期刊
BIOSCIENCE REPORTS
卷 35, 期 -, 页码 -出版社
PORTLAND PRESS LTD
DOI: 10.1042/BSR20150007
关键词
energetics; fetal programming; heart; metabolism; mitochondria; obesity
资金
- Canadian Institutes of Health Research (CIHR) [MOP57810]
- Alexander Graham Bell scholarship from the Natural Sciences and Engineering Research Council
- CIHR Training Program in Neurodegenerative Lipidomics
- Vanier Canada Graduate Scholarship
- CIHR postdoctoral fellowship
Intrauterine growth restriction (IUGR) is associated with an increased risk of developing obesity, insulin resistance and cardiovascular disease. However, its effect on energetics in heart remains unknown. In the present study, we examined respiration in cardiac muscle and liver from adult mice that were undernourished in utero. We report that in utero undernutrition is associated with impaired cardiac muscle energetics, including decreased fatty acid oxidative capacity, decreased maximum oxidative phosphorylation rate and decreased proton leak respiration. No differences in oxidative characteristics were detected in liver. We also measured plasma acylcarnitine levels and found that short-chain acylcarnitines are increased with in utero undernutrition. Results reveal the negative impact of suboptimal maternal nutrition on adult offspring cardiac energy metabolism, which may have life-long implications for cardiovascular function and disease risk.
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