Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

Mutational analysis identifies therapeutic biomarkers in inflammatory bowel disease-associated colorectal cancers

(2018) Shahida Din et al.   CLINICAL CANCER RESEARCH

Evolutionary history of human colitis-associated colorectal cancer

(2018) Ann-Marie Baker et al.   GUT

Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia

(2018) Yoshinari Nakatsuka et al.   Mucosal Immunology

IκBζ is a key transcriptional regulator of IL-36–driven psoriasis-related gene expression in keratinocytes

(2018) Anne Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

(2018) Akira Yokoyama et al.   NATURE

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Clonal evolution of colorectal cancer in IBD

(2017) Chang-Ho R. Choi et al.   Nature Reviews Gastroenterology & Hepatology

Genomic landscape of colitis-associated cancer indicates the impact of chronic inflammation and its stratification by mutations in the Wnt signaling

(2017) Masashi Fujita et al.   Oncotarget

IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae

(2016) Kong Chen et al.   Cell Host & Microbe

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease−Associated Colorectal Cancers

(2016) Ana I. Robles et al.   GASTROENTEROLOGY

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

(2015) Takashi Mino et al.   CELL

Correlation of Biomarker Expression in Colonic Mucosa with Disease Phenotype in Crohn’s Disease and Ulcerative Colitis

(2015) Maria E. C. Bruno et al.   DIGESTIVE DISEASES AND SCIENCES

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

IκBζ is a key driver in the development of psoriasis

(2015) Claus Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

hnRNP F Complexes with Tristetraprolin and Stimulates ARE-mRNA Decay

(2014) Boris Reznik et al.   PLoS One

Enhanced Apoptosis by Disruption of the STAT3-IκB-ζ Signaling Pathway in Epithelial Cells Induces Sjögren’s Syndrome-like Autoimmune Disease

(2013) Atsushi Okuma et al.   IMMUNITY

The burden of inflammatory bowel disease in Europe

(2013) Johan Burisch et al.   Journal of Crohns & Colitis

I B  Is a Transcriptional Key Regulator of CCL2/MCP-1

(2013) D. G. Hildebrand et al.   JOURNAL OF IMMUNOLOGY

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

(2013) Hiroyuki Miyoshi et al.   Nature Protocols

An empirical Bayesian framework for somatic mutation detection from cancer genome sequencing data

(2013) Yuichi Shiraishi et al.   NUCLEIC ACIDS RESEARCH

Direct Measurements of Human Colon Crypt Stem Cell Niche Genetic Fidelity: The Role of Chance in Non-Darwinian Mutation Selection

(2013) Haeyoun Kang et al.   Frontiers in Oncology

The inflammation theory of disease

(2012) Philip Hunter   EMBO REPORTS

Th17 Cells Upregulate Polymeric Ig Receptor and Intestinal IgA and Contribute to Intestinal Homeostasis

(2012) Anthony T. Cao et al.   JOURNAL OF IMMUNOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-κB pathways in intestinal epithelial cells

(2011) M E C Bruno et al.   Mucosal Immunology

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

(2011) Hidenori Iwasaki et al.   NATURE IMMUNOLOGY

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

(2011) Vladimir Ramirez-Carrozzi et al.   NATURE IMMUNOLOGY

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL