Article
Biology
Xiaoting Wu, Takashi Saito, Takaomi C. Saido, Anna M. Barron, Christiane Ruedl
Summary: The study conducted a comprehensive fate-mapping analysis of murine microglia and border-associated macrophages (BAMs). Results showed that microglia remain a stable embryonic-derived population, while BAMs are minimally replaced by bone marrow-derived cells. These findings are crucial for identifying potential therapeutic targets in neurodegenerative diseases.
Review
Neurosciences
Dilara Hasavci, Thomas Blank
Summary: Recent studies have shown that age-related diseases such as Alzheimer's and Parkinson's disease, as well as other brain disorders, are associated with changes in the gut microbiome. Aging is a major factor that affects the composition of the microbiome, and levels of microbiota-derived metabolites are elevated in older individuals with age-associated diseases. These metabolites can trigger the immune response in the central nervous system by influencing the development and activation status of brain-resident macrophages.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Immunology
Can Xu, Menglin Xiao, Xiang Li, Lei Xin, Jia Song, Qi Zhan, Changsheng Wang, Qisong Zhang, Xiaoye Yuan, Yanli Tan, Chuan Fang
Summary: The glioma tumor microenvironment and the role of glioma-associated macrophages (GAMs) in tumor development and response to therapies are reviewed. GAMs, derived from brain-resident microglia or bone marrow-derived monocytes, exert immune functions and affect various biological functions of gliomas. The plasticity of M1 and M2 macrophages under malignant conditions is also discussed, highlighting the potential therapeutic targets of GAMs in glioma therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Siyuan Hu, Meng Yang, Shumin Huang, Senjie Zhong, Qian Zhang, Haichao Ding, Xiajun Xiong, Zhixi Hu, Yi Yang
Summary: This article summarizes the relationship between inflammation and cardiac fibrosis, discusses the regulatory role of macrophages in cardiac fibrosis, and analyzes the functional heterogeneity of macrophages from different sources.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Eunju Lee, Jun-Cheol Eo, Changjun Lee, Je-Wook Yu
Summary: Tissue-resident macrophages, including microglia and non-parenchymal brain macrophages, are essential for maintaining tissue homeostasis and immune defense. Microglia, in particular, exhibit diverse phenotypes and play dual roles in brain homeostasis and neuroinflammation.
MOLECULES AND CELLS
(2021)
Article
Biochemistry & Molecular Biology
Christof Vorsatz, Niklas Friedrich, Falk Nimmerjahn, Markus Biburger
Summary: The effector functions of antibodies rely on the binding to cellular Fc gamma receptors, including tissue-resident macrophages. These macrophages play a crucial role in clearing pathogens, immune complexes, and in therapeutic interventions, with a pronounced heterogeneity in Fc gamma receptor expression patterns among different tissue macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Amelia Kulle, Ajitha Thanabalasuriar, Taylor S. Cohen, Marta Szydlowska
Summary: Resident macrophages play a crucial role in tissue maintenance by defending against pathogens and regulating inflammatory tone and tissue structure. This review focuses on the developmental origin of liver and lung resident macrophages, their contribution to host defense, and the mechanisms they use to regulate tissue homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Carlos Ardavin, Natalia Alvarez-Ladron, Margarita Ferriz, Alejandra Gutierrez-Gonzalez, Adrian Vega-Perez
Summary: Large peritoneal macrophages (LPMs) are tissue-resident macrophages with important roles in defense against peritoneal pathologies and maintenance of self-tolerance. Recent research in mice has revealed the mechanisms by which LPMs repair peritoneal injuries, control infections, and protect against tumor metastasis. However, peritoneal tumors can subvert LPM function and promote tumor growth. The plasticity of LPMs can be harnessed to develop immunotherapeutic approaches against peritoneal tumor metastasis based on macrophage reprogramming.
Review
Multidisciplinary Sciences
Tomi Lazarov, Sergio Juarez-Carreno, Nehemiah Cox, Frederic Geissmann
Summary: Embryo-derived tissue-resident macrophages are the first cells of the hematopoietic lineage in metazoans and play crucial roles in tissue growth, homeostasis, and repair. These specialized macrophages are distinct from other types of macrophages and sense and integrate local and systemic information to support the needs of specific tissue cells. Dysfunction of resident macrophages can lead to various diseases, emphasizing their importance in human health. This review provides an overview of macrophage physiology and its significance in human diseases, which can guide future research studies.
Article
Cardiac & Cardiovascular Systems
Xavier Revelo, Preethy Parthiban, Chen Chen, Fanta Barrow, Gavin Fredrickson, Haiguang Wang, Dogacan Yucel, Adam Herman, Jop H. van Berlo
Summary: This study assessed the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload and found that cardiac resident macrophages play a key role in stimulating angiogenesis and inhibiting fibrosis in response to cardiac pressure overload.
CIRCULATION RESEARCH
(2021)
Article
Immunology
Marie Siwicki, Nicolas A. Gort-Freitas, Marius Messemaker, Ruben Bill, Jeremy Gungabeesoon, Camilla Engblom, Rapolas Zilionis, Christopher Garris, Genevieve M. Gerhard, Anna Kohl, Yunkang Lin, Angela E. Zou, Chiara Cianciaruso, Evangelia Bolli, Christina Pfirschke, Yi-Jang Lin, Cecile Piot, John E. Mindur, Nilesh Talele, Rainer H. Kohler, Yoshiko Iwamoto, Mari Mino-Kenudson, Sara Pai, Claudio DeVito, Thibaud Koessler, Doron Merkler, Alexander Coukos, Alexandre Wicky, Montserrat Fraga, Christine Sempoux, Rakesh K. Jain, Pierre-Yves Dietrich, Olivier Michielin, Ralph Weissleder, Allon M. Klein, Mikael J. Pittet
Summary: This study highlights the role of liver macrophages and neutrophils in mediating and executing aberrant inflammation in TH1-promoting immunotherapy, with IL-12 and IFN-gamma playing crucial roles in regulating the severity of tissue damage.
SCIENCE IMMUNOLOGY
(2021)
Article
Environmental Sciences
Konstantinos Matthaios Doulgeris, Ville Vakkari, Ewan J. O'Connor, Veli-Matti Kerminen, Heikki Lihavainen, David Brus
Summary: This study investigated the impact of different long-range transport air masses on the microphysical properties of low-level clouds in a clean subarctic environment. Cloud measurements were conducted using ground-based techniques during eight Pallas Cloud Experiments (PaCEs) between 2004 and 2019. The analysis revealed clear differences in cloud microphysical properties for different air mass source regions. The Arctic air masses had low liquid water content (LWC), low cloud droplet number concentration (Nc), and larger droplet diameter compared to other regions.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2023)
Review
Immunology
Livia J. De Picker, Gerardo Mendez Victoriano, Rhys Richards, Alexander J. Gorvett, Simeon Lyons, George R. Buckland, Tommaso Tofani, Jeanette L. Norman, David S. Chatelet, James A. R. Nicoll, Delphine Boche
Summary: The study investigated the immunophenotype of immune cells in the brains of schizophrenia patients, finding that microglia in these patients expressed more immune receptors, suggesting the importance of communication between central and peripheral immune systems in schizophrenia. Additionally, the symptomatic state and age of patients also affected the alterations in the immune environment.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Cell Biology
Tiziana Cotechini, Aline Atallah, Arielle Grossman
Summary: Different populations of macrophages within solid tumors and metastatic sites play crucial roles in tumor progression and response to treatment. Targeting these populations with specific strategies has the potential to become a promising therapeutic avenue. Both recruited and tissue-resident macrophages contribute to tumor growth and metastasis, as well as resistance to chemotherapy, radiation therapy, and immune checkpoint blockade.
Review
Cell Biology
Sophie Besse, Sophie Nadaud, Elise Balse, Catherine Pavoine
Summary: Cardiac hypertrophy is an early adaptive compensatory response of the heart, and its progression to pathological hypertrophy and heart failure is still largely unknown. Inflammation and cardiac macrophages play important roles in non-infarction pathophysiology, with early inflammation often having a reparative or protective function, but late-stage heart failure being associated with activated inflammatory signaling.
Article
Multidisciplinary Sciences
Mariko L. Bennett, F. Chris Bennett, Shane A. Liddelow, Bahareh Ajami, Jennifer L. Zamanian, Nathaniel B. Fernhoff, Sara B. Mulinyawe, Christopher J. Bohlen, Aykezar Adil, Andrew Tucker, Irving L. Weissman, Edward F. Chang, Gordon Li, Gerald A. Grant, Melanie G. Hayden Gephart, Ben A. Barres
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Neurosciences
Christopher J. Bohlen, F. Chris Bennett, Andrew F. Tucker, Hannah Y. Collins, Sara B. Mulinyawe, Ben A. Barres
Article
Neurosciences
F. Chris Bennett, Mariko L. Bennett, Fazeela Yaqoob, Sara B. Mulinyawe, Gerald A. Grant, Melanie Hayden Gephart, Edward D. Plowey, Ben A. Barres
Article
Oncology
Shelli R. Kesler, F. Chris Bennett, Misty L. Mahaffey, David Spiegel
CLINICAL CANCER RESEARCH
(2009)
Article
Cell Biology
Kieran F. Harvey, Jaakko Mattila, Avi Sofer, F. Christian Bennett, Matthew R. Ramsey, Leif W. Ellisen, Oscar Puig, Iswar K. Hariharan
JOURNAL OF CELL BIOLOGY
(2008)
Article
Immunology
Jordan Jacobelli, F. Chris Bennett, Priya Pandurangi, Aaron J. Tooley, Matthew F. Krummel
JOURNAL OF IMMUNOLOGY
(2009)
Review
Immunology
F. C. Bennett, A. V. Molofsky
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2019)
Editorial Material
Cell Biology
F. Chris Bennett, Shane A. Liddelow
Review
Neurosciences
Andrew D. Greenhalgh, Sam David, F. Chris Bennett
NATURE REVIEWS NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
F. Christian Bennett, Kieran F. Harvey
