期刊
NANOMEDICINE
卷 15, 期 6, 页码 625-641出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2019-0388
关键词
cell membrane; detoxification; drug delivery; immune regulation; nanoparticle
资金
- National Natural Science Foundation of China [81673348]
Cell membranes have been continuously imitated and used for the modification of nanoparticles (NPs) to improve NP biological properties. Cell membrane-coated NPs, where core NPs are wrapped with plasma membrane vesicles, show high biocompatibility, targeting specificity and low side effects. Compared with conventional strategies, this novel approach directly leverages intact and natural functions of cell membranes, instead of replicating these features via synthetic techniques. This top-down technique bestows NPs with enhanced biointerfacing capabilities with potential in the diagnosis and treatment of cancer, infection and other diseases. Herein, we report on the advances in cell membrane-coated NPs, including the preparation process, source cell membranes for wrapping and potential applications of these cell membrane-coated NPs.
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