Article
Engineering, Biomedical
Chenyang Zhang, Xin Wang, Xinghua Dong, Linqiang Mei, Xiaochen Wu, Zhanjun Gu, Yuliang Zhao
Summary: The proposed methodology accelerates the enzymatic activity of nanomaterials for tumor therapy by enhancing redox cycling in the presence of X-ray. The nanocomposite under external X-ray irradiation persists in generating ROS, indicating a synergistic effect for cancer treatment.
Article
Chemistry, Multidisciplinary
Zhen Xu, Li Zhang, Min Pan, Qunying Jiang, Yunjie Huang, Fuan Wang, Xiaoqing Liu
Summary: Nanozymes have great potential in nanomedicine, but their clinical translation is limited by biotoxicity. A new type of bionanozyme with ultrahigh and light-controlled catalytic activity has been developed through self-assembly and in situ polymerization, showing potential for tumor-specific therapy with minimal biotoxicity.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Article
Medicine, Research & Experimental
Praveenkumar Basavaraj, Po-Fan Hsieh, Wen-Ping Jiang, Da-Tian Bau, Guan-Jhong Huang, Wen-Chin Huang
Summary: This study evaluates the potential efficacy and molecular mechanism of scandenolone (SCA), a natural isoflavone, in the progression of prostate cancer (PCa). The findings demonstrate that SCA can suppress cell viability and progression, induce apoptosis, and modulate metabolic and antioxidant factors in PCa cells. Furthermore, SCA shows potential efficacy against castration-resistant prostate cancer (CRPC) tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Qing Xia, Wenjing Wang, Zijie Liu, Jiaying Xiao, Cong Qiao, Yu Zhao, Bowen Li, Yuanli Liu, Yahui Peng, Xinyu Yang, Jiabin Shi, Xu Gao, Dayong Wang
Summary: Polycystic ovary syndrome (PCOS) is a complex reproductive disorder that seriously harms female reproductive health and decreases quality of life. Berberine, a traditional Chinese medicine, has been shown to improve ovulation and live birth rates in women with PCOS. However, its anti-inflammatory properties in PCOS reproductive disorders have been less studied.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Liping Chen, Di Feng, Yafang Qian, Xiao Cheng, Huizhu Song, Yifan Qian, Xu Zhang, Yali Wu, Huawei Lv, Qi Liu, Gang Cheng, Bo Yang, Mancang Gu
Summary: Valtrate exhibits anti-cancer activity against pancreatic cancer cells by directly targeting Stat3 through a covalent linkage to inhibit Stat3 activity, leading to apoptosis and cell cycle arrest.
Article
Biochemistry & Molecular Biology
Nadia Gruber, Liliana Orelli, Cristina Minnelli, Luca Mangano, Emiliano Laudadio, Giovanna Mobbili, Pierluigi Stipa
Summary: Nitrones have potential as therapeutic antioxidants by scavenging C- and O-centered radicals, with the ability to modulate their structure by introducing proper substituents to interact with cell membranes and neutralize radicals in water compartments. The antioxidant efficacy of amidinoquinoxaline nitrones is based on properties such as lipophilicity, free radical scavenging ability, and single electron transfer reactions.
Review
Pharmacology & Pharmacy
Na An, Guoxia Zhang, Yingjian Li, Chao Yuan, Fan Yang, Lijing Zhang, Yonghong Gao, Yanwei Xing
Summary: This article summarizes the mechanisms of action of berberine (BBR) in the prevention and treatment of cardiovascular diseases (CVDs). Research has shown that BBR has various pharmacological effects, such as lowering blood sugar, reducing lipid levels, and exerting antioxidant activities. It can protect the myocardium and has therapeutic effects on coronary atherosclerosis, myocardial ischemia/reperfusion, arrhythmias, and heart failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hee Jin Jung, Dong Chan Choi, Sang Gyun Noh, Heejeong Choi, Inkyu Choi, Il Young Ryu, Hae Young Chung, Hyung Ryong Moon
Summary: Thirteen (Z)-2-(substituted benzylidene)benzimidazothiazolone analogs were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. Among these compounds, compounds 1-3 displayed stronger tyrosinase inhibitory activity and could inhibit melanin production through different pathways.
Article
Chemistry, Multidisciplinary
Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Summary: Novel ER-targeted prodrugs have been developed with activation only in cancer cells, demonstrating anticancer efficacy and cancer cell specificity. These prodrugs induce ER stress, attenuate mitochondrial membrane potential, and generate mitochondrial ROS leading to cell death via necrosis. Activation of the new prodrugs has also been demonstrated in the Nemeth-Kellner lymphoma murine model.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Seong-Yeong Heo, Yeachan Lee, Tae-Hee Kim, Soo-Jin Heo, Hwarang Shin, Jiho Lee, Myunggi Yi, Hyun Wook Kang, Won-Kyo Jung
Summary: Chlorophyllin-assisted photodynamic therapy has shown strong anti-cancer effects on human cervical cancer by inducing apoptosis through oxidative stress. The optimal conditions for photodynamic therapy have been determined, and it regulates the expression of several proteins and suppresses the phosphorylation of AKT1. Overall, chlorophyllin-assisted photodynamic therapy has the potential to be used as an antitumor therapy for cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nerilson M. Lima, Gagan Preet, Sara R. Marqui, Thais de O. R. S. Falcoski, Geovana Navegante, Christiane P. Soares, Teresinha de Jesus A. S. Andrade, Felipe A. La Porta, Harinantenaina Liva R. Rakotondraie, Marcel Jaspars, Dulce H. S. Silva
Summary: This study evaluated the metabolic profiling and antigenotoxicity of Inga species with potential antitumor effects. It also used a proteomic approach to investigate the response of HepG2 cells to polyphenols isolated from I. laurina. The results showed cytotoxic activity against cancer cell lines and identified potential bioactive compounds. The proteomic analysis revealed proteins related to ROS elimination, DNA repair, tumor protein expression, and apoptosis.
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Article
Chemistry, Medicinal
Xiang-Zhe Shi, Sheng Zhao, Yan Wang, Meng-Yao Wang, Su-Wen Su, Yan-Zhao Wu, Chen Xiong
Summary: The present study aimed to assess the therapeutic effect of berberine (BER) in human anaplastic thyroid carcinoma (ATC) cell lines CAL-62 and BHT-101, as well as the underlying mechanisms by which BER regulates apoptosis and autophagy. The results showed that BER significantly inhibited cell growth and induced apoptosis in ATC cells. Moreover, BER regulated autophagy and apoptosis through the PI3K/AKT/mTOR pathways in human ATC cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Danling Cheng, Xiaoying Wang, Xiaojun Zhou, Jingchao Li
Summary: Immunotherapy is a promising strategy for cancer treatment, but it faces challenges of low immune responses and immune-related adverse events. Sonodynamic therapy combined with immunotherapy can enhance antitumor immunity, and research on nanosonosensitizers for ROS generation is ongoing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Jin-Yi Wu, En-Tung Tsai, Fang-Yu Yang, Jui-Feng Lin, Hui-Fen Liao, Yu-Jen Chen, Cheng-Deng Kuo
ANTICANCER RESEARCH
(2020)
Article
Health Care Sciences & Services
Yung-Sheng Chen, Wan-An Lu, Jeffrey C. Pagaduan, Cheng-Deng Kuo
JMIR MHEALTH AND UHEALTH
(2020)
Article
Biology
Wan-An Lu, Yung-Sheng Chen, Chun-Hsiung Wang, Cheng-Deng Kuo
Review
Environmental Sciences
Ghazi Rekik, Yosra Belkhir, Mohamed Jarraya, Mohamed Amine Bouzid, Yung-Sheng Chen, Cheng-Deng Kuo
Summary: Dynamic visualizations like videos or animations are used to exchange information in various professional/academic contexts, and different instructional designs can improve learning outcomes. For novice learners, the effectiveness of static visualizations and reducing presentation speed in learning tactical scenes through dynamic visualizations depends on factors such as expertise level, type of depicted knowledge, and content complexity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Wan-An Lu, Jui-Feng Lin, Chen-Hsu Wang, Yung-Sheng Chen, Ying-Hua Shieh, Cheng-Deng Kuo
Summary: Respiration affects heart rate variability, with spectral analysis showing two respiratory frequencies at around 0.03 Hz and 0.3 Hz. Cross-spectral analysis enhances high-frequency power and suppresses very low-frequency power, indicating the role of respiration in modulating heart rate.
JOURNAL OF HEALTHCARE ENGINEERING
(2021)
Article
Medicine, General & Internal
Chew-Teng Kor, Kai-Huang Lin, Chen-Hsu Wang, Jui-Feng Lin, Cheng-Deng Kuo
Summary: This study investigated the usefulness of ventilator parameters in predicting the development and outcome of ARDS in postoperative patients with esophageal or lung cancer. Analysis of ventilator variables found that some parameters, such as RPPv, RPVI, and MW/IER, could be used to predict the occurrence and results of ARDS.
Article
Pediatrics
Ghazi Rekik, Yosra Belkhir, Nourhen Mezghanni, Mohamed Jarraya, Yung-Sheng Chen, Cheng-Deng Kuo
Summary: This study explored gender differences in learning basketball tactical actions from video modeling and static pictures. Results showed that males had higher spatial ability than females. An interaction between gender and type of visualization supported the ability-as-compensator hypothesis.
Article
Multidisciplinary Sciences
Yung-Sheng Chen, Filipe Manuel Clemente, Jeffrey Cayaban Pagaduan, Zachary Crowley-McHattan, Yu-Xian Lu, Chia-Hua Chien, Pedro Bezerra, Yi-Wen Chiu, Cheng-Deng Kuo
Summary: This study investigated the relationship between subjective physical exertions and wellness status during short-term overseas training camps with different tasks among elite young adult futsal players. The findings suggested that mean and sum sRPE were negatively related to wellness scores, indicating the importance of monitoring psychophysiological health using these measures during short-term OTCs.
Article
Anesthesiology
Shin-Hwar Wu, Chew-Teng Kor, I-Chieh Mao, Chun-Ching Chiu, Kai-Huang Lin, Cheng-Deng Kuo
Summary: Gattinoni's equation is commonly used to calculate the mechanical power of ventilation, but it only calculates inspiratory power. Including PEEP in the equation is debated because PEEP does not contribute to power. Measuring the area within the pressure-volume loop accurately reflects the power received in a ventilation cycle and is not influenced by PEEP.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Environmental Sciences
Nourhen Mezghanni, Ghazi Rekik, Zachary J. Crowley-McHattan, Yosra Belkhir, Rayda Ben Ayed, Atyh Hadadi, Turki Mohsen Alzahrani, Cheng-Deng Kuo, Yung-Sheng Chen
Summary: This study aimed to investigate whether the use of coordinated visual and verbal cues in narrated diagrams would enhance novices' learning of soccer scenes. The findings demonstrated the instructional benefits of using dual-modality cues in complex multimedia materials, improving both immediate and delayed recall performances.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Ana Filipa Silva, Francisco Tomas Gonzalez-Fernandez, Rafael Oliveira, Filipe Manuel Clemente, Pedro Bezerra, Chin-Hwai Hung, Yi-Wen Chiu, Cheng-Deng Kuo, Yung-Sheng Chen
Summary: There are differences in physical fitness and training intensity between selected and non-selected futsal players. Selected players performed better in 15 m and 30 m sprints, exercise heart rate responses, and locomotion profiles.
Article
Psychology, Multidisciplinary
Yung-Sheng Chen, Jeffrey C. Pagaduan, Pedro Bezerra, Zachary J. Crowley-McHattan, Cheng-Deng Kuo, Filipe Manuel Clemente
Summary: The study investigated ultra-short-term heart rate variability recordings under stabilization or post-stabilization periods in four overseas training camps for U-20 male national team futsal players. The results showed excellent agreement and high correlation coefficients for all time segments of HRVUST, suggesting that stabilization may be unnecessary for measuring morning resting LnRMSSD in overseas training camps among young adult futsal players. The findings indicate that 30 or 60-second LnRMSSD recordings can be used to evaluate daily cardiac-autonomic function during overseas training camps.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Sport Sciences
Yung-Sheng Chen, Wan-An Lu, Filipe Manuel Clemente, Jose Pedro Bezerra, Cheng-Deng Kuo
Article
Cardiac & Cardiovascular Systems
Anne Leonard, Serge Clement, Cheng-Deng Kuo, Mario Manto
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2019)