Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments

CAVER Analyst 2.0: analysis and visualization of channels and tunnels in protein structures and molecular dynamics trajectories

(2018) Adam Jurcik et al.   BIOINFORMATICS

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

“Pinching” the ammonia tunnel of CTP synthase unveils coordinated catalytic and allosteric-dependent control of ammonia passage

(2018) Gregory D. McCluskey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structural basis for regulation of human acetyl-CoA carboxylase

(2018) Moritz Hunkeler et al.   NATURE

The glycolytic enzyme phosphofructokinase-1 assembles into filaments

(2017) Bradley A. Webb et al.   JOURNAL OF CELL BIOLOGY

Reconstituted IMPDH polymers accommodate both catalytically active and inactive conformations

(2017) Sajitha A. Anthony et al.   MOLECULAR BIOLOGY OF THE CELL

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Human CTP synthase filament structure reveals the active enzyme conformation

(2017) Eric M Lynch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of cytidine-5-triphosphate synthase1-selective inhibitory peptide from random peptide library displayed on T7 phage

(2017) Kotaro Sakamoto et al.   PEPTIDES

Human CTP synthase filament structure reveals the active enzyme conformation

(2017) Eric M Lynch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of Escherichia coli CTP Synthetase by NADH and Other Nicotinamides and Their Mutual Interactions with CTP and GTP

(2016) Chris Habrian et al.   BIOCHEMISTRY

Exploring the Potent Inhibition of CTP Synthase by Gemcitabine-5′-Triphosphate

(2016) Gregory D. McCluskey et al.   CHEMBIOCHEM

CTP Synthase 1 Deficiency in Successfully Transplanted Siblings with Combined Immune Deficiency and Chronic Active EBV Infection

(2016) Zeynep Yesim Kucuk et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Filamentation of Metabolic Enzymes in Saccharomyces cerevisiae

(2016) Qing-Ji Shen et al.   Journal of Genetics and Genomics

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Glutamine deprivation initiates reversible assembly of mammalian rods and rings

(2014) S. John Calise et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ack kinase regulates CTP synthase filaments during Drosophila oogenesis

(2014) T. I. Strochlic et al.   EMBO REPORTS

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

(2014) Emmanuel Martin et al.   NATURE

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

(2014) Ivana Petrovska et al.   eLife

Large-scale filament formation inhibits the activity of CTP synthetase

(2014) Rachael M Barry et al.   eLife

Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism

(2014) G. N. Aughey et al.   Biology Open

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Induction of Cytoplasmic Rods and Rings Structures by Inhibition of the CTP and GTP Synthetic Pathway in Mammalian Cells

(2011) Wendy C. Carcamo et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Regulation of Human Cytidine Triphosphate Synthetase 2 by Phosphorylation

(2010) Karen M. Kassel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of novel filament-forming proteins inSaccharomyces cerevisiaeandDrosophila melanogaster

(2010) Chalongrat Noree et al.   JOURNAL OF CELL BIOLOGY

Intracellular compartmentation of CTP synthase in Drosophila

(2010) Ji-Long Liu   Journal of Genetics and Genomics

The metabolic enzyme CTP synthase forms cytoskeletal filaments

(2010) Michael Ingerson-Mahar et al.   NATURE CELL BIOLOGY

Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch

(2010) F. Bai et al.   SCIENCE

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS