Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

(2017) Xun Jin et al.   NATURE MEDICINE

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

(2017) Faizaan Mohammad et al.   NATURE MEDICINE

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

(2017) Julia Pollak et al.   PLoS One

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

(2016) Baoli Hu et al.   CELL

Regulation of Genome Architecture and Function by Polycomb Proteins

(2016) Marianne Entrevan et al.   TRENDS IN CELL BIOLOGY

Simultaneous targeting of Eph receptors in glioblastoma

(2016) Sara Ferluga et al.   Oncotarget

Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis

(2016) Vincent van den Boom et al.   Cell Reports

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

(2016) Anna Segerman et al.   Cell Reports

miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition viaEphA8

(2015) Yan Yan et al.   FEBS LETTERS

Targeting Polycomb systems to regulate gene expression: modifications to a complex story

(2015) Neil P. Blackledge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

(2015) Yuan Xie et al.   EBioMedicine

Eph receptors as therapeutic targets in glioblastoma

(2014) B W Day et al.   BRITISH JOURNAL OF CANCER

Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics

(2014) Erika Gucciardo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

(2014) Rintaro Hashizume et al.   NATURE MEDICINE

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

PRC1 complex diversity: where is it taking us?

(2014) Jesús Gil et al.   TRENDS IN CELL BIOLOGY

In Vivo RNAi Screen for BMI1 Targets Identifies TGF-β/BMP-ER Stress Pathways as Key Regulators of Neural- and Malignant Glioma-Stem Cell Homeostasis

(2013) Gaetano Gargiulo et al.   CANCER CELL

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

RHPN2 Drives Mesenchymal Transformation in Malignant Glioma by Triggering RhoA Activation

(2013) C. Danussi et al.   CANCER RESEARCH

MicroRNA-218 Inhibits Glioma Invasion, Migration, Proliferation, and Cancer Stem-like Cell Self-Renewal by Targeting the Polycomb Group Gene Bmi1

(2013) Y. Tu et al.   CANCER RESEARCH

The integrated landscape of driver genomic alterations in glioblastoma

(2013) Veronique Frattini et al.   NATURE GENETICS

Therapeutic targeting of EPH receptors and their ligands

(2013) Andrew W. Boyd et al.   NATURE REVIEWS DRUG DISCOVERY

Eph Receptor Signaling and Ephrins

(2013) E. M. Lisabeth et al.   Cold Spring Harbor Perspectives in Biology

An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma

(2013) Esther Rheinbay et al.   Cell Reports

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo

(2012) Aaron Petty et al.   PLoS One

Histone Demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Protein Nuclear Stabilization

(2012) Chibawanye I. Ene et al.   PLoS One

A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke

(2012) J. J. Overman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Regulation of Survivin by Bmi1 Is Cell Type Specific During Corticogenesis and in Gliomas

(2012) Serena Acquati et al.   STEM CELLS

The H3K27 Demethylase JMJD3 Is Required for Maintenance of the Embryonic Respiratory Neuronal Network, Neonatal Breathing, and Survival

(2012) Thomas Burgold et al.   Cell Reports

RYBP and Cbx7 Define Specific Biological Functions of Polycomb Complexes in Mouse Embryonic Stem Cells

(2012) Lluis Morey et al.   Cell Reports

The time of timing: How Polycomb proteins regulate neurogenesis

(2011) Giuseppe Testa   BIOESSAYS

Conditional Activation of Bmi1 Expression Regulates Self-renewal, Apoptosis, and Differentiation of Neural Stem/Progenitor Cells In Vitro and In Vivo

(2011) Gokhan Yadirgi et al.   STEM CELLS

Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia

(2010) S.-Q. Kuang et al.   BLOOD

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors

(2010) T. Subkhankulova et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Architecture of Eph receptor clusters

(2010) J. P. Himanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

(2009) Francesca De Santa et al.   EMBO JOURNAL

Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes

(2009) Thomas S Jacques et al.   EMBO JOURNAL

BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal

(2009) M. Abdouh et al.   JOURNAL OF NEUROSCIENCE

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor

(2009) J-J Li et al.   ONCOGENE

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

Association of MicroRNA-223 Expression with Hepatic Ischemia/Reperfusion Injury in Mice

(2008) Chao-Hui Yu et al.   DIGESTIVE DISEASES AND SCIENCES

The Histone H3 Lysine 27-Specific Demethylase Jmjd3 Is Required for Neural Commitment

(2008) Thomas Burgold et al.   PLoS One

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY