期刊
MOLECULES
卷 25, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules25030655
关键词
bile acids; lithocholic acid; deoxycholic acid; hyodeoxycholic acid; cholic acid; steroidal diamines; platinum(II) complexes
资金
- National Science Centre, Poland, Grant OPUS 8 [2014/15/B/ST5/02129]
- European Regional Development Fund-Project ENOCH [CZ.02.1.01/0.0/0.0/16_019/0000868]
A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.
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