in patients with oropharyngeal and hypopharyngeal cancers. Therefore, DO-IMRT should be considered as a new standard treatment for patients receiving radiotherapy for pharyngeal cancers.
Article
Oncology
Toshihiko Masui, Kazuyuki Nagai, Takayuki Anazawa, Yosuke Kasai, Akitada Yogo, Michio Yoshimura, Takashi Mizowaki, Norimitsu Uza, Akihisa Fukuda, Shigemi Matsumoto, Masashi Kanai, Hiroyoshi Isoda, Yoshiya Kawaguchi, Shinji Uemoto, Etsuro Hatano
Summary: This study evaluated the safety and efficacy of hypofractionated intensity-modulated radiation therapy (IMRT) as neoadjuvant therapy for resectable pancreatic cancer. The results showed that hypofractionated IMRT can safely guide surgical treatment for pancreatic cancer and prolong overall survival for patients.
Article
Biochemistry & Molecular Biology
Wing-Keen Yap, Ming-Chieh Shih, Yu-Chen Chang, Chia-Hsin Lin, Shih-Ming Huang, Tsung-You Tsai, Ching-Fu Chang, Chih-Chung Hsu, Chen-Kan Tseng, Miao-Fen Chen, Din-Li Tsan, Chi-Ting Liau, Ming-Mo Hou, Yin-Kai Chao, Chien-Hung Chiu, Tsung-Min Hung
Summary: This study found that adjuvant chemoradiotherapy was associated with improved clinical outcomes in patients with resected esophageal squamous cell carcinoma staged as ypT3/T4 and/or ypN+ after undergoing neoadjuvant chemoradiotherapy.
Review
Otorhinolaryngology
Yongyuan Xue, Guoping Li, Tao Xie, Hongyang Xu, Tianrui Xu, Zhengfei Li, Lixiu Zhu, Xin Li, Zhiyao Li, Wei Xiong
Summary: This study systematically reviewed the significance of concurrent chemoradiotherapy for stage II nasopharyngeal cancer. The results showed that in the era of intensity-modulated radiotherapy, concurrent chemoradiotherapy and radiotherapy alone have the same survival benefits and concurrent chemoradiotherapy increases acute hematological toxicity. Subgroup analysis showed that for people with N1 nasopharyngeal cancer at risk of distant metastases, concurrent chemoradiotherapy and radiotherapy alone also had equal survival benefits.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Maarten C. C. M. Hulshof, Elisabeth D. Geijsen, Tom Rozema, Vera Oppedijk, Jeroen Buijsen, Karen J. Neelis, Joost J. M. E. Nuyttens, Maurice J. C. van der Sangen, Paul M. Jeene, Jannie G. Reinders, Mark I. van Berge Henegouwen, Adriana Thano, Jeanin E. van Hooft, Hanneke W. M. van Laarhoven, Ate van der Gaast
Summary: In definitive chemoradiation for esophageal cancer, escalating radiation dose up to 61.6 Gy to the primary tumor did not significantly improve local tumor control compared to 50.4 Gy. The absence of a dose-effect was observed in both adenocarcinoma and squamous cell carcinoma.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Xin Wang, Wei-Hu Wang, Shu-Lian Wang, Yong-Wen Song, Yue-Ping Liu, Yuan Tang, Ning Li, Wen-Yang Liu, Hui Fang, Ye-Xiong Li, Dong-Bing Zhao, Yihebali Chi, Lin Yang, Jing Jin
Summary: The ACRT protocol in this study showed acceptable safety and efficacy, with a 3-year disease-free survival rate of 66.2% and overall survival rate of 75% in patients with locally advanced gastric cancer who underwent radical gastrectomy and D1/2 LND.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Environmental Sciences
Yu Wang, Tan-Tzu Lo, Lily Wang, Shih-Tien Hsu, Sheau-Feng Hwang, Chien-Hsing Lu, Lou Sun
Summary: The use of intensity-modulated radiotherapy (IMRT) for the treatment of bulky cervical cancer is safe and effective. A retrospective study of 98 patients with cervical cancer who completed IMRT and point A-based brachytherapy showed a median follow-up time of 6.84 years, with a 5-year overall survival rate of 66.33% and disease-free survival rate of 75.12%. The rates of local recurrence and overall efficacy were comparable to other studies involving traditional pelvic external beam radiation therapy with concurrent chemotherapy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
David Paul Peschel, Mathias Duesberg, Jan C. Peeken, Jan Christian Kaiser, Kai Joachim Borm, Katharina Sommer, Stephanie E. Combs, Stefan Muench
Summary: This dosimetric study evaluated the extent of incidental nodal irradiation in patients with esophageal squamous cell carcinoma undergoing definitive chemoradiotherapy. The results showed that volumetric-modulated arc therapy was associated with significantly lower doses to regional lymph node areas compared to three-dimensional conformal radiotherapy.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Lei Xu, Xian-kai Chen, Hou-nai Xie, Zhen Wang, Jian-jun Qin, Yin Li
Summary: The optimal treatment strategy for resectable cervical esophageal cancer varies according to disease stage. Surgery alone improves long-term survival for patients with localized disease, while surgery-based multimodal therapy increases survival rate for patients with regional disease.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Jun Hong, Ji-Hua Han, Hong-Lei Luo, Ya-Qi Song
Summary: The study found that the 0.5 and 1.0 cm MSW groups had better dosimetric parameters and plan quality, but the 0.5 cm group had poorer delivery accuracy and efficiency.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Dan Li, Xiaoxiao Liu, Yuchen Wang, Yingying Jin, Fang Li, Hongbing Ma
Summary: The aim of this study was to discuss the treatment mode of radical radiotherapy for elderly patients with esophageal cancer. Clinical data from 136 elderly patients who received radical intensity-modulated radiotherapy were analyzed. Cox regression analysis showed that ECOG score, basic diseases, T stage, radiation dose, radiation injury, and chemotherapy were prognostic factors for elderly patients. The study found that oral drugs and high-dose involved field irradiation exhibited better curative effects and safety for elderly patients with inoperable esophageal cancer.
BIOMOLECULES AND BIOMEDICINE
(2023)