Article
Oncology
Jing Zhang, Zhimin Hu, Calista A. Horta, Jing Yang
Summary: Epithelial-mesenchymal transition (EMT) is involved in various aspects of tumor development. The tumor microenvironment, consisting of different stroma cells and biochemical factors, influences the EMT program and tumor progression. This review explores the effects of tumor microenvironmental signals on EMT regulation, discusses the molecular mechanisms of EMT in therapy resistance, and proposes new therapeutic approaches targeting the tumor microenvironment to impact EMT and tumor progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Article
Multidisciplinary Sciences
Shunhao Wang, Jingchao Li, Mei Chen, Liting Ren, Wenya Feng, Lining Xu, Xiaolan Chen, Tian Xia, Nanfeng Zheng, Sijin Liu
Summary: Palladium nanoplates inhibit lung metastasis by suppressing EMT signaling in breast cancer cells and interacting with TGF-beta proteins, leading to reduced downstream signaling activation. NIR irradiation enhances the inhibitory effects of PdPL on both primary tumors and metastasis.
NATIONAL SCIENCE REVIEW
(2021)
Article
Oncology
Pelin Balcik-Ercin, Laure Cayrefourcq, Rama Soundararajan, Sendurai A. Mani, Catherine Alix-Panabieres
Summary: Metastasis is a complex and not fully understood process in cancer, where circulating tumor cells (CTCs) play a crucial role. CTCs possess a unique ability to transition between epithelial and mesenchymal states, known as epithelial-to-mesenchymal plasticity (EMP), which aids in their metastatic potential. This study focuses on the EMP phenotype of colon CTC lines, showing that these cells have minimal mesenchymal features but exhibit an increase in mesenchymal-epithelial transition (MET) markers, suggesting a quick reversion to the epithelial state for successful metastasis.
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Cell Biology
Adriana Carneiro, Paulina Piairo, Alexandra Teixeira, Dylan Ferreira, Sofia Cotton, Carolina Rodrigues, Alexandre Chicharo, Sara Abalde-Cela, Lucio Lara Santos, Luis Lima, Lorena Dieguez
Summary: Gastrointestinal cancers, such as colorectal cancer and gastric cancer, have high morbidity rates worldwide. Epithelial-to-mesenchymal transition (EMT) in cancer promotes the formation of circulating tumor cells (CTCs), which are important for cancer diagnosis and monitoring. However, current CTC isolation approaches are not ideal for capturing EMT or mesenchymal CTCs.
Review
Oncology
Qiang Zhao, Bingbing Li, Qi Gao, Yang Luo, Liang Ming
Summary: This meta-analysis investigated the prognostic role of EMT-CTCs in patients with breast cancer, revealing that EMT-CTCs were associated with poorer survival outcomes in breast cancer patients. Subgroup analysis showed the association of EMT-CTCs with various factors such as cancer stage, identification method, and sampling volume.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jiazhang Wei, Weiming Deng, Jingjin Weng, Min Li, Guiping Lan, Xiang Li, Linsong Ye, Yongli Wang, Fei Liu, Huashuang Ou, Yunzhong Wei, Wenlin Huang, Sifang Xie, Guohu Dong, Shenhong Qu
Summary: CTC classification allows for a better understanding of cellular phenotypic changes responsible for locoregional invasion and distant metastasis in nasopharyngeal carcinoma (NPC), and predicts clinical outcomes in patients with progressive NPC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jingnan Zhang, Ze Zhang, Zhenlin Huang, Manlin Li, Fan Yang, Zeqi Wu, Qian Guo, Xiyu Mei, Bin Lu, Changhong Wang, Zhengtao Wang, Lili Ji
Summary: This study reported that a natural compound isotoosendanin (ITSN) reduced TNBC metastasis by inhibiting TGF-P-induced EMT and the formation of invadopodia. ITSN can directly interact with TGF-P receptor type-1 (TGFPR1) and abrogated the kinase activity of TGFPR1, thereby blocking the TGF-P-initiated downstream signaling pathway. Moreover, ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1 (PD-L1) antibody for TNBC in vivo via inhibiting the TGF-P-mediated EMT in the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Oncology
Jingwen Jiang, Jiayu Li, Xiumei Zhou, Xueqin Zhao, Biao Huang, Yuan Qin
Summary: Exosomes play an important role in intercellular communication and can regulate the EMT process in tumor cells. They have potential applications in cancer diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Tong Zhu, Xiaoming Zou, Chunfa Yang, Liangliang Li, Bing Wang, Rong Li, Hongxuan Li, Zhangxuan Xu, Di Huang, Qingyun Wu
Summary: Neutrophil extracellular traps (NETs) in gastric cancer (GC) are associated with tumor progression, metastasis risk, and tumor microenvironment. The study found that NETs formation is affected by the tumor microenvironment and may exacerbate GC progression through promoting epithelial-mesenchymal transition (EMT). Hence, targeting NETs may be therapeutically beneficial in GC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Immunology
Junquan Song, Rongyuan Wei, Shiying Huo, Jianpeng Gao, Xiaowen Liu
Summary: Through the analysis of differentially expressed genes between metastatic gastric cancer and primary gastric cancer, a metastasis-related epithelial-mesenchymal transition signature (MEMTS) was constructed. High MEMTS indicates a poor prognosis in patients with gastric cancer, and patients with low MEMTS may benefit more from adjuvant chemoradiotherapy. MEMTS reliably predicts the response to immunotherapy in gastric cancer and is significantly associated with cancer-associated fibroblasts and stromal score in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Nicholas S. Mastronikolis, Efthymios Kyrodimos, Despoina Spyropoulou, Alexander Delides, Evangelos Giotakis, Zoi Piperigkou, Nikos K. Karamanos
Summary: Exosomes are nanosized vesicles produced by cells that play important roles in head and neck cancer development and metastasis by altering signaling pathways in recipient cells through the cargoes they carry. This article focuses on exosome biogenesis, their cargoes, and their involvement in epithelial-to-mesenchymal transition (EMT) induction and metastasis in head and neck cancer. It also discusses the key role of exosomes in extracellular matrix remodeling and degradation, and their potential as diagnostic and therapeutic tools.
Review
Oncology
Benedikt Heitmeir, Miriam Deniz, Wolfgang Janni, Brigitte Rack, Fabienne Schochter, Lisa Wiesmueller
Summary: This review summarizes published information on regulatory circuits relevant to the design of biomarkers reflecting CTC functions, aiming to monitor therapeutic responses and detect evolving chemoresistance mechanisms in real-time.
Article
Biochemical Research Methods
Marco Ruscone, Arnau Montagud, Philippe Chavrier, Olivier Destaing, Isabelle Bonnet, Andrei Zinovyev, Emmanuel Barillot, Vincent Noël, Laurence Calzone
Summary: In this study, a multiscale model is used to investigate the invasion process of tumor cells. The model combines agent-based modeling and continuous time Markov processes applied on Boolean network models. By considering both spatial information from the agent-based simulation and intracellular regulation from the Boolean model, the model aims to study different modes of cell migration and predict means to block it. The multiscale model successfully reproduces single and collective migration processes and is validated on published experiments on cell invasion, suggesting possible targets to block invasive tumor phenotypes through in silico experiments.
Article
Oncology
Yu-Chen Tang, Yan Zhang, Jin Zhou, Qiaoming Zhi, Meng-Yao Wu, Fei-Ran Gong, Meng Shen, Lu Liu, Min Tao, Bairong Shen, Dong-Mei Gu, Jie Yu, Meng-Dan Xu, Yuan Gao, Wei Li
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Oncology
Meng-Dan Xu, Lu Liu, Meng-Yao Wu, Min Jiang, Liu-Mei Shou, Wen-Jie Wang, Jing Wu, Yan Zhang, Fei-Ran Gong, Kai Chen, Min Tao, Qiaoming Zhi, Wei Li
Article
Oncology
Lian Lian, Xiang-Li Li, Meng-Dan Xu, Xian-Min Li, Meng-Yao Wu, Yan Zhang, Min Tao, Wei Li, Xiao-Ming Shen, Chong Zhou, Min Jiang
Article
Pharmacology & Pharmacy
Wen-Jie Wang, Ying Li, Jie Zhu, Min-jie Gao, Jian-ping Shi, Yue-qing Huang
Article
Immunology
Congqing Wu, Wei Lu, Yan Zhang, Guoying Zhang, Xuyan Shi, Yohei Hisada, Steven P. Grover, Xinyi Zhang, Lan Li, Binggang Xiang, Jumei Shi, Xiang-An Li, Alan Daugherty, Susan S. Smyth, Daniel Kirchhofer, Toshihiko Shiroishi, Feng Shao, Nigel Mackman, Yinan Wei, Zhenyu Li
Article
Oncology
Yi-Hang Yuan, Jian Zhou, Yan Zhang, Meng-Dan Xu, Jing Wu, Wei Li, Meng-Yao Wu, Dao-Ming Li
Article
Gastroenterology & Hepatology
Rui Ren, Jie Yu, Yan Zhang, Sheng-M Wang, Xia Guo, Meng Shen, Meng-Dan Xu, Min Jiang, Qiaoming Zhi, Kai Chen, Min Tao, Meng-Yao Wu, Dong-Mei Gu, Wei Li
Review
Medicine, General & Internal
Chen Dai, Yan Zhang, Hao Ni, Yuting Kuang, Zhihua Xu
POSTGRADUATE MEDICAL JOURNAL
(2020)
Article
Oncology
Chen Dai, Yan Zhang, Zhihua Xu, Mengxian Jin
CANCER CELL INTERNATIONAL
(2020)
Article
Hematology
Yan Zhang, Jian Cui, Guoying Zhang, Congqing Wu, Ahmed Abdel-Latif, Susan S. Smyth, Toshihiko Shiroishi, Nigel Mackman, Yinan Wei, Min Tao, Zhenyu Li
Summary: The crosstalk between coagulation and innate immunity contributes to the progression of many diseases, and the activation of inflammasome and pyroptosis play important roles in the development of venous thrombosis. Deficiency of caspase-1 or GSDMD may protect against venous thrombosis, and tissue factor released from pyroptotic monocytes and macrophages triggers thrombosis.
Review
Biochemistry & Molecular Biology
Yinan Wei, Ling Yang, Ankit Pandeya, Jian Cui, Yan Zhang, Zhenyu Li
Summary: Programmed cell death involves cells actively participating in their own destruction. It can be categorized into pro-inflammatory and non-inflammatory types, with pyroptosis being a pro-inflammatory form. Pyroptosis releases cytokines upon cell death, triggering responses from neighboring cells. It can have both beneficial and detrimental effects in inflammatory disorders and diseases, often resulting in tissue damage. This review focuses on the inflammatory response and tissue damage caused by pyroptosis in selected organs.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Zhang, Congqing Wu, Lan Li, Ankit Pandeya, Guoying Zhang, Jian Cui, Daniel Kirchhofer, Jeremy P. Wood, Susan S. Smyth, Yinan Wei, Zhenyu Li
Summary: Histones can trigger coagulation activation, and lytic cell death is a novel mechanism of histone-induced coagulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Ankit Pandeya, Yan Zhang, Jian Cui, Ling Yang, Jeffery Li, Guoying Zhang, Congqing Wu, Zhenyu Li, Yinan Wei
Summary: Inflammasome activation is crucial in defending against bacterial infection. In this study, we discovered that inflammasome activation plays a critical role in the pathogenesis of Salmonella systemic infection. Deficiency of caspase-1 or gasdermin-D prolonged survival, reduced proinflammatory cytokine concentrations, and protected against coagulopathy during Salmonella infection. The activation of NAIP/NLRC4 inflammasome and SPI1 was found to trigger Salmonella-induced coagulopathy, while the caspase-11/NLRP3 pathway was also involved.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Hematology
Binggang Xiang, Guoying Zhang, Yan Zhang, Congqing Wu, Smita Joshi, Andrew J. Morris, Jerry Ware, Susan S. Smyth, Sidney W. Whiteheart, Zhenyu Li
Summary: The rapid clearance of cold-stored platelets is mainly due to integrin activation and apoptosis. Pretreatment of platelets with the cell impermeable calcium ion chelator EGTA prolongs their circulation and significantly reduces bleeding time and blood loss in mice.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)