Article
Agriculture, Multidisciplinary
Zhang Yan-mei, Ao De, Lei Kai-wen, Lin Xi, Jerry W. Spears, Shi Hai-tao, Huang Yen-ling, Yang Fa-long
Summary: This study investigated the effects of dietary copper supplementation on the performance, serum lipid profile, and relative mRNA abundance of genes involved in lipid metabolism in male Lezhi black goat kids. The results showed that dietary copper supplementation did not significantly affect growth performance and blood lipid levels, but it did modify lipid metabolism by increasing muscular fat and decreasing serum low density lipoprotein cholesterol. These modifications may be associated with the reduction of relative mRNA abundance of genes for oxidation of long-chain fatty acid in muscle and liver of goat kids.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Cardiac & Cardiovascular Systems
J. C. Muskat, C. F. Babbs, C. J. Goergen, V. L. Rayz
Summary: During acute cardiovascular stress or strenuous exercise, enhanced production of nitric oxide by vascular endothelial cells raises nitrite concentrations in near-wall layers of flowing blood, resulting in cumulative NO concentrations in downstream arterioles sufficient for vasodilation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Masahiro Horiuchi, Gabriella M. K. Rossetti, Samuel J. Oliver
Summary: The study found that increasing nitric oxide bioavailability through dietary nitrate supplementation did not restore the reduction in dynamic cerebral autoregulation induced by hypoxia. Nitrate did not affect dynamic cerebral autoregulation in either normoxic or hypoxic conditions, suggesting that the hypoxia-induced reduction in dynamic autoregulation may not be related to nitric oxide availability.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Veterinary Sciences
Gerardo A. Abascal-Ponciano, Samuel F. Leiva, Joshua J. Flees, Luis P. Avila, Jessica D. Starkey, Charles W. Starkey
Summary: Vitamin D signaling plays an important role in maintaining intestinal homeostasis by regulating cell phenotype and cytokine secretion. Inflammation in intestinal tissues can disrupt the cell structure and compromise the protective barrier. This study found that dietary supplementation with 25OHD3 can decrease the abundance of inflammatory cytokines in the ileum of broiler chickens.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Fisheries
Seyyed Morteza Hoseini, Abbasali Aghaei Moghaddam, Melika Ghelichpour, Esmaeil Pagheh, Abdollah Haghpanah, Behrouz Gharavi, Behrooz Mansouri, Mohammad Arghideh
Summary: The study found that dietary glycine supplementation at 0.25%-0.5% could reduce plasma cortisol levels and improve antioxidant and immunological parameters in beluga, but had no significant effects on fish growth performance.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Panagiota Kyriakaki, Alexandros Mavrommatis, Eleni Tsiplakou
Summary: This study investigated the effects of dietary supplementation with Schizochytrium spp., rich in omega 6-DPA and DHA, on the transcriptional profiling of genes involved in oxidative homeostasis and innate immunity of dairy goats' monocytes and neutrophils. The results showed that the inclusion of more than 20g Schizochytrium spp./day in goats' diet caused imbalances in the antioxidant system and suppressed pro-inflammatory pathways in monocytes and neutrophils.
Article
Dentistry, Oral Surgery & Medicine
Leopoldo Cosme-Silva, Renan Dal-Fabbro, Luciano Tavares Angelo Cintra, Edilson Ervolino, Alana Sant'Ana do Prado, Daniel Pinto de Oliveira, Priscylla Goncalves Correia Leite de Marcelos, Joao Eduardo Gomes-Filho
Summary: The study showed that the multi-strain probiotic formula was effective in reducing inflammation and bone resorption in apical periodontitis induced in rats.
JOURNAL OF APPLIED ORAL SCIENCE
(2021)
Article
Microbiology
Kaili Xie, Shenghua Chang, Jiao Ning, Yarong Guo, Cheng Zhang, Tianhai Yan, Fujiang Hou
Summary: Compared to traditional herbage, functional native herbage is more important in ruminant agriculture by improving digestion, metabolism, and health of livestock. However, their effects on rumen microbial communities and hindgut fermentation are still unclear. This study aimed to evaluate the effects of dietary addition of Allium mongolicum on bacterial communities in the rumen and feces of claves.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Hany Salah Mahmoud, Amani A. Almallah, Heba Nageh Gad El-Hak, Tahany Saleh Aldayel, Heba M. A. Abdelrazek, Howayda E. Khaled
Summary: The experiment demonstrated that Nigella sativa seeds exhibit immunostimulatory function through their antioxidant potential, induction of cytokine production, promotion of CD8 expression, and reduction of splenic apoptosis.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Ana Carolina Laureano Paganin, Paulo Sergio Monzani, Marcelo Falsarella Carazzolle, Raquel Bighetti Araujo, Ricardo Gonzalez-Esquerra, Douglas Haese, Joao L. Kill, Graziela Silva Rezende, Cesar Goncalves de Lima, Iran Malavazi, Caio Cesar de Melo Freire, Anderson Ferreira da Cunha
Summary: This study investigated the effects of different copper sources on the gut microbiota of piglets. The results showed that different copper sources can alter the composition of the gut microbiota, promoting gut health. In particular, copper methionine hydroxy analogue chelate can modify the abundance and activity of certain bacteria involved in feed efficiency and short chain fatty acid production.
Article
Agriculture, Dairy & Animal Science
Michaela Bunting, Bethan Challice, Amanda Gibson, Steven van Winden
Summary: This study investigated the association between copper levels and monocyte plasticity, showing that increased copper levels reduced cell viability and affected the types of monocytes in cows of different ages. CD14 expression influenced CD16 expression and nitric oxide production.
Article
Biochemistry & Molecular Biology
Nathalia da Silva Costa, Patricia Pereira Almeida, Beatriz Oliveira Da Cruz, Michele Lima Brito, Johnatas Maldonado-Campos, Agatha Cristie Menezes, Mariana Sarto Figueiredo, D' Angelo Carlo Magliano, Aline D'Avila Pereira, Milena Barcza Stockler-Pinto
Summary: This study found that Brazil nut supplementation improved bone parameters, high-density lipoprotein-cholesterol levels, and lipid peroxidation in healthy rats.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fan Li, Xiaojing Wu, Hongli Liu, Bin Zhang, Lei Liu, Fuchang Li
Summary: By adding different levels of copper to the diets, lipid metabolism in various parts of Rex Rabbits was affected to different extents, with high-copper diets promoting skeletal muscle growth, reducing fat accumulation, and inhibiting de novo lipogenesis in the liver, thus playing a role in regulating lipid metabolism. PPAR-alpha signaling in liver, skeletal muscle, and adipose tissues was involved in the regulation of lipid metabolism by copper.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vivian Naa Amua Wellington, Vijaya Lakshmi Sundaram, Soudamani Singh, Uma Sundaram
Summary: The gut microbiome plays a significant role in gastrointestinal health and can be affected by dietary choices. Dietary supplementation with anti-inflammatory supplements may help restore gut microbiota homeostasis and reduce intestinal inflammation in inflammatory bowel disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Fernando Fernando, Caroline L. Candebat, Jan M. Strugnell, Nikos Andreakis, Leo Nankervis
Summary: This study investigated the effects of astaxanthin and vitamin E on the growth performance, body coloration, and antioxidant status of giant grouper. The results showed that astaxanthin supplementation improved fin coloration and antioxidant capacity, while vitamin E had no significant effects.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Bartosz Fotschki, Katarzyna Ognik, Joanna Fotschki, Dorota Napiorkowska, Ewelina Cholewinska, Magdalena Krauze, Jerzy Juskiewicz
Summary: The study investigated the effects of chromium supplementation and switching dietary habits on lipid metabolism, inflammation, and oxidative stress in Wistar rats. The combination of chromium nanoparticles and dietary changes showed the strongest reduction in fat content and cholesterol in the liver. This combination also had favorable antioxidative effects. Supplementation with chromium nanoparticles alone also improved lipid metabolism and oxidative stress, although to a lesser extent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Beata Olas
Summary: The caper, derived from the Latin word capra meaning goat, refers to the salt-fermented floral buds of the perennial shrubs from the Capparis genus. C. spinosa is one of the most popular species, and its aromatic floral buds are collected before blooming, dried, and pickled. Capers are commonly marinated and enjoyed in vinegar, brine, or oil. They have potential as dietary supplements due to their low calorie content and abundance of bioactive phytochemicals. Research has shown that C. spinosa possesses various nutritional and biological properties, including antioxidant activity from its phenolic compounds. This paper reviews the biological properties, including toxicity, of the fruits, buds, seeds, roots, and leaves of C. spinosa.
Article
Nutrition & Dietetics
Bartosz Fotschki, Ewelina Cholewinska, Katarzyna Ognik, Michal Sojka, Joanna Milala, Joanna Fotschki, Wieslaw Wiczkowski, Jerzy Juskiewicz
Summary: The required amount of berry polyphenols for health benefits is difficult to achieve through fresh fruit consumption, suggesting polyphenol-rich extracts as a dietary alternative. This study fed rats high-fat diets supplemented with 0.1 or 0.3% raspberry polyphenols and found that the higher dose of extract had more noticeable health-promoting effects, including reduced white adipose tissue weight, hepatic triglyceride content, and plasma IL-6 concentration, as well as increased acetic acid concentration in the cecal digesta. The enhanced content of ellagitannin and anthocyanin metabolites in the blood plasma of rats administered the high dose extract may partially explain these effects.
Article
Nutrition & Dietetics
Natalia Slawinska, Jerzy Zuchowski, Anna Stochmal, Beata Olas
Summary: Sea buckthorn, a small tree, has been valued for its medicinal properties. Its berries and leaves are known to contain phytochemicals and have been used in folk medicine for the treatment of various conditions. This study examined the phytochemical content and biological activity of sea buckthorn seeds. The results showed that sea buckthorn seeds contain various flavonoids and have antioxidant and anticoagulant potential. However, further research is needed to identify the specific compounds responsible for these effects, especially in vivo models.
Review
Nutrition & Dietetics
Natalia Slawinska, Beata Olas
Summary: Seeds contain various phytochemicals with diverse biological activities. This review summarizes the chemical content and biological activity of seeds from eight plant species. Studies have shown that these seeds have health-promoting effects and could be used in drug development and functional food preparation. However, further animal studies and clinical trials are needed to determine their potential application in disease prevention and treatment.
Review
Nutrition & Dietetics
Beata Olas
Summary: Schisandra chinensis berries are valuable agents in modern phototherapy with anti-cancer, hepatoprotective, anti-inflammatory, and antioxidant properties. The unique chemical composition of these berries, particularly their lignan content, contributes to their therapeutic potential. The selected lignans, including schisandrin, schisandrin B, schisantherin A, schisantherin B, schisanhenol, deoxyschisandrin, and gomisin A, possess cardioprotective properties.
Review
Biochemistry & Molecular Biology
Joanna Fotschki, Anna M. M. Ogrodowczyk, Barbara Wroblewska, Jerzy Juskiewicz
Summary: The vegetable processing industry generates large amounts of by-products that are susceptible to microbial degradation. Inadequate management leads to the loss of valuable compounds in vegetable by-products. Scientists are exploring the possibility of reusing discarded biomass to create higher value products. The by-products contain bioactive compounds with health-promoting properties. This review emphasizes the importance of these by-products in promoting health through their impact on the microbiota, immune system, and gut milieu.
Article
Nutrition & Dietetics
Ewelina Cholewinska, Aleksandra Marzec, Przemyslaw Solek, Bartosz Fotschki, Piotr Listos, Katarzyna Ognik, Jerzy Juskiewicz
Summary: The aim of this study was to investigate the effects of different types of dietary fibre (cellulose, inulin, pectin, and psyllium) in combination with recommended or enhanced levels of CuNPs on selected biological parameters of intestinal integrity in rats. The results showed that replacing CuCO3 with CuNPs in the diet reduced lactic acid and apoptosis markers levels in the small intestine, but it also increased DNA oxidation. Inulin had the most beneficial effect on DNA repair mechanisms, while pectin had the highest ability to inhibit inflammatory processes and apoptotic cell death in the small intestine. These findings suggest that dietary fibre supplementation can protect the small intestine against oxidative effects of CuNPs by enhancing the intestinal barrier.
Article
Biochemistry & Molecular Biology
Monika Cendrowska-Pinkosz, Magdalena Krauze, Jerzy Juskiewicz, Bartosz Fotschki, Katarzyna Ognik
Summary: The aim of this study is to evaluate the effect of different forms and dosages of copper on neurodegenerative markers in the brain and jejunum. The experiment involved feeding male Wistar rats a rat diet with two CuCO3 dosages and two CuNP dosages. Nanoparticles reduced the level of GAChE, increased the levels of AChE and LRP1, and decreased β-amyloid and Tau protein in both the brain and intestine of rats. The highest levels of beneficial markers and lowest levels of toxic markers were observed in rats receiving a standard dose of Cu.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Grzegorz Chmielewski, Michal S. Majewski, Jakub Kuna, Mateusz Mikiewicz, Magdalena Krajewska-Wlodarczyk
Summary: Fatigue is a common symptom in various rheumatic diseases, affecting patients' quality of life and exacerbating disability. Its nature involves multiple factors, including physiological, psychological, and social aspects. Despite its significance, fatigue is often underestimated in clinical practice. Comprehensive assessment of the subjective components of fatigue is crucial for effective management of this symptom in inflammatory joint diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Michal Majewski, Leszek Gromadzinski, Ewelina Cholewinska, Katarzyna Ognik, Bartosz Fotschki, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of dietary fiber supplementation with different types of nanoparticles on the cardiovascular system in rats. The results showed that compared to pectin, inulin and psyllium supplementation with a standard dose of copper nanoparticles improved antioxidant capacity and reduced heart malondialdehyde levels. Furthermore, with an enhanced dose of copper nanoparticles, inulin and psyllium enhanced vasodilation through up-regulation of COX-2-derived vasodilator prostanoids.
Article
Nutrition & Dietetics
Jerzy Juskiewicz, Katarzyna Ognik, Joanna Fotschki, Dorota Napiorkowska, Ewelina Cholewinska, Katarzyna Grzelak-Blaszczyk, Magdalena Krauze, Bartosz Fotschki
Summary: This study assessed the changes in faecal microbial activity in obese rats fed high-fat or low-fat diets supplemented with different forms of chromium. The results showed that switching from a high-fat to a low-fat diet had beneficial effects, and supplementing with chromium nanoparticles further modulated microbial activity.
Article
Nutrition & Dietetics
Bartosz Fotschki, Michal Sojka, Monika Kosmala, Jerzy Juskiewicz
Summary: Previous studies have shown that dietary supplementation with prebiotic fructooligosaccharides (FOSs) and polyphenols can alleviate disorders related to the early stage of nonalcoholic fatty liver disease (NAFLD). This experiment aimed to investigate whether raspberry polyphenols together with FOSs can regulate advanced-stage NAFLD in genetically obese Zucker rats. The results showed that the addition of FOSs and raspberry polyphenolic extract to the diet reduced liver fat accumulation, improved antioxidant potential, lowered plasma enzyme activities, and increased insulin sensitivity. These effects may be attributed to the upregulation of specific receptors in the liver responsible for regulating lipid metabolism and glucose and bile acid synthesis.
Article
Nutrition & Dietetics
Bartosz Fotschki, Katarzyna Ognik, Ewelina Cholewinska, Katarzyna Grzelak-Blaszczyk, Kamil Myszczynski, Magdalena Krauze, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of supplementation with chromium nanoparticles (Cr-NPs) on the gut microenvironment in rats fed a high-fat diet. The results showed that Cr-NPs mainly acted by altering the activity of gut microbiota, leading to decreased concentration of short-chain fatty acids and increased level of cecal lithocholic acid. Switching to a low-fat diet had a more significant impact on obesity-related disorders, improving microbial activity, composition, and the production of short-chain fatty acids.
Review
Nutrition & Dietetics
Klaudia Kitala, Damian Tanski, Janusz Godlewski, Magdalena Krajewska-Wlodarczyk, Leszek Gromadzinski, Michal Majewski
Summary: Copper and zinc are essential micronutrients that control various cellular pathways and enzyme activity. Imbalances in their concentrations can lead to cardiovascular dysfunction. Dietary intake of excessive zinc can cause copper deficiency. Copper plays a role in vascular remodeling, while zinc is important in the development of heart damage. Metal nanoparticles and their effects on vascular health require further investigation.
