期刊
ORGANIC LETTERS
卷 21, 期 24, 页码 10164-10168出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04263
关键词
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资金
- WWU Munster
- Alexander von Humboldt Foundation
Light-enabled enantiodivergence is demonstrated in which the alkene substrate configuration is manipulated (E -> Z) prior to organocatalytic reduction with a chiral thiourea and Hantzsch ester. This allows stereodivergent reduction to be regulated at the substrate level with high fidelity and mitigates the need for a second, enantiomeric catalyst (up to 93:07 and 95:5 er). The synthetic utility of this strategy has been demonstrated in the synthesis of the weight-loss drug (R)-Lorcaserin (Belviq) and a potent AMPA modulator.
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