Article
Medicine, General & Internal
Manfred Accrombessi, Jackie Cook, Edouard Dangbenon, Boulais Yovogan, Hilaire Akpovi, Arthur Sovi, Constantin Adoha, Landry Assongba, Aboubacar Sidick, Bruno Akinro, Razaki Osse, Rock Aikpon, Aurore Ogouyemi-Hounto, Germain Gil Padonou, Immo Kleinschmidt, Louisa A. Messenger, Mark Rowland, Corine Ngufor, Natacha Protopopoff, Martin Akogbeto, Filemon Tokponnon
Summary: This study evaluated the efficacy of pyriproxyfen-pyrethroid LLINs and chlorfenapyr-pyrethroid LLINs compared to standard LLINs in an area with high pyrethroid resistance. The findings showed that chlorfenapyr-pyrethroid LLINs provided greater protection from malaria than pyrethroid-only LLINs in an area with pyrethroid-resistant mosquitoes. Pyriproxyfen-pyrethroid LLINs conferred protection similar to pyrethroid-only LLINs.
Article
Entomology
Tatcheme Filemon Tokponnon, Razaki Osse, Germain Gil Padonou, Cyriaque Dossou Affoukou, Aboubakar Sidick, Wilfried Sewade, Arsene Fassinou, Come Z. Koukpo, Bruno Akinro, Louisa A. Messenger, Mariam Oke, Alexis Tchevoede, Aurore Ogouyemi-Hounto, Dorothee Kinde Gazard, Martin Akogbeto
Summary: Through a study on vector dynamics and transmission, it was found that there are low, medium, and high levels of malaria transmission in different areas of Benin. The study also revealed the heterogeneity of malaria transmission in the country. The findings will be used to improve vector control strategies and protect the most at-risk populations.
Article
Multidisciplinary Sciences
Thomas Syme, Boris N'dombidje, Martial Gbegbo, Damien Todjinou, Victoria Ariori, Patricia De Vos, Olivier Pigeon, Corine Ngufor
Summary: Pyrethroid-chlorfenapyr nets have shown improved impact in controlling malaria transmission in Africa, leading to increased demand for this net type. The PermaNet Dual, a deltamethrin-chlorfenapyr net, outperformed other nets in terms of mosquito mortality both before and after washes. It was also found non-inferior to a pyrethroid-chlorfenapyr net in terms of vector mortality, but not in terms of blood-feeding protection. Overall, PermaNet Dual provides an additional option for effective control of malaria transmitted by pyrethroid-resistant mosquitoes.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Aziz Bouraima, Armel Djenontin, Yannelle Dossou, Lenucthadius Houessou, Christophe Soares, Montchede Anato, Boris-Enock Zinsou, Celia Dechavanne, Jerome Clain, Achille Massougbodji, Gilles Cottrell
Summary: The objective of this study was to estimate malaria transmission and insecticide resistance status in malaria vectors in Adjrako village from Ze District in Southern Benin. Human landing collections (HLCs) were performed to collect mosquitoes in the village. The study showed that An. gambiae s.l. is the main malaria vector in the area and it is resistant to deltamethrin and possibly bendiocarb.
Article
Medicine, General & Internal
Samuel Odarkwei Blankson, Lauriane Rietmeyer, Patrick Tettey, Liliane Dikroh, Bernard Tornyigah, Rafiou Adamou, Azizath Moussiliou, Caroline Padounou, Annick Amoussou, Benedicta Ayiedu Mensah, Maroufou J. J. Alao, Gordon Awandare, Nicaise Tuikue Ndam, Christian Roussilhon, Rachida Tahar
Summary: This study evaluated the levels of plasma soluble neopterin in severe malaria patients and assessed its prognostic accuracy. The results showed that neopterin levels were higher in patients with severe malarial anemia and in patients who died from the disease. Plasma neopterin levels may serve as a potential biomarker for predicting fatality in severe falciparum malaria patients.
Article
Multidisciplinary Sciences
Edwige Guissou, Jessica L. Waite, Matthew Jones, Andrew S. Bell, Eunho Suh, Koudraogo B. Yameogo, Nicaise Djegbe, Dari F. Da, Domonbabele F. D. S. Hien, Rakiswende S. Yerbanga, Anicet G. Ouedraogo, Kounbobr Roch. Dabire, Anna Cohuet, Matthew B. Thomas, Thierry Lefevre
Summary: The study introduces a novel non-destructive assay to estimate the extrinsic incubation period (EIP) of Plasmodium parasites in individual mosquitoes, and tests it across various malaria mosquito species and temperatures. Results show that at 27 degrees Celsius, the median EIP of Plasmodium falciparum ranges from 11 to 14 days depending on mosquito species and parasite isolate. Individual tracking also revealed that sporozoites can transfer onto cotton wool up to day 40 post-infection. Trade-offs and constraints between mosquito/parasite traits are important for understanding the evolution of parasite transmission strategies.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Delenasaw Yewhalaw, Eba Alemayehu Simma, Endalew Zemene, Kassahun Zeleke, Teshome Degefa
Summary: The aim of this study was to assess the persistence of SumiShield((TM)) 50WG by spraying on different wall surfaces and determine its decay rates over time in Ethiopia. The results showed that SumiShield((TM)) 50WG had a residual efficacy of up to nine months on all treated wall surface types, making it a potential candidate insecticide formulation for indoor residual spraying in malaria endemic countries with long transmission seasons.
Article
Public, Environmental & Occupational Health
Vy Bui, Colleen R. Higgins, Sarah Laing, Sachiko Ozawa
Summary: This study examines the impact of substandard and falsified antimalarials on health and economy in Benin, showing the significant cost and death associated with poor-quality antimalarials. Replacing all antimalarials with quality-assured artemisinin combination therapies has the potential to save costs and prevent deaths.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Multidisciplinary Sciences
Jessica McCaffery, Balwan Singh, Douglas Nace, Ashenafi Assefa, Jimee Hwang, Mateusz Plucinski, Nidia Calvo, Alberto Moreno, Venkatachalam Udhayakumar, Eric Rogier
Summary: This study evaluated the utility of a P. vivax/P. falciparum chimeric antigen for assessing serological responses. The results showed that the chimeric antigen could accurately detect antibodies to multiple species of malaria parasites, making it suitable for use in serosurveys.
Article
Infectious Diseases
Joseph Keating, Joshua O. Yukich, John M. Miller, Sara Scates, Busiku Hamainza, Thomas P. Eisele, Adam Bennett
Summary: The study retrospectively analyzed the epidemiological data of introducing Actellic 300CS and the mSpray platform into indoor residual spraying programs in Zambia, showing that the use of these two interventions appears to effectively reduce malaria incidence.
Article
Multidisciplinary Sciences
Armel Djenontin, Daleb Alfa, Aziz Bouraima, Christophe Soares, Amal Dahounto, Sylvie Cornelie, Marc Egrot, Georgia Damien, Franck Remoue, Andre Barembaye Sagna, Nicolas Moiroux, Cedric Pennetier
Summary: In this study, the durability and community acceptance of LifeNet(R) in a rural area of Benin were evaluated. The results showed that LifeNet(R) met WHO's bio-efficacy criteria throughout the three-year trial period and was well accepted by the population.
Article
Engineering, Electrical & Electronic
Long Yang, Jiangtao Wang, Xuan Xue, Jia Shi, Yongchao Wang
Summary: This paper investigates the secure hybrid beamforming design in an intelligent reflecting surface assisted millimeter-wave system. The joint optimization of hybrid beamforming and passive beamforming is formulated to maximize secrecy capacity. The proposed algorithms solve the problem by decomposing it into subproblems and sequentially solving them. Simulation results demonstrate the superior performance of the proposed algorithms.
IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS
(2023)
Article
Immunology
E. Guillochon, J. Fraering, V Joste, C. Kamaliddin, B. Vianou, L. Houze, L. G. Baudrin, J. F. Faucher, A. Aubouy, S. Houze, M. Cot, N. Argy, O. Taboureau, G. Bertin
Summary: This study characterized the gene expression profile associated with cerebral malaria (CM) using RNA sequencing data. The findings revealed that CM parasites had reduced circulation times and increased cytoadherence capacity. Differential expression analyses identified specific transcriptome profiles related to malaria severity. Dysregulated expression of genes involved in adhesion and erythrocyte invasion was also observed.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Theresa Reiker, Monica Golumbeanu, Andrew Shattock, Lydia Burgert, Thomas A. Smith, Sarah Filippi, Ewan Cameron, Melissa A. Penny
Summary: Individual-based models are essential in the global fight against infectious diseases, but the complexity of the models can pose challenges for calibration. The authors propose using a Bayesian optimization framework to calibrate a complex malaria transmission simulator, resulting in improved fitting outcomes compared to previous calibrations.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xiaomin Shang, Shijun Shen, Jianxia Tang, Xiaoqin He, Yuemeng Zhao, Changhong Wang, Xiaohui He, Gangqiang Guo, Meng Liu, Liping Wang, Qianshu Zhu, Guang Yang, Cizhong Jiang, Meihua Zhang, Xinyu Yu, Jiping Han, Richard Culleton, Lubin Jiang, Jun Cao, Liang Gu, Qingfeng Zhang
Summary: The process of gametocytogenesis in malaria parasites is complex and largely unknown. However, a new study has identified a key transcription factor, PfAP2-G5, which is essential for this process. PfAP2-G5 suppresses the transcriptional activity of the pfap2-g gene, preventing sexual commitment and influencing gametocyte maturation.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Manfred Accrombessi, Martin C. Akogbeto, Edouard Dangbenon, Hilaire Akpovi, Arthur Sovi, Boulais Yovogan, Constantin Adoha, Landry Assongba, Aurore Ogouyemi-Hounto, Germain Gil Padonou, Charles Thickstun, Mark Rowland, Corine Ngufor, Natacha Protopopoff, Jackie Cook
Summary: Despite the extensive use of long-lasting insecticidal nets (LLINs), indoor residual spraying, and malaria case management in Benin, malaria still poses a significant burden in this country. This study focused on a rural area of Benin with high net coverage and pyrethroid-resistant mosquito vectors to determine the malaria burden and its associated risk factors. The results showed a high prevalence of malaria infection despite the high usage of nets. Factors such as high household density, low socioeconomic status, young age (<15 years), poor net conditions, and low net usage were significantly associated with malaria infection. Therefore, the development of new classes of LLINs effective against resistant vectors is crucial in reducing malaria transmission in this area.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Medicine, General & Internal
Manfred Accrombessi, Jackie Cook, Edouard Dangbenon, Boulais Yovogan, Hilaire Akpovi, Arthur Sovi, Constantin Adoha, Landry Assongba, Aboubacar Sidick, Bruno Akinro, Razaki Osse, Rock Aikpon, Aurore Ogouyemi-Hounto, Germain Gil Padonou, Immo Kleinschmidt, Louisa A. Messenger, Mark Rowland, Corine Ngufor, Natacha Protopopoff, Martin Akogbeto, Filemon Tokponnon
Summary: This study evaluated the efficacy of pyriproxyfen-pyrethroid LLINs and chlorfenapyr-pyrethroid LLINs compared to standard LLINs in an area with high pyrethroid resistance. The findings showed that chlorfenapyr-pyrethroid LLINs provided greater protection from malaria than pyrethroid-only LLINs in an area with pyrethroid-resistant mosquitoes. Pyriproxyfen-pyrethroid LLINs conferred protection similar to pyrethroid-only LLINs.
Article
Entomology
Tatcheme Filemon Tokponnon, Razaki Osse, Germain Gil Padonou, Cyriaque Dossou Affoukou, Aboubakar Sidick, Wilfried Sewade, Arsene Fassinou, Come Z. Koukpo, Bruno Akinro, Louisa A. Messenger, Mariam Oke, Alexis Tchevoede, Aurore Ogouyemi-Hounto, Dorothee Kinde Gazard, Martin Akogbeto
Summary: Through a study on vector dynamics and transmission, it was found that there are low, medium, and high levels of malaria transmission in different areas of Benin. The study also revealed the heterogeneity of malaria transmission in the country. The findings will be used to improve vector control strategies and protect the most at-risk populations.
Article
Entomology
Germain Gil Padonou, David Mahouton Zoungbedji, Arthur Sovi, Albert Sourou Salako, Alphonse Keller Konkon, Boulais Yovogan, Constantin Jesukede Adoha, Esdras Mahoutin Odjo, Razaki Osse, Haziz Sina, Renaud Govoetchan, Casimir Dossou Kpanou, Hermann W. Sagbohan, Lamine Baba-Moussa, Martin Akogbeto
Summary: The main objective of this study was to assess the preferences in terms of vertebrate hosts of Anopheles coluzzii, the main malaria vector in the pastoral area of Malanville, Benin, where rice cultivation and livestock are the main source of income for the populations. The study revealed that in the pastoral area, An. coluzzii showed opportunistic and zoophagic behavior, with goats, humans, bovines, and pigs being the main vertebrate hosts. The importance score for this study is 7 out of 10.
JOURNAL OF MEDICAL ENTOMOLOGY
(2023)
Article
Infectious Diseases
Esdras Mahoutin Odjo, Albert Sourou Salako, Germain Gil Padonou, Boulais Yovogan, Constantin Jesukede Adoha, Bruno Adjottin, Andre Aime Sominahouin, Arthur Sovi, Razaki Osse, Casimir D. Kpanou, Hermann W. Sagbohan, Armel Djenontin, Clement Agbangla, Martin C. Akogbeto
Summary: This study assessed the residual efficacy of two insecticides used in high malaria incidence areas in Northern Benin. The results showed resistance to deltamethrin and possible resistance to bendiocarb, while no resistance was observed for pirimiphos-methyl and clothianidin. Clothianidin demonstrated better residual activity compared to pirimiphos-methyl and can provide improved control of pyrethroid resistant vectors.
Article
Entomology
Constantin J. Adoha, Arthur Sovi, Boulais Yovogan, Bruno Akinro, Manfred Accrombessi, Edouard Dangbenon, Esdras M. Odjo, Hermann Watson Sagbohan, Casimir Dossou Kpanou, Gil G. Padonou, Louisa A. Messenger, Clement Agbangla, Corine Ngufor, Jackie Cook, Natacha Protopopoff, Martin C. Akogbeto
Summary: This study compared the impact of two dual-active ingredient long-lasting insecticidal nets (LLINs) and a standard pyrethroid-only LLIN on the density of Culex spp. and Mansonia spp., and assessed their seasonality. The density of both mosquito species decreased in all three study arms over the study period. There was no significant reduction in the indoor or outdoor density of Culex spp. or Mansonia spp. in the dual-a.i. LLIN arms compared to the standard pyrethroid-only net arm. These findings suggest that the novel insecticides in the dual-a.i. LLINs did not have an additional impact on these mosquito species.
Article
Entomology
Razaki A. Osse, Filemon Tokponnon, Germain Gil Padonou, Mariette E. Glitho, Aboubakar Sidick, Arsene Fassinou, Come Z. Koukpo, Bruno Akinro, Arthur Sovi, Martin Akogbeto
Summary: This study demonstrates that malaria cases in Benin are not solely caused by Plasmodium falciparum, but also involves other non-falciparum species. By assessing the prevalence of various Plasmodium species in locally collected mosquito cohorts, the study reveals the variation in the distribution of Plasmodium species prevalence in Benin.
Article
Infectious Diseases
Germain Gil Padonou, Alphonse Keller Konkon, Albert Sourou Salako, David Mahouton Zoungbedji, Razaki Osse, Arthur Sovi, Roseric Azondekon, Aboubakar Sidick, Juvenal Minassou Ahouandjinou, Constantin Jesukede Adoha, Andre Aime Sominahouin, Filemon Tatcheme Tokponnon, Bruno Akinro, Haziz Sina, Lamine Baba-Moussa, Martin Codjo Akogbeto
Summary: This study aimed to assess the distribution, abundance, and biting behavior of Aedes aegypti and Aedes albopictus in Benin. The results showed that Aedes aegypti was widely distributed across the country, while Aedes albopictus was mainly found in the southern part, particularly in Avrankou. Both vectors exhibited exophagic behavior. This updated information on the distribution of Aedes mosquito species in Benin will contribute to accurately identifying areas at risk of arboviral diseases and planning effective vector control interventions.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Tropical Medicine
Alphonse Keller Konkon, Germain Gil Padonou, Razaki Osse, Albert Sourou Salako, David Mahouton Zoungbedji, Haziz Sina, Arthur Sovi, Filemon Tokponnon, Rock Aikpon, Herbert Noukpo, Lamine Baba-Moussa, Martin Codjo Akogbeto
Summary: This study aims to assess the susceptibility of Aedes aegypti and Aedes albopictus to commonly used insecticides in Southern Benin and investigate the mechanisms involved. The results showed that Aedes aegypti exhibited resistance or suspected resistance to all tested pyrethroids, while Aedes albopictus showed good susceptibility to bendiocarb and pirimiphos-methyl. These findings can guide the implementation of effective control strategies for Aedes vector populations in Benin.
TROPICAL MEDICINE AND HEALTH
(2023)
