期刊
NEUROLOGY
卷 94, 期 7, 页码 E718-E728出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000008677
关键词
-
资金
- NINDS [NS097437, NS075321, NS097799, NS41509, NS058714, NS48924, P30 NS048056]
- NIH NCRR [UL1RR024992]
- American Parkinson Disease Association (APDA) Advanced Research Center for PD at WUSTL
- Greater St. Louis Chapter of the APDA
- McDonnell Center for Systems Neuroscience
- Barnes Jewish Hospital Foundation
ObjectiveTo evaluate resting-state functional connectivity as a potential prognostic biomarker of Parkinson disease (PD) progression. The study examined longitudinal changes in cortical resting-state functional connectivity networks in participants with PD compared to controls as well as in relation to baseline protein measures and longitudinal clinical progression.MethodsIndividuals with PD without dementia (n = 64) and control participants (n = 27) completed longitudinal resting-state MRI scans and clinical assessments including full neuropsychological testing after overnight withdrawal of PD medications (off). A total of 55 participants with PD and 20 control participants also completed baseline beta -amyloid PET scans and lumbar punctures for CSF protein levels of alpha -synuclein, beta -amyloid, and tau. Longitudinal analyses were conducted with multilevel growth curve modeling, a type of mixed-effects model.ResultsFunctional connectivity within the sensorimotor network and the interaction between the dorsal attention network with the frontoparietal control network decreased significantly over time in participants with PD compared to controls. Baseline CSF alpha -synuclein protein levels predicted decline in the sensorimotor network. The longitudinal decline in the dorsal attention-frontoparietal internetwork strength correlated with the decline in cognitive function.ConclusionsThese results indicate that alpha -synuclein levels may influence longitudinal declines in motor-related functional connectivity networks. Further, the interaction between cortical association networks declines over time in PD prior to dementia onset and may serve as a prognostic marker for the development of dementia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据