Systematic genetics and single‐cell imaging reveal widespread morphological pleiotropy and cell‐to‐cell variability

Systems Properties and Spatiotemporal Regulation of Cell Position Variability during Embryogenesis

(2019) Xiaoyu Li et al.   Cell Reports

Global Genetic Networks and the Genotype-to-Phenotype Relationship

(2019) Michael Costanzo et al.   CELL

The Causes and Consequences of Genetic Interactions (Epistasis)

(2019) Júlia Domingo et al.   Annual Review of Genomics and Human Genetics

From observing to predicting single-cell structure and function with high-throughput/high-content microscopy

(2019) Anatole Chessel et al.   Essays in Biochemistry

Retrograde trafficking and plasma membrane recycling pathways of the budding yeast Saccharomyces cerevisiae

(2019) Mengxiao Ma et al.   TRAFFIC

OUP accepted manuscript

(2018)   Briefings in Functional Genomics

Large‐scale image‐based profiling of single‐cell phenotypes in arrayed CRISPR‐Cas9 gene perturbation screens

(2018) Reinoud de Groot et al.   Molecular Systems Biology

Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome

(2018) Brandon Ho et al.   Cell Systems

From single cells to tissue self-organization

(2018) Aline Xavier da Silveira dos Santos et al.   FEBS Journal

Replicative aging as a source of cell heterogeneity in budding yeast

(2018) Dmitry A. Knorre et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

(2018) Florian Heigwer et al.   eLife

The background puzzle: how identical mutations in the same gene lead to different disease symptoms

(2017) Jan E. Kammenga   FEBS Journal

Automated analysis of high‐content microscopy data with deep learning

(2017) Oren Z Kraus et al.   Molecular Systems Biology

TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network

(2017) Matej Usaj et al.   G3-Genes Genomes Genetics

Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

(2017) Audrey P. Gasch et al.   PLOS BIOLOGY

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

(2016) Atray Dixit et al.   CELL

Clathrin-mediated endocytosis in budding yeast at a glance

(2016) Rebecca Lu et al.   JOURNAL OF CELL SCIENCE

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

High-Content Screening for Quantitative Cell Biology

(2016) Mojca Mattiazzi Usaj et al.   TRENDS IN CELL BIOLOGY

Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci

(2016) Erin B. Styles et al.   Cell Systems

Systematic Functional Annotation and Visualization of Biological Networks

(2016) Anastasia Baryshnikova   Cell Systems

The Natural Variation in Lifespans of Single Yeast Cells Is Related to Variation in Cell Size, Ribosomal Protein, and Division Time

(2016) Georges E. Janssens et al.   PLoS One

Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis

(2015) Yolanda T. Chong et al.   CELL

Microscopy-Based High-Content Screening

(2015) Michael Boutros et al.   CELL

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

Actin and Endocytosis in Budding Yeast

(2015) Bruce L. Goode et al.   GENETICS

Single-cell phenomics in budding yeast

(2015) Yoshikazu Ohya et al.   MOLECULAR BIOLOGY OF THE CELL

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells

(2015) Florian Buettner et al.   NATURE BIOTECHNOLOGY

Yeast Replicator: A High-Throughput Multiplexed Microfluidics Platform for Automated Measurements of Single-Cell Aging

(2015) Ping Liu et al.   Cell Reports

Actin and Endocytosis in Budding Yeast

(2015) Bruce L. Goode et al.   GENETICS

Local statistics allow quantification of cell-to-cell variability from high-throughput microscope images

(2014) Louis-François Handfield et al.   BIOINFORMATICS

Endoplasmic reticulum stress response in yeast and humans

(2014) Haoxi Wu et al.   BIOSCIENCE REPORTS

A Hierarchical Map of Regulatory Genetic Interactions in Membrane Trafficking

(2014) Prisca Liberali et al.   CELL

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Role of Endosomes and Lysosomes in Human Disease

(2014) F. R. Maxfield   Cold Spring Harbor Perspectives in Biology

Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

(2013) David N. Cooper et al.   HUMAN GENETICS

CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion

(2013) H. J. k. Balderhaar et al.   JOURNAL OF CELL SCIENCE

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes

(2013) Zheng Yin et al.   NATURE CELL BIOLOGY

SGAtools: one-stop analysis and visualization of array-based genetic interaction screens

(2013) Omar Wagih et al.   NUCLEIC ACIDS RESEARCH

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

(2013) Yingying Zhao et al.   eLife

Coiled-coil networking shapes cell molecular machinery

(2012) Yongqiang Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae

(2012) Mohan Babu et al.   NATURE

Interactome3D: adding structural details to protein networks

(2012) Roberto Mosca et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The many faces of pleiotropy

(2012) Annalise B. Paaby et al.   TRENDS IN GENETICS

Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant

(2012) Sasha F. Levy et al.   PLOS BIOLOGY

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

(2011) Zhijian Li et al.   NATURE BIOTECHNOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans

(2011) M. O. Casanueva et al.   SCIENCE

Clathrin-mediated endocytosis in budding yeast

(2011) Jasper Weinberg et al.   TRENDS IN CELL BIOLOGY

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

(2011) Marcus J. Taylor et al.   PLOS BIOLOGY

The Yeast vps Class E Mutants: The Beginning of the Molecular Genetic Analysis of Multivesicular Body Biogenesis

(2010) Emily M. Coonrod et al.   MOLECULAR BIOLOGY OF THE CELL

Systems survey of endocytosis by multiparametric image analysis

(2010) Claudio Collinet et al.   NATURE

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

(2010) Anastasia Baryshnikova et al.   NATURE METHODS

The BioGRID Interaction Database: 2011 update

(2010) C. Stark et al.   NUCLEIC ACIDS RESEARCH

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Regulators of yeast endocytosis identified by systematic quantitative analysis

(2009) Helen E. Burston et al.   JOURNAL OF CELL BIOLOGY

Quantification of the yeast transcriptome by single-molecule sequencing

(2009) Doron Lipson et al.   NATURE BIOTECHNOLOGY

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae

(2008) Renata Zadrag-Tecza et al.   BIOGERONTOLOGY

Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions

(2008) Philip I. Merksamer et al.   CELL

A mother’s sacrifice: what is she keeping for herself?

(2008) Kiersten A Henderson et al.   CURRENT OPINION IN CELL BIOLOGY

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

(2008) David Teis et al.   DEVELOPMENTAL CELL

High-Quality Binary Protein Interaction Map of the Yeast Interactome Network

(2008) H. Yu et al.   SCIENCE

An in Vivo Map of the Yeast Protein Interactome

(2008) K. Tarassov et al.   SCIENCE

Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae

(2008) Sasha F Levy et al.   PLOS BIOLOGY