Article
Multidisciplinary Sciences
Michael J. Shanahan, Steven W. Cole, Sudharshan Ravi, Justin Chumbley, Wenjia Xu, Cecilia Potente, Brandt Levitt, Julien Bodelet, Allison Aiello, Lauren Gaydosh, Kathleen Mullan Harris
Summary: This study explores the relationship between socioeconomic status and molecular underpinnings of chronic diseases. The results indicate that inequalities in molecular risk factors for chronic diseases can already be observed in individuals in their 30s. These findings provide future directions for understanding how social circumstances influence the human genome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Steven W. Cole, John T. Cacioppo, Stephanie Cacioppo, Kyle Bone, Laura A. Del Rosso, Abigail Spinner, Jesusa M. G. Arevalo, Thomas P. Dizon, John P. Capitanio
Summary: Social isolation during the pandemic can lead to reduction in immune cell populations and down-regulation of antiviral gene expression, but engaging in prosocial behavior may help alleviate some of these impacts.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Public, Environmental & Occupational Health
Julia Klinger, Eva-Maria Berens, Doris Schaeffer
Summary: Social support is an important factor in improving individuals' health literacy and should be addressed in interventions. However, it is necessary to differentiate between age groups. While both young adults and particularly old-old persons face challenges in health information management, young adults can greatly benefit from social support, whereas it has little impact on the low health literacy of old-old persons. Additionally, different challenges in information management steps in different age groups need to be considered when designing health literacy interventions. Therefore, target group-specific services and programs are needed.
Article
Medicine, General & Internal
Botong Shen, Nicolle A. Mode, Nicole Noren Hooten, Natasha L. Pacheco, Ngozi Ezike, Alan B. Zonderman, Michele K. Evans
Summary: This study examined the association between race, poverty status, and DunedinPACE scores, which is a DNA methylation biomarker associated with health issues. The findings suggest that DunedinPACE scores are influenced by race and poverty status, highlighting the importance of considering social determinants of health when measuring accelerated aging.
Review
Biotechnology & Applied Microbiology
Nyarai D. Soko, Sipho Dlamini, Mpiko Ntsekhe, Collet Dandara
Summary: This article evaluates the impact of COVID-19 genetic variations on the spread of the pandemic in Africa and globally, suggesting that genomic variation should be considered an important factor in determining infection and outcomes.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Consuelo Quispe-Haro, Andrzej Pajak, Abdonas Tamosiunas, Nadezda Capkova, Martin Bobak, Hynek Pikhart
Summary: This study found that disadvantaged socioeconomic position (SEP) is associated with impaired lung function in young and late adulthood. However, the role of SEP at different life stages is still not well understood in Central and Eastern Europe.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Joost Oude Groeniger, Tanja A. J. Houweling, Pauline W. Jansen, Nil Horoz, J. Marieke Buil, Pol A. C. van Lier, Frank J. van Lenthe
Summary: This study used data from a population-based birth cohort in the Netherlands and found that differential exposure to financial stress in the family has a significant impact on the socioemotional development, cognitive development, and educational attainment of children of less-educated mothers.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Gastroenterology & Hepatology
Jacob Antonsen, Susanne Hansen, Camilla S. Morgen, Tine Jess, Lars N. Jorgensen, Kristine H. Allin
Summary: This study aimed to investigate the association between antibiotic use in a pediatric population and the risk of appendicitis. Results showed that children who received at least one course of antibiotics had an increased risk of developing appendicitis, especially if they were exposed to antibiotics within the first six months of life or exposed to broad-spectrum antibiotics. However, after adjusting for the number of antibiotic courses, the association between early age of antibiotic exposure and risk of appendicitis, as well as the association between exposure to broad-spectrum antibiotics and the risk of appendicitis, disappeared.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Geriatrics & Gerontology
Elena Sabini, Alison O'Mahony, Patrizio Caturegli
Summary: This study compares the therapeutic effects of two drugs, MyMD-1 and rapamycin, on aging and age-related diseases. The results demonstrate that MyMD-1 has better effects on lifespan and health span characteristics in mice, and exhibits stronger anti-proliferative, anti-inflammatory, and anti-fibrotic properties in vitro.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Cell Biology
Alexander Richard Mendenhall
Summary: The Mediterranean diet, which includes foods with high levels of cis-monounsaturated fatty acids (MUFAs) such as olive oil, is associated with increased human lifespan. A recent study demonstrates that MUFAs stimulate a lipid droplet-peroxisome organelle network, reducing lipid oxidation and protecting cell membranes during ageing.
NATURE CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
James W. Vaupel, Francisco Villavicencio, Marie-Pier Bergeron-Boucher
Summary: This article reviews key strands of demographic research on past trends in human longevity and explores possible future trends in life expectancy at birth. Life expectancy has been increasing at a steady pace, leading to a more equal distribution of individual life spans, but there is considerable uncertainty in forecasting future trends.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Sonnie Kim, Thomas C. Williams, Cecile Viboud, Harry Campbell, Jiani Chen, David J. Spiro
Summary: RSV is a common cause of serious respiratory illness in infants, and efforts are being made to develop vaccines and therapeutics, although the impact of RSV genomic variability on treatment remains unclear. Research gaps and priorities were discussed at a workshop, focusing on the implications of viral evolution and genomic variability for vaccine development.
Article
Multidisciplinary Sciences
Ren Dodge, Eric W. Jones, Haolong Zhu, Benjamin Obadia, Daniel J. Martinez, Chenhui Wang, Andres Aranda-Diaz, Kevin Aumiller, Zhexian Liu, Marco Voltolini, Eoin L. Brodie, Kerwyn Casey Huang, Jean M. Carlson, David A. Sivak, Allan C. Spradling, William B. Ludington
Summary: The gut is exposed to various bacteria from the diet and environment, but the composition of the gut microbiome remains stable over time in different host species. This study used gnotobiotic Drosophila to investigate the stability of different strains of bacteria in the fly gut. The researchers found that a physical niche in the foregut selectively binds bacteria with strain-specificity, stabilizing their colonization. Initial colonization by Lactobacillus species remodels the niche to favor secondary colonization by unrelated commensals. These findings provide insights into the establishment and stability of a multi-species intestinal microbiome.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yoshiki Hayashi, Soshiro Kashio, Kazutoshi Murotomi, Shinjiro Hino, Woojin Kang, Kenji Miyado, Mitsuyoshi Nakao, Masayuki Miura, Satoru Kobayashi, Masakazu Namihira
Summary: Tissue aging is a major factor contributing to disabilities and shortened lifespan. The mechanism of tissue aging is not completely understood, but this study suggests that the biosynthesis of S-adenosyl-methionine (SAM) can accelerate aging-related defects during Drosophila oogenesis. The study also reveals an aging-related increase in SAM levels in mouse reproductive tissue and the brain.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sher Bahadur Poudel, Manisha Dixit, Gozde Yildirim, Jose Cordoba-Chacon, Manuel D. Gahete, Ikeno Yuji, Thorsten Kirsch, Rhonda D. Kineman, Shoshana Yakar
Summary: The study found that adult-onset isolated GH deficiency can lead to increased severity of OA and extended lifespan in female mice. However, high levels of lymphomas were observed in both sexes with AOiGHD. Additionally, males with AOiGHD showed increased cell senescence and significantly decreased health span.