Article
Chemistry, Multidisciplinary
Junyi Chen, Yadan Zhang, Yao Chai, Zhao Meng, Yahan Zhang, Longming Chen, Dongqin Quan, Yongan Wang, Qingbin Meng, Chunju Li
Summary: This study demonstrates the effectiveness of a supramolecular detoxification system in treating organophosphorus poisoning. The formation of compound complexes enhances the inhibition effect of ACh-induced hyperstimulation on ACh receptors, thereby alleviating cholinergic crisis symptoms.
Article
Agronomy
Xiaohong Zhang, Tingfei Zhu, Xiaoyang Bi, Sifan Yang, Jiguang Huang, Lijuan Zhou
Summary: Evaluation of herbicidal activities and 3D-QSAR analysis on 39 berberine analogues revealed that introducing an electropositive group in the N-7, C-9 and C-10 positions may improve the inhibition rate, while the hydrophobicity of the C-10 position was associated with high activity. The study provides valuable insights for designing more potent herbicidal compounds in the future.
PEST MANAGEMENT SCIENCE
(2021)
Article
Food Science & Technology
Wenli Shi, Guowen Zhang, Yijing Liao, Xiaoyun Fei, Deming Gong, Xing Hu
Summary: Kaempferol, a natural flavonoid compound, was found to reversibly inhibit the activity of AChE through the formation of a complex with the enzyme, leading to a decrease in its catalytic activity. Additionally, kaempferol was found to increase the binding affinity of other drugs to AChE, resulting in a synergistic inhibition of its activity. This study provides new insights into the potential use of kaempferol as a functional food component for the treatment of AD.
Article
Biochemistry & Molecular Biology
Ghadha Ibrahim Fouad, Kawkab A. Ahmed
Summary: The study demonstrates that berberine has significant neuroprotective potential in a rodent model of doxorubicin-induced neurotoxicity by reducing oxidative stress, neuroinflammation, and genotoxicity. Berberine exhibits cholinergic, anti-oxidative, genoprotective, anti-inflammatory, and anti-apoptotic activities, making it a promising pre-clinical neuroprotective agent against doxorubicin-induced neurotoxicity during anti-neoplastic therapy.
NEUROCHEMICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yash Pal Singh, Harish Kumar
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by memory impairment and decline in thinking ability. The exact cause of the disease is not fully understood, but factors like low acetylcholine levels, aggregation of A beta peptide, hyperphosphorylation of tau, bio-metal imbalance, and oxidative stress play a role. Currently, there is no specific treatment available, and the development of new drug candidates is urgently needed.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Microbiology
Caisheng Zhang, Huan Chen, Liumei Sun, Pu Zhao, Chuanxiang Qi, Ying Yang, Anqi Si, Yingjuan Qian, Yong-Sam Jung
Summary: Berbamine (BBM), Fangchinoline (FAN), and (+)-Fangchinoline (+FAN) are effective anti-PEDV natural products that suppress PEDV activity by inhibiting virus entry and decreasing the activity of Cathepsin L (CTSL) and Cathepsin B (CTSB) through lysosome acidification inhibition. They show potential as novel antiviral drugs.
Article
Environmental Sciences
Muhammad Sajid Hamid Akash, Moazzama Akbar, Kanwal Rehman, Muhammad Ajmal Shah, Pharkphoom Panichayupakaranant, Muhammad Imran, Mohammed A. Assiri
Summary: Currently, only a few cholinesterase inhibitor drugs are effective in relieving symptoms of Alzheimer's disease (AD), but they do not treat the underlying causes and have adverse effects. Berberine has shown therapeutic potential against AD, and this study evaluated its activity in an AD rat model. The results showed that both pure berberine (PB) and berberine-enriched extract (BEE) had neuroprotective effects and improved cognitive function in the rats, suggesting their potential as treatments for AD. However, further clinical trials are needed to assess their efficacy and safety.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Immunology
Chunyi Xu, Linxian Zhao, Weiling Zhou, Yanyan Li, Huiling Hu, Zhanguo Wang
Summary: This study demonstrates the significant therapeutic effects of berberine hydrochloride and dehydrocostus lactone in combination for the treatment of ulcerative colitis. The co-administration of these two drugs regulates gut microbiota, protects the intestinal barrier, and reduces inflammatory damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Gisele Dias da Silva, Helimar Goncalves de Lima, Humberto Fonseca de Freitas, Samuel Silva da Rocha Pita, Yann dos Santos Luz, Mauro Pereira de Figueiredo, Rosangela Soares Uzeda, Alexsandro Branco, Silvia Lima Costa, Maria Jose Moreira Batatinha, Mariana Borges Botura
Summary: This study evaluated the larvicidal effect of berberine and piperine against R. microplus larvae and their inhibitory mechanisms against the acetylcholinesterase enzyme. The results showed strong larvicidal activity of both alkaloids, with berberine exhibiting better inhibition of the acetylcholinesterase enzyme. Docking studies suggested that berberine may stabilize RmAChE and fill the peripheral anionic site to exert its inhibitory effect.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Ping Chen, Chun-Hua Dai, Zhi-Hao Shi, Yi Wang, Jian-Nong Wu, Kang Chen, Jin-Yu Su, Jian Li
Summary: The combination of BBR and icotinib has a synergistic inhibitory effect on non-small cell lung cancer cells by inducing autophagic cell death and apoptosis. The anti-tumor activities of this combination therapy were confirmed in xenograft mouse models, suggesting a potential effective strategy to overcome icotinib resistance in the treatment of NSCLC. This synergistic effect was achieved through intracellular ROS accumulation, mediated autophagy and apoptosis, and resulted in the suppression of cell migration and invasion.
Article
Chemistry, Physical
Xiaoxing Ma, Xiaoyu Sui, Chang Liu, Hui Li, Cuiyan Han, Tao Xu, Hongyu Zhang, Yujing Zhang, Defu Cai, Yongji Li, Wenquan Zhu
Summary: In this study, researchers developed chondroitin sulfate modified liposomes containing berberine and magnolol. These liposomes showed excellent targeting ability towards A549 lung cancer cells and demonstrated a sustained drug release profile. They effectively inhibited tumor growth and induced apoptosis in tumor cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Pharmacology & Pharmacy
Na An, Guoxia Zhang, Yingjian Li, Chao Yuan, Fan Yang, Lijing Zhang, Yonghong Gao, Yanwei Xing
Summary: This article summarizes the mechanisms of action of berberine (BBR) in the prevention and treatment of cardiovascular diseases (CVDs). Research has shown that BBR has various pharmacological effects, such as lowering blood sugar, reducing lipid levels, and exerting antioxidant activities. It can protect the myocardium and has therapeutic effects on coronary atherosclerosis, myocardial ischemia/reperfusion, arrhythmias, and heart failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Keting Bao, Yongyun Li, Jinlian Wei, Ruoxi Li, Jie Yang, Jiahao Shi, Baoli Li, Jin Zhu, Fei Mao, Renbing Jia, Jian Li
Summary: Conjunctival melanoma is a rare and fatal ocular tumor with poor prognosis. This study identified fangchinoline as a potential therapeutic target for CM, which can inhibit DNA repair and enhance the efficacy of other treatment drugs, reducing drug dosage and toxicity.
CELL DEATH & DISEASE
(2021)
Article
Plant Sciences
Qin Tang, Zhengcai Ma, Xiang Tang, Yan Liu, Huimin Wu, Yu Peng, Baihua Jiao, Rui Wang, Xiaoli Ye, Hang Ma, Xuegang Li
Summary: The study aimed to find the most effective alkaloid against Helicobacter pylori in Rhizoma Coptidis and illustrate the probable mechanisms. The results showed that coptisine was the most effective alkaloid against H. pylori and could eradicate the bacteria through multiple mechanisms while reducing inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tingting Lu, Yu Wang, Fang Liu, Lu Zhang, Simin Huang, Yuanyuan Zhou, Hui Wu, Yanmei Mao, Chufeng Jin, Wencheng Song
Summary: This study explores the comprehensive antitumor effect of a novel dual cancer therapeutic method integrating berberine (BER) and low-temperature plasma (LTP) on non-small-cell lung cancer (NSCLC) cell lines. The results demonstrate that cotreatment significantly inhibits cell viability, induces cell apoptosis, and affects the PI3K-AKT signaling pathway. This approach holds promise as a supplementary therapy in the fight against NSCLC.