Article
Chemistry, Multidisciplinary
Simona Braccini, Giacomo Provinciali, Lorenzo Biancalana, Guido Pampaloni, Federica Chiellini, Fabio Marchetti
Summary: The study presents diiron complexes with anticancer activity, along with a synthetic procedure. The reaction of the compounds may lead to iron oxidation and active monoiron species. Additionally, neutral complexes exhibit moderate inhibition on ovarian cancer cell lines.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Inorganic & Nuclear
Giulio Bresciani, Jan Vanco, Tiziana Funaioli, Stefano Zacchini, Tomas Malina, Guido Pampaloni, Zdenek Dvorak, Zdenek Travnicek, Fabio Marchetti
Summary: Diruthenacyclopentenone complexes were synthesized and characterized. The complexes exhibited stronger cytotoxicity than cisplatin against various cancer cell lines, with the 17α-estradiol derived complex showing the highest activity. Further studies revealed that some complexes affected the cell cycle, apoptosis, oxidative stress, and autophagy.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Silvia Schoch, Mouna Hadiji, Sarah A. P. Pereira, M. Lucia M. F. S. Saraiva, Simona Braccini, Federica Chiellini, Tarita Biver, Stefano Zacchini, Guido Pampaloni, Paul J. Dyson, Fabio Marchetti
Summary: A series of bioactive molecules were synthesized through condensation reactions, leading to novel diiron complexes with bridging vinyliminium ligands. These complexes showed high potency and selectivity in cytotoxicity assays, triggering intracellular ROS production. Further studies on DNA alkylation and protein binding were also conducted.
Article
Pharmacology & Pharmacy
Simona Braccini, Giorgia Rizzi, Lorenzo Biancalana, Alessandro Pratesi, Stefano Zacchini, Guido Pampaloni, Federica Chiellini, Fabio Marchetti
Summary: A series of novel diiron complexes were synthesized and evaluated for their anticancer activity, showing potent cytotoxicity against cancer cell lines with remarkable selectivity and good performance in inhibiting cell proliferation. Additionally, these complexes were capable of inducing significant ROS production and had the potential to inhibit the enzyme thioredoxin reductase.
Article
Chemistry, Inorganic & Nuclear
Chiara Zappelli, Gianluca Ciancaleoni, Stefano Zacchini, Fabio Marchetti
Summary: In this study, the authors investigated the reactions of [Fe2Cp2(CO)(mu-CO){mu-eta 1:eta 3-C gamma(Fc)-C beta HC alpha(CN)NMe2}] complex with isocyanides (CNR). They were able to characterize and understand the structure and properties of the resulting products.
Article
Biochemistry & Molecular Biology
Maura Pellei, Carlo Santini, Luca Bagnarelli, Chiara Battocchio, Giovanna Iucci, Iole Venditti, Carlo Meneghini, Simone Amatori, Paolo Sgarbossa, Cristina Marzano, Michele De Franco, Valentina Gandin
Summary: By synthesizing different ligand derivatives and preparing Cu(I) and Cu(II) complexes, this study found that these copper complexes exhibited significant anti-tumor activity and were able to overcome cisplatin resistance. Notably, Cu complexes showed more effectiveness than cisplatin in 3D spheroid cultures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Sara Benetti, Maria Dalla Pozza, Lorenzo Biancalana, Stefano Zacchini, Gilles Gasser, Fabio Marchetti
Summary: Novel diiron vinyliminium complexes were synthesized and characterized by various spectroscopic techniques. Their solubility in D2O, Log Pow coefficients, and stability in aqueous media were determined. The antiproliferative activity of these complexes on cancer cell lines was evaluated and their mechanism of action was investigated by assessing their influence on mitochondrial respiration.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Applied
Giulio Bresciani, Lorenzo Biancalana, Stefano Zacchini, Guido Pampaloni, Gianluca Ciancaleoni, Fabio Marchetti
Summary: The catalytic activity of a series of diiron complexes based on the {Fe2Cp2(CO)(x)} core (x = 2-3) and containing a bridging aminocarbyne ligand was screened in the transfer hydrogenation reaction of cyclohexanone from isopropanol. The best catalyst among these complexes was [Fe2Cp2(CN)(CO)(mu-CO){mu-CN(Me)(4-C6H4OMe)}], 3a, which exhibited moderate activity and showed a carbyne-centered mechanism, stabilized by the cyanide co-ligand, as supported by DFT calculations and IR analyses.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Monika Absolonova, Lucie Melounkova, Jaromir Vinklarek, Jan Honzicek, Libor Dostal, Ondrej Mrozek
Summary: Cytotoxic complexes containing molybdenum are studied as potential alternatives to commercial drugs, with different ligands having a significant impact on cytotoxicity. Functionalization of the Cp ring in Mo complexes can improve cytotoxicity against cancer cells, suggesting a potential strategy for designing highly efficient cytotoxic drugs in the future.
Article
Multidisciplinary Sciences
Joanna Drzezdzon, Celina Mokwa, Artur Sikorski, Patrycja Parnicka, Adriana Zaleska-Medynska, Jacek Malinowski, Magdalena Kwiatkowska, Barbara Gawdzik, Dagmara Jacewicz
Summary: Nowadays, there are studies on the design and synthesis of new catalysts for olefin oligomerization and polymerization, with non-toxic metals and high catalytic activities. Transition metal complex compounds, such as Fe(II), Cr(III), and Zr(II), that contain pyridine or quinoline ligands have been found to exhibit moderate catalytic activity in ethylene and propylene polymerizations. In this study, a new cobalt(II) complex compound with bis(5-chloroquinolin-8-olato)-bis(pyridine) ligands was synthesized and tested for its catalytic activity in reactions of 2-chloro-2-propen-1-ol and norbornene oligomerizations. The results showed that the activated bis(5-chloroquinolin-8-olato)-bis(pyridine)-cobalt(II) catalyst can promote the formation of oligomers in nitrogen atmosphere, at atmospheric pressure, and at room temperature, demonstrating moderate catalytic activity in norbornene oligomerization and low catalytic activity in 2-chloro-2-propen-1-ol oligomerization.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Inorganic & Nuclear
Yating Chen, Zhilin Ke, Lingyu Yuan, Meixiang Liang, Shuhua Zhang
Summary: We synthesized and analyzed nine unique copper(II) hydrazylpyridine salicylaldehyde and 1,10-phenanthroline complexes. It was found that these complexes exhibited higher anticancer activity and lower cytotoxicity towards normal cells compared to other substances. Specifically, Cugdupt1 and Cugdupt8 induced cell death through ATP depletion and activation of mitophagy pathways.
DALTON TRANSACTIONS
(2023)
Article
Multidisciplinary Sciences
Armin Ahmad Nejhad, Behrooz Alizadeh Behbahani, Mohammad Hojjati, Alireza Vasiee, Mohammad Amin Mehrnia
Summary: This study demonstrates that Calotropis procera leaf aqueous extract is rich in phenolic and flavonoid compounds, exhibiting high antioxidant properties. The extract shows high cytotoxicity against HT 29 cells in vitro, with varying resistance against Escherichia coli and Staphylococcus aureus. Morphological changes of these strains were observed through microscopy.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Inorganic & Nuclear
Salah S. Massoud, Febee R. Louka, Madison T. Dial, Andrew J. Malek, Roland C. Fischer, Franz A. Mautner, Jan Vanco, Tomas Malina, Zdenek Dvorak, Zdenek Travnicek
Summary: A series of heteroleptic copper(II) complexes were synthesized and evaluated for their cytotoxicity. Complexes 1 and 2 showed the highest efficacy against human cancer cells, inducing apoptosis by increasing ROS production.
DALTON TRANSACTIONS
(2021)
Article
Polymer Science
Ibrahim Bargathulla, Babu Aadhil Ashwaq, S. Sathiyaraj, A. Sultan Nasar, ElangovanVellaichamy
Summary: PEGylated polyurethane dendrimers showed significant cytotoxicity in human cancer cells, especially in breast and lung cancer cells. Protein marker analysis revealed that the PEGylated dendrimers induced apoptosis in cancer cells, suggesting potential anticancer activity.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Lukas Masaryk, Barbora Tesarova, Duane Choquesillo-Lazarte, Vedran Milosavljevic, Zbynek Heger, Pavel Kopel
Summary: In this study, a nickel(II) coordination compound with interesting biological behavior was synthesized, showing higher uptake by malignant cells, significant cytotoxicity differences, and the ability to hydrolyze DNA.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Applied
Giulio Bresciani, Lorenzo Biancalana, Stefano Zacchini, Guido Pampaloni, Gianluca Ciancaleoni, Fabio Marchetti
Summary: The catalytic activity of a series of diiron complexes based on the {Fe2Cp2(CO)(x)} core (x = 2-3) and containing a bridging aminocarbyne ligand was screened in the transfer hydrogenation reaction of cyclohexanone from isopropanol. The best catalyst among these complexes was [Fe2Cp2(CN)(CO)(mu-CO){mu-CN(Me)(4-C6H4OMe)}], 3a, which exhibited moderate activity and showed a carbyne-centered mechanism, stabilized by the cyanide co-ligand, as supported by DFT calculations and IR analyses.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Melissa Santi, Valentina Frusca, Maria Laura Ermini, Ana Katrina Mapanao, Patrizia Sarogni, Alessandra Gonnelli, Noemi Giannini, Agata Zamborlin, Lorenzo Biancalana, Fabio Marchetti, Valerio Voliani
Summary: Head and neck squamous cell carcinomas (HNSCCs) are a complex group of malignancies that currently rely on platinum-based chemotherapy with severe side effects. Researchers are exploring alternative metal complexes to reduce adverse reactions. The concurrent administration of cisplatin and emerging metal complexes shows promising results in increasing the efficacy of HNSCC treatment while reducing side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Editorial Material
Chemistry, Analytical
B. Campanella, F. Poggialini, S. Legnaioli, B. Cocciaro, G. Lorenzetti, S. Raneri, V. Palleschi
ANALYTICA CHIMICA ACTA
(2023)
Article
Cardiac & Cardiovascular Systems
Nicola Ferri, Alberto Corsini, Massimiliano Ruscica
Summary: The knowledge that a significant proportion of ACS survivors are at risk of recurrent ischemic cardiovascular events highlights the importance of lipid-lowering strategies in secondary prevention. Statin treatment has been shown to improve clinical outcomes. This review critically discusses the use of statin and non-statin lipid-lowering approaches, including PCSK9 inhibitors, in early management of ACS patients. Cost is a major barrier to the widespread prescription of non-statin agents in this field.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2023)
Article
Agricultural Engineering
Jose Gonzalez-Rivera, Beatrice Campanella, Elena Pulidori, Emilia Bramanti, Maria Rosaria Tine, Luca Bernazzani, Massimo Onor, Paolo Barberi, Celia Duce, Carlo Ferrari
Summary: Novel green extraction method (US-IMWAE) using simultaneous ultrasound and microwave irradiation allows for full exploitation of aromatic herbs while minimizing energy consumption and extraction cost. This method has successfully yielded essential oils with appealing composition profiles for cosmetic and medical industries, as well as valuable solid residues for alternative fuel production.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Polymer Science
Giovanni Ricci, Giuseppe Leone, Giorgia Zanchin, Francesco Masi, Stefano Zacchini, Giulio Bresciani, Massimo Guelfi, Guido Pampaloni
Summary: Novel copper complexes were synthesized by reacting copper(II) dichloride and copper(II) dibromide with pyridyl-imine ligands with different substituents. The complexes were characterized and their molecular structure was determined. When combined with methylaluminoxane (MAO), the complexes acted as active and selective catalysts for the polymerization of 1,3-dienes, resulting in polymers with unusual structures.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Giulio Bresciani, Stefano Zacchini, Guido Pampaloni, Marco Bortoluzzi, Fabio Marchetti
Summary: Diiron mu-aminocarbyne complexes can be synthesized by reacting sodium cyanate and tetrabutylammonium thiocyanate with pre-prepared diiron aminocarbyne complexes, yielding different substituted diiron cyanide complexes with yields of 67-81%, through substitution of the acetonitrile ligand. When reacted with potassium selenocyanate at reflux temperature, cyanide complexes can be obtained with yields of 45-67%. When reacted at room temperature in acetone, a small amount of potassium selenocyanate complexes can be obtained. All products were fully characterized and the chiral structure was determined by single crystal X-ray diffraction. DFT calculations shed light on the coordination mode and stability of the {NCSe-} fragment.
Review
Peripheral Vascular Disease
Nicola Ferri, Massimiliano Ruscica, Raul D. Santos, Alberto Corsini
Summary: Lipid-lowering fixed-dose combinations may be a better approach to control plasma lipids and reduce the burden of ASCVD. Recent studies suggest that combination therapy of moderate-intensity statin with ezetimibe is as effective as high-intensity statin monotherapy in reducing cardiovascular outcomes. Fixed-dose combinations of bempedoic acid with ezetimibe and fenofibrate with atorvastatin have shown superior results in lowering LDL-C and triglycerides respectively.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Chemistry, Inorganic & Nuclear
Giulio Bresciani, Serena Boni, Tiziana Funaioli, Stefano Zacchini, Guido Pampaloni, Natalia Busto, Tarita Biver, Fabio Marchetti
Summary: We synthesized and evaluated the anticancer potential of two series of diruthenium biscyclopentadienyl carbonyl complexes. Novel dimetallacyclopentenone compounds (2-4) were obtained from the thermal reaction of [Ru2Cp2(CO)(μ-CO)(μ-η^1:η^3-C(Ph)C(Ph)C(O)}], 1, with alkynes HCCR [R = C5H4FeCp (Fc), 3-C6H4(Asp), 2-naphthyl; Cp = η(5)-C5H5, Asp = OC(O)-2-C6H4C(O)Me]. The resulting complexes showed cytotoxic activity against cancer cells, different interactions with nucleic acids, and production of ROS.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Liyan Zhang, Peiyuan Wang, Xue-Quan Zhou, Ludovic Bretin, Xiaolong Zeng, Yurii Husiev, Ehider A. Polanco, Gangyin Zhao, Lukas S. Wijaya, Tarita Biver, Sylvia E. Le Devedec, Wen Sun, Sylvestre Bonnet
Summary: Investigation of tumor-targeting photoactivated chemotherapy using a chiral ruthenium-based anticancer warhead conjugated to an RGD-containing peptide showed strong phototoxicity and tumor-killing effects both in vitro and in vivo. The designed ruthenium-chelating peptide had triple action by preventing biomolecule coordination, self-assembling into nanoparticles, and specifically binding to tumor cells. These results demonstrate the potential of light-sensitive integrin-targeted ruthenium-based compounds for brain cancer treatment.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Marchi, Simone Fantuzzi, Andrea Cingolani, Alessandro Messori, Rita Mazzoni, Stefano Zacchini, Marina Cocchi, Luca Rigamonti
Summary: Iron(ii) bis-pyrazolilpyridyl (bpp-R) complexes [Fe(bpp-R)(2)](X)(2)·solvent undergo spin transition from high spin (S = 2, HS) to low spin (S = 0, LS) in the solid state, known as spin crossover (SCO). The distortion of the octahedral coordination environment is affected by crystal packing and modulates the SCO behavior. This study used a multivariate approach combining Principal Component Analysis and Partial Least Squares regression to analyze the structural data of HS structures and efficiently model and predict the spin transition temperature T-1/2 for complexes with different R groups, X- anions, and co-crystallized solvents.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Silvia Schoch, Giulio Bresciani, Chiara Saviozzi, Tiziana Funaioli, Marco Bortoluzzi, Guido Pampaloni, Fabio Marchetti
Summary: The reactivity of diiron bis-cyclopentadienyl cationic complexes containing a vinyliminium ligand coordinated to a diiron scaffold and decorated with a ferrocenyl group, [1a-g]CF3SO3, was investigated towards NBu4CN and NaBH4. Various addition products were obtained depending on the nature of the iminium substituents. The products were characterized using analytical and spectroscopic methods, and the molecular structures and thermodynamics were studied using DFT calculations.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Sara Benetti, Maria Dalla Pozza, Lorenzo Biancalana, Stefano Zacchini, Gilles Gasser, Fabio Marchetti
Summary: Novel diiron vinyliminium complexes were synthesized and characterized by various spectroscopic techniques. Their solubility in D2O, Log Pow coefficients, and stability in aqueous media were determined. The antiproliferative activity of these complexes on cancer cell lines was evaluated and their mechanism of action was investigated by assessing their influence on mitochondrial respiration.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Analytical
Michelle Buoso, Beatrice Campanella, Massimo Onor, Emanuela Pitzalis, Alessandro D'Ulivo
Summary: The use of BH intermediates as derivatization reagents significantly improves the tolerance to interference from transition metal ions in the generation of SbH3 and BiH3, and shows high tolerance in a wide range of acidity. The method has been successfully applied to the determination of Sb and Bi in complex samples, providing further understanding of the chemical behavior of borohydrides.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2024)
