Article
Food Science & Technology
Chunyue Wang, Hongbo Jiang, Honghan Liu, Shanshan Chen, Hangyu Guo, Shuoshuo Ma, Weiwei Han, Yu Li, Di Wang
Summary: In this study, the researchers investigated the protective effects of isoforsythiaside (IFY) against ferroptosis and neuroinflammation. They found that IFY can alleviate the expression levels of pro-inflammatory factors and improve mitochondria morphology, and regulate the activation of Nrf2 and NF-xB signaling in erastin-damaged HT22 cells and APP/PS1 mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Immunology
Shiqi Zhou, Yanyan Li, Zhao Zhang, Yuhe Yuan
Summary: The TAM receptors may have a role in delaying the progression of Alzheimer's disease (AD), the most common neurodegenerative disease associated with aging. These receptors are associated with immune responses, cellular differentiation and migration, and clearance of apoptotic cells and debris. Research suggests that the TAM system is involved in AD pathology and regulates microglia, the key sensors of disorder in the central nervous system (CNS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Wangyu Bi, Tong Lei, Shanglin Cai, Xiaoshuang Zhang, Yanjie Yang, Zhuangzhuang Xiao, Lei Wang, Hongwu Du
Summary: This review summarizes the role of astrocytes in Alzheimer's disease (AD) and explores the potential therapeutic strategies targeting astrocytes. Astrocytes play an important role in the pathogenesis of AD, and therapies targeting astrocytes have shown high efficacy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
L. van Olst, L. Coenen, J. M. Nieuwland, C. Rodriguez-Mogeda, N. M. de Wit, A. Kamermans, J. Middeldorp, H. E. de Vries
Summary: Alzheimer's disease is the most common form of dementia, and currently there are only medications that can improve symptoms but not cure the disease. Recent studies have shown that T cells play an important role in the pathogenesis of Alzheimer's disease, and targeting T cells can combat the pathology and cognitive decline.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Virology
Alperen Aksakal, Bugra Kerget, Ferhan Kerget, Seda Askin
Summary: The study revealed the correlation between serum migration inhibitory factor (MIF) level and disease severity in COVID-19, with higher MIF levels potentially indicating a more severe condition. MIF levels can serve as an important predictive indicator for early disease prognosis in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Zhiyu Wang, Donald F. Weaver
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by the progressive deterioration of multiple cognitive functions. Microglial cells play a crucial role in the pathogenesis of Alzheimer's disease through the recognition and response to misfolded proteins like beta-amyloid and tau. These proteins contribute to neuroinflammation and neurotoxicity, while microglia's primary function is to maintain brain homeostasis and synaptic integrity. However, prolonged activation of microglia can be harmful. This review discusses the role of microglia in Alzheimer's disease pathogenesis and explores potential drug candidates targeting microglial receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Swetha Pavani Rao, Wei Xie, Ye In Christopher Kwon, Nicholas Juckel, Jiashu Xie, Venkateshwara Rao Dronamraju, Robert Vince, Michael K. Lee, Swati S. More
Summary: This study demonstrates the feasibility of managing AD by enhancing 3MST function in the brain and identifies sulfanegen as a potential AD therapeutic.
Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Immunology
Panagiota Pagoni, Roxanna S. Korologou-Linden, Laura D. Howe, George Davey Smith, Yoav Ben-Shlomo, Evie Stergiakouli, Emma L. Anderson
Summary: This study suggests a causal role of cytokines in the pathogenesis of Alzheimer's disease and fluid intelligence.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Mauro Vasella, Stefan Wolf, Eamon C. Francis, Gerrit Grieb, Pablo Pfister, Gregory Reid, Juergen Bernhagen, Nicole Lindenblatt, Epameinondas Gousopoulos, Bong-Sung Kim
Summary: Lipedema is a chronic disorder mainly affecting women, with an unknown etiology. Recent research suggests that the accumulation and polarization of macrophages may be involved in lipedema. This study provides evidence for the potential involvement of the MIF family, specifically the MIF-1-CD74 axis, in lipedema.
Article
Biochemistry & Molecular Biology
Ji Ae Kim, Ye Young Kim, Seung Hak Lee, Chul Jung, Mi Hee Kim, Dae Yul Kim
Summary: The macrophage migration inhibitory factor (MIF) exerts a neuroprotective effect, facilitating neurological recovery and protecting brain tissue from ischemic injury in an in vivo model of ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Lee Wei Lim, Md . Sahab Uddin
Summary: Alzheimer's disease is a neurodegenerative disorder with unclear pathogenesis. Recent research suggests that microglia and astrocytes may play a role in the development of AD and could be potential therapeutic targets.
AGEING RESEARCH REVIEWS
(2022)
Article
Medicine, Research & Experimental
Jie Liu, Dezhao Li, Yaoshan Dun, Hui Li, Jeffrey W. Ripley-Gonzalez, Jie Zhang, Ling Qiu, Baiyang You, Suixin Liu
Summary: The study found that Rhodiola can reduce lipid accumulation in the liver of NAFLD by facilitating the MIF pathway and the downstream lipophagy and lipid metabolism.
Review
Endocrinology & Metabolism
Wei Xuan, Wanqing Xie, Fengshi Li, Dan Huang, Ziyu Zhu, Yuxuan Lin, Binwei Lu, Weifeng Yu, Yan Li, Peiying Li
Summary: This review summarizes the regulatory functions of macrophage migration inhibitory factor (MIF) in brain injury and neurodegenerative diseases, including its effects on immune cells, endothelial cells, and neurons, as well as the possible link with the severity of stroke and the development of neurodegenerative diseases.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Yuxin Zhang, Zhonglong Liu, Kexin Wang, Shenji Lu, Shuai Fan, Lili Xu, Bin Cai
Summary: This study revealed the role of MIF and TGF-β1 in post-traumatic joint contracture, showing that MIF can enhance TGF-β1 production in fibroblasts through MAPK signaling, leading to fibroblast function changes and joint capsule fibrosis. Further investigation into this mechanism may lead to potential therapeutic targets for PTJC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Roberta Celli, Pasquale Striano, Rita Citraro, Luisa Di Menna, Milena Cannella, Tiziana Imbriglio, Mahmoud Koko, Euro Epinomics-Cogie Euro Epinomics-Cogie Consortium, Giovambattista De Sarro, James A. Monn, Giuseppe Battaglia, Gilles van Luijtelaar, Ferdinando Nicoletti, Emilio Russo, Antonio Leo
Summary: Previous studies suggest that modulation of mGlu3 receptors may be a potential treatment for absence epilepsy. This study found that mGlu3 receptor expression and signaling were decreased in the somatosensory cortex and thalamus of epileptic rats, and selective activation of mGlu3 receptors reduced seizures and depressive-like behavior. However, no association was found between genetic variants of GRM3 and absence epilepsy.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Immunology
Qing Li, Jialuo He, Senlin Li, Cheng Tian, Jian Yang, Huimin Yuan, Yi Lu, Paolo Fagone, Ferdinando Nicoletti, Ming Xiang
Summary: Pancreatic cancer (PC) has a cold tumor immune microenvironment (TIME) with minimal dendritic cell (DC) and T cell infiltration, leading to inadequate immunotherapy and chemotherapy. Combining gemcitabine (GEM) with ginsenoside Rh2 (Rh2) can enhance tumor immunogenicity and induce lasting anti-tumor immunity in PC. The activation of DCs by Rh2 via the CARD9-BCL10-MALT1/NF-KB pathway may reverse the cold TIME and optimize GEM chemotherapy, providing a potentially feasible and safe treatment strategy for PC.
CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Simona Aleksandrova, Ralitza Alexova, Stela Dragomanova, Reni Kalfin, Ferdinando Nicoletti, Paolo Fagone, Maria Cristina Petralia, Katia Mangano, Lyubka Tancheva
Summary: Pomegranate is a polyphenol-rich food and medicinal plant that contains various beneficial compounds. Studies have shown that these compounds can target brain cells and support their functions by regulating redox balance, proliferation, and survival. The neuroprotective effects of pomegranate are mediated by its antioxidant and anti-inflammatory properties, ability to activate signaling pathways, and regulation of mitochondrial damage. In vitro and in vivo studies have demonstrated that pomegranate polyphenols can directly affect neuronal and glial cells, as well as influence blood-brain barrier function and increase blood flow to the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thomas Hach, Kasra Shakeri-Nejad, Marc Bigaud, Frank Dahlke, Massimiliano de Micco, Olivier Petricoul, Gordon Graham, Daniela Piani-Meier, Renato Turrini, Volker Brinkmann, Ferdinando Nicoletti
Summary: Maladjusted immune responses to COVID-19 can lead to immunopathology and acute respiratory distress syndrome. Sphingosine-1-phosphate and its receptors play a crucial role in maintaining endothelial cell chemotaxis and barrier integrity. S1PR modulators can attenuate cytokine release and enhance the pulmonary endothelial barrier. Certain drugs used in multiple sclerosis have shown effectiveness and potential in COVID-19 patients.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2023)
Article
Neurosciences
Nicole Piera Palomba, Giorgio Fortunato, Giuseppe Pepe, Nicola Modugno, Sara Pietracupa, Immacolata Damiano, Giada Mascio, Federica Carrillo, Luca Giovanni Di Giovannantonio, Laura Ianiro, Katiuscia Martinello, Viola Volpato, Vincenzo Desiato, Riccardo Acri, Marianna Storto, Ferdinando Nicoletti, Caleb Webber, Antonio Simeone, Sergio Fucile, Vittorio Maglione, Teresa Esposito
Summary: This study focuses on the common and rare variants identified in the lysosomal K+ channel TMEM175 and their association with Parkinson's disease. Through clinical and genetic analysis, the study identified several common variants and 13 highly penetrant detrimental mutations in the TMEM175 gene. Functional analysis revealed a loss of K+ conductance and impaired autophagic/lysosomal proteolytic flux in patient-derived cells, suggesting a potential role of TMEM175 gene mutations in the pathophysiology of PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Carla Letizia Busceti, Albino Carrizzo, Franca Bianchi, Massimiliano De Lucia, Antonio Damato, Chiara Cazzin, Eleonora Venturini, Paola Di Pietro, Roxana Paula Ginerete, Luisa Di Menna, Maria Cotugno, Rosita Stanzione, Simona Marchitti, Serena Migliarino, Michele Ciccarelli, Sebastiano Sciarretta, Valeria Bruno, Giuseppe Battaglia, Francesco Fornai, Massimo Volpe, Speranza Rubattu, Ferdinando Nicoletti, Carmine Vecchione
Summary: Dkk3 plays a crucial role in cardiovascular homeostasis, and its deficiency leads to hypertension and impaired vascular function, which can be rescued by restoring Dkk3 expression. This effect is achieved through promoting VEGF expression and activating the VEGF/Akt/eNOS hypotensive pathway.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ralitza Alexova, Simona Alexandrova, Stela Dragomanova, Reni Kalfin, Ayten Solak, Sidharth Mehan, Maria Cristina Petralia, Paolo Fagone, Katia Mangano, Ferdinando Nicoletti, Lyubka Tancheva
Summary: Pomegranate is a rich source of polyphenols that have anti-inflammatory and antioxidant activity, and can support the immune system during viral infection and recovery. Studies have shown that pomegranate polyphenol extract and its components can control immune cell infiltration, regulate cytokine secretion, inhibit viruses like SARS-CoV-2, and modulate the NF-κB pathway. Further research is needed to understand the interactions between polyphenols, viruses, and the host immune response.
Review
Medicine, General & Internal
Gian Marco Leone, Katia Mangano, Maria Cristina Petralia, Ferdinando Nicoletti, Paolo Fagone
Summary: Due to the important role of TNF-alpha in immunoinflammatory diseases, TNF-alpha inhibitors have been successfully developed and used in the treatment of autoimmune disorders. Currently, there are five approved anti-TNF-alpha drugs and biosimilars available. This review discusses the historical development, current and potential future applications, as well as the search for biomarkers to predict responsiveness to these therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Hazael Ramiro Ceja-Galvez, Francisco Israel Renteria-Flores, Ferdinando Nicoletti, Jorge Hernandez-Bello, Gabriela Macedo-Ojeda, Jose Francisco Munoz-Valle
Summary: By January of 2023, the COVID-19 pandemic had resulted in 6,700,883 deaths and 662,631,114 cases worldwide, with no effective therapies or standardized treatment schemes available. This review aims to analyze the most efficient and promising therapies and drugs for prevention and treatment of severe COVID-19, providing support for healthcare professionals in choosing the best pharmacological approach.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Luisa Di Menna, Rosamaria Orlando, Giovanna 'Errico, Roxana Paula Ginerete, Agata Machaczka, Carmela Maria Bonaccorso, Andrea Arena, Michela Spatuzza, Roberta Celli, Marika Alborghetti, Eleonora Ciocca, Anna Rita Zuena, Mariarosaria Scioli, Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Maria Vincenza Catania
Summary: The involvement of mGlu5 receptors in monogenic autism has been supported by various studies, but there is a lack of research on the canonical signal transduction pathway activated by these receptors in mouse models of autism. In this study, we developed a method to assess PI hydrolysis in vivo and found that mGlu5 receptor-mediated PI hydrolysis was impaired in different brain regions of mice modeling Angelman syndrome and fragile-X syndrome. These findings provide the first evidence that the canonical transduction pathway of mGlu5 receptors is downregulated in mouse models of monogenic autism.
Article
Medicine, General & Internal
Nikola Ralchev Ralchev, Silviya Lyubenova Bradyanova, Yana Valerieva Doneva, Nikolina Mihaylova, Elena Vikentieva Elefterova-Florova, Andrey Ivanov Tchorbanov, Jose Francisco Munoz-Valle, Maria Cristina Petralia, Paola Checconi, Ferdinando Nicoletti, Paolo Fagone
Summary: The COVID-19 pandemic poses a significant threat to global public health. The involvement of CD74 and D-DT in COVID-19 patients has been investigated, and further research is needed to fully understand the mechanisms and potential therapeutic value of targeting CD74 and IL-13 in COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Paolo Fagone, Eliana Piombino, Katia Mangano, Rocco De Pasquale, Ferdinando Nicoletti, Rosario Caltabiano
Summary: This study found a negative correlation between HMOX1 levels and the inflammatory status, as well as the infiltration of M1 macrophages and activated mastocytes in DLE lesions. These findings suggest that HMOX1 plays a crucial role in the regulation of inflammation in DLE and could be a potential therapeutic target and biomarker for DLE.
Meeting Abstract
Gastroenterology & Hepatology
M. Ferhat, K. Mangano, F. Nicoletti, C. Landlinger, T. Michael
JOURNAL OF CROHNS & COLITIS
(2023)
