Article
Environmental Sciences
Hutao Wang, Caiye Hu, Yi Wang, Yangguo Zhao, Chunji Jin, Liang Guo
Summary: This study investigated the removal mechanism and transformation pathways of sulfadiazine (SDZ), a typical sulfonamide antibiotic commonly found in wastewater, through hydrolysis, photodegradation, and biodegradation by Chlorella pyrenoidosa. The results showed that under SDZ stress, higher superoxide dismutase activity and accumulation of biochemical components were obtained. The SDZ removal efficiencies ranged from 65.9% to 67.6% at different initial concentrations, and the removal rate followed a pseudo first-order kinetic model. Batch tests and HPLC-MS/MS analyses suggested that biodegradation and photodegradation, through reactions such as amine group oxidation, ring opening, hydroxylation, and cleavage of S-N, C-N, C-S bonds, were the dominant removal mechanisms and pathways.
ENVIRONMENTAL POLLUTION
(2023)
Article
Infectious Diseases
Edward Portal, Kirsty Sands, Artjoms Portnojs, Victoria J. Chalker, Owen B. Spiller
Summary: This study compared different AST methods for Legionella, finding that the BMD and LASARUS methods showed the most similar results, while BCYE agar and gradient strip overlay methods gave higher MIC results. Additionally, the range of MIC values for azithromycin was influenced by the presence of the lpeAB gene.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Environmental Sciences
Lorenzo Rambaldo, Hector Avila, Monica Escola Casas, Miriam Guivernau, Marc Vinas, Rosa Trobajo, Javier Perez-Burillo, David G. Mann, Belen Fernandez, Carme Biel, Luigi Rizzo, Josep M. Bayona, Victor Matamoros
Summary: Groundwater pollution has increased due to intensified agricultural and livestock activities, leading to a reduction in freshwater resources. This study investigated a green technology using a photobioreactor and cork filter to remove pollutants from groundwater. The results showed that the technology was moderately effective in removing nitrates, antibiotics, and pesticides, but its efficiency decreased with shorter hydraulic retention time, with pesticides being the most affected compounds.
Article
Environmental Sciences
Zhiwei Han, Hongrao Wang, Jian Zheng, Shanshan Wang, Shuyu Yu, Lei Lu
Summary: The immobilization of bacterial laccase into laccase-inorganic hybrid nanoflowers (Lac-hNFs) significantly enhances its stability and degradation capacity, particularly for tetracycline antibiotics. Lac-hNFs demonstrate high efficiency in the removal of tetracyclines and maintain their effectiveness after multiple cycles of reuse. This study provides a new approach for the efficient removal of toxic organic pollutants.
ENVIRONMENTAL RESEARCH
(2023)
Article
Infectious Diseases
Lisa Knoche, Jan Lisec, Tanja Schwerdtle, Matthias Koch
Summary: This study systematically investigated the formation and identification of transformation products (TPs) of the drug salinomycin (SAL) using electrochemistry and liver microsome incubation methods. A total of 14 new TPs were found, including decarbonylation for electrochemistry-derived TPs and oxidation for liver microsome-derived TPs. The identification of potassium-based TPs is of particular interest as they may have been overlooked in previous studies. The obtained knowledge contributes to understanding the transformation reactions and predicting the structure of SAL metabolites.
Review
Pharmacology & Pharmacy
Khashayar Afshari, Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Nazgol-Sadat Haddadi, Arvin Haj-Mirzaian, Malihe Hassan Nejad, Hamed Shafaroodi, Mehdi Ghasemi, Ahmad Reza Dehpour, Amir Hossein Abdolghaffari
Summary: This review paper discusses the therapeutic effects of antibiotics on spinal cord injury, which include anti-inflammatory and neuroprotective effects. Different families of antibiotics have been found to improve the sequels and complications of spinal cord injury by targeting similar signaling pathways. The mechanisms include reducing inflammatory microglial activity, promoting autophagy, inhibiting neuronal apoptosis, and modulating SCI-related mitochondrial dysfunction.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Georg Spaeth, Alois Fuerstner
Summary: The introduction of aldgarose sugar to the C5-OH group of the macrocyclic aglycone of aldgamycin N is difficult. Hence, a revised synthesis route was used, and a new scalable method for the synthesis of this sugar was developed to reduce costs. The formation of the glycoside required mild conditions and allowed for late-stage functionalization of the macrolide ring.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yalong Zhang, Jian Bai, Le Zhang, Chen Zhang, Bingyu Liu, Youcai Hu
Summary: A unique self-resistance mechanism for fungal antibiotics was discovered, utilizing an oxidative-reductive cycle to prevent self-harm. This work contributes to the understanding of antibiotic biosynthesis and resistance mechanisms.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Environmental Sciences
Camila Silva Rocha, Leticia Yoshie Kochi, Gabriela Breternitz Ribeiro, Daiane Cristina Rocha, Daniella Nogueira Moraes Carneiro, Marcelo Pedrosa Gomes
Summary: Water contamination by antibiotics, especially erythromycin, is a global issue affecting public health and the environment. This study found that submerged macrophyte species are the most efficient at removing erythromycin from contaminated waters, making them more suitable for antibiotic phytoremediation projects. The research also highlighted the importance of understanding plant physiological responses in relation to phytoremediation capacity in order to improve remediation programs in the future.
INTERNATIONAL JOURNAL OF PHYTOREMEDIATION
(2022)
Article
Chemistry, Medicinal
Rongguo Ren, Xiaofang Wang, Derek A. Leas, Christian Scheurer, Sarah Hoevel, Monica Cal, Gong Chen, Longjin Zhong, Kasiram Katneni, Thao Pham, Rahul Patil, Diptesh Sil, Matthias J. Walters, Thomas T. Schulze, Andrew J. Neville, Yuxiang Dong, Sergio Wittlin, Marcel Kaiser, Paul H. Davis, Susan A. Charman, Jonathan L. Vennerstrom
Summary: We discovered a new type of antimalarial compound - dibenzannulated medium-ring keto lactams. These compounds exhibited good kinetic solubilities and metabolic stability, with relatively low cytotoxicity and high antimalarial activity against Plasmodium falciparum. These keto lactams were converted into poorly soluble quinolone condensation products in vivo.
ACS INFECTIOUS DISEASES
(2023)
Article
Environmental Sciences
Miguel Gonzalez-Pleiter, Alicia Pedrouzo-Rodriguez, Irene Verdu, Francisco Leganes, Eduardo Marco, Roberto Rosal, Francisca Fernandez-Pinas
Summary: This study reveals that microplastics can serve as carriers of chemicals toxic to aquatic microorganisms, impacting the growth and chlorophyll content of cyanobacteria. Antibiotics sorbed on microplastics can be released upon contact with water, leading to observed toxicity to cyanobacteria.
Article
Environmental Sciences
Xiaofang Xue, Linli Wang, Dexin Wang, Xuesong Yi, Fei Yang, Yangyang Li
Summary: This study developed a biocathode system coupled with different co-metabolism conditions to degrade quinolones, specifically enrofloxacin (ENR). The study found that the degradation rate of ENR was significantly increased when co-metabolism conditions were applied, and different transformation pathways of ENR were observed. Additionally, the study identified the sensitive response of biocathodic communities to carbon source switch-over. This research provides valuable information on treating refractory quinolone antibiotics using a green bioelectrochemical method.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Organic
Tomohiro Tsutsumi, Moe Matsumoto, Hitomi Iwasaki, Kei Tomisawa, Keita Komine, Hayato Fukuda, Jacques Eustache, Rolf Jansen, Susumi Hatakeyama, Jun Ishihara
Summary: This study describes the first total synthesis of thuggacin cmc-A and the confirmation of its absolute structure. The thuggacin family of antibiotics is of interest due to its antibiotic activity against Mycobacterium tuberculosis. Through a stereocontrolled approach, all seven stereogenic centers in thuggacin cmc-A were constructed to match the stereochemistry of thuggacin-A, confirming the stereostructure of the compound.
Review
Biochemistry & Molecular Biology
Ana R. Millanao, Aracely Y. Mora, Nicolas A. Villagra, Sergio A. Bucarey, Alejandro A. Hidalgo
Summary: Quinolones, with broad antibacterial spectrum, high oral bioavailability, and excellent tissue penetration, are one of the most widely used antimicrobials in clinics. However, overuse has led to the rise of resistance and threats to the effectiveness of this class of drugs in treating infections.
Article
Agriculture, Dairy & Animal Science
Seyed Hossien Kairmi, Khaled Taha-Abdelaziz, Alexander Yitbarek, Mehdi Sargolzaei, Heidi Spahany, Jake Astill, Bahram Shojadoost, Mohammadali Alizadeh, Raveendra R. Kulkarni, John Parkinson, Shayan Sharif
Summary: This study investigated the effects of therapeutic doses of dietary antibiotics on the cecal microbiome of chickens and found that the use of these antibiotics can have negative effects on the microbial diversity and evenness of the cecal microbiome. Adjusting gut bacteria may be necessary to restore microbial richness and diversity following treatment with these antibiotics.
Article
Audiology & Speech-Language Pathology
Vanessa Veis Ribeiro, Leonardo Wanderley Lopes, Allan Carlos Franca da Silva, Agostinho Hermes de Medeiros Neto, Jackie Gartner-Schmidt, Mara Behlau
Summary: This study aimed to translate and cross-culturally adapt the Cough Severity Index into Brazilian Portuguese. The process included five stages of translation, synthesis, back translation, committee review, and pretesting. The questionnaire was reviewed by judges, and modifications were made based on their feedback. The final version of the translated questionnaire was developed and found to be suitable for use in the Brazilian Portuguese-speaking population.
Letter
Rheumatology
Martin Sebastian Winkler, Peter Korsten, Claudia Binder, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Oncology
Yi Liao, Senmao Li, Hao Chen, Chunyu Chen, Jintuan Huang, Feng Lin, Jianping Wang, Zuli Yang
Summary: A risk prediction system combining FIT and risk factors was developed to improve the sensitivity of colonoscopy screening. The system effectively stratified participants into high risk and low risk groups, with better predictive ability for colorectal neoplasia compared to using FIT alone.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente Martin, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia
Summary: This study aimed to examine the association between height and risk of gastric cancer. Through a large pooled analysis of case-control studies, the study found no significant association between adult height and gastric cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Maria A. Karalexi, Marina Servitzoglou, Vassilios Papadakis, Denis Kachanov, Maja Cesen Mazic, Margaret Baka, Maria Moschovi, Maria Kourti, Sofia Polychronopoulou, Eftichia Stiakaki, Emmanuel Hatzipantelis, Helen Dana, Kalliopi Stefanaki, Astero Malama, Marios S. Themistocleous, Katerina Strantzia, Tatyana Shamanskaya, Panagiota Bouka, Paraskevi Panagopoulou, Maria Kantzanou, Evangelia Ntzani, Nick Dessypris, Eleni Th. Petridou
Summary: The prognosis of children with neuroblastoma varies depending on the stage and biology of the tumor, and early-stage neuroblastoma has a better prognosis. Treatment with anti-GD2 antibody can improve the prognosis of high-risk patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Review
Clinical Neurology
Christoph Eckhard Heyde, Ulrich Josef Albert Spiegl, Anna Voelker, Nicolas von der Hoeh, Jeanette Henkelmann
Summary: The prevalence of nonspecific pyogenic spondylodiskitis has increased, causing high morbidity and mortality. The diagnosis is often delayed due to nonspecific clinical manifestations at the early stage. CT can assess the bony condition, while MRI is still the gold standard for diagnosis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Environmental Sciences
Joao P. F. Venancio, Sara Ribeirinho-Soares, Luisa C. Lopes, Luis M. Madeira, Olga C. Nunes, Carmen S. D. Rodrigues
Summary: In this study, a combination of coagulation/flocculation and Fenton processes was used for tertiary treatment of urban wastewater. The results showed that the best removals of turbidity and enterobacteria were achieved with a coagulant dosage of 120 mg/L and the natural pH of the effluent. The treated water met the strictest limit for E. coli, but had a high relative abundance of potentially hazardous bacteria, emphasizing the need for microbiological characterization before reuse.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Celia M. Manaia, Diana S. S. Aga, Eddie Cytryn, William H. H. Gaze, David W. W. Graham, Jianhua Guo, Anne F. C. Leonard, Liguan Li, Aimee K. K. Murray, Olga C. C. Nunes, Sara Rodriguez-Mozaz, Edward Topp, Tong Zhang
Summary: Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are prevalent environmental contaminants. Factors driving the evolution and dissemination of antibiotic resistance are not well understood. ARB and ARGs are often found in areas impacted by human activity, particularly in environments affected by fecal wastes or mixed chemical contaminants. Our review explores the relationship between chemical contaminants and ARB/ARGs, including co-occurrence, potential biostimulation, selective pressure effects, and mitigation strategies. We also discuss evidence and strategies for assessing human health risks associated with environmental antibiotic resistance.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Helena M. Amaro, Joana F. Sousa, Eva M. Salgado, Jose C. M. Pires, Olga C. Nunes
Summary: This study assessed the ability of Chlorella vulgaris and UWW autochthonous microalgal species (AMS) to simultaneously remove PO4-P, and reduce the proliferation of coliforms and ARGs. Results showed that AMS performed better in all aspects, indicating its potential as an effective final treatment for urban wastewater.
APPLIED SCIENCES-BASEL
(2023)
Article
Environmental Sciences
Catarina Ferreira, Lara Luzietti, Sara Ribeirinho-Soares, Olga C. Nunes, Ivone Vaz-Moreira, Celia M. Manaia
Summary: This study compared the behavior of a clinical and an environmental K. pneumoniae strain harboring the blaKPC-3 gene in water. The abundance of the genes phoE and blaKPC-3 was monitored in urban runoff water and sterile ultra-pure water microcosms to assess survival, blaKPC-3 persistence, and the effect of the water microbiota. The results showed that K. pneumoniae and the blaKPC-3 gene decreased in urban runoff water, indicating competition with native microbiota, but the bacteria could still survive for at least one week.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Andre Torres-Pinto, Inmaculada Velo-Gala, Sara Ribeirinho-Soares, Olga C. Nunes, Claudia G. Silva, Joaquim L. Faria, Adrian M. T. Silva
Summary: Graphitic carbon nitride (GCN) is a promising optical semiconductor with excellent photoactivity under visible light irradiation. This study successfully improved the photocatalytic and electrocatalytic activities of GCN through thermal and chemical modification, leading to efficient organic micropollutant removal and microorganism inactivation in contaminated water.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Helena M. Amaro, Eva M. Salgado, Olga C. Nunes, Jose C. M. Pires, Ana F. Esteves
Summary: Water, the most valuable resource, faces threats from anthropogenic activities that generate high levels of pollutants. Conventional wastewater treatment systems are not efficient in removing these pollutants. Microalgal systems have been seen as an environmentally friendly solution to remove pollutants, antibiotics, coliforms, and antibiotic resistance genes. Recent studies have evaluated the effectiveness of microalgal systems in various types of wastewater treatment.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Pedro H. Presumido, Sara Ribeirinho-Soares, Rosa Montes, Jose Benito Quintana, Rosario Rodil, Marta Ribeiro, Teresa Neuparth, Miguel M. Santos, Manuel Feliciano, Olga C. Nunes, Ana I. Gomes, Vitor J. P. Vilar
Summary: A membrane ozone contactor was used for the tertiary treatment of urban wastewater, focusing on the removal of emerging contaminants, disinfection, and toxicity reduction. The system utilized a borosilicate tubular membrane coated with titanium dioxide and four UV lamps for radiation. By optimizing ozone concentration and gas flow rate, high removal rates of contaminants and disinfection efficacy were achieved. Antibiotic resistant bacteria were reduced but not eliminated after ozone treatment, and subsequent granular activated carbon adsorption further improved the water quality.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Joaquin A. Marrero, Rui S. Ribeiro, Sara Ribeirinho-Soares, Marta Pedrosa, Adrian M. T. Silva, Olga C. Nunes
Summary: This study demonstrates the suitability of carbon-based catalytic membranes for persulfate activation and water disinfection in continuous flow mode. The PVDF membranes with and without nitrogen-doped reduced graphene oxide (rGO-M) were tested. The rGO-M-PVDF membrane showed better microbial removal efficiency and persulfate activation capacity compared to the pristine PVDF membrane. It can effectively remove harmful microbiota in drinking water production.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Engineering, Environmental
Joana Abreu-Silva, Sara Ribeirinho-Soares, Ines Oliveira-Inocencio, Marta Pedrosa, Adrian M. T. Silva, Olga C. Nunes, Celia M. Manaia
Summary: This study investigated the performance of three types of filtering membranes (PC, CN, and PES) for bacterial analysis in demineralized and disinfected waters. CN or PES membranes required shorter filtration periods compared to PC membranes, although they had slightly lower DNA extraction yields. However, there were no significant differences in the abundance of genes per volume of water. CN membranes are a cost-effective alternative for analyzing waters with low microbial loads.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
