Article
Chemistry, Analytical
Yan Gong, Wei Yuan, Peng Zhang, Ke Zheng, Qian Zhang, Caifeng Ding
Summary: A smart nano platform was constructed by loading upconversion nanoparticles (UCNPs) with photosensitizers Ce6, which can specifically light up tumor tissues and stimulate reactive oxygen species (ROS) production under near-infrared (NIR) irradiation, showing remarkable fluorescence imaging and photodynamic therapy (PDT) effect for deep tumors. The judicious introduction of anti-fouling peptide improved the PDT efficiency and obtained an excellent anti-fouling performance in complex biological substrate. By modifying polypeptide targeting for HER2, the nanoplatform achieved specificity to malignant breast cancer cells. This anti-fouling nanoplatform provides a new approach for the development of fluorescence imaging and PDT for deep tumor tissue with high targeting and therapeutic efficacy, promising to be used in the early therapy of malignant breast cancer specifically.
ANALYTICA CHIMICA ACTA
(2023)
Article
Crystallography
Wei Wu, Wei Wei, Dingli Xu, Yunpeng Liu, Jin Li, Kaifeng Gan, Liang Liu
Summary: The study introduced a rhodamine-derived probe for detecting Hg(II), discussing its absorption and emission responses to Hg(II) and the recognizing mechanism. It was found that Hg(II) directly bonded with the probe in a 1:1 stoichiometry, with an association constant of 2.59 x 10(5) M-1. Such a high value indicated a strong coordination affinity between Hg(II) and the rhodamine-derived probe.
Article
Engineering, Environmental
Tong Zhou, Qianya Cheng, Lei Zhang, Duoteng Zhang, Lin Li, Tianyue Jiang, Ling Huang, Heng Xu, Ming Hu, Su Jing
Summary: In this study, core-shell nanoparticles were successfully prepared with three intense upconversion emissions, one of which can activate photo-Fenton reaction to induce cancer cell apoptosis, while the other two are suitable for upconversion luminescence imaging. By loading a specific substance and encapsulating it in liposomes, this nano system achieves near-infrared promoted cytotoxicity and biological upconversion luminescence imaging.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Bo Liu, Yonghao Ge, Yahui Lu, Yibo Huang, Xiaoru Zhang, Xunyi Yuan
Summary: A novel photoelectrochemical sensor was developed for detecting carcinoembryonic antigen (CEA) by utilizing the composite of UCNPs with semiconductors and conformational changes in the DNA structure. The sensor showed enhanced photoelectric reaction under near-infrared light excitation and achieved sensitive on-off-on detection of CEA with a low detection limit of 0.3 pg mL-1 under optimal experimental conditions.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Yu Wang, Xudong Zhao, Man Zhang, Xuan Sun, Jialei Bai, Yuan Peng, Shuang Li, Dianpeng Han, Shuyue Ren, Jiang Wang, Tie Han, Yifei Gao, Baoan Ning, Zhixian Gao
Summary: An avidin biotin complex immunosorbent assay based on upconversion nanoparticles was developed for accurate detection of antibiotics in a shorter period of time. The method utilizes double signal amplification for improved sensitivity and uses a 96-well enzyme-linked plate for high-throughput detection.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Medicine, Research & Experimental
Xin Xue, Qiyi Li, Pengjun Zhang, Yilin Xue, Yuetong Zhao, Yuting Ye, Jia Li, Yuyan Li, Li Zhao, Guoqiang Shao
Summary: Cancer poses a major threat to human health due to delays in diagnosis and incomplete surgical resection. A new PET/NIRF bimodal imaging agent, [Ga-68]-Ga-DOTA-NPC, shows promise for tumor detection, resection during surgery, and postoperative monitoring. It provides good biosafety and high-contrast tumor accumulation, allowing visualization and differentiation of tumors from adjacent tissue.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Caiping Ding, Yuting Gu, Weiwei Chen, Long Chen, Longhua Guo, Youju Huang
Summary: Near-infrared (NIR) fluorescent probes offer highly sensitive detection of Al3+ for human health purposes. This study introduces new Al3+ response molecules (HCMPA) and NIR upconversion fluorescent nanocarriers (UCNPs) that respond to Al3+ through ratio NIR fluorescence. The use of UCNPs improves photobleaching and addresses the lack of visible light in specific HCMPA probes. The NIR ratiometric fluorescence sensing system successfully detects Al3+ within the range of 0.1-1000 nM with an accuracy limit of 0.06 nM.
ANALYTICA CHIMICA ACTA
(2023)
Review
Pharmacology & Pharmacy
Habeeb Saheb Naher, Bassam Ali Hussein Al-Turaihi, Safa H. Mohammed, Salam M. Naser, Mohammed A. Albark, Hussein Ali Madlool, Hamid Abbas Mohammed Al-Marzoog, Abduladheem Turki Jalil
Summary: The widespread usage of lanthanide group in recent years has fascinated researchers worldwide. This review introduces upconversion nanoparticles (UCNPs) in biomedical engineering, imaging, and drug delivery, with a focus on designing nano-drug carriers and theranostic applications for effective cancer treatment. The study also explores the mechanisms, synthesis methods, and functionalized properties of UCNPs in nanoscience.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Jingrong Liu, Chunxiao Yu, Luodan Han, Yiping Shen, Yao Fang, Yaokun Xia, Xu Yao, Fang Wu, Chunyan Li, Jinghua Chen, Xi Zhang, Jianming Lan
Summary: A wash-free biological aptasensor based on UCNPs and TAMRA was developed for high sensitive detection of TSH. The sensor achieved detection by changing the distance between UCNPs and TAMRA, and effectively eliminated background interference. With its high sensitivity and operational convenience, it is a promising method for clinical TSH determination.
Article
Multidisciplinary Sciences
Raquel Leon, Himar Fabelo, Samuel Ortega, Juan F. Pineiro, Adam Szolna, Maria Hernandez, Carlos Espino, Aruma J. O'Shanahan, David Carrera, Sara Bisshopp, Coralia Sosa, Mariano Marquez, Jesus Morera, Bernardino Clavo, Gustavo M. Callico
Summary: This research introduces a new methodology for fusing visible and near-infrared (VNIR) and near-infrared (NIR) hyperspectral data to delineate brain tumor tissue during neurosurgical procedures, which improves classification accuracy by up to 21% compared to the use of each data modality independently.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Min Hou, Rui Guo, Tianyu Ren, Tao Wang, Jian-Hui Jiang, Jianjun He
Summary: This study reports the use of a DNA thalidomide conjugate (PASTE) to selectively bind and induce proteolysis of targeted activated transcription factor (PROTAF), providing a potential tool for studying signaling pathways and developing precision medicines.
Article
Chemistry, Analytical
Chenchen Yang, Yueyue Li, Na Wu, Yinchan Zhang, Wei Feng, Mingming Yu, Zhanxian Li
Summary: In this study, core-shell rare earth upconversion nanoparticles were synthesized and utilized for the fabrication of mercury ion colorimetric nanoprobes with rapid response and low detection limits. These nanoprobes could also be applied for Hg2+ imaging and localization in living cells and lysosomes.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Editorial Material
Biochemical Research Methods
Nina Vogt
Summary: iGECI, a near-infrared calcium sensor, shows promise for imaging neuronal activity in vivo.
Article
Plant Sciences
Jannat Yasmin, Mohammed Raju Ahmed, Collins Wakholi, Santosh Lohumi, Perez Mukasa, Geonwoo Kim, Juntae Kim, Hoonsoo Lee, Byoung-Kwan Cho
Summary: This study describes a prototype online near-infrared hyperspectral imaging system for rapid detection of seed viability. The system employed a wavelength range of 900-1700 nm to obtain spectral images of aged watermelon seed samples. The results demonstrated the potential of the system for quality monitoring in the seed industry.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Food Science & Technology
Fei Tan, Xiaoming Mo, Shiwei Ruan, Tianying Yan, Peng Xing, Pan Gao, Wei Xu, Weixin Ye, Yongquan Li, Xiuwen Gao, Tianxiang Liu
Summary: This study proposes a hyperspectral imaging system for the nondestructive detection of key qualities of cherry tomatoes. The effects of individual and fused spectral information on the detection of firmness, soluble solid content (SSC), and titratable acidity (TA) were compared. The results show that the multi-quality prediction model established by Vis-NIR spectra has a better performance, making it suitable for nondestructive quality detection of cherry tomatoes.