Article
Biochemistry & Molecular Biology
Michal Kacprzak, Magdalena Brzeczek, Marzenna Zielinska
Summary: The study examined the association between atrial infarction (AI) and the prognostic value of N-terminal proANP (NT-proANP) in patients with myocardial infarction (MI) treated with primary percutaneous coronary intervention (PCI). The results showed that AI did not affect the prognosis of patients with MI, while NT-proANP was identified as a strong predictor of death.
Article
Cardiac & Cardiovascular Systems
Camilla F. Thomsen, Tina S. Goharian, Kristian T. Larsen, Jens P. Goetze, Lars B. Andersen, Jorgen L. Jeppesen
Summary: The study demonstrates that an intensive lifestyle intervention increases plasma MR-proANP among overweight children, improving fitness and reducing body mass index.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Shang-Feng Yang, Szu-Yuan Li, Feng-Yen Lin, Tsung-Han Hsieh, Po-Hsun Huang, Shing-Jong Lin
Summary: Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease. This study found that in CKD patients, levels of corin are increased in the heart and serum, but its activity is suppressed. These findings suggest that corin dysfunction may play a significant role in the pathogenesis of CKD-associated cardiomyopathy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Respiratory System
Georgia K. Thomas, Cory R. Trankle, Salvatore Carbone, Hayley Billingsley, Benjamin W. Van Tassell, Ronald K. Evans, Ryan Garten, Elisabeth Weiss, Antonio Abbate, Justin M. Canada
Summary: Cardiorespiratory fitness is a strong predictor of cardiovascular health and overall mortality. Patients with lung cancer receiving radiotherapy may experience reduced CRF, with diastolic dysfunction and NTproBNP levels inversely correlated with peak VO2. NTproBNP is the strongest independent variable associated with peak VO2 in this population, indicating its significance in predicting CRF.
Review
Physiology
Gustavo Jose Justo da Silva, Raffaele Altara, George W. Booz, Alessandro Cataliotti
Summary: Atrial natriuretic peptide is a crucial cardiac hormone that helps maintain heart function through potent natriuretic, diuretic, and vasodilating actions. Its main effects involve promoting the function of different tissues and organs in the body, and it shows potential in cardiorenal protective actions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jairo Azocar-Gallardo, Alex Ojeda-Aravena, Eduardo Baez-San Martin, Victor Campos-Uribe, Luis Gonzalez-Rojas, Maria A. Castillo Cerda, Jose Manuel Garcia-Garcia
Summary: The aim of this study was to determine the influence of body composition on cardiorespiratory fitness and metabolic markers. The results showed that higher fat-free mass and lower body mass index were positively related to better cardiorespiratory fitness, regardless of insulin resistance status.
APPLIED SCIENCES-BASEL
(2023)
Review
Clinical Neurology
Tyler A. Powell, Vincent Mysliwiec, Matthew S. Brock, Michael J. Morris
Summary: The effects of untreated obstructive sleep apnea (OSA) on cardiopulmonary function remain unclear. Cardiorespiratory fitness (CRF), commonly reflected by VO2 max measured during cardiopulmonary exercise testing, has gained popularity in evaluating numerous cardiopulmonary conditions and may provide a novel means of identifying OSA patients with the most clinically significant disease.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Nutrition & Dietetics
Mayada Demashkieh, Rinkoo Dalan, Stephen Francis Burns
Summary: This study compared cardiorespiratory fitness and fat oxidation among Chinese, Indian, and Malay men. The results showed similar cardiorespiratory fitness and resting fat oxidation levels among the groups. However, Indian and Malay men had lower maximal fat oxidation levels during exercise, which may contribute to obesity risk in Asian populations.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Baruch Vainshelboim, Jonathan Myers, Charles E. Matthews
Summary: This study assessed the association between a pragmatic non-exercise estimated cardiorespiratory fitness (NEE-CRF) method and mortality outcomes in a large prospective cohort, and found that higher NEE-CRF was independently associated with lower mortality risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Psychiatry
Markus Gerber, Robyn Cody, Johannes Beck, Serge Brand, Lars Donath, Anne Eckert, Martin Hatzinger, Christian Imboden, Jan-Niklas Kreppke, Undine E. E. Lang, Sebastian Ludyga, Sarah Mans, Thorsten Mikoteit, Anja Oswald, Nina Schweinfurth-Keck, Lukas Zahner, Oliver Faude
Summary: Compared to the general population, individuals with depression have a higher risk for cardiovascular diseases. It is unclear how cardiorespiratory fitness affects this relationship. This study evaluated differences in cardiovascular risk factors between patients with depression and healthy controls, differences in cardiorespiratory fitness between the two groups, and the association between higher fitness levels and lower cardiovascular risk in both groups.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Cell Biology
Fei Sun, Ke Zhou, Ke-yong Tian, Xin-yu Zhang, Wei Liu, Jie Wang, Cui-ping Zhong, Jian-hua Qiu, Ding-jun Zha
Summary: Strategies using bioactive molecules that regulate neurite regeneration and neuronal survival to reestablish connections between auditory epithelium or implanted electrodes and SGN neurites would become attractive therapeutic candidates for sensorineural hearing loss.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Marcelo Roberto Choi, Belisario Enrique Fernandez
Summary: Atrial natriuretic peptide, part of the natriuretic peptide family, has natriuretic, diuretic, and vasodilator effects that oppose the renin-angiotensin system. It also exerts nephroprotective effects due to its antioxidant and anti-inflammatory properties, making it a beneficial agent against acute and chronic kidney diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Veterinary Sciences
Zohreh Khaki, Parviz Nooshirvani, Darioush Shirani, Majid Masoudifard
Summary: This study aimed to assess the serum concentrations of ANP, BNP, and lipoproteins in dogs with MMVD and evaluate their correlation. The results showed that serum BNP has a greater diagnostic value than serum ANP in dogs with MMVD, and it can be used to determine the subclinical stages of B1 and B2 MMVD. Additionally, dogs with subclinical MMVD showed an increase in BNP, a decrease in HDL-C, and an increase in LDL-C, which are known risk factors for cardiovascular diseases in humans.
BMC VETERINARY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Zhenjiang Yang, Tuerdi Subati, Kyungsoo Kim, Matthew B. Murphy, Owen P. Dougherty, Isis L. Christopher, Joseph C. Van Amburg, Kaylen K. Woodall, Joey Barnett, Katherine T. Murray
Summary: Natriuretic peptide oligomers increase susceptibility to atrial arrhythmia, and the accelerated formation of oligomers by mutANP is associated with familial atrial fibrillation mutations. Oligomers inhibit mitochondrial function and regulate ion currents in atrial cells.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Mario Leone, Patrick Levesque, Sabrina Bourget-Gaudreault, Jean Lemoyne, Emilia Kalinova, Alain Steve Comtois, Hung Tien Bui, Luc Leger, Pierre Fremont, Maxime Allisse
Summary: This study reveals a decline in cardiorespiratory fitness (CRF) and functional capacity among Canadian youth, which raises concerns from a public health perspective. The maximal oxygen uptake (VO2max) of boys and girls at the age of 10 and 17 has decreased by 18% and 12% respectively, reaching a significant level. Moreover, there has been a decrease of over 30% in functional capacity. Therefore, it is imperative to develop strategies to promote a physically active lifestyle among youth.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Surgery
Rebecca Andrea Conradsen Skov, Jonas P. Eiberg, Laurence Rouet, Nikolaj Eldrup, Alexander H. Zielinski, Magdalena A. Broda, Jens P. Goetze, Qasam M. Ghulam
Summary: This study aims to evaluate the relationship between antithrombotic therapy and intraluminal thrombus (ILT) size in patients with abdominal aortic aneurysm (AAA). The results show that patients on anticoagulant therapy have smaller ILT size compared to those on antiplatelet therapy and those without antithrombotic therapy. These findings are important for further investigations into the growth and rupture risk of AAA and for optimizing AAA surveillance strategy.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Transplantation
Juan Brignone, Mia Jensen, Boye L. Jensen, Kasper Bostlund Assersen, Jens P. Goetze, Lars Jodal, Trine Borup Andersen, Sigridur Olga Magnusdottir, Brian Kloster, Morten Jonler, Lars Lund
Summary: The present study tested if treatment with the combined angiotensin II-angiotensin II receptor type 1 and neprilysin blocker Entresto protects the filtration barrier and kidney function after ischaemia and partial nephrectomy in pigs. It was found that Entresto increased GFR in the uninjured kidney and reduced albuminuria from both kidneys.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Public, Environmental & Occupational Health
Sarah Overgaard Sorensen, Anne Kaer Gejl, Jesper Pedersen, Martin Gillies Rasmussen, Line Gronholt Olesen, Peter Lund Kristensen, Anders Grontved
Summary: This study found that parents' screen media habits and attitudes are strongly associated with their children's recreational screen use. Children whose parents use screens excessively are more likely to have excessive screen use on both weekdays and weekends. Moreover, children whose parents have a positive attitude towards their screen use or are at risk of smartphone addiction tend to have higher screen use and more frequent problematic use.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Pediatrics
Sofie Rath Mortensen, Jesper Schmidt-Persson, Line Gronholt Olesen, Heidi Klakk Egebaek, Henriette Boye, Niels Bilenberg, Anders Grontved
Summary: This study aimed to investigate the association between parental recreational screen media practices, including time use and level of smartphone addiction, and behavioral difficulties in 7-year-old children. The findings showed no consistent association between parental recreational screen time and behavioral difficulties in their children, but revealed a link between excessive maternal smartphone use and behavioral difficulties in their children.
ACADEMIC PEDIATRICS
(2023)
Article
Peripheral Vascular Disease
August Adelsten Olsen, Stefan Burgdorf, Dennis Richard Bigler, Mette Siemsen, Eske Kvanner Aasvang, Jens P. Goetze, Morten Bo Sondergaard Svendsen, Lars Bo Svendsen, Michael Patrick Achiam
Summary: Currently, the diagnosis and grading of mesenteric traction syndrome rely on a subjective assessment of facial flushing, which has limitations. In this study, Laser Speckle Contrast Imaging and a predefined cut-off value were assessed and validated for the objective identification of severe mesenteric traction syndrome.
MICROVASCULAR RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Marlene Rietz, Jesper Schmidt-Persson, Martin Gillies Banke Rasmussen, Heidi Klakk Egebaek, Niels Wedderkopp, Peter Lund Kristensen, Anders Grontved
Summary: This study investigated the association between trajectories of screen time from ages 3 to 7 and body composition at age 7. The results suggest that recreational screen time during this period is not associated with adiposity or other measures of body composition.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Natascha H. Pedersen, Anders Grontved, Jan C. Brond, Niels C. Moller, Kristian T. Larsen, Birgit Debrabant, Sofie Koch, Jens Troelsen, Soren Brage, Jasper Schipperijn, Jacob Hjelmborg, Niels Wedderkopp, Lars B. Christiansen, Peter L. Kristensen
Summary: A new Danish school policy requiring 45 minutes of physical activity daily during school hours was introduced in 2014. This study evaluated the effect of this nationwide policy on physical activity in Danish children and adolescents. The results showed that the policy interrupted the decreasing trend of physical activity during school hours and increased physical activity among students.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Cardiac & Cardiovascular Systems
Tomoko Ichiki, Valentina Cannone, Christopher G. Scott, Seethalakshmi R. Iyer, S. Jeson Sangaralingham, Kent R. Bailey, Jens P. Goetze, Yoshihisa Tsuji, Richard J. Rodeheffer, John C. Burnett
Summary: Males have lower levels of ANP and BNP and higher prevalence of cardiometabolic disease. The ANP gene variant rs5068 is associated with better metabolic function in males, while the BNP gene variant rs198389 is not associated with metabolic profile in the general population. ANP may play a more significant role in metabolic homeostasis, especially in males.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Environmental Sciences
Frederik Damsgaard Hojsager, Annika Sigvaldsen, Marianne Skovsager Andersen, Anders Juul, Flemming Nielsen, Soren Moller, Henrik Boye Thybo Christesen, Anders Grontved, Philippe Grandjean, Tina Kold Jensen
Summary: This study found that prenatal and early postnatal exposure to perfluoroalkyl substances (PFAS) is associated with lower bone mineral density (BMD) at age 7. The association is stronger for exposure at 18 months than prenatal exposure.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Petros Andrikopoulos, Judith Aron-Wisnewsky, Rima Chakaroun, Antonis Myridakis, Sofia K. Forslund, Trine Nielsen, Solia Adriouch, Bridget Holmes, Julien Chilloux, Sara Vieira-Silva, Gwen Falony, Joe-Elie Salem, Fabrizio Andreelli, Eugeni Belda, Julius Kieswich, Kanta Chechi, Francesc Puig-Castellvi, Mickael Chevalier, Emmanuelle Le Chatelier, Michael T. Olanipekun, Lesley Hoyles, Renato Alves, Gerard Helft, Richard Isnard, Lars Kober, Luis Pedro Coelho, Christine Rouault, Dominique Gauguier, Jens Peter Gotze, Edi Prifti, Philippe Froguel, Jean-Daniel Zucker, Fredrik Backhed, Henrik Vestergaard, Torben Hansen, Jean-Michel Oppert, Matthias Bluher, Jens Nielsen, Jeroen Raes, Peer Bork, Muhammad M. Yaqoob, Michael Stumvoll, Oluf Pedersen, S. Dusko Ehrlich, Karine Clement, Marc-Emmanuel Dumas
Summary: The study reveals that kidney function is the main determinant of circulating TMAO levels, while microbiota composition and diet play minor but significant roles. Mediation analysis suggests a causal relationship between TMAO and kidney function, which is supported by preclinical models. The study also finds that anti-diabetic drugs with reno-protective properties can lower TMAO levels.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Peter Kamstrup, Ema Rastoder, Pernille Hogh Hellmann, Pradeesh Sivapalan, Emil List Larsen, Jorgen Vestbo, Charlotte Suppli Ulrik, Jens P. Goetze, Filip Krag Knop, Jens Ulrik Staehr Jensen
Summary: Synthetic corticosteroids are commonly used for their anti-inflammatory and immunosuppressant effects, although their association with venous thromboembolism remains unclear. A trial was conducted to investigate the effects of prednisolone on haemostasis in healthy men. The results showed that prednisolone did not affect clot formation but influenced certain prothrombotic markers and antithrombotic markers.
Article
Multidisciplinary Sciences
Sasha A. S. Kjeldsen, Lise L. Gluud, Mikkel P. Werge, Julie S. Pedersen, Flemming Bendtsen, Kleopatra Alexiadou, Tricia Tan, Signe S. Torekov, Eva W. Iepsen, Nicole J. Jensen, Michael M. Richter, Jens P. Goetze, Jorgen Rungby, Bolette Hartmann, Jens J. Holst, Birgitte Holst, Joachim Holt, Finn Gustafsson, Sten Madsbad, Maria S. Svane, Kirstine N. Bojsen-Moller, Nicolai J. Wewer Albrechtsen
Summary: Inhibitors of neprilysin improve glycemia in patients with heart failure and type 2 diabetes. NEPa, but not neprilysin protein, was enhanced in obesity, T2D, and MASLD. MASLD may drive exaggerated NEPa, and lowered NEPa following bariatric surgery or liraglutide therapy may contribute to the reported improved cardiometabolic effects.
Article
Sport Sciences
Stine Buus Nymand, Jacob Hartmann, Iben Elmerdahl Rasmussen, Ulrik Winning Iepsen, Mathias Ried-Larsen, Regitse Hojgaard Christensen, Ronan Martin Griffin Berg
Summary: This study investigated the potential benefits of high-intensity interval training (HIIT) during pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). However, it is still unknown whether long or short intervals are more effective and tolerable for COPD patients.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Article
Sport Sciences
Sidsel L. Domazet, Jakob Tarp, Reimar W. Thomsen, Kurt Hojlund, Jacob V. Stidsen, Jan C. Brond, Anders Grontved, Jens Steen Nielsen
Summary: This study investigated the physical activity behaviors of individuals with newly diagnosed type 2 diabetes, finding that 62% of patients met the recommendations for physical activity. However, the majority of participants were highly sedentary and accumulated very few daily steps, emphasizing the need to focus on both increasing physical activity and reducing sedentary behaviors in the prevention of diabetes-related complications.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2023)
Article
Sport Sciences
Kristian Karstoft, Mathias Ried-Larsen, Lea Bruhn, Nanna Skytt Pilmark, Katrine Bagge Hansen, Frederik Persson, Marit Eika Jorgensen, Martin Baek Blond, Kristine Faerch
Summary: This study investigated the effect of metformin on the free-living physical activity level of individuals with overweight/obesity and prediabetes. The results showed that short-term metformin treatment did not reduce the free-living physical activity level of these individuals.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.
