Article
Biochemistry & Molecular Biology
Shuifu Chen, Yuqun Huang, Jingluan Han, Shijuan Zhang, Qiaoyu Yang, Zhijie Li, Ya Zhang, Runyuan Mao, Ling Fan, Yaoguang Liu, Yuanling Chen, Xianrong Xie
Summary: This study identified and characterized a new allele of LA1 in a rice spreading-tiller mutant. The mutation caused loss of shoot gravitropism and revealed the significance of the TM domain in LA1's biological function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Songyan Zou, Shoukun Ji, Hongjian Xu, Mingya Wang, Beibei Li, Yizhao Shen, Yan Li, Yanxia Gao, Jianguo Li, Yufeng Cao, Qiufeng Li
Summary: Excessive protein intake leads to increased nitrogen excretion, but reducing dietary protein content and adding rumen amino acids can help reduce nitrogen emissions. The study found that supplementing low-protein diets with rumen-protected lysine and methionine can improve the growth performance and nitrogen metabolism of Holstein bulls.
Article
Cell Biology
Mariana Borsa, Sandrine Obba, Felix C. Richter, Hanlin Zhang, Thomas Riffelmacher, Joana Carrelha, Ghada Alsaleh, Sten Eirik W. Jacobsen, Anna Katharina Simon
Summary: This study investigates the importance of autophagy in stem cells and finds that autophagy deficiency leads to stem cell loss and bone marrow failure, while inhibition of MTOR can rescue this loss and improve stem cell function.
Article
Agriculture, Multidisciplinary
Yi Wang, Xin Pu, Chan Ma, Ziyi Wang, Qi Wu, Chao Yang, Lina Liu, Yajuan Li, Mian Wei, Yuhan Shi, Chengyun Li
Summary: This study examined the behaviors of two different strains of Magnaporthe oryzae in coinfection and cocultivation. By labeling the strains with fluorescent proteins, the researchers observed their interactions in vivo and in vitro. Multiomics analyses were used to explore the underlying mechanisms, revealing that coinfection can affect disease severity and that weaker strains can benefit from coinfection. Amino acid variation was also found to negatively impact the interactions at the transcriptomic and metabolomic levels, while the overexpression of a glutamine-related gene improved strain competitiveness during mixture cultivation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Genetics & Heredity
Teresa Rubio, Judith Weyershaeuser, Marta G. Montero, Andreas Hoffmann, Pablo Lujan, Martin Jechlinger, Rocio Sotillo, Maja Koehn
Summary: Overexpression of the phosphatase PRL-3 leads to the death of intestinal stem cells and expansion of Paneth cells, while elevated PRL-3 phosphatase activity in healthy intestinal epithelium impairs intestinal cell homeostasis, increasing susceptibility to tumor formation.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Chemistry, Multidisciplinary
Tsuneomi Kawasaki, Yoshiyasu Kaimori, Seiya Shimada, Natsuki Hara, Susumu Sato, Kenta Suzuki, Toru Asahi, Arimasa Matsumoto, Kenso Soai
Summary: TGS acts as a chiral trigger in the Soai reaction for asymmetric autocatalysis, controlling the molecular chirality of highly enantioenriched organic compounds by altering the polarization of the ferroelectric crystal TGS with an electric field.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biology
Xiaoxi Yan, He Zhang, Ailian Lin, Yong Su
Summary: This study investigated the effects of ghrelin antagonization on muscle protein deposition, eating patterns, and gut microbiota in pigs. The results showed that the antagonization of ghrelin affected the eating patterns of animals, resulting in changes in the absorption of amino acids and gut microbiota, and it reduced protein deposition in muscles.
Article
Chemistry, Organic
Yudai Shinkawa, Toshiki Furutani, Takumi Ikeda, Mugen Yamawaki, Toshio Morita, Yasuharu Yoshimi
Summary: The side-chain functionalization of aspartic/glutamic acid derivatives was achieved through photoinduced decarboxylation using organic two-molecule photoredox catalysts without racemization under mild conditions. A facile process involving the preparation of substrates and photoinduced decarboxylative radical additions provides easy access to the linked amino acids with carbohydrates and amino acids at the side chain.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Sho Hosokawa, Tatsuya Morinishi, Kazuaki Ohara, Kentaro Yamaguchi, Satoshi Tada, Yasunori Tokuhara
Summary: This study improved the color reaction method for tryptophan and established a simple colorimetric method for its determination. It can be performed using safe materials and quantified by simple spectrophotometry in just 10 minutes.
Article
Chemistry, Organic
Yifan Li, Changhui Dai, Shentong Xie, Ping Liu, Peipei Sun
Summary: This study presents an efficient visible-light-induced decarboxylative coupling reaction of N-protecting alpha-amino acids with heterocycles for the generation of aminoalkylated heterocycles. A series of aminoalkylated heterocycles were obtained in moderate to good yields, utilizing an inexpensive organic photocatalyst under transition-metal-free conditions.
Article
Biochemistry & Molecular Biology
Kevin M. Rattigan, Martha M. Zarou, Zuzana Brabcova, Bodhayan Prasad, Desiree Zerbst, Daniele Sarnello, Eric R. Kalkman, Angela Ianniciello, Mary T. Scott, Karen Dunn, Engy Shokry, David Sumpton, Mhairi Copland, Saverio Tardito, Johan Vande Voorde, Francis Mussai, Paul Cheng, G. Vignir Helgason
Summary: In order to fuel accelerated proliferation, leukaemic cells undergo metabolic deregulation, which leads to specific nutrient dependencies. Arginine is identified as an essential nutrient for primary human CML cells through an amino acid drop-out screen and pre-clinical models. Deprivation of arginine completely blocks the proliferation of CML CD34(+) cells and induces higher levels of apoptosis compared to cell lines. Moreover, treatment with the arginine-depleting enzyme, BCT-100, is highly effective in reducing the number of human leukaemic stem cells (LSCs) in a patient-derived xenograft model.
Article
Biochemistry & Molecular Biology
Jinbiao Zhao, Jinhua Hu, Xi Ma
Summary: The study demonstrated that sodium caprylate can enhance antioxidant capacity and intestinal barrier function in IPEC-J2 cells and mice, leading to improvements in gut health.
Article
Chemistry, Multidisciplinary
Wen-Di Liu, Jia-Qi Wang, Shang-Fu Yuan, Xi Chen, Quan-Ming Wang
Summary: Silver nanoclusters protected by amino acids were synthesized and characterized in this study. Chiral superatomic silver nanoclusters with T symmetry were prepared, showing homochirality as evidenced by CD measurements. The CD signals were mainly contributed by the Ag s,p states near the Fermi level.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Mechanics
Bang-Fuh Chen, Chih-Hua Wu, Odd Magnus Faltinsen
Summary: This study provides a detailed description of the mechanism of rotating waves and the direction switch in a three-dimensional tank under nearly resonant excitation and oblique excitation angle. The change in the external excitation moment affects the circulation intensity, while the instantaneous tank motion is found to be a key factor in determining the swirling flow direction.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Multidisciplinary Sciences
Kristaps Sokolovskis, Max Lundberg, Susanne Akesson, Mikkel Willemoes, Tianhao Zhao, Violeta Caballero-Lopez, Staffan Bensch
Summary: Two interacting genes determine the migration direction in birds, and most hybrids follow either the South-West or South-East direction of their parents rather than taking an intermediate route.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Sarah D. Turner, Shelby L. Ellison, Douglas A. Senalik, Philipp W. Simon, Edgar P. Spalding, Nathan D. Miller
FRONTIERS IN PLANT SCIENCE
(2018)
Article
Plant Sciences
Mona Mazaheri, Marlies Heckwolf, Brieanne Vaillancourt, Joseph L. Gage, Brett Burdo, Sven Heckwolf, Kerrie Barry, Anna Lipzen, Camila Bastos Ribeiro, Thomas J. Y. Kono, Heidi F. Kaeppler, Edgar P. Spalding, Candice N. Hirsch, C. Robin Buell, Natalia de Leon, Shawn M. Kaeppler
Article
Plant Sciences
Guosheng Wu, Nathan D. Miller, Natalia de Leon, Shawn M. Kaeppler, Edgar P. Spalding
FRONTIERS IN PLANT SCIENCE
(2019)
Review
Plant Sciences
Minmin Du, Edgar P. Spalding, William M. Gray
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 71, 2020
(2020)
Article
Agronomy
Celeste M. Falcon, Shawn M. Kaeppler, Edgar P. Spalding, Nathan D. Miller, Nicholas Haase, Naser AlKhalifah, Martin Bohn, Edward S. Buckler, Darwin A. Campbell, Ignacio Ciampitti, Lisa Coffey, Jode Edwards, David Ertl, Sherry Flint-Garcia, Michael A. Gore, Christopher Graham, Candice N. Hirsch, James B. Holland, Diego Jarquin, Joseph Knoll, Nick Lauter, Carolyn J. Lawrence-Dill, Elizabeth C. Lee, Aaron Lorenz, Jonathan P. Lynch, Seth C. Murray, Rebecca Nelson, M. Cinta Romay, Torbert Rocheford, Patrick S. Schnable, Brian Scully, Margaret Smith, Nathan Springer, Mitchell R. Tuinstra, Renee Walton, Teclemariam Weldekidan, Randall J. Wisser, Wenwei Xu, Natalia de Leon
Article
Agronomy
Zhi Li, Sara B. Tirado, Dnyaneshwar C. Kadam, Lisa Coffey, Nathan D. Miller, Edgar P. Spalding, Aaron J. Lorenz, Natalia de Leon, Shawn M. Kaeppler, Patrick S. Schnable, Nathan M. Springer, Candice N. Hirsch
THEORETICAL AND APPLIED GENETICS
(2020)
Article
Plant Sciences
Scott H. Brainard, Julian A. Bustamante, Julie C. Dawson, Edgar P. Spalding, Irwin L. Goldman
Summary: Advances in digital image acquisition and analysis have enabled the construction of a platform for rapid measurement of carrot root shape features, including curvature analysis to detect a novel quantitative trait - root fill. The platform's performance was validated in two experimental panels, showcasing its potential in characterizing the genetic control of complex quantitative traits in carrots.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Stephen D. Deslauriers, Edgar P. Spalding
Summary: The study found that the permeability of ABCB4 and PIN2 to auxin anions significantly increased when expressed outside of cells; the synergistic effect between the two may be essential for generating asymmetric auxin efflux; auxin can also stimulate ABCB4 activity, contributing to a self-reinforcement of auxin transport.
Article
Chemistry, Applied
Jose I. Varela, Nathan D. Miller, Valentina Infante, Shawn M. Kaeppler, Natalia de Leon, Edgar P. Spalding
Summary: Researchers have developed a flatbed platform that can efficiently acquire and analyze the traits of maize kernels, accurately predicting protein content, density, and endosperm vitreousness.
Article
Multidisciplinary Sciences
Takeshi Yoshihara, Nathan D. Miller, Fernando A. Rabanal, Hannah Myles, Il-Youp Kwak, Karl W. Broman, Boris Sadkhin, Ivan Baxter, Brian P. Dilkes, Matthew E. Hudson, Edgar P. Spalding
Summary: By conducting large-scale experiments on two plant species, we have discovered four naturally varying components of a conserved process in gravitropism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
John N. Ferguson, Samuel B. Fernandes, Brandon Monier, Nathan D. Miller, Dylan Allen, Anna Dmitrieva, Peter Schmuker, Roberto Lozano, Ravi Valluru, Edward S. Buckler, Michael A. Gore, Patrick J. Brown, Edgar P. Spalding, Andrew D. B. Leakey
Summary: This study addressed the association between water use efficiency and biomass production in sorghum through advanced methods, revealing key genes related to these traits and their complex genetic relationships.
Article
Biology
Bridget A. McFarland, Naser AlKhalifah, Martin Bohn, Jessica Bubert, Edward S. Buckler, Ignacio Ciampitti, Jode Edwards, David Ertl, Joseph L. Gage, Celeste M. Falcon, Sherry Flint-Garcia, Michael A. Gore, Christopher Graham, Candice N. Hirsch, James B. Holland, Elizabeth Hood, David Hooker, Diego Jarquin, Shawn M. Kaeppler, Joseph Knoll, Greg Kruger, Nick Lauter, Elizabeth C. Lee, Dayane C. Lima, Aaron Lorenz, Jonathan P. Lynch, John McKay, Nathan D. Miller, Stephen P. Moose, Seth C. Murray, Rebecca Nelson, Christina Poudyal, Torbert Rocheford, Oscar Rodriguez, Maria Cinta Romay, James C. Schnable, Patrick S. Schnable, Brian Scully, Rajandeep Sekhon, Kevin Silverstein, Maninder Singh, Margaret Smith, Edgar P. Spalding, Nathan Springer, Kurt Thelen, Peter Thomison, Mitchell Tuinstra, Jason Wallace, Ramona Walls, David Wills, Randall J. Wisser, Wenwei Xu, Cheng-Ting Yeh, Natalia de Leon
BMC RESEARCH NOTES
(2020)
Article
Plant Sciences
Tara A. Enders, Susan St Dennis, Justin Oakland, Steven T. Callen, Malia A. Gehan, Nathan D. Miller, Edgar P. Spalding, Nathan M. Springer, Cory D. Hirsch