Article
Chemistry, Applied
Beatriz de la Fuente, Carlos Luz, Carla Puchol, Giuseppe Meca, Francisco J. Barba
Summary: It was found that orange-juice milk beverages are a good medium for the growth of L. brevis POM and L. plantarum (TR-71, TR-14), with higher antioxidant properties observed in the fermented beverages compared to the control ones.
Article
Plant Sciences
Anna Berim, David R. Gang
Summary: Salicylic acid (SA) is a key plant hormone involved in various physiological processes, with its concentration in plants finely regulated by structural modifications. The lycophyte Selaginella moellendorffii, representing an ancient clade of vascular plants, primarily stores SA and related metabolites as glucosides in its aerial parts. The study highlights the need for further experimental characterization of enzymes in SA metabolism to elucidate physiological functions and mechanisms in ancestral plant species.
Article
Biochemistry & Molecular Biology
Maria Del Carmen Razola-Diaz, Eduardo Jesus Guerra-Hernandez, Belen Garcia-Villanova, Vito Verardo
Summary: Fruits and vegetables are rich in nutrients and bioactive compounds, which are believed to prevent chronic diseases. This study evaluated the nutritional quality, polyphenol, and vitamin C content of smoothies in the Spanish market. It was found that coconut and banana had a negative impact on the polyphenol content, while ingredients like orange, mango, and passion fruit had a positive correlation with vitamin C content.
Review
Food Science & Technology
Mack Moyo, Adeyemi O. Aremu
Summary: Cleome gynandra is becoming increasingly popular as a leafy vegetable due to its high nutritional content and beneficial health-promoting properties. It contains a rich pool of diverse antioxidant phytochemicals, including polyphenols, glucosinates, and terpenoids. Cleome gynandra's nutritional compounds have potential applications in food supplements, colorants, and extending the shelf-life of food products. Extracts of Cleome gynandra have shown promising effects in various biological assays. Including Cleome gynandra in diversified diets can contribute to food and nutrition security.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Maher Al Khatib, Jessica Costa, Daniele Spinelli, Eliana Capecchi, Raffaele Saladino, Maria Camilla Baratto, Rebecca Pogni
Summary: In this study, water soluble melanins were successfully biosynthesized from homogentisic acid and gentisic acid by the oxidative enzyme T. versicolor laccase at physiological pH. The melanins showed high antioxidant activity, persistent paramagnetism, and broad band visible light absorption. EPR analysis revealed the presence of at least two different radical species in each case, contributing to the paramagnetism observed in the samples. This achievement may have implications for understanding the composition of the ochronotic pigment in Alkaptonuria disease, and the soluble pyomelanin mimics could serve as a viable alternative to replace insoluble melanin pigment in biotechnological applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Xiao-Hua Zhang, Xiang-Dong Qing, Shu-Ting Mu, Deguo Wang, Jing-Jing Zheng, San-Jiu Zhou, Chao Kang, Zhi Liu
Summary: The chemometric second-order multivariate calibration method was successfully used for qualitative and quantitative analysis of phenolic acids in honey, showing strong association between major phenolic acid content and floral sources. The results contribute to the development of honey products and market choices.
Article
Chemistry, Applied
Haitian Fang, Xiuxiu Yin, Jiequn He, Shihua Xin, Huiling Zhang, Xingqian Ye, Yunyun Yang, Jinhu Tian
Summary: The study investigated the effects of different cooking methods on the phytochemicals and antioxidant activities of potatoes from different varieties. The results showed that frying, roasting, and air-drying had a more significant negative impact on the nutrients and antioxidant activities of potatoes compared to steaming or microwaving. Zhongshubahao variety may be an ideal potato sample in terms of retaining phytochemicals and antioxidant activities.
Article
Plant Sciences
Anna Kurek-Gorecka, Saban Keskin, Otilia Bobis, Rafael Felitti, Michal Gorecki, Michal Otreba, Jerzy Stojko, Pawel Olczyk, Sevgi Kolayli, Anna Rzepecka-Stojko
Summary: The composition of propolis varies depending on geographical location and plant sources. There are differences in propolis composition and antioxidant activity among different regions. Polish and Romanian propolis are similar, while Turkish and Uruguayan propolis are different. The observed antioxidant activity of propolis may suggest its potential in preventing and treating cardiovascular, metabolic, neurodegenerative, and cancerous diseases.
Article
Biochemistry & Molecular Biology
Danijela Skroza, Vida Simat, Lucija Vrdoljak, Nina Jolic, Anica Skelin, Martina Cagalj, Roberta Frleta, Ivana Generalic Mekinic
Summary: Phenolic compounds are powerful antioxidants, and their molecular interactions affect their antioxidant activity. In this study, the individual and combined antioxidant activity of equimolar mixtures of 10 phenolic acids were investigated. Some mixtures showed synergistic effects, while others showed antagonistic effects.
Review
Plant Sciences
Mohamed Ahmed Hassan, Tao Xu, Yang Tian, Yongheng Zhong, Fatma Abo Zakaib Ali, Xuan Yang, Baiyi Lu
Summary: Moringa oleifera, a plant native to India, contains a variety of phenolic compounds that have shown potential therapeutic properties against a range of diseases, including neurodegenerative disorders, kidney damage, diabetes, and hypertension. More research is needed to explore the full potential of these compounds for drug development and disease treatment.
Article
Polymer Science
Katia Bacha, Julien Estager, Sylvie Brassart-Pasco, Catherine Chemotti, Antony E. Fernandes, Jean-Pierre Mbakidi, Magali Deleu, Sandrine Bouquillon
Summary: New dendrimers were synthesized from PPI and PAMAM dendrimers using an efficient acid-base reaction with various phenolic acids, and the syntheses were optimized in both microwave and microfluidic reactors. These dendrimers, which are ionic and hydrophilic, exhibited excellent antioxidant properties and showed cytotoxic effects on fibroblast dermal cells.
Article
Plant Sciences
Marius Lasinskas, Elvyra Jariene, Jurgita Kulaitiene, Nijole Vaitkeviciene, Erika Jakiene, Dominika Skiba, Ewelina Hallmann
Summary: The study found that different growing systems and solid-phase fermentation have a significant impact on the active substances in fireweed leaves. Fermented fireweed leaves grown organically can be recommended as a source of polyphenols (especially phenolic acids and flavonoids), leaves grown biodynamically as a source of carotenoids (particularly lutein and beta-carotene) and chlorophyll, and naturally grown leaves for better antioxidant activity.
Article
Biochemistry & Molecular Biology
Usama W. Hawas, Lamia T. Abou El-Kassem, Fekri M. Shaher, Radwan Al-Farawati, Mohamed Ghandourah
Summary: This study examined the chemical compositions of four Red Sea halophytes and found that they contain various beneficial compounds with antioxidant and anticancer effects.
Article
Chemistry, Physical
Syed Muddassir Ali Mashhadi, Andrei S. Batsanov, Syed Arslan Sajjad, Yasir Nazir, Moazzam Hussain Bhatti, Uzma Yunus
Summary: The cocrystal of isoniazid with gentisic acid demonstrates improved pharmaceutical properties, including high free radical scavenging activity and optimized solubility, stability, and flowability.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Food Science & Technology
Bianca Beatriz Torres de Assis, Tatiana Colombo Pimentel, Aline Macedo Dantas, Marcos dos Santos Lima, Graciele da Silva Campelo Borges, Marciane Magnani
Summary: This study evaluated the fermentation of fruit purees with probiotic strains to increase phenolic content and bioaccessibility, while decreasing pH and glucose/fructose content. The results showed promising effects on antioxidant activity, indicating the potential for future use of synergistic probiotics in fruit fermentation.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Leila Mohammadzadeh, Mahboobeh Ghasemzadeh Rahbardar, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: Long-term exposure to organophosphates, such as the pesticide malathion, can lead to neurodegenerative diseases like Parkinson's disease. Crocin, a component of saffron, has been found to have anti-apoptotic, anti-inflammatory, and antioxidant properties. This study investigated the effects of crocin on the biochemical deficits induced by malathion in rat striatum tissue. The results showed that crocin could inhibit the toxic effects of malathion by its anti-apoptotic activity and regulation of proteins involved in Parkinson's disease pathogenesis.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Review
Chemistry, Medicinal
Nahid Najafi, Soghra Mehri, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Summary: This study discusses the effects of alpha-lipoic acid (alpha-LA) on different components of metabolic syndrome (MetS) and the underlying molecular mechanisms. Alpha-LA has various pharmacological effects, including antidiabetic, antiobesity, hypotensive, and hypolipidemic actions. It can improve the components of MetS, reduce cholesterol biosynthesis and atherosclerosis, and increase insulin secretion and sensitivity.
PHYTOTHERAPY RESEARCH
(2022)
Review
Medicine, General & Internal
Navid Omidkhoda, Farshad Abedi, Vahid Ghavami, Hossein Rahimi, Sara Samadi, Omid Arasteh, Amir Hooshang Mohammadpour
Summary: This study reviewed the application of heparin in DIC patients and found that heparin and its preparations have a significant impact on reducing mortality rate and duration of hospitalization, especially in the early stages of DIC.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Review
Chemistry, Medicinal
Reza Rajabalizadeh, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Summary: This article reviews the potential effects of several herbal medicines and their preparations on reducing chemotherapy-induced nausea and vomiting (CINV) and calls for further high-quality research to confirm their clinical effectiveness and safety.
PHYTOTHERAPY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Ali Ahmadi, Zoha Mortazavi, Soghra Mehri, Hossein Hosseinzadeh
Summary: This paper provides a narrative review of the protective and antidotal effects of Scutellaria baicalensis (SB) and its main constituents against natural toxicities and physical hazards. The study found that treatment with baicalein (BE), baicalin (BA), or total SB extract can prevent or counteract the toxic effects of various natural compounds and physical hazards by increasing antioxidant enzyme expression and inhibiting pro-inflammatory cytokines.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Chemistry, Medicinal
Motahareh Boozari, Hossein Hosseinzadeh
Summary: This paper provides an updated and comprehensive review of the molecular mechanisms of crocin, a hydrophilic carotenoid synthesized in the flowers of the Crocus genus. The biological and pharmacological properties of crocin, including its memory-enhancing, anxiolytic, aphrodisiac, antidepressant, and neuroprotective effects, are discussed. Various studies have confirmed the significant impact of crocin on controlling pathological conditions such as oxidative stress, inflammation, metabolic disorders, neurodegenerative disorders, and cancer. The regulatory effects of crocin on multiple signaling pathways, particularly the PI3K/AKT/mTOR pathway, play a crucial role in these effects.
PHYTOTHERAPY RESEARCH
(2022)
Review
Chemistry, Medicinal
Farshad Abedi, Navid Omidkhoda, Omid Arasteh, Vahid Ghavami, Hossein Hosseinzadeh
Summary: This systematic review and meta-analysis evaluated the efficacy of fasudil in the management of pulmonary hypertension (PH) through human clinical trials. The results suggest that fasudil is effective and safe in improving some hemodynamic parameters in PH patients in the short and mid-term periods. However, more long-term randomized controlled trials are needed to confirm these benefits.
Review
Plant Sciences
Azar Hosseini, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: This study reviewed the protective effects of pomegranate against natural and chemical toxins. Pomegranate and its active components, such as ellagic acid and punicalagin, demonstrated protective effects against aflatoxins, endotoxins, arsenic, diazinon, and carbon tetrachloride. These effects were attributed to mechanisms such as antioxidant activity, reduction of inflammation, modulation of apoptosis, and improvement of liver or cardiac function. Despite the lack of clinical trials, these findings provide valuable insights for further research on the protective effects of pomegranate.
Review
Pharmacology & Pharmacy
Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Summary: Saffron petals, the primary by-product of saffron processing, contain various substances and have a range of pharmacological properties, including antioxidant, anti-inflammatory, and antiapoptotic effects. These properties, based on their compounds such as alkaloids, flavonoids, and glycosides, contribute to saffron's antibacterial, antidepressant, antidiabetic, antihypertensive, and other therapeutic effects. This review discusses the mechanisms of action of saffron and its compounds, particularly their involvement in the Nrf2 and NF-kappa B signaling pathways.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Farima Kaviani, Bibi Marjan Razavi, Mahdieh Sadat Mohsenzadeh, Maryam Rameshrad, Hossein Hosseinzadeh
Summary: This study demonstrates the effectiveness of TQ on OLZ-induced metabolic abnormalities, which are related to its antioxidant activity and regulation of glucose homeostasis and lipid metabolism.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Pharmacology & Pharmacy
Fatemeh Babaei, Mohammadreza Mirzababaei, Alireza Tavakkoli, Marjan Nassiri-Asl, Hossein Hosseinzadeh
Summary: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of musculoskeletal disorders, pain, and fever. This review explores the antifungal effects of NSAIDs alone or in combination with antifungal drugs in vitro and in vivo. Studies have shown that NSAIDs have antifungal activities against various species of fungi, including inhibiting biofilm formation and yeast-to-hypha conversion. Modulating prostaglandin E2 levels during fungal infection may be a possible mechanism. The combination therapy of NSAIDs and antifungal drugs shows potential as a novel therapeutic strategy in clinical studies, reducing resistance and toxicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Sahar Fanoudi, Mohaddeseh Sadat Alavi, Soghra Mehri, Hossein Hosseinzadeh
Summary: Cigarette smoking is a significant risk factor for developing various diseases and cancers, and curcumin has the potential to attenuate the toxic effects of smoking and provide protection.
PHYTOTHERAPY RESEARCH
(2023)
Review
Multidisciplinary Sciences
Karim Naraki, Mahboobeh Ghasemzadeh Rahbardar, Basiru Olaitan Ajiboye, Hossein Hosseinzadeh
Summary: Ellagic acid has the potential to treat or manage metabolic syndrome and its associated complications through various mechanisms, such as regulating insulin secretion, glucose transporter expression, lipid levels, and oxidative stress. It also improves mitochondrial function, regulates adipose tissue activity, and affects vascular relaxation.
Article
Environmental Sciences
Farivar Ghobakhlou, Farhad Eisvand, Bibi Marjan Razavi, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Summary: This study aimed to investigate the protective effects of alpha-mangostin against ACR-induced neurotoxicity in rats and PC12 cells. The results showed that alpha-mangostin could alleviate ACR-induced motor disorders and oxidative stress in the cerebral cortex, as well as increase glutathione levels.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Medicinal
Seyyed Hamed Hashemi Shahri, Ghasem Soltani, Mohammad Abbasi Teshnizi, Aliasghar Moeinipour, Mohammad Tayyebi, Reza Javidi Dasht Bayaz, Farshad Abedi, Vahid Ghavami, Shahram Amini, Amir Hooshang Mohammadpour
Summary: This study suggests that prophylactic use of crocin can effectively reduce the incidence of POAF in patients undergoing heart surgeries by reducing prooxidant-antioxidant balance levels.
AVICENNA JOURNAL OF PHYTOMEDICINE
(2022)
