期刊
POLYMER TESTING
卷 81, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.polymertesting.2019.106266
关键词
Agarose; NIPAAm; Carboxymethylation; Graft copolymerization; Thermoresponsive materials
资金
- DICYT
- Universidad de Santiago de Chile [021941ZR_POSTDOC_DICYT]
- CONICYT [21120261]
- Becas Chile
- FONDECYT [1170226]
- [MAT201788923-P]
Carboxymethylation of agarose with ClCH2COOH in 2-propanol, formamide or dimethyl sulfoxide were evaluated in order to obtain water soluble derivatives. Higher yield (86%) and degree of substitution of carboxymethylation in primary alcoholic groups (0.70) were obtained using dimethyl sulfoxide. Carboxymethylagarose-g-PNIPAAm copolymers were synthesized by free radical graft copolymerization using Ce4+ and S2O82/TEMED as initiators via conventional or microwave-assisted methods. Carboxymethyl derivatives and graft copolymers were characterized by FT-IR and NMR spectroscopies, elemental analysis, TGA and DSC and morphology analysis by SEM and AFM. High nitrogen content (9.7%) was found with Ce4+ by conventional method and the obtained analysis allowed to confirm the NIPAAm grafting on the carboxymethylagarose chain. Thermoresponsive materials have a low critical solution temperature between 32 and 34 degrees C. Thermal stability increased ca. 60% with PNIPAAm grafting. Surface analysis of copolymers reveals a microfibrillar type morphology with diameter of 4-6 mu m. Synthesized glycoconjugates could find applications in bioactive compounds transport in biological systems.
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