Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells

Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines and in a mouse model

(2019) Changtian Yin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting Metabolic–Redox Circuits for Cancer Therapy

(2019) Kui Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway

(2019) Wei He et al.   FREE RADICAL RESEARCH

PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers

(2019) Patrick G. Pilié et al.   CLINICAL CANCER RESEARCH

Reactive oxygen species and cancer: A complex interaction

(2019) Sankaralingam Saikolappan et al.   CANCER LETTERS

Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells

(2019) Xiaoguang Xu et al.   LIFE SCIENCES

Perspectives on PARPs in S Phase

(2019) Hana Hanzlikova et al.   TRENDS IN GENETICS

Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity

(2019) Lynnette Marcar et al.   Cell Reports

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

An Effective Epigenetic-PARP Inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA Mutations

(2018) Nicholas Pulliam et al.   CLINICAL CANCER RESEARCH

Metabolism and pharmacokinetics of alantolactone and isoalantolactone in rats: Thiol conjugation as a potential metabolic pathway

(2018) Bailun Zhou et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53

(2018) Qi Liu et al.   ONCOGENE

Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies

(2018) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

(2018) George E. Ronson et al.   Nature Communications

CHK2-mediated regulation of PARP1 in oxidative DNA damage response

(2018) Pei-Ching Hsu et al.   ONCOGENE

State-of-the-art strategies for targeting the DNA damage response in cancer

(2018) Patrick G. Pilié et al.   Nature Reviews Clinical Oncology

Coordination of DNA single strand break repair

(2017) Rachel Abbotts et al.   FREE RADICAL BIOLOGY AND MEDICINE

Drugging the Cancers Addicted to DNA Repair

(2017) Jac A. Nickoloff et al.   JNCI-Journal of the National Cancer Institute

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Auranofin, Et3PAuCl, and Et3PAuI Are Highly Cytotoxic on Colorectal Cancer Cells: A Chemical and Biological Study

(2017) Tiziano Marzo et al.   ACS Medicinal Chemistry Letters

Drugging the Cancers Addicted to DNA Repair

(2017) Jac A. Nickoloff et al.   JNCI-Journal of the National Cancer Institute

Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells

(2016) Junmin Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability

(2016) Safnas F. AbdulSalam et al.   BIOCHEMISTRY

High body clearance and low oral bioavailability of alantolactone, isolated fromInula helenium, in rats: extensive hepatic metabolism and low stability in gastrointestinal fluids

(2016) Jae-Young Lee et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors

(2016) Xiumei Huang et al.   CANCER CELL

APR-246 (PRIMA-1 MET ) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines

(2016) Christophe Deben et al.   CANCER LETTERS

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

(2016) Jessica S. Brown et al.   Cancer Discovery

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Alantolactone Induces Apoptosis and Cell Cycle Arrest on Lung Squamous Cancer SK-MES-1 Cells

(2015) Peng Zhao et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Disruption of PARP1 function inhibits base excision repair of a sub-set of DNA lesions

(2015) Pamela Reynolds et al.   NUCLEIC ACIDS RESEARCH

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer

(2015) P. A. Konstantinopoulos et al.   Cancer Discovery

Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

(2014) A. R. Venkitaraman   SCIENCE

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Cisplatin Resistance Associated with PARP Hyperactivation

(2013) J. Michels et al.   CANCER RESEARCH

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer

(2010) M. Graeser et al.   CLINICAL CANCER RESEARCH

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma

(2008) J. N. Sarkaria et al.   CLINICAL CANCER RESEARCH

Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks

(2008) Bethany C. Woodhouse et al.   DNA REPAIR