High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

(2019) Ayelet Alpert et al.   NATURE MEDICINE

Circuit Design Features of a Stable Two-Cell System

(2018) Xu Zhou et al.   CELL

Mice lacking all of the Skint family genes

(2018) Tomoya Narita et al.   INTERNATIONAL IMMUNOLOGY

High throughput automated analysis of big flow cytometry data

(2018) Albina Rahim et al.   METHODS

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

(2018) Etienne Patin et al.   NATURE IMMUNOLOGY

The 100 000 Genomes Project: bringing whole genome sequencing to the NHS

(2018) Clare Turnbull et al.   BMJ-British Medical Journal

The 100 000 Genomes Project: bringing whole genome sequencing to the NHS

(2018) Clare Turnbull et al.   BMJ-British Medical Journal

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

(2018) Yury Goltsev et al.   CELL

Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years

(2018) Luke C. Pilling et al.   PLoS One

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

The translation of non-canonical open reading frames controls mucosal immunity

(2018) Ruaidhrí Jackson et al.   NATURE

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

The 10,000 Immunomes Project: Building a Resource for Human Immunology

(2018) Kelly A. Zalocusky et al.   Cell Reports

Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency

(2017) Taco W. Kuijpers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

(2017) Danish Saleheen et al.   NATURE

Overexpression of the Cytokine BAFF and Autoimmunity Risk

(2017) Maristella Steri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

(2017) Barbara Piasecka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence of sexual dimorphism in mammalian phenotypic traits

(2017) Natasha A. Karp et al.   Nature Communications

A combined large-scale meta-analysis identifiesCOG6as a novel shared risklocusfor rheumatoid arthritis and systemic lupus erythematosus

(2016) Ana Márquez et al.   ANNALS OF THE RHEUMATIC DISEASES

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events

(2016) Olga Sobolev et al.   NATURE IMMUNOLOGY

The cellular composition of the human immune system is shaped by age and cohabitation

(2016) Edward J Carr et al.   NATURE IMMUNOLOGY

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

(2015) Martin Kolev et al.   IMMUNITY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data

(2015) Natalja Kurbatova et al.   PLoS One

Real-time resolution of point mutations that cause phenovariance in mice

(2015) Tao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelet and red blood cell interactions and their role in rheumatoid arthritis

(2015) Oore-ofe O. Olumuyiwa-Akeredolu et al.   RHEUMATOLOGY INTERNATIONAL

Applying the ARRIVE Guidelines to an In Vivo Database

(2015) Natasha A. Karp et al.   PLOS BIOLOGY

flowDensity: reproducing manual gating of flow cytometry data by automated density-based cell population identification

(2014) Mehrnoush Malek et al.   BIOINFORMATICS

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

(2014) John S. Tsang et al.   CELL

Red blood cell distribution width: A simple parameter with multiple clinical applications

(2014) Gian Luca Salvagno et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Impact of Temporal Variation on Design and Analysis of Mouse Knockout Phenotyping Studies

(2014) Natasha A. Karp et al.   PLoS One

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

(2013) Jacqueline K. White et al.   CELL

Genetic Variants Regulating Immune Cell Levels in Health and Disease

(2013) Valeria Orrù et al.   CELL

Identification of BACH2 as a susceptibility gene for Graves’ disease in the Chinese Han population based on a three-stage genome-wide association study

(2013) Wei Liu et al.   HUMAN GENETICS

Molecular Characterization of Mutant Mouse Strains Generated from the EUCOMM/KOMP-CSD ES Cell Resource

(2013) Edward Ryder et al.   MAMMALIAN GENOME

BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

(2013) Rahul Roychoudhuri et al.   NATURE

Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes

(2012) Katja Christodoulou et al.   GUT

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene

(2012) C Xuan et al.   ONCOGENE

Mouse Estrous Cycle Identification Tool and Images

(2012) Shannon L. Byers et al.   PLoS One

Robust and Sensitive Analysis of Mouse Knockout Phenotypes

(2012) Natasha A. Karp et al.   PLoS One

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

(2012) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

Skint-1 is a highly specific, unique selecting component for epidermal T cells

(2011) S. D. Barbee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

(2008) Jason D Cooper et al.   NATURE GENETICS

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

(2008) Ying Liu et al.   PLoS Genetics