Article
Cell & Tissue Engineering
Xiu Cai, Zhi-yu Zhang, Jin-tao Yuan, Dickson Kofi Wiredu Ocansey, Qiang Tu, Xu Zhang, Hui Qian, Wen-rong Xu, Wei Qiu, Fei Mao
Summary: The study demonstrated that hucMSC-derived exosomes inhibited the activation of NLRP3 inflammasomes, reducing cell pyroptosis and protecting against DSS-induced colitis. Furthermore, miR-378a-5p played a vital role in this process.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Xunwei Lai, Yang Wang, Xiaokang Wang, Bin Liu, Limin Rong
Summary: Modified exosomes targeting neurotoxic astrocytes can promote neurological function recovery in spinal cord injury.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyue Wei, Ruijie Li, Xiangyu Li, Boyan Wang, Jianyang Huang, Hanyiqi Mu, Qinmu Zhang, Ziyuan Zhang, Yifei Ru, Xinxiang Wu, Yuan Qiu, Yanchen Ye, Yuanyuan Feng, Shiyu Wang, Hui Chen, Chenju Yi, Jiancheng Wang
Summary: Perimenopause is a natural transition to menopause that can cause hormone disturbances leading to mental disorders and neuroinflammation. This study aims to find effective treatments to prevent these neurological consequences.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Milton D. Chiang, Chao-Yuan Chang, Hung-Jen Shih, Van Long Le, Yen-Hua Huang, Chun-Jen Huang
Summary: Exosomes derived from human placenta choriodecidual membrane-derived mesenchymal stem cells can alleviate pulmonary endoplasmic reticulum stress, inflammation, oxidation, apoptosis, and lung injury in lipopolysaccharide-treated obese mice.
Article
Cell & Tissue Engineering
Liyang Dong, Ying Wang, Tingting Zheng, Yanan Pu, Yongbin Ma, Xin Qi, Wenzhe Zhang, Fei Xue, Zirui Shan, Jiameng Liu, Xuefeng Wang, Chaoming Mao
Summary: Hypoxic human umbilical cord MSC-derived EVs attenuated allergic airway inflammation and airway remodeling in chronic asthma mice, potentially offering new avenues for asthma treatment.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zhiqiang Zhang, Lei Chen, Xueheng Chen, Yiran Qin, Chao Tian, Xuening Dai, Runqi Meng, Yuanyuan Zhong, Wenyan Liang, Cheng Shen, Jinguo Zhang, Bin Zhang, Xiqing Wei
Summary: Diabetic cardiomyopathy is a cardiovascular disease caused by diabetes, with a high incidence, complex pathophysiology, and poor treatment outcomes. Autophagy, inflammation, and mitochondrial damage have been identified as key factors in the development of diabetic cardiomyopathy. Human umbilical cord mesenchymal stem cells-derived exosomes show potential in repairing and protecting cardiomyocytes. This study evaluated the therapeutic benefits of HUCMSC-EXO for diabetic cardiomyopathy and explored their mechanisms of action.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Environmental Sciences
Lianjie Zeng, Chong Zhou, Wenqing Xu, Yupei Huang, Wencan Wang, Zhangqiang Ma, Jian Huang, Jia Li, Liaoliao Hu, Yue Xue, Tao Luo, Liping Zheng
Summary: Nanoplastics are more toxic than macroplastics and microplastics due to their tiny sizes and cellular accessibility. They have been found to cause female reproductive toxicity in aquatic animals, but their effects in mammals are still poorly understood. This study showed that nanoplastics can penetrate ovarian cells and accumulate in the ovaries, leading to cell apoptosis and impaired ovarian function, resulting in reduced fertility in female mice.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Jorge Sanz-Ros, Nekane Romero-Garcia, Cristina Mas-Bargues, Daniel Monleon, Juozas Gordevicius, Robert T. Brooke, Mar Dromant, Ana Diaz, Aksinya Derevyanko, Ana Guio-Carrion, Aurora Roman-Dominguez, Marta Ingles, Maria A. Blasco, Steve Horvath, Jose Vina, Consuelo Borras
Summary: This study found that treatment of old animals with ADSC-sEVs derived from young animals can improve various parameters associated with aging and reduce frailty. This treatment induces proregenerative effects and reduces oxidative stress, inflammation, and senescence in muscle and kidney. Additionally, tissue epigenetic age decreases and metabolome shifts to a youth-like pattern after this treatment.
Article
Orthopedics
Shixun Li, Chuangran Wu, Sipeng Lin, Zhenkang Wen, Wenqiang Luo, Changchuan Li, Xiaoyan Wang, Xuejia Li, Liangbin Gao, Yue Ding
Summary: This study aimed to investigate whether human umbilical cord mesenchymal stem cells (HUCMSCs) could inhibit titanium particles-induced osteolysis and elucidate its mechanism. The results showed that HUCMSCs and exosomes derived from HUCMSCs could suppress titanium particles-induced osteolysis by inhibiting CCL2 and CCL3.
ORTHOPAEDIC SURGERY
(2023)
Review
Genetics & Heredity
Emma Trawick, Jillian Pecoriello, Gwendolyn Quinn, Kara N. Goldman
Summary: Few high-quality guidelines address counseling on female age-related fertility decline, with most focusing on related topics. Most high-quality guidelines mention the age at which female fertility declines, but there is inconsistency in discussing obstetric and perinatal risks of advanced maternal age among these guidelines.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Cell Biology
Xingyu Li, Heng Zhang, Xuemeng Wang, Meng Lu, Qianqian Ding, Alex F. Chen, Meng Xiang, Sifeng Chen
Summary: Exosomes derived from induced pluripotent stem cells (iPSCs) have shown to enhance angiogenesis in naturally aged mice, improve antioxidant capacity and cell proliferation, and reduce aging gene expression. These findings suggest that iPSC-derived exosomes may rejuvenate the vascular system and have anti-aging effects.
Article
Biochemistry & Molecular Biology
Xian Xiao, Meiqian Xu, Hongliang Yu, Liping Wang, Xiaoxia Li, Janusz Rak, Shihua Wang, Robert Chunhua Zhao
Summary: Research has shown that small extracellular vesicles play a crucial role in mitigating endothelial cell senescence and stimulating angiogenesis through the miR-146a/Src mechanism.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Behavioral Sciences
William H. Gendron, Emre Fertan, Stephanie Pelletier, Kyle M. Roddick, Timothy P. O'Leary, Younes Anini, Richard E. Brown
Summary: In addition to cognitive decline, patients with Alzheimer's disease may exhibit sensory, motor, and neuropsychiatric deficits, as well as weight loss. The 5xFAD mouse model has been found to show age-related weight loss compared to wildtype controls, suggesting potential metabolic dysfunction.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Nutrition & Dietetics
Ban Sato, Seiya Kanai, Daiki Sakaguchi, Kodai Yajima, Yu Matsumoto, Kazunori Morohoshi, Shinji Kagaya, Nobuo Izumo, Minoru Ichinose, Woojin Kang, Mami Miyado, Kenji Miyado, Natsuko Kawano
Summary: LF supplementation ameliorates fertility problems in overweight mice but does not effectively reverse female infertility in obese mice.
Review
Pharmacology & Pharmacy
Feng Gu, Jiyu Jiang, Peng Sun
Summary: Exosomes are small vesicles secreted by various cells and contain biologically active substances. They play important roles in intercellular communication in various physiological processes. In this article, we discuss the latest developments in exosomes related to age-related macular degeneration (AMD), including its pathogenesis, potential as diagnostic markers, and therapeutic vectors. Further research and clinical trials are needed to explore the application of exosomes in the treatment and diagnosis of AMD in order to develop personalized strategies to halt its progression.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
C. L. Wu, T. Zhao, S. Zhang, Z. Y. Wang, C. H. Zhang, J. Z. Tan
Summary: Surface machining techniques such as cutting, rolling, and grinding were used to machine 304 austenitic stainless steels in order to enhance the hardening layer and corrosion resistance. Among the tested samples, the rolling sample exhibited the best surface quality with the lowest surface roughness and fewest defects. The rolling sample also displayed the highest degree of work hardening and corrosion resistance, attributed to the residual compressive stress and fewer micro-defects.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Materials Science, Multidisciplinary
Guangyan Wang, Sugui Tian, Ning Tian, Xinjie Zhu, Shunke Zhang, Song Zhang
Summary: This study investigated the stacking fault energy and creep mechanism of a single-crystal nickel-based superalloy at different temperatures. The results revealed that the stacking fault energy increased with temperature and that the presence of element Ru significantly reduced the stacking fault energy compared to other elements in the alloy. The creep mechanism involved <110> super-dislocation shearing into the gamma ' phase below 850 degrees C, which could be decomposed into (a/3) <112> partial dislocations and super-lattice intrinsic stacking fault. However, above 850 degrees C, the resistance to dislocation decomposition increased, and the a <110> super-dislocation did not decompose when it cut into the gamma ' phase along the {111} plane.
MATERIALS SCIENCE AND TECHNOLOGY
(2023)
Article
Fisheries
Felix Gyawu Addo, Songhe Zhang, Benjamin Manirakiza, Yu Ma, Shudong Yuan, Salah Alden Alklaf, Shaozhuang Guo, Godwin Abakari
Summary: In this study, a 30-day culture trial was conducted to investigate the effects of brown sugar addition on nutrient removal, feed conversion ratio, growth performance, and microbial community in a rice straw-based biofloc shrimp system. The results showed that the addition of brown sugar significantly reduced ammonium and nitrite nitrogen concentrations and improved nutrient removal rates. Furthermore, the addition of brown sugar also resulted in lower feed conversion ratio and higher shrimp survival rates. The dominant microbial phyla identified in all treatments played a crucial role in nutrient cycling and promoting water quality.
Article
Environmental Sciences
Xin He, Songhe Zhang, Xin Lv, Min Liu, Yu Ma, Shaozhuang Guo
Summary: This study investigated the role of rhizospheric biofilms on methane release in wastewater stabilization ponds (WSPs) with floating plants. The results showed that E. crassipes effectively reduced methane release and nutrients, with a higher inhibition effect on CH4 fluxes in treatments with high nutrients. Additionally, the rhizospheric bacterial community contributed to nutrients removal. In conclusion, E. crassipes plants play an important role in reducing methane release and nutrients removal.
Article
Environmental Sciences
Liu Yang, Songhe Zhang, Xin Lv, Yuansi Liu, Shaozhuang Guo, Xiuren Hu, Benjamin Manirakiza
Summary: This study investigated the impacts of Vallis-neria natans senescence on methanotroph community and methane release in wetlands. The results showed that nutrient loadings increased methane fluxes, while healthy V. natans plants reduced methane flux. Environmental parameters and the physiological status of V. natans affected methanotrophs.
ENVIRONMENTAL RESEARCH
(2023)
Review
Materials Science, Multidisciplinary
Ying Sun, Wenchao Hu, Chenliang Wu, Hai Kuang, Jie Wang, Song Zhang, Tingting Yan, Qiang Wang
Summary: This paper reviews the research progress of 3D printing titanium alloys, focusing on the basic phases, alloying elements and mechanical properties of titanium alloys, and discusses the effects of defects, microstructures and surface roughness on fatigue properties. It also introduces the research progress of mechanical properties of porous titanium alloys, including the influence of structural design, microstructure and surface roughness on fatigue properties. Finally, future development trends and potential research topics are pointed out.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Oncology
Yongdong Dai, Xiang Lin, Na Liu, Libing Shi, Feng Zhuo, Qianmeng Huang, Weijia Gu, Fanxuan Zhao, Yi Zhang, Yinli Zhang, Yinbin Pan, Songying Zhang
Summary: Endometriosis is a common gynecological disorder that causes female infertility. Excessive oxidative stress in ovaries of endometriosis patients induced senescence of cumulus granulosa cells. Our research analyzed the transcriptomic and metabolomic profiles of follicles in a mouse model of endometriosis and in patients with endometriosis, and investigated the potential function of changed metabolites in granulosa cells.
JOURNAL OF PATHOLOGY
(2023)
Article
Chemistry, Physical
Chao Wang, Maomao Gong, Yongjun Cheng, Victor Kimberg, Xiao-Jing Liu, Oriol Vendrell, Kiyoshi Ueda, Song Bin Zhang
Summary: We suggest using a femtosecond X-ray pulse to trigger Resonant Auger scattering (RAS) in a distorted molecule, which provides information on the core-valence electronic transition and impresses a rich fingerprint of the electronic structure and nuclear configuration. By controlling the amount of molecular distortion with varied time delay, the RAS measurements imprint both their electronic structures and changing geometries. This work showcases a new alternative pump-probe technique for mapping the core and valence dynamics with ultrashort X-ray probe pulses.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Materials Science, Coatings & Films
Qizhong Li, Tao Huang, Mai Yang, Tenghua Gao, Baifeng Ji, Song Zhang, Lianmeng Zhang, Rong Tu
Summary: Hard coatings with gradient and multilayer structures were prepared by high-power pulsed magnetron sputtering. The modulation period was found to significantly affect the microstructure, mechanical, and tribological properties of the coatings. Shorter modulation periods improved the adhesion strength and resulted in higher hardness and lower friction coefficients.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Genetics & Heredity
Jiamin Jin, Peipei Ren, Xiang Li, Yinyi Zhang, Weijie Yang, Yerong Ma, Mengru Lai, Chao Yu, Songying Zhang, Yin-Li Zhang
Summary: Histone deacetylation is observed in granulosa cells during the process of ovulation, which is mediated by FSH and hCG. This process is regulated by CK2 alpha-mediated HDAC2 phosphorylation and is essential for successful ovulation.
EPIGENETICS & CHROMATIN
(2023)
Article
Obstetrics & Gynecology
Yichao Tian, Jin Huang, Chi-Chiu Wang, Huizhen Lin, Xiaona Huang, Yue Zhao, Liu Liu, Songying Zhang
Summary: The value of endometrial scratch in women with recurrent embryo transfer is controversial, and it is unclear if endometrial scratch in the previous mid-luteal phase affects the whole genome transcriptomic profile of peri-implantation endometrium in the subsequent cycle.
Article
Chemistry, Physical
Song Zhang, Wei Liu, Weimin Wang, Ying Gao, Aiyang Wang, Qianglong He, Wenhui Bai, Runfeng Li
Summary: This article uses a thermal-electric-mechanical coupled model to simulate the spark plasma sintering process of boron carbide, and conducts parameter optimization and simulation analysis.
Article
Materials Science, Ceramics
Kai Liu, Lei Qiu, Yuzhen Zhang, Yanying Du, Ce Sun, Song Zhang, Rong Tu, Yanjiao Wu, Huajun Sun, Yusheng Shi
Summary: A material extrusion (MEX) technology was developed for additive manufacturing of continuous carbon fiber-reinforced silicon carbide ceramic (C-f/SiC) composites. A slurry with high solid loading and viscosity was proposed based on rheological properties. Complex structures of C-f/SiC composites were printed using this MEX technique. Phenolic resin impregnation-carbonization process and reactive melting infiltration (RMI) were used to prepare samples with different C-f contents, with the highest bending strength and fracture toughness achieved at 1 K C-f content.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2023)
Article
Obstetrics & Gynecology
Xiaomei Tong, Jiamin Jin, Yamei Xue, Lu Fang, Haiyan Zhu, Lingying Jiang, Songying Zhang
Summary: This study investigated the clinical outcomes of frozen-thawed blastocyst transfers derived from zygotes with no or one pronucleus (0PN or 1PN). The results showed that the developmental potential and clinical outcomes of 0PN and 1PN embryos were similar to those of 2PN embryos in both IVF and ICSI cycles. This suggests that 0PN and 1PN embryos from ICSI cycles can be transferred when there is an insufficient number of 2PN embryos.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Cell & Tissue Engineering
Ying-Yi Zhang, Weijie Yang, Yi Zhang, Zhanhong Hu, Yingyan Chen, Yerong Ma, Anran Yang, Zhan Shi, Hanjing Zhou, Peipei Ren, Libing Shi, Jiamin Jin, Yan Rong, Xiaomei Tong, Yin-Li Zhang, Songying Zhang
Summary: Follicle developmental capacity and oocyte quality decline with advanced maternal age. Extracellular vesicles from human umbilical cord mesenchymal stem cells (HucMSC-EVs) have potential therapeutic effects on age-related ovarian dysfunction. In vitro culture (IVC) of preantral follicles is a useful method for understanding follicle development and improving female fertility. This study demonstrated that HucMSC-EVs can improve the growth and quality of aged follicles and oocytes in vitro through gene transcription regulation.
STEM CELL REVIEWS AND REPORTS
(2023)