Communication, Cross Talk, and Signal Integration in the Adult Hippocampal Neurogenic Niche

Radial glia-like. aural stem cells (RGLs) in the dentate gyrus subregion of the hippocampus give rise to dentate granule cells (DeCs) and astrocytes throughout life, a process referred to as adult hippocampal neurogenesis. Adult hippocampal neurogenesis is sensitive to experiences, suggesting that it may represent an adaptive mechanism by which hippocampal circuitry is modified in response to environmental demands. Experiential information is conveyed to RGLs, progenitors, and adult-born DGCs via the neurogenic niche that is composed of diverse cell types, extracellular matrix, and afferents. Understanding how the niche performs its functions may guide strategies to maintain its health span and provide a permissive milieu for neurogenesis. Here, we first discuss representative contributions of niche cell types to regLlation of neural stem cell (NSC) homeostasis and maturation of adult-born DGCs. We then consider mechanisms by which the activity of multiple niche cell types may be coordinated to commun cate signals to NSCs. Finally, we speculate how NSCs integrate niche-derived signals to govern their regulation.