Article
Plant Sciences
Xingwei Wang, Yanfei Hu, Wei Wang
Summary: This study compares the circadian characteristics of Arabidopsis and soybean, revealing notable differences and contrasting biological activities under circadian regulation.
Article
Pharmacology & Pharmacy
Kotomi Miura, Jun-ichi Morishige, Jotaro Abe, Pingping Xu, Yifan Shi, Zheng Jing, Naoto Nagata, Ryo Miyazaki, Naoki Sakane, Michihiro Mieda, Masanori Ono, Yoshiko Maida, Tomoko Fujiwara, Hiroshi Fujiwara, Hitoshi Ando
Summary: The study demonstrates that Imeglimin profoundly affects the circadian clock in mouse embryonic fibroblasts (MEFs), prolonging the period and increasing the amplitude of the rhythm. Metformin, on the other hand, has minimal effects on these parameters. Imeglimin also impacts the rhythmic mRNA expression of clock genes. Further research is needed to evaluate the effects of Imeglimin treatment in vivo.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Review
Plant Sciences
Luis Cervela-Cardona, Benjamin Alary, Paloma Mas
Summary: A fundamental principle shared by all organisms is the conversion of nutrients into energy, requiring precise spatiotemporal programming. Cellular metabolism can adapt to external time, relying on the circadian clock. The circadian clock plays a prevalent role in controlling the timing of mitochondrial activity and cellular energy in Arabidopsis thaliana, with evidence showing metabolic signals can feedback to the clock.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Jun Hyeok Kim, Laura J. Bell, Xiao Wang, Rinuckshi Wimalasekera, Hugo P. Bastos, Krystyna A. Kelly, Matthew A. Hannah, Alex A. R. Webb
Summary: Our study found that PARPs and sirtuins do not regulate the circadian oscillator in Arabidopsis, but sirtuin 1 is associated with daytime regulation of gene expression.
PLANT CELL AND ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Hang Zhao, Di Xu, Tian Tian, Fanying Kong, Ke Lin, Shuo Gan, Haisen Zhang, Gang Li
Summary: ELF3 and ELF4 are key negative regulators in plant circadian clock control, forming complexes to repress the transcription of multiple clock-related genes, affecting growth and flowering. They are also involved in thermomorphogenesis and shade responses, and form complexes with other proteins for transcriptional repression.
Article
Plant Sciences
Takahiro N. Uehara, Saori Takao, Hiromi Matsuo, Ami N. Saito, Eisuke Ota, Azusa Ono, Kenichiro Itami, Toshinori Kinoshita, Takafumi Yamashino, Junichiro Yamaguchi, Norihito Nakamichi
Summary: A novel synthetic small molecule called TU-892 has been found to affect the amount of PRR7 protein, leading to lengthening of the circadian clock period in plants. The study showed that TU-892 treatment upregulates the expression of CCA1 gene and reduces the amount of PRR7 protein. This novel clock modulator provides new tools and avenues for studying the circadian clock in plants.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Alicja B. Kunkowska, Fabrizia Fontana, Federico Betti, Raphael Soeur, Gerold J. M. Beckers, Christian Meyer, Geert De Jaeger, Daan A. Weits, Elena Loreti, Pierdomenico Perata
Summary: Plants respond to oxygen deprivation by activating a set of hypoxia-responsive genes through a group of transcription factors. However, the activity of these factors is greatly reduced when the plant has limited sugar reserves, suggesting the involvement of another sensing pathway related to energy availability. The energy sensor target of rapamycin (TOR) is responsible for the oxygen sensing in plants, and its inhibition leads to a lower induction of hypoxia-responsive genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Plant Sciences
Yongtao Yu, Sergi Portoles, Yi Ren, Guangyu Sun, Xiao-Fang Wang, Huihui Zhang, Shaogui Guo
Summary: The F-box protein ZEITLUPE (ZTL) negatively regulates ABA signaling in Arabidopsis thaliana during early seedling growth and stomatal closure induced by ABA. ZTL interacts with and ubiquitinates its substrate CHLH/ABAR to modulate CHLH stability. ABA induces ZTL phosphorylation and CHLH degradation, suggesting a reciprocal regulation mechanism between ABA signaling and the circadian clock.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Endocrinology & Metabolism
Olga Barca-Mayo, Miguel Lopez
Summary: The endogenous timekeeping system anticipates the time of the day through the 24-hour cycle of the Earth's rotation. The circadian clock in mammals regulates rhythmic physiological and behavioral processes, including glucose metabolism, food intake, and insulin sensitivity. Changes in the circadian cycle have been strongly associated with metabolic diseases like obesity and type 2 diabetes in humans and rodents.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Plant Sciences
Reynel Urrea-Castellanos, Camila Caldana, Rossana Henriques
Summary: Plants integrate external cues and metabolic signals to coordinate the activity of the TOR signalling pathway and adjust growth accordingly. The TOR pathway plays a crucial role in integrating environmental signals and metabolic processes to regulate plant growth and development.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Letter
Plant Sciences
James Ronald, Anthony J. Wilkinson, Seth J. Davis
Summary: The sub-nuclear localization of EARLY FLOWERING3 gene responds to changes in ambient temperature.
Review
Cell Biology
Daniel C. Levine, Kathryn M. Ramsey, Joseph Bass
Summary: Intrinsic circadian clocks regulate daily anticipation of light/dark cycles and energy storage/utilization cycles. Disruption of the core clock can contribute to disease. Peripheral clocks can be influenced by metabolic cues. NAD(P)(H) nucleotides and NAD+-dependent sirtuin deacetylases play a key role in integrating circadian and metabolic cycles.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Titouan Bonnot, Dawn H. Nagel
Summary: Plants regulate their transcriptome in response to heat stress by modulating gene expression through the circadian clock, highlighting potential regulatory nodes for improving heat stress tolerance.
Article
Multidisciplinary Sciences
Yasuhiro Umemura, Nobuya Koike, Yoshiki Tsuchiya, Hitomi Watanabe, Gen Kondoh, Ryoichiro Kageyama, Kazuhiro Yagita
Summary: Circadian clocks are suppressed during early embryonic stages and pluripotent stem cells in mammals, but gradually emerge during ontogenesis. The expression of CLOCK/BMAL1 affects the oscillation of the segmentation clock, which controls somitogenesis in the early developmental stage.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Jan-Frieder Harmsen, Michel van Weeghel, Rex Parsons, Georges E. Janssens, Jakob Wefers, Dirk van Moorsel, Jan Hansen, Joris Hoeks, Matthijs K. C. Hesselink, Riekelt H. Houtkooper, Patrick Schrauwen
Summary: This study investigates the 24-hour muscle metabolome in young, healthy men and older, metabolically compromised men. The results show that metabolites involved in glycolysis and hexosamine biosynthesis are increased in the metabolically compromised men, while metabolites related to glutamine-alpha-ketoglutarate, ketone, and redox metabolism are decreased. The findings suggest a plasticity of the skeletal muscle metabolome over the 24-hour period and significant differences between healthy and metabolically compromised individuals.
Review
Plant Sciences
Elias Feitosa-Araujo, Paula da Fonseca-Pereira, Lena S. Knorr, Markus Schwarzlaender, Adriano Nunes-Nesi
Summary: NAD is a ubiquitous metabolic coenzyme that plays a critical role in plant metabolism. Recent evidence suggests that NAD also functions in signaling and regulation, with a specific association with the plant stress hormone ABA. This relationship cannot be explained by pleiotropic interference, and further study is needed to dissect the interaction mechanisms.
TRENDS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kim C. Heimsch, Christoph G. W. Gertzen, Anna Katharina Schuh, Thomas Nietzel, Stefan Rahlfs, Jude M. Przyborski, Holger Gohlke, Markus Schwarzlaender, Katja Becker, Karin Fritz-Wolf
Summary: This study describes an improved redox biosensor, sfroGFP2, which can be used to measure oxidative effects within small cells. sfroGFP2 exhibits improved fluorescence intensity and structural stability, making it of significant interest for studying oxidative processes in small cells such as Plasmodium.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Plant Sciences
Jay Jethva, Sophie Lichtenauer, Romy Schmidt-Schippers, Anja Steffen-Heins, Gernot Poschet, Markus Wirtz, Joost T. van Dongen, Juergen Eirich, Iris Finkemeier, Wolfgang Bilger, Markus Schwarzlaender, Margret Sauter
Summary: Submergence stress is a growing problem for global agriculture, and the cellular mechanisms for reoxygenation stress management are not fully understood. Our study on Arabidopsis revealed that alternative NADH dehydrogenases (NDs) play a crucial role in the management of anoxia-reoxygenation stress.
Article
Biochemistry & Molecular Biology
Yuhan Hao, Zexian Zeng, Xiaolin Zhang, Dixiang Xie, Xu Li, Libang Ma, Muqing Liu, Hongtao Liu
Summary: Using a pure green light source, this study found that green light promotes hypocotyl elongation in Arabidopsis thaliana and other plants by activating the brassinosteroid signaling pathway. This discovery is important for understanding the physiological response of plants to green light and their adaptation to a green-light-dominant environment.
Article
Plant Sciences
Taotao Wang, Wenbin Ye, Jiaxiang Zhang, Han Li, Weike Zeng, Sheng Zhu, Guoli Ji, Xiaohui Wu, Liuyin Ma
Summary: High-salt stress induces global alternative polyadenylation (APA) dynamics in Spartina alterniflora, leading to 3'UTR lengthening of transcripts and increased protein synthesis. These alternative 3'UTRs are mainly enriched in salt stress-related ion transporters, such as SaHKT1. Regulatory AU-rich elements in alternative 3'UTRs enhance the protein level of SaHKT1, and the biogenesis of 3'UTR lengthening in SaHKT1 is controlled by SaCPSF30. Over-expression of SaHKT1 with an alternative 3'UTR in rice protoplasts promotes the mRNA accumulation of salt-tolerance genes.
Article
Multidisciplinary Sciences
Florian Grziwotz, Chun -Wei Chang, Vasilis Dakos, Egbert H. van Nes, Markus Schwarzlaender, Oliver Kamps, Martin Hessler, Isao T. Tokuda, Arndt Telschow, Chih-hao Hsieh
Summary: Critical transitions occur in various real-world systems and forecasting their occurrence is of great interest. This study introduces a powerful early warning signal called dynamical eigenvalue (DEV) that estimates the dominant eigenvalue of a system using bifurcation theory. The efficacy of the DEV approach is demonstrated in model systems with known bifurcation types and tested on various critical transitions in real-world systems.
Article
Plant Sciences
Yong Yang, Yanan Guo, Ziyuan Yin, Han Li, Weike Zeng, Jiaxiang Zhang, Liuyin Ma
Summary: In this study, it was found that sacred lotus Cryptochrome 1a (NnCRY1a) regulates photomorphogenesis in a blue light-dependent manner. NnCRY1a showed a dynamic tissue expression pattern and interacted with AtCOP1 and NnCOP1 to stimulate the accumulation of AtHY5 mRNAs under blue light. The conserved function of CRY1 in blue light-mediated hypocotyl elongation was observed from core eudicot-Arabidopsis to the basal eudicot-sacred lotus.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Plant Sciences
Manuel Balparda, Maroua Bouzid, Maria del Pilar Martinez, Ke Zheng, Markus Schwarzlaender, Veronica G. Maurino
Summary: The flexibility of plant growth, development and stress responses is controlled by signaling cascades and genetic programs, while metabolism executes these programs through selective delivery of building blocks and energy. Photosynthetic carbon fixation is essential for plant metabolism, which is influenced by environmental fluctuations. The regulation of carbon assimilation metabolism requires versatility and rapidity to maintain efficiency. Post-translational modifications (PTMs) have a significant impact on carbon assimilation metabolism, altering protein characteristics and function. The exploitation of PTMs has the potential to control metabolic flux, influence crop yields, modify metabolite composition, optimize stress tolerance, and regulate growth and developmental programs.
Article
Plant Sciences
Valeria F. Lima, Francisco Bruno S. Freire, Silvio A. Candido-Sobrinho, Nicole P. Porto, David B. Medeiros, Alexander Erban, Joachim Kopka, Markus Schwaerzlander, Alisdair R. Fernie, Danilo M. Daloso
Summary: Evidence suggests that guard cells have higher rate of phosphoenolpyruvate carboxylase (PEPc)-mediated dark CO2 assimilation than mesophyll cells. However, it is unknown which metabolic pathways are activated following dark CO2 assimilation in guard cells. Furthermore, it remains unclear how the metabolic fluxes throughout the tricarboxylic acid (TCA) cycle and associated pathways are regulated in illuminated guard cells.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Zhenzhen Zhang, Zhaochen Zhong, Yan Xiong
Summary: Sessile plants have developed internal signaling networks to respond to internal and external cues, allowing them to diagnose spatial and temporal information and make accurate responses. The comprehensive study of nutrient signaling networks can improve crop yield strategies.
Article
Plant Sciences
Jonas Giese, Juergen Eirich, Dirk Walther, Youjun Zhang, Ines Lassowskat, Alisdair R. Fernie, Marlene Elsaesser, Veronica G. Maurino, Markus Schwarzlaender, Iris Finkemeier
Summary: The transition from dark to light in the diurnal cycle causes significant physiological changes in plant metabolism, which require specific modes of regulation. While the activities of key metabolic enzymes regulated by light-dependent post-translational modifications (PTMs) have been extensively studied at the protein level, a comprehensive understanding of the global dynamics of light-dependent PTMs is lacking. In this study, we investigated the changes in the metabolome and proteome in Arabidopsis rosettes in response to light in a time-dependent manner, focusing on phosphorylation, lysine acetylation, and cysteine-based redox switches. Our findings revealed that over 1700 out of more than 24,000 detected PTM sites were altered during the transition from dark to light, with different compartments showing distinct PTM changes at different timepoints.
Correction
Plant Sciences
Taotao Wang, Wenbin Ye, Jiaxiang Zhang, Han Li, Weike Zeng, Sheng Zhu, Guoli Ji, Xiaohui Wu, Liuyin Ma
Article
Plant Sciences
Lea Hembach, Philipp W. Niemeyer, Kerstin Schmitt, Jaccoline M. S. Zegers, Patricia Scholz, Dennis Brandt, Janis J. Dabisch, Oliver Valerius, Gerhard H. Braus, Markus Schwarzlaender, Jan de Vries, Stefan A. Rensing, Till Ischebeck
Summary: The establishment of moss spores is an important milestone in plant evolution. The proteomes of spores, seeds, and young seedlings show functional similarities, but also remarkable differences. There are similarities in terms of desiccation tolerance and lipid droplet proteome composition, but spores lack obvious storage proteins. The pathway for triacylglycerol degradation in moss differs from that in Arabidopsis seeds.
Article
Biochemistry & Molecular Biology
Jose Manuel Ugalde, Isabel Aller, Lika Kudrjasova, Romy R. Schmidt, Michelle Schloesser, Maria Homagk, Philippe Fuchs, Sophie Lichtenauer, Markus Schwarzleander, Stefanie J. Mueller-Schuessele, Andreas J. Meyer
Summary: This study investigates the redox dynamics in the ER lumen by isolating ero1 ero2 mutants and expressing the glutathione redox potential sensor Grx1-roGFP2iL-HDEL in Arabidopsis plants. The results reveal the central role of EROs in maintaining redox homeostasis in the ER lumen.
Article
Biochemistry & Molecular Biology
Philippe Fuchs, Finja Bohle, Sophie Lichtenauer, Jose Manuel Ugalde, Elias Feitosa Araujo, Berivan Mansuroglu, Cristina Ruberti, Stephan Wagner, Stefanie J. Mueller-Schuessele, Andreas J. Meyer, Markus Schwarzlaender
Summary: Redox processes are essential for cellular functions, and mitochondria play a key role in enhancing tolerance to reductive stress. The study on Arabidopsis mutants reveals that mitochondrial respiratory flexibility and retrograde signaling regulate mitochondrial respiratory capacity to aid cells in tolerating thiol-mediated reductive stress.
