Article
Chemistry, Multidisciplinary
Rio S. Boothello, Nehru Viji Sankaranarayanan, Jyothi C. Sistla, Balaji Nagarajan, Chetna Sharon, John E. Chittum, Rabiya Y. Niyaz, Swarnali Roy, Aditi Nandi, Connor P. O'Hara, Rahaman Navaz Gangji, Daniel K. Afosah, Ravikumar Ongolu, Bhaumik B. Patel, Umesh R. Desai
Summary: This study reveals the inhibitory effect of shorter soluble heparan sulfate sequences on IGF-1R, contrary to the traditional relationship. Smaller oligosaccharides competitively bind in a unique pocket in the IGF-1R structure, inhibiting its activation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Plant Sciences
Lu Liu, Jun Liu, Ning Xu
Summary: Lectin receptor-like kinases (LecRKs) are located on the cell membrane and play diverse roles in environmental perception in higher plants. They are involved in plant development and response to abiotic and biotic stresses. This review summarizes the identified ligands of LecRKs in Arabidopsis, as well as discussing the posttranslational modification of these receptors in plant innate immunity and future research perspectives on plant LecRKs.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Yusuke Gonda, Akina Matsuda, Kenichiro Adachi, Chiharu Ishii, Masataka Suzuki, Akina Osaki, Masashi Mita, Naoto Nishizaki, Yoshiyuki Ohtomo, Toshiaki Shimizu, Masato Yasui, Kenji Hamase, Jumpei Sasabe
Summary: Mammals maintain systemic dominance of L-amino acids through enzymatic degradation and excretion of D-amino acids. The majority of microbial D-amino acids are catabolized by host enzymes, while urinary excretion plays a minor role. This active regulation of amino acid homochirality depends on maternal catabolism during the prenatal period and switches to host catabolism after birth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Akanksha Gandhi, Ralf Oelmueller
Summary: Plants rely on membrane-bound receptor-like kinases (RLKs) to perceive and respond to stress signals. While they play a crucial role in growth, reproduction, hormone perception, and defense responses against biotic stresses, their involvement in abiotic stress responses is not well-documented. This review summarizes the sub-classes of RLKs based on their domain structure and discusses their specific role in abiotic stress adaptation. The importance of RLKs in abiotic stress responses and their potential for engineering stress-tolerant crop varieties are highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hector Montero, Tak Lee, Boas Pucker, Gabriel Ferreras-Garrucho, Giles Oldroyd, Samuel F. Brockington, Akio Miyao, Uta Paszkowski
Summary: Receptor-like kinases play crucial roles in plant cell signaling, with OsARK1 and OsARK2 genes in rice regulating arbuscular mycorrhizal symbiosis. These two genes cooperate in symbiosis by co-regulating a set of genes in a common pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-Francois Spinella, Patrick Thomas, Guy Sauvageau, David J. Adams, Chi C. Wong
Summary: This study demonstrates that elevated levels of the anti-apoptotic factor CFLAR promotes apoptosis evasion in AML cells haploinsufficient for the CUX1 transcription factor. CUX1 deficiency alleviates CUX1 repression of the CFLAR promoter, driving CFLAR expression and leukemia survival. These findings establish CFLAR as a potential therapeutic target in poor-prognosis leukemias with CUX1 deficiency.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Plant Sciences
Ralf Muller-Xing, Qian Xing
Summary: The study reveals that MAZZA is a novel intracellular interactor of the CLV1f receptors, shedding light on how CLV1f signals are transmitted intracellularly.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Antonino M. Lecona, Kalpana Nanjareddy, Lourdes Blanco, Valeria Piazza, Jose Antonio Vera-Nunez, Miguel Lara, Manoj-Kumar Arthikala
Summary: Cysteine-rich receptor-like kinases (CRKs) are important for pathogen resistance, extracellular ROS signaling, and programmed cell death in plants. In this study, we characterized the role of CRK12 in the Phaseolus-Rhizobia symbiotic interaction using overexpression and silencing techniques. We found that CRK12 regulates root hair length and the expression of root hair regulatory genes, as well as the number and function of nodules. Our findings suggest that CRK12 is a novel regulator of symbiosis in Phaseolus vulgaris-Rhizobium tropici.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Zhen Gong, Guan-Zhu Han
Summary: Phylogenomic analyses of RLKs across plants revealed their presence in streptophytes, some chlorophytes, one prasinodermophyte, and one glaucophyte, but not in rhodophytes. The copy number of RLKs in streptophytes increased drastically after a certain point in evolution. Charophyte RLKs are diverse and seed the major diversity of land plant RLKs, suggesting modular evolution through domain gains or losses. Positive selection in charophyte RLK groups indicates potential functions in host-microbe interaction.
Review
Plant Sciences
Qingfeng Zhu, Yanzhao Feng, Jiao Xue, Pei Chen, Aixia Zhang, Yang Yu
Summary: As plants grow and develop, they face changing environments which trigger stress responses. The large protein family known as receptor-like protein kinases (RLKs) play a role in regulating plant growth, development, and response to stresses. Understanding RLKs' function and mechanisms is important for crop breeding. This review focuses on the recent findings that RLKs simultaneously regulate plant growth and stress adaptation, offering insight into crop improvement.
Article
Medicine, Research & Experimental
Zhou Jiang, Seung-Oe Lim, Meisi Yan, Jennifer L. Hsu, Jun Yao, Yongkun Wei, Shih-Shin Chang, Hirohito Yamaguchi, Heng-Huan Lee, Baozhen Ke, Jung-Mao Hsu, Li-Chuan Chan, Gabriel N. Hortobagyi, Liuqing Yang, Chunru Lin, Dihua Yu, Mien-Chie Hung
Summary: Research shows that tumors with high TYRO3 expression exhibit resistance to PD-1/PD-L1 therapy by inhibiting tumor cell ferroptosis and altering the tumor microenvironment. Inhibition of TYRO3 promotes tumor ferroptosis and sensitizes resistant tumors to PD-1 therapy. This suggests that TYRO3 could be a predictive biomarker for patient selection and a promising therapeutic target to overcome resistance to PD-1/PD-L1 therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Ahmed M. Shaman, Stephen C. Bain, George L. Bakris, John B. Buse, Thomas Idorn, Kenneth W. Mahaffey, Johannes F. E. Mann, Michael A. Nauck, Soren Rasmussen, Peter Rossing, Benjamin Wolthers, Bernard Zinman, Vlado Perkovic
Summary: The study assessed the impact of semaglutide and liraglutide on kidney outcomes in patients with type 2 diabetes, showing significant kidney-protective effects with these medications and more pronounced effects in patients with preexisting chronic kidney disease.
Article
Plant Sciences
Qian Zhang, Shuxian Chen, Yazhou Bao, Dongmei Wang, Weijie Wang, Rubin Chen, Yixin Li, Guangyuan Xu, Xianzhong Feng, Xiangxiu Liang, Daolong Dou
Summary: This study identified the roles of MRLKs in soybean immunity and identified them as candidate susceptible genes that could be useful for improving soybean resistance.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yingchao Sun, Xiaojie Wang, Feiyang Liu, Haoyu Guo, Jianfeng Wang, Zetong Wei, Zhensheng Kang, Chunlei Tang
Summary: Plant cell surface RLKs play a crucial role in recognizing and responding to pathogen invasion. In this study, a specific RLK gene (TaBIR1) was found to be upregulated during wheat resistance to Puccinia striiformis f. sp. tritici (Pst) infection. TaBIR1 was shown to be located on the plasma membrane and its knockdown resulted in decreased wheat resistance to stripe rust. Overexpression of TaBIR1 triggered constitutive immune responses in Nicotiana benthamiana. Moreover, TaBIR1's immune response is dependent on the homologues of NbBAK1 in wheat.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Hyun Kyung Lee, Daphne R. Goring
Summary: The study reveals new functions for A. thaliana Receptor-Like Kinase (RLK) genes in regulating compatible pollen hydration and early stages of pollen tube growth in the female reproductive tract. Mutant pistils for the A. thaliana RKF1 gene cluster were observed to support reduced wild-type pollen hydration and reduced pollen tube travel distances when combined with SERK1 and SERK3/BAK1 mutations. This suggests that impaired pollen-pistil dialogue at these early stages leads to altered compatible pollen responses.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Plant Sciences
Jeongmin Choi, William Summers, Uta Paszkowski
ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 56
(2018)
Article
Plant Sciences
Chai Hao Chiu, Jeongmin Choi, Uta Paszkowski
Review
Plant Sciences
Ruairidh J. H. Sawers, M. Rosario Ramirez-Flores, Victor Olalde-Portugal, Uta Paszkowski
Editorial Material
Plant Sciences
Keiko Sugimoto, Lin Xu, Uta Paszkowski, Makoto Hayashi
PLANT AND CELL PHYSIOLOGY
(2018)
Article
Plant Sciences
Hector Montero, Jeongmin Choi, Uta Paszkowski
Article
Biology
Ming Wang, Martin Schaefer, Dapeng Li, Rayko Halitschke, Chuanfu Dong, Erica McGale, Christian Paetz, Yuanyuan Song, Suhua Li, Junfu Dong, Sven Heiling, Karin Groten, Philipp Franken, Michael Bitterlich, Maria J. Harrison, Uta Paszkowski, Ian T. Baldwin
Article
Multidisciplinary Sciences
Ronelle Roth, Marco Chiapello, Hector Montero, Peter Gehrig, Jonas Grossmann, Kevin O'Holleran, Denise Hartken, Fergus Walters, Shu-Yi Yang, Stefan Hillmer, Karin Schumacher, Sarah Bowden, Melanie Craze, Emma J. Wallington, Akio Miyao, Ruairidh Sawers, Enrico Martinoia, Uta Paszkowski
NATURE COMMUNICATIONS
(2018)
Article
Biology
M. Rosario Ramirez-Flores, Sergio Perez-Limon, Meng Li, Benjamin Barrales-Gamez, Doris Albinsky, Uta Paszkowski, Victor Olalde-Portugal, Ruairidh J. H. Sawers
Editorial Material
Multidisciplinary Sciences
Chai Hao Chiu, Uta Paszkowski
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Hector Montero, Tak Lee, Boas Pucker, Gabriel Ferreras-Garrucho, Giles Oldroyd, Samuel F. Brockington, Akio Miyao, Uta Paszkowski
Summary: Receptor-like kinases play crucial roles in plant cell signaling, with OsARK1 and OsARK2 genes in rice regulating arbuscular mycorrhizal symbiosis. These two genes cooperate in symbiosis by co-regulating a set of genes in a common pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Hector Montero, Uta Paszkowski
Summary: This study developed a simple co-staining method for simultaneous imaging of arbuscules and lipid distribution within arbuscule-containing cells. By applying this method, the researchers observed lipid distribution patterns in wild-type plants and mutants, and found that specific genes may not be essential for symbiotic lipid biosynthesis and transfer in certain plant species.
Article
Biochemistry & Molecular Biology
Chai Hao Chiu, Pawel Roszak, Martina Orvosova, Uta Paszkowski
Summary: This study reveals that chitin-derived molecules, rather than symbiosis-specific signals, can trigger lateral root formation. The LysM receptors integrate MAMP perception with developmental responses, and their role in coordinating the interaction between roots and the rhizosphere biota is conserved across different plant species.
Article
Biodiversity Conservation
Jennifer McGaley, Uta Paszkowski
Summary: Despite the vast abundance and global importance of plant and microbial species, the large majority go unnoticed and unappreciated by humans, contributing to pressing issues including the neglect of study and research of these organisms; sharing the wealth of visual data produced during scientific research with a broader audience can alleviate the issues of low awareness.
PLANTS PEOPLE PLANET
(2021)
Article
Plant Sciences
Ronelle Roth, Stefan Hillmer, Charlotta Funaya, Marco Chiapello, Karin Schumacher, Libera Lo Presti, Regine Kahmann, Uta Paszkowski