Article
Biophysics
Manoharan Murphy, K. Theyagarajan, Kathavarayan Thenmozhi, Sellappan Senthilkumar
Summary: A novel biosensor was developed for monitoring hydrogen peroxide concentration, based on the covalent immobilization of hemoglobin on a newly developed NIBA-IL/MWCNT/GCE platform. The biosensor demonstrated effective direct electrochemistry of hemoglobin, with low detection limit, high sensitivity, good stability, and reliable reproducibility.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Yudong Xue, Yunting Wang, Zhenhua Pan, Kazuhiro Sayama
Summary: This paper reviews recent developments in EC/PEC H2O2 production through water oxidation, including fundamental aspects, benchmark activity evaluation, material/catalyst selection, and strategies for increasing selectivity, efficiency, and accumulation. The challenges and outlook for water oxidation in H2O2 production are also discussed, with a focus on device-level development, accumulation and stability, and industrial applications. The review aims to inspire further research in improving EC/PEC H2O2 production.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Fanny Girard-Sahun, Pauline Lefrancois, Vasilica Badets, Stephane Arbault, Franck Clement
Summary: This study aims to detect the in situ production of reactive oxygen and nitrogen species (RONS), specifically superoxide anion (O-2(center dot-)), in aqueous buffer solutions exposed to cold atmospheric plasmas (CAPs). The production and accumulation of RONS in the liquids were found to depend on the plasma composition, with N-2-based shieldings providing the highest concentrations of superoxide. The study provides valuable insights into the interactions between CAPs and physiological solutions for biomedical applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Anqi Lin, Quanyi Liu, Yihong Zhang, Quan Wang, Sirong Li, Bijun Zhu, Leiying Miao, Yan Du, Sheng Zhao, Hui Wei
Summary: This study develops a universal strategy to measure CAT and CAT-like activity, overcoming the limitations of current assays and facilitating insightful studies on applications of CAT and CAT-like nanozymes. The oxygen-sensitive and H2O2-inhibitory self-polymerization of dopamine is demonstrated as an activity indicator for CAT or CAT-like nanozymes. This assay shows allround advantages in sensitivity, specificity, and versatility.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Di Cheng, Huimin Wu, Chuanqi Feng, Yu Ding, He Mei
Summary: In this study, a bifunctional photoelectrochemical sensor based on Bi/Bi2S3/BiVO4 was prepared and evaluated. The results showed that 0.3-Bi-BSV-15% exhibited the best photoelectrochemical performance and demonstrated good detection capabilities for hexavalent chromium and hydrogen peroxide.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Zhou Sha, Jiawen Xu, Yufei Wang, Lei Ma, Xiaodong Li, Yanpei Chen, Hai-Ying Gu
Summary: The direct electrochemistry of fresh tobacco RNA on the surface of the pretreated glassy carbon electrode (PGCE) is investigated, and it shows good electrochemical activity in a specific buffer solution. Cyclic voltammetry and differential pulse voltammetry were used to study the electrochemical behavior of tobacco RNA, which provided a paradigm for the direct electrochemical study of RNA. The RNA also exhibited peroxidase-like activity and showed promising potential for electrocatalytic oxidation of H2O2, making it suitable for the development of an electrochemical H2O2 sensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Runfei Xu, Haoyang Huang, Wenjing Wang, Lei Ding, Qiang Lin, Jinbing Li, Yu Zhang, Yongsheng Han, Jianguo Wang, Xiaohua Lu
Summary: We propose a novel approach for direct production of H2O2 from water through electro-catalysis. By periodically switching potentials between positive and negative, oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) occur sequentially on a single electrode loaded with catalysts, resulting in the direct formation of H2O2. The production of H2O2 is optimized by controlling the time and potentials of OER and ORR. Furthermore, the addition of zinc into the catalysts inhibits the decomposition of H2O2, allowing for its utilization in the partial oxidation of propylene to generate valuable chemicals.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Weijie Zhang, Shunshun Zhao, Yupeng Xing, Hongjie Qin, Qiling Zheng, Penghui Zhang, Shouwei Zhang, Xijin Xu
Summary: The sustainable conversion from solar energy to chemical energy is achieved by using photocatalytic technology and constructing a direct Z-scheme heterojunction, which greatly improves the efficiency and stability of photocatalytic hydrogen evolution (PHE) and photocatalytic hydrogen peroxide production (PHP). The study demonstrates that using PBN/ZnIn2S4 hierarchical heterostructures can significantly enhance the photocatalytic performance of PHE and PHP.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Shaoda Huang, Bingyan Zhang, Huimin Sun, Hongyin Hu, Jinyan Wang, Fang Duan, Han Zhu, Mingliang Du, Shuanglong Lu
Summary: We developed a series of single atom catalysts anchored on bipyridine-rich COFs. The optimal Py-Bpy-COF-Zn shows the highest selectivity of 99.1% and excellent stability in H2O2 production via oxygen reduction, attributed to its high *OOH dissociation barrier. As a proof of concept, it acts as a cathodic catalyst in a homemade Zn-air battery and enables efficient wastewater treatment.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Shichao Ding, Zhaoyuan Lyu, Lingzhe Fang, Tao Li, Wenlei Zhu, Suiqiong Li, Xin Li, Jin-Cheng Li, Dan Du, Yuehe Lin
Summary: Developing novel substitutes for heme enzymes, such as Fe-N-C based single-atomic site catalysts (SASCs), can provide high catalytic activity and selectivity in biosensing applications. Synthesizing a SASC (Fe-SASC/NW) by doping single iron atoms into carbon nanowires shows promising heme enzyme-like catalytic performance for hydrogen peroxide detection. The electrochemical sensor based on Fe-SASC/NW exhibits excellent detection capabilities for H2O2 due to the isolated Fe-N-x active sites and their structural similarity with natural metalloproteases.
Article
Engineering, Environmental
Zaiyong Yang, Zengxi Wei, Shunxin Zhou, Bo Bao, Shuangliang Zhao, Fuzhong Gong
Summary: This study reports a new continuous DSHP process by constructing a feasible microreactor upon microfluidic chip under ambient condition, which achieved continuous production of H2O2 with high concentration. The study provides a promising on-site route to produce H2O2 in a green, safe yet ready-to-use process.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Yujie Yang, Hui Dong, Hewen Yin, Yintang Zhang, Yanli Zhou, Maotian Xu, Xiaobing Wang
Summary: A novel electrochemical platform was developed for ultrasensitive and simultaneous determination of hydrogen peroxide, dopamine, and ascorbic acid. The platform showed excellent linear range and ultrasensitive response, with low detection limits for the three components. The sensor also exhibited excellent stability and reproducibility, and satisfactory results were obtained in real samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Angelina Kerschbaumer, Dominik Wielend, Elisabeth Leeb, Corina Schimanofsky, Nadine Kleinbruckner, Helmut Neugebauer, Mihai Irimia-Vladu, Niyazi Serdar Sariciftci
Summary: When studying electrochemical oxygen reduction reactions, attention must be given to background activity with conventional electrode materials. Complementary methods such as rotating ring-disc electrode technique and chronoamperometric electrolysis were used to investigate the electrocatalytic activity of different materials. A detailed investigation of hydroxy anthraquinone derivatives and riboflavin electrocatalytic ability for hydrogen peroxide production was conducted, providing valuable insights for improving the oxygen reduction reaction.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Linyi Xu, Jing Li, Weishan Shi, Ning Bao, Chunmei Yu
Summary: The synthesis of MnCO3-Au hybrid microspheres and their application in electrochemical biosensing of hydrogen peroxide based on hemoglobin immobilization are reported. The microspheres exhibit unique properties that benefit direct electron transfer of Hb, with high performance and stability for H2O2 detection. The biosensor shows excellent selectivity, repeatability, and long-term stability, with potential for real sample analysis of H2O2.
Article
Chemistry, Multidisciplinary
Rasmus Svensson, Henrik Gronbeck
Summary: Single atom alloy catalysts offer higher turnover frequencies and selectivities than monometallic catalysts. Pd embedded in Au nanoparticles was studied as a catalyst for the direct formation of H2O2 from O2 and H2 in an aqueous solution. The simulations revealed that Pd monomers facilitated H2 dissociation, while H2O2 was formed over undercoordinated Au sites. Tuning the nanoparticle composition and reaction conditions was found to enhance the selectivity towards H2O2. This approach is applicable for various hydrogenation reactions over single atom alloy nanoparticles.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Qinghua Wang, Tiantian Liu, Yingyu Chen, Qingxiang Wang
Summary: The study describes the synthesis of a nanocomposite with heterostructure of metallic nickel and nickel sulfide, which exhibits excellent energy storage capabilities in both supercapacitors and zinc ion batteries.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Xinyi Liang, Xu Du, Ao Liu, Zhixiong Cai, Jingwen Li, Maosheng Zhang, Qingxiang Wang, Jingbin Zeng
Summary: This study proposes a plasmonic nanosenosr for the detection of mercury(II) in natural samples. The sensor shows high selectivity and feasibility, making it suitable for analyzing complex matrices directly.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Physical
Yun Ling, Ya-ru Chu, Feng Gao, Qing-yun Feng, Hui-qi Xie, Yong Shao, Qing-xiang Wang
Summary: Metal-organic frameworks (MOFs) have promising applications in electrochemical sensing, and this study developed a novel label-free electrochemical sensing strategy for detecting cardiac troponin I (cTnI) using Cu-MOF-74. The electrochemical assay demonstrated that the immunoaffinity reaction between cTnI and anticTnI effectively inhibited the electrochemical signal of Cu-MOF-74, indicating the potential of Cu-MOF-74-based interface in label-free cTnI analysis.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Biophysics
Feng Gao, Fengping Zhan, Songling Li, Philip Antwi-Mensah, Li Niu, Qingxiang Wang
Summary: Dual signal interface was achieved by in-situ grafting signal tags on Pb2+-binding aptamer and Hg2+-binding aptamer immobilized on gold electrode, enabling simultaneous detection of Pb2+ and Hg2+. The sensor showed low detection limits and was successfully applied for determination of Pb2+ and Hg2+ in real water samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Zhiping Song, Juan Song, Feng Gao, Xiaoping Chen, Qinghua Wang, Yanan Zhao, Xuguang Huang, Chaoyong Yang, Qingxiang Wang
Summary: In this study, a novel electrochemical aptasensor was developed for the rapid and accurate determination of cardiac troponin I. The sensor exhibited ultra-low detection limit and a wide linear range.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Environmental
Manli Wang, Xuan Zheng, Yi Li, Zehua Zou, Yun Ling, Qingxiang Wang
Summary: Developing bifunctional electrocatalysts with abundant reserves and efficient performance is crucial for alkaline water electrolysis. In this study, antiperovskite nitride (FexCu1-x)4N particles anchored on Cu2O nanosheets were synthesized via one-step solution combustion synthesis using KCl. The assembly of (FexCu1-x)4N and Cu2O promotes charge transfer and increases reaction kinetics and active sites. The optimized (Fe1xCux)4N-Cu2O heterostructure exhibits superior bifunctional performance for water electrolysis compared to precious metal couples.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Electrochemistry
Qinghua Wang, Limei Zheng, Yun Ling, Philip Antwi-Mensah, Qingxiang Wang
Summary: The facile and low-cost technology for the fabrication of high-performance electrode material for supercapacitors is crucial for green energy storage. By utilizing thermal treatment and potentiostatic oxidation, the capacitance of commercial carbon cloth is significantly increased, resulting in a high-performance self-standing cathode. This research has a significant impact on energy storage technology.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Zehao Wang, Ningning Gao, Zhenmao Chen, Feng Gao, Qingxiang Wang
Summary: An electroactive metal-organic coordination polymer was prepared for immobilizing the bioprobe and constructing label-free biosensors. The biosensor was characterized using AFM, ATR-FTIR, and electrochemical methods. The aptasensor showed high sensitivity and selectivity for thrombin detection in complex samples.
Article
Nanoscience & Nanotechnology
Zhenmao Chen, Yijing Ai, Weiqiang Yang, Li Niu, Qingxiang Wang, Feng Gao
Summary: A novel immobilization-and label-free electrochemical strategy has been developed for the detection of miRNA let-7a using magnetic Fe3O4@hydroxyapatite (Fe3O4@HAP) and the specific adsorption of a duplex structure. With the introduction of the label-free signal molecule Nile blue (NB) and its intercalation into the pDNA-miRNA duplex, a strong sensing signal is achieved without the need for nuclease-assisted cyclic amplification. The sensing system shows a wide linear range (1.0 fM to 100 nM) and a low detection limit (0.051 fM) for miRNA let-7a analysis, and exhibits high specificity.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Analytical
Zehao Wang, Yangyi Wu, Philip Antwi-Mensah, Zhenmao Chen, Weiqiang Yang, Li Niu, Feng Gao, Qingxiang Wang
Summary: The construction of an anti-fouling biosensing interface with inherent electroactivity is advantageous for improving the practicality of electrochemical biosensors. In this study, an electroactive biosensing interface with excellent biofouling resistance ability was developed using a hybrid membrane of Ce3+-poly(dopamine) (PDA) and Prussian blue (PB). The hybrid film not only enhances the hydrophilicity and biofouling resistance ability of the interface, but also acts as the immobilization matrix for the detection of miRNA Let-7a. The biosensor was capable of detecting miRNA Let-7a in human serum samples within a wide concentration range.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yun Ling, Qingyun Feng, Huiqi Xie, Xuan Zheng, Xiaoping Chen, Zehua Zou, Aifen Liu, Jing Tang, Yi Li, Qingxiang Wang
Summary: A phase-transition engineering strategy is developed to regulate oxygen vacancy and metal doping on the surface of M-TiO2, promoting both the selectivity and activity of the nitrogen reduction reaction (NRR). The strategy features simple synthesis process, high phase-transition efficiency, cost-effective materials, and scalability. Experimental results and density functional theory calculations show that surface oxygen vacancies and doping Fe atoms play crucial roles in the NRR, resulting in high NH3 yield and Faradaic efficiency.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Analytical
Fengping Zhan, Yanan Zhao, Xiaohui Dai, Jingbin Zeng, Qingxiang Wang
Summary: The development of a new method for rapid screening of antibiotics residues in food is important for food safety. A nanocomposite of polyaniline@copper-1,3,5-benzenetricarboxylic acid was directly prepared on an electrode surface, and a tetracycline aptamer was assembled onto the electrode to create an electrochemical aptasensor for tetracycline detection. The aptasensor showed high sensitivity and a wide detection range.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Applied
Chenxin Chen, Suqi He, Kamran Dastafkan, Zehua Zou, Qingxiang Wang, Chuan Zhao
Summary: Sea urchin-like NiMoO4 nanorod arrays demonstrate efficient catalytic activity and stability for urea oxidation and hydrogen evolution. The difference in electrocatalytic activity and selectivity is attributed to the variation in lattice oxygen content. This material shows great potential for energy conversion.
CHINESE JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Wu Yangyi, Chen Jianping, Ai Yijing, Wang Qingxiang, Gao Fei, Gao Feng
Summary: A new electrochemical DNA sensor based on the HMP-C-60 modified electrode was constructed, showing good linear relationship and detection limit in analyzing characteristic DNA fragments. The biosensor demonstrated high selectivity in identifying complementary sequences, base-mismatched sequences, and non-complementary sequences.
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
(2021)
Article
Chemistry, Analytical
Yang Hai-Zhu, Chu Ya-Ru, Wang Qing-Xiang, Ding Cai-Feng, Gao Feng
Summary: A novel electrochemical sensor based on MIL-101(Fe) /NH2-GR was successfully constructed for label-free detection of cTnI with a good linear range and low detection limit. The sensor showed good selectivity and reproducibility, and was applicable for detection of cTnI in human serum samples with high recoveries.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)