Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint

Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures

(2018) R. Michael Sivley et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis

(2018) Mikael S. Lindström et al.   ONCOGENE

MDM2 controls gene expression independently of p53 in both normal and cancer cells

(2018) Giuseppe Arena et al.   CELL DEATH AND DIFFERENTIATION

Translation deregulation in human disease

(2018) Soroush Tahmasebi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma

(2017) Isabel J.F. Hofman et al.   HAEMATOLOGICA

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types

(2017) Laura Fancello et al.   Oncotarget

3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

(2017) Jianjiong Gao et al.   Genome Medicine

Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma

(2017) Isabel J.F. Hofman et al.   HAEMATOLOGICA

RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response

(2016) I J F Hofman et al.   LEUKEMIA

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis

(2016) S Liu et al.   ONCOGENE

The relationship between the nucleolus and cancer: Current evidence and emerging paradigms

(2016) Ines Orsolic et al.   SEMINARS IN CANCER BIOLOGY

Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress

(2016) Emilien Nicolas et al.   Nature Communications

Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice

(2016) Shideh Kazerounian et al.   Journal of Cancer

Driver and Passenger Mutations in Cancer

(2015) Julia R. Pon et al.   Annual Review of Pathology-Mechanisms of Disease

Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation

(2015) Jiangge Zheng et al.   GENES & DEVELOPMENT

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

(2015) Søren Lykke-Andersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comprehensive assessment of cancer missense mutation clustering in protein structures

(2015) Atanas Kamburov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

(2015) Kazuho Nishimura et al.   Cell Reports

Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis

(2015) Lucia Morgado-Palacin et al.   Cell Reports

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells

(2015) Lukas Badertscher et al.   Cell Reports

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

p53 and ribosome biogenesis stress: The essentials

(2014) Lior Golomb et al.   FEBS LETTERS

Realizing the promise of cancer predisposition genes

(2014) Nazneen Rahman   NATURE

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Clinical phenotype and genetic analysis ofRPS19,RPL5, andRPL11genes in Greek patients with Diamond Blackfan Anemia

(2014) Polyxeni Delaporta et al.   PEDIATRIC BLOOD & CANCER

The Complexity of Human Ribosome Biogenesis Revealed by Systematic Nucleolar Screening of Pre-rRNA Processing Factors

(2013) Lionel Tafforeau et al.   MOLECULAR CELL

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

(2013) Georgia Velimezi et al.   NATURE CELL BIOLOGY

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

(2013) Gannie Tzoneva et al.   NATURE MEDICINE

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

(2013) Giulio Donati et al.   Cell Reports

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry

(2012) A. Vlachos et al.   BLOOD

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

(2012) Kim De Keersmaecker et al.   NATURE GENETICS

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

(2012) S. Bursac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the Eukaryotic Ribosome at 3.0 A Resolution

(2011) A. Ben-Shem et al.   SCIENCE

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

The ribosomal basis of diamond-blackfan anemia: mutation and database update

(2010) Ilenia Boria et al.   HUMAN MUTATION

Evolution of Protein Synthesis from an RNA World

(2010) H. F. Noller   Cold Spring Harbor Perspectives in Biology

Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations

(2009) P. Quarello et al.   HAEMATOLOGICA

Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia

(2009) Radek Cmejla et al.   HUMAN MUTATION

Ribosomal Protein L5 and L11 Mutations Are Associated with Cleft Palate and Abnormal Thumbs in Diamond-Blackfan Anemia Patients

(2008) Hanna T. Gazda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

(2008) H F Horn et al.   ONCOGENE

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE