Article
Cell Biology
Xiangkun Wu, Lihua Yan, Yongxi Liu, Lilin Shang
Summary: This study demonstrates that ROR1-AS1 acts as an oncogene in osteosarcoma by regulating miR-504 expression and influencing cell migration and proliferation. The expression of ROR1-AS1 is lower in osteosarcoma tissues compared to non-tumor samples, showing a negative correlation with miR-504 expression.
Article
Oncology
Bo Liu, Duocheng Qian, Weidong Zhou, Huiyang Jiang, Zhendong Xiang, Denglong Wu
Summary: The study reveals that FAM83H-AS1 is upregulated in prostate cancer and plays a critical role in tumorigenesis by modulating cell proliferation, cell cycle, and migration. Mechanistically, FAM83H-AS1 functions as an oncogene through sponging miR-15a to promote CCNE2 expression, indicating its potential as a novel diagnostic and therapeutic marker for prostate cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Jianhua Zhu, Yan Huang, Yong Zhang, Rongfu Huang, Chunmei Huang
Summary: In this study, we found that lncRNA KCNMB2-AS1 is significantly upregulated in bladder cancer tissues and cell lines, promoting the progression of bladder cancer. Mechanistically, lncRNA KCNMB2-AS1 functions as a competitive endogenous RNA (ceRNA) by sponging miR-374a-3p and regulating the expression of S100A10, contributing to bladder cancer progression.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Yeyu Zhang, Yuxing Zhu, Mengqing Xiao, Yaxin Cheng, Dong He, Jianye Liu, Liang Xiang, Lian Gong, Zhanwang Wang, Liping Deng, Ke Cao
Summary: The study reveals that TMPO-AS1 is upregulated in bladder cancer and promotes cell proliferation, migration, invasion, and inhibits apoptosis. Mechanistically, TMPO-AS1 interacts with E2F1, leading to E2F1 stabilization and ultimately promoting malignant behaviors in bladder cancer. Additionally, rescue experiments demonstrate that TMPO-AS1 promotes bladder cancer growth in an E2F1-dependent manner.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yanling Tao, Jingjing Zhang, Lulu Chen, Xin Liu, Mingkang Yao, Hao Zhang
Summary: High expression of CD27-AS1 in AML is associated with shorter overall survival time, its downregulation can inhibit the proliferation and induce apoptosis of AML cells, while overexpression enhances the malignant phenotype. CD27-AS1 regulates the growth of AML cells through the miR-224-5p/PBX3/MAPK signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jen-Hao Yang, Ming-Wen Chang, Dimitrios Tsitsipatis, Xiaoling Yang, Jennifer L. Martindale, Rachel Munk, Aiwu Cheng, Elizabeth Izydore, Poonam R. Pandey, Yulan Piao, Krystyna Mazan-Mamczarz, Supriyo De, Kotb Abdelmohsen, Myriam Gorospe
Summary: In this study, the researchers discovered a noncoding RNA regulatory network that promotes myoblast fusion into multinucleated myotubes by modulating the degradation of miR-7.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Reproductive Biology
Yang Shen, Mengmeng Lv, Yichen Fang, Jin Lu, Yuzhong Wu
Summary: In this study, it was found that MNX1-AS1 promotes ovarian cancer (OC) development through the miR-744-5p/SOX12 axis. MNX1-AS1 was upregulated in OC tumor tissues and cells, competitively binding with miR-744-5p and affecting cell proliferation, migration, invasion, and apoptosis. This novel mechanism of MNX1-AS1 in OC may provide a new treatment target for this malignancy.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Cell Biology
Lei Wang, Ying Tan, Ziyu Zhu, Jun Chen, Qiang Sun, Zhibin Ai, Chunqi Ai, Yu Xing, Guohou He, Yong Liu
Summary: The study demonstrates that ATP2B1-AS1 is upregulated in cerebral ischemia/reperfusion injury, and regulates cell survival, apoptosis, and inflammation through miR-330-5p and TLR4. Additionally, ATP2B1-AS1 affects neurological function in rats and their performance in the Morris water maze test.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Dexiang Feng, Jiancheng Lv, Kai Li, Qiang Cao, Jie Han, Hao Yu, Yidong Cheng, Juntao Zhuang, Lingkai Cai, Haiwei Yang, Xiao Yang, Qiang Lu
Summary: Studies have shown that circZNF609, a circular RNA, is significantly upregulated in bladder cancer and is associated with poor patient survival. Overexpression of circZNF609 promotes bladder cancer cell proliferation, migration, and resistance to cisplatin chemotherapy. Mechanistically, circZNF609 acts as a sponge for miR-1200, alleviating its inhibitory effect on the target gene CDC25B. These findings suggest that circZNF609 has significant potential as a new diagnostic biomarker and therapeutic target in bladder cancer.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Jin Wang, Haihua Huang, Xiaomiao Zhang, Haitao Ma
Summary: The study showed that LOXL1-AS1 and HSPA9 are highly expressed in thymoma and thymic carcinoma, while miR-525-5p is expressed at low levels and associated with poor prognosis. LOXL1-AS1 acts as a sponge targeting miR-525-5p to promote HSPA9 expression, thereby promoting the growth and invasion of thymoma and thymic carcinoma cells.
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jia Zhang, Kaisa Cui, Liuying Huang, Fan Yang, Shengbai Sun, Zehua Bian, Xue Wang, Chaoqun Li, Yuan Yin, Shengling Huang, Leyuan Zhou, Bojian Fei, Zhaohui Huang
Summary: SLCO4A1-AS1 is upregulated in colorectal cancer (CRC) and associated with poor prognosis. SLCO4A1-AS1 acts as a molecular scaffold to regulate the Hsp90/Cdk2/c-Myc axis and promote the growth of CRC.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Cell Biology
Tianming Chen, Bin Huang, Yaozhen Pan
Summary: The study found that lncRNA MAFG-AS1 is upregulated in drug-resistant HCC cells, and it promotes growth and migration of HCC by upregulating STRN4 through absorbing miR-3196, suggesting it may be a potential target for HCC treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hui Zhang, Jie Song
Summary: The study revealed that C5orf66-AS1 was significantly upregulated while miR-149-5p was downregulated in osteosarcoma tissues and cells. C5orf66-AS1 negatively regulated miR-149-5p in osteosarcoma cells, inhibiting cell proliferation and invasion. The findings suggest that C5orf66-AS1 may serve as a potential therapeutic target for osteosarcoma.
Article
Genetics & Heredity
Huiyuan Xiao, Wen Huang, Yanlei Li, Rongxin Zhang, Long Yang
Summary: The study showed that higher expression of TTN-AS1 was associated with poorer DFS in BC patients, especially in those who underwent Re-TURBT. Knocking down TTN-AS1 could inhibit the proliferation and invasion abilities of BC cells. ATF2 may act as a downstream target of TTN-AS1 in BC, and high expression of ATF2 is also related to adverse DFS in patients.
FRONTIERS IN GENETICS
(2021)