Article
Chemistry, Analytical
Xiaofei He, Fengxia Su, Yutong Chen, Zhengping Li
Summary: This paper presents a novel visual reverse transcription-multiple inner primer loop-mediated isothermal amplification (RT-MIPLAMP) method based on RT-LAMP, which has higher sensitivity and shorter reaction time. The feasibility of visual RT-MIPLAMP for SARS-CoV-2 identification is validated.
ANALYTICAL METHODS
(2022)
Article
Agriculture, Dairy & Animal Science
Witsanu Rapichai, Wichayet Saejung, Kotchaporn Khumtong, Chaiwat Boonkaewwan, Supansa Tuanthap, Peter A. Lieberzeit, Kiattawee Choowongkomon, Jatuporn Rattanasrisomporn
Summary: A rapid, sensitive, specific, and easy-to-visualize colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay using neutral red as an indicator dye was developed to detect feline coronavirus (FCoV) associated with feline infectious peritonitis (FIP). It showed great potential for FIP surveillance and could be used as an alternative molecular diagnostic tool for the veterinary inspection of FCoV.
Article
Chemistry, Analytical
Meng Chen, Qidi He, Yanli Tong, Zuanguang Chen
Summary: This study successfully combined LAMP with RCA to achieve rapid detection and quantification of pathogens. By using a strand displacement strategy in a single-tube reaction, different pathogen target genes were successfully detected, demonstrating the universality and reliability of the method.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Infectious Diseases
Sayamon Hongjaisee, Natteewan Doungjinda, Woottichai Khamduang, Tanawan Samleerat Carraway, Jiraprapa Wipasa, Jose D. Debes, Khuanchai Supparatpinyo
Summary: The study developed a reverse transcription loop-mediated isothermal amplification (RTLAMP) assay for detecting hepatitis C virus (HCV) in a single closed tube. The assay showed high sensitivity, specificity, and stability in detecting different HCV genotypes, making it a potentially useful tool for identifying individuals in need of HCV treatment, particularly in resource-limited settings.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Meng Yee Lai, Soo Nee Tang, Yee Ling Lau
Summary: A novel WarmStart colorimetric RT-LAMP assay for detecting SARS-CoV-2 was developed, showing simplicity, speed, and high sensitivity. Clinical testing with positive and negative samples demonstrated 100% sensitivity and specificity. This detection technology eliminates the need for complex post-amplification processing steps and is suitable for virus detection in resource-limited settings.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biotechnology & Applied Microbiology
Yi Wang, Xiaoxia Wang, Hai Chen, Limei Han, Licheng Wang, Ting Chen, Sha Li, Huan Li, Yuanli Li, Zhengkun Li, Xiaoying Fu, Shaojin Chen, Mei Xing, Jun Tai, Xiong Zhu
Summary: A novel detection platform called rRT-LAMP was developed for the diagnosis of COVID-19, which integrates reverse transcription, LAMP amplification, restriction endonuclease cleavage, and real-time fluorescence detection. This method showed high sensitivity with no cross-reactivity and can diagnose COVID-19 in just 35 minutes. It has the potential to be a valuable tool for detecting SARS-CoV-2 infection and controlling the COVID-19 epidemic.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hye-Soon Song, Hyeon-Su Kim, Ji-Ye Kim, Yong-Kuk Kwon, Hye-Ryoung Kim
Summary: Newcastle disease (ND) is a highly pathogenic viral infection of poultry with significant economic impacts worldwide. Novel sets of visual reverse transcription loop-mediated isothermal amplification (RT-LAMP) assays have been developed for the rapid detection and differentiation of NDV, showing potential for field or resource-limited environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yajuan Dong, Xiuming Wu, Shenwei Li, Renfei Lu, Yingxue Li, Zhenzhou Wan, Jianru Qin, Guoying Yu, Xia Jin, Chiyu Zhang
Summary: This study compared the performance of 19 sets of primers in COVID-19 detection and identified 6 sets of primers with faster amplification. Among them, the Set-4 primer set had the highest positive detection rate of SARS-CoV-2.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Peng Chen, Chen Chen, Huiying Su, Mengfan Zhou, Shunji Li, Wei Du, Xiaojun Feng, Bi-Feng Liu
Summary: The integration of gLAMP and mu FAchip allows for simultaneous detection of different types of bacterial pathogens. The developed mu FAchip features a simple operation process with high specificity and sensitivity, making it a rapid and effective platform for pathogen detection, especially in field settings.
Article
Microbiology
Mengtao Yu, Pei Huang, Yuanguo Li, Yumeng Song, Xingqi Liu, Na Feng, Hongli Jin, Yujie Bai, Haili Zhang, Yuanyuan Li, Xianzhu Xia, Yuwei Gao, Hualei Wang
Summary: In this study, a novel visual nucleic acid detection method was established to rapidly and accurately detect SARS-CoV-2. Compared to the traditional RT-qPCR method, this approach is easy to perform and does not require special equipment, making it suitable for sample screening in field and local laboratories.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
In Hee Lee, Jin Hyang Jung, Soo Jung Lee, Jeeyeon Lee, Ho Yong Park, Ji-Young Park, Jee Young Park, Jae-Hwan Jung, Hyunchul Lee, Hyo-Sung Jeon, Yee Soo Chae
Summary: The study aimed to assess the feasibility of using direct RT-LAMP assay as a substitute for detecting lymph node metastasis in breast cancer patients. Results showed that direct RT-LAMP assay had high sensitivity and specificity, making it a reliable method for intraoperative detection of lymph node metastasis.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Chemistry, Analytical
Ian T. Hull, Enos C. Kline, Gaurav K. Gulati, Jack Henry Kotnik, Nuttada Panpradist, Kamal G. Shah, Qin Wang, Lisa Frenkel, James Lai, Joanne Stekler, Barry R. Lutz
Summary: The study presents a novel quantitative detection method for HIV DNA or RNA using a combination of recombinase polymerase amplification and lateral flow detection technologies, allowing for rapid and accurate testing in low-resource healthcare settings, with the potential to improve the quality of HIV treatment.
ANALYTICAL CHEMISTRY
(2022)
Article
Microbiology
Jong-Min Kim, Hye-Ryung Kim, Ji-Su Baek, Oh-Kyu Kwon, Hae-Eun Kang, Yeun-Kyung Shin, Choi-Kyu Park
Summary: A visual RT-LAMP assay using a hydroxynaphthol blue (HNB) metal indicator was developed for the rapid detection of canine parainfluenza virus 5 (CPIV5) in clinical samples. The assay showed high specificity and sensitivity, and the results can be directly observed with the naked eye without any additional detection apparatuses. The detection rate of CPIV5 using this assay was higher than that of conventional reverse-transcription polymerase chain reaction (cRT-PCR) assay and comparable to real-time RT-PCR (qRT-PCR) assay.
Article
Food Science & Technology
Mei Xie, Tianlan Chen, Xiong Xin, Zongwei Cai, Cheng Dong, Bo Lei
Summary: A method using a digital microfluidic chip and loop-mediated isothermal amplification technology was developed for multiplex detection of foodborne pathogens. The method showed higher sensitivity, simpler operation, higher efficiency, and smaller size compared to the commercial benchtop LAMP method.
Article
Chemistry, Analytical
Beatriz Jorge Coelho, Bruno Veigas, Luis Bettencourt, Hugo Aguas, Elvira Fortunato, Rodrigo Martins, Pedro Baptista, Rui Igreja
Summary: We introduce a digital microfluidics (DMF) platform for loop-mediated isothermal amplification (LAMP) of DNA, and apply it to real-time amplification for monitoring c-Myc, a cancer biomarker associated with 40% of human tumors. We demonstrate successful manipulation of samples and reagents on the DMF platform, achieving amplification of 90 pg of target DNA in less than one hour. Innovative mixing strategies in DMF, including low frequency AC actuation and back-and-forth droplet motion, improve fluorescence readouts. On-chip sample partitioning and sequential droplet irradiation minimize fluorophore bleaching effects.
Article
Chemistry, Analytical
Yu-Jen Cheng, Chih-Hung Wang, Keng-Fu Hsu, Gwo-Bin Lee
Summary: In this study, an integrated microfluidic system was developed to automatically capture and quantify the methylation level of cfDNA. The system achieved high capture rate and low limit of quantification, allowing for efficient detection of methylated cfDNA from plasma samples in a short time.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Rishabh Gandotra, Hung-Bin Wu, Priya Gopinathan, Yi-Cheng Tsai, Feng-Chih Kuo, Mel S. Lee, Gwo-Bin Lee
Summary: Periprosthetic joint infections (PJIs) are serious complications that are difficult to diagnose accurately, but a newly developed HNP 1 aptamer and associated assay may help improve diagnostic accuracy and assess treatment responses for PJI.
Article
Chemistry, Analytical
Yu-Hung Cheng, Chih-Hung Wang, Keng-Fu Hsu, Gwo-Bin Lee
Summary: Ovarian cancer is one of the most severe gynecologic cancers with asymptomatic early stages. This study developed an integrated microfluidic chip that can extract cfDNA from plasma, detect and quantify mutations in the OvCa biomarker BRCA1. By automating the cfDNA extraction and qPCR processes, this chip can be used for clinical screening of OvCa-associated mutations.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yi-Sin Chen, Chihchen Chen, Charles Pin-Kuang Lai, Gwo-Bin Lee
Summary: This study developed a membrane-based EV isolation/counting platform that can efficiently isolate and quantify specific EVs from blood. The platform has a limit of detection of 105 EVs/mL, demonstrating high sensitivity for disease diagnostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
You-Ru Jhou, Chih-Hung Wang, Huey-Pin Tsai, Yan-Shen Shan, Gwo-Bin Lee
Summary: An integrated microfluidic platform utilizing real-time reverse-transcription loop-mediated isothermal amplification was developed for detection and quantification of three genes of SARS-CoV-2, providing a useful tool for COVID-19 diagnostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Rishabh Gandotra, To -Wen Chen, Feng-Chih Kuo, Mel S. Lee, Gwo-Bin Lee
Summary: In this study, a new microfluidic platform based on magnetic beads and fluorescent probes was developed to detect α-defensin and human neutrophil protein 1 (HNP 1) in synovial fluid. The method showed high sensitivity and specificity, and could rapidly and accurately detect infection biomarkers within 60 minutes. This compact device with a wide dynamic range has great potential for future diagnostics of periprosthetic joint infection.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Tsung-Han Lu, Nai-Jung Chiang, Yi-Cheng Tsai, Priya Gopinathan, Chien-Jui Huang, Jui-Lin Chang, Hsiu-Chi Tu, Yan-Shen Shan, Shang-Cheng Hung, Gwo-Bin Lee
Summary: Cancer can have devastating consequences and is often difficult to detect in its early stages. A new automated integrated microfluidic system has been developed to improve the diagnosis of bile duct cholangiocarcinoma (CCA), a type of cancer that is challenging to diagnose. This system uses three CCA-specific affinity reagents to detect tumor cells in a small sample of CCA patient bile and can automate the entire detection process in just 80 minutes.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
To-Wen Chen, Rishabh Gandotra, Hwan-You Chang, Mel S. Lee, Feng-Chih Kuo, Gwo-Bin Lee
Summary: This study developed a novel integrated microfluidic system (IMS) for detecting two common periprosthetic joint infection (PJI) biomarkers, alpha defensin human neutrophil peptide 1 (HNP-1) and C-reactive protein (CRP), from synovial fluid (SF). The system automatically carried out a magnetic bead-based one-aptamer-one-antibody assay within 45 minutes on a single chip, enabling simultaneous detection of both biomarkers at specific concentration ranges. It is the first report to utilize these two biomarkers as targets in an on-chip assay, and the IMS showed promising diagnostic accuracy in clinical samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Rishabh Gandotra, Feng-Chih Kuo, Mel S. Lee, Gwo-Bin Lee
Summary: This study introduces a paper-based microfluidic chip for the quantitative detection of HNP 1 in synovial fluid, providing a rapid and cost-effective diagnostic tool for periprosthetic joint infections (PJI) cases. The chip demonstrates high sensitivity and selectivity, with a wide dynamic range, making it a promising solution for PJI diagnosis in clinical settings.
ANALYTICA CHIMICA ACTA
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Chi-Chien Huang, Chia-Yu Sung, Yi-Sin Chen, Keng-Fu Hsu, Gwo-Bin Lee
Summary: This study reports an integrated microfluidic system for automated extraction and quantification of extracellular vesicle-derived microRNA from ovarian cancer. By using specific beads, the capture rate of extracellular vesicles was improved and two microRNA biomarkers were simultaneously detected and quantified, providing a precise and specific diagnostic tool for OvCa.
2022 IEEE 35TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE (MEMS)
(2022)
Article
Biochemical Research Methods
Yi-Da Chung, Ting-Hang Liu, Yu-Ling Liang, Chang-Ni Lin, Keng-Fu Hsu, Gwo-Bin Lee
Summary: An integrated microfluidic system was developed for detecting the ovarian clear cell carcinoma biomarker FXYD2 automatically. This system could perform a series of operations from handling ascites to detecting RNA levels on a single microfluidic chip, offering potential for OCCC diagnosis and prognosis.
Article
Biochemical Research Methods
Mohammad Osaid, Yi-Sin Chen, Chih-Hung Wang, Anirban Sinha, Wen-Bin Lee, Priya Gopinathan, Hung-Bin Wu, Gwo-Bin Lee
Summary: The study developed a microfluidic platform for rapid antimicrobial susceptibility testing, including dilution of antibiotics and distribution of bacteria, which can improve efficiency and accuracy of the testing process.
Article
Biochemical Research Methods
Yi-Sin Chen, Charles Pin-Kuang Lai, Chihchen Chen, Gwo-Bin Lee
Summary: This study presents a novel method for label-free, contact-free isolation and recovery of extracellular vesicles (EVs) using optically-induced dielectrophoresis (ODEP) on a microfluidic platform, achieving rapid enrichment and automatic isolation and recovery of EVs with high efficiency.
Article
Biochemical Research Methods
Kuo-Wei Hsu, Wen-Bin Lee, Huey-Ling You, Mel S. Lee, Gwo-Bin Lee
Summary: Urinary tract infections are common in females, posing risks to kidney function and often requiring broad-spectrum antibiotics. The rise of drug-resistant strains has led to high recurrence rates, emphasizing the need for accurate antibiotic selection. A newly developed portable system allows for rapid and precise measurement of antibiotic sensitivity in urine samples, offering promise for future personalized medicine.
Article
Biochemical Research Methods
Cheng-Sheng Lin, Yi-Cheng Tsai, Keng-Fu Hsu, Gwo-Bin Lee
Summary: An integrated microfluidic system was developed to automatically optimize aptamer selection, providing a new approach for screening cancer-associated aptamers for cancer diagnosis.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)