The gut in Parkinson’s disease: Bottom‐up, top‐down, or neither?

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

(2019) Nathalie Van Den Berge et al.   ACTA NEUROPATHOLOGICA

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

(2018) Carolina Pellegrini et al.   ACTA NEUROPATHOLOGICA

In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study

(2018) Karoline Knudsen et al.   LANCET NEUROLOGY

Bidirectional Neural Interaction Between Central Dopaminergic and Gut Lesions in Parkinson’s Disease Models

(2018) Pablo Garrido-Gil et al.   MOLECULAR NEUROBIOLOGY

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

(2018) Norihito Uemura et al.   Molecular Neurodegeneration

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

(2018) Paula Perez-Pardo et al.   GUT

Can the gut be the missing piece in uncovering PD pathogenesis?

(2018) Guillaume Chapelet et al.   PARKINSONISM & RELATED DISORDERS

The Gut and Parkinson’s Disease: Hype or Hope?

(2018) Filip Scheperjans et al.   Journal of Parkinsons Disease

Decreased intestinal acetylcholinesterase in early Parkinson disease

(2017) Tatyana D. Fedorova et al.   NEUROLOGY

Gut–brain and brain–gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet

(2017) Paula Perez-Pardo et al.   NUTRITIONAL NEUROSCIENCE

The Threshold Theory for Parkinson's Disease

(2017) Simone Engelender et al.   TRENDS IN NEUROSCIENCES

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration

(2016) Carolina Pellegrini et al.   Journal of Neuroinflammation

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

(2014) Ellen Gelpi et al.   MOVEMENT DISORDERS

Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron loss

(2012) Dana M. Annerino et al.   ACTA NEUROPATHOLOGICA

Intestinal dysmotility and enteric neurochemical changes in a Parkinson's disease rat model

(2012) Mario Colucci et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Reduced expression of choline acetyltransferase in vagal motoneurons and gastric motor dysfunction in a 6-OHDA rat model of Parkinson's disease

(2011) Li-Fei Zheng et al.   BRAIN RESEARCH

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neurotoxin-based models of Parkinson's disease

(2011) J. Bové et al.   NEUROSCIENCE

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

(2011) Evangelia Emmanouilidou et al.   PLoS One

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms

(2010) Thibaud Lebouvier et al.   PLoS One