标题
Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
作者
关键词
-
出版物
Nature Chemical Biology
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-03-03
DOI
10.1038/s41589-020-0490-4
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Accurate analysis of genuine CRISPR editing events with ampliCan
- (2019) Kornel Labun et al. GENOME RESEARCH
- Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance
- (2019) Kesavan Babu et al. BIOCHEMISTRY
- A highly specific SpCas9 variant is identified by in vivo screening in yeast
- (2018) Antonio Casini et al. NATURE BIOTECHNOLOGY
- Genome editing by natural and engineered CRISPR-associated nucleases
- (2018) Wen Y. Wu et al. Nature Chemical Biology
- Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis
- (2018) Digvijay Singh et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The CRISPR tool kit for genome editing and beyond
- (2018) Mazhar Adli Nature Communications
- Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis
- (2018) Digvijay Singh et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DNA Unwinding Is the Primary Determinant of CRISPR-Cas9 Activity
- (2018) Shanzhong Gong et al. Cell Reports
- Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
- (2018) Johnny H. Hu et al. NATURE
- A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
- (2018) Christopher A. Vakulskas et al. NATURE MEDICINE
- Role of nucleotide identity in effective CRISPR target escape mutations
- (2018) Tim Künne et al. NUCLEIC ACIDS RESEARCH
- Directed evolution of CRISPR-Cas9 to increase its specificity
- (2018) Jungjoon K. Lee et al. Nature Communications
- Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
- (2017) Janice S. Chen et al. NATURE
- Pooled CRISPR screening with single-cell transcriptome readout
- (2017) Paul Datlinger et al. NATURE METHODS
- The initiation, propagation and dynamics of CRISPR-SpyCas9 R-loop complex
- (2017) Yan Zeng et al. NUCLEIC ACIDS RESEARCH
- Mechanism of duplex DNA destabilization by RNA-guided Cas9 nuclease during target interrogation
- (2017) Vladimir Mekler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing
- (2017) Namita Bisaria et al. Cell Systems
- A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
- (2017) Yavuz S. Dagdas et al. Science Advances
- Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
- (2016) Josh Tycko et al. MOLECULAR CELL
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
- (2016) F. Jiang et al. SCIENCE
- Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
- (2016) Digvijay Singh et al. Nature Communications
- Engineering Pseudomonas putida KT2440 for simultaneous degradation of organophosphates and pyrethroids and its application in bioremediation of soil
- (2015) Zhenqiang Zuo et al. BIODEGRADATION
- Conformational control of DNA target cleavage by CRISPR–Cas9
- (2015) Samuel H. Sternberg et al. NATURE
- CRISPR interference and priming varies with individual spacer sequences
- (2015) Chaoyou Xue et al. NUCLEIC ACIDS RESEARCH
- A Cas9-guide RNA complex preorganized for target DNA recognition
- (2015) F. Jiang et al. SCIENCE
- Rationally engineered Cas9 nucleases with improved specificity
- (2015) I. M. Slaymaker et al. SCIENCE
- Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
- (2014) Hiroshi Nishimasu et al. CELL
- Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
- (2014) Carolin Anders et al. NATURE
- DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
- (2014) Samuel H. Sternberg et al. NATURE
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage
- (2014) Regina Cencic et al. PLoS One
- Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
- (2014) Mark D. Szczelkun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Degenerate target sites mediate rapid primed CRISPR adaptation
- (2014) P. C. Fineran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
- (2014) M. Jinek et al. SCIENCE
- Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
- (2013) Ines Fonfara et al. NUCLEIC ACIDS RESEARCH
- Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
- (2012) G. Gasiunas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system
- (2012) Kirill A. Datsenko et al. Nature Communications
- CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
- (2011) Elitza Deltcheva et al. NATURE
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