Review
Biochemistry & Molecular Biology
Yuhan Xia, Zhiyuan Ma, Xuechen Wu, Huidan Wei, Han Zhang, Guang Li, Yuqi Qian, Mina Shahriari-Khalaji, Kai Hou, Ran Cao, Meifang Zhu
Summary: Sustainable and controllable drug transport is an efficient method for disease treatment. Chitosan hydrogel, characterized by high biocompatibility, good biodegradability, and low costs, has been widely used in biomedical fields. The abundant amino and hydroxyl groups in chitosan hydrogel allow it to interact with human tissues and enable drugs to pass through biological barriers. The multi-responsive nature of chitosan hydrogel, including pH, temperature, ions strength, and magnetic field, makes precise drug release possible. This review summarizes the synthesis methods, modification strategies, stimuli-responsive mechanisms, and recent progress of chitosan-based hydrogels in drug delivery, focusing on subcutaneous, oral, and facial administration. The challenges towards clinical application and future prospects are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Applied
Khadijeh Soleimani, Hossein Derakhshankhah, Mehdi Jaymand, Hadi Samadian
Summary: Natural gums can be utilized as stimuli-responsive DDSs for cancer treatment due to their beneficial characteristics, though they may require modification to overcome certain limitations. This review article aims to compile natural gums-based stimuli-responsive DDSs and briefly highlight different types of stimuli, fundamental features of natural gums, and chemical modification approaches.
CARBOHYDRATE POLYMERS
(2021)
Review
Polymer Science
Sudipta Chatterjee, Patrick Chi-leung Hui
Summary: Thermo-responsive polysaccharides and protein-like materials have temperature-dependent sol-gel transitions, making them valuable for drug delivery and tissue engineering applications. Their biocompatibility, biodegradability, and non-toxicity make them ideal for such medical uses.
Review
Nanoscience & Nanotechnology
Ruixin Jia, Lesheng Teng, Lingyu Gao, Ting Su, Lu Fu, Zhidong Qiu, Ye Bi
Summary: Nanomedicines offer unique advantages in tumor therapy, but traditional nanomedicines are hindered by complex physiological fluids and tumor microenvironments. Stimuli-responsive drug-delivery systems have emerged as a promising tool to overcome these barriers and deliver therapeutic agents to target sites effectively.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Medicine, Research & Experimental
Yuxiao Wang, Jiaxin Li, Maomao Tang, Chengjun Peng, Guichun Wang, Jingjing Wang, Xinrui Wang, Xiangwei Chang, Jian Guo, Shuangying Gui
Summary: Periodontitis is a chronic inflammatory disease that damages tooth-supporting tissues. Traditional treatment methods face difficulties due to the oral cavity's physiological functions and complex pathogenic mechanisms. Hydrogels have gained attention as a potential solution, especially smart stimuli-responsive hydrogels that can control drug release based on various stimuli.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Multidisciplinary
Xiao Li, Minghao Li, Lisa Tang, Diwei Shi, Emily Lam, Jinhye Bae
Summary: This review explores the potential of stimuli-responsive hydrogels in mimicking the morphing behavior of living tissues or organisms, and discusses how functional additives can be combined with hydrogels to extend their functionalities. It also highlights the potential applications of stimuli-responsive composite hydrogels in various fields including soft robotics, information encryption/decryption, biomedical research, flexible electronics, and engineering living materials.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Review
Polymer Science
Zhengzou Fang, Ping Chen, Qing Ji, Cheng Yan, Aihua Gong
Summary: The routine systemic administration of therapeutic drugs is challenging due to physiological barriers and clearance mechanisms that limit drug bioavailability. Therefore, finding alternative drug delivery systems is essential. Hydrogel can serve as an effective local drug administration system with adjustable physical characteristics and protective properties for unstable drugs. Stimuli-responsive hydrogels show potential in precise drug delivery and release, minimizing adverse effects and maximizing therapeutic effects. This review summarizes recent applications of hydrogel in disease therapy and highlights its advantages in targeted drug delivery for various damaged areas. It also suggests the potential for further modifications to enhance targeted drug delivery.
Review
Polymer Science
Elena Ruxandra Radu, Augustin Semenescu, Stefan Ioan Voicu
Summary: Doxorubicin is a commonly used drug in liver cancer treatment. However, traditional chemotherapy with this drug has limitations, including side effects. Researchers have explored responsive drug delivery systems that can control the release of doxorubicin in liver cancer therapy, using internal and external stimuli. The future prospects of these smart delivery systems in liver cancer therapy are also discussed.
Review
Biochemistry & Molecular Biology
Kai Xu, Jie Weng, Jianshu Li, Xingyu Chen
Summary: Microneedles (MNs) are a new drug delivery method that has gained attention for their effectiveness, safety, and painlessness. To improve their application, the concept of intelligent stimuli-responsive MNs has been proposed. These MNs can exhibit unique biomedical functions according to changes in the internal and external environment.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Neha Kaushik, Shweta B. Borkar, Sondavid K. Nandanwar, Pritam Kumar Panda, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Nanocarriers (NCs) have attracted significant attention for their structural ability, good biocompatibility, and biodegradability. The development of NCs with stimuli-responsive properties has become a hot topic among scientists. These NCs can deliver drugs to tumors by regulating their pH, temperature, and enzyme responsiveness, thereby improving the accuracy of drug delivery and minimizing side effects. Material carriers for chemotherapeutic medicines are discussed in this review, with a focus on their structural properties and targeting methods that enhance therapeutic efficacy and trigger metabolic pathways. Overall, the development of NCs that respond to endogenous and exogenous stimuli in tumor regions and the understanding of their mechanisms have great potential for advancing tumor therapy and precision diagnosis in the future.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xueqi Lin, Xingdi Wu, Xiang Chen, Ben Wang, Wen Xu
Summary: This review introduces stimuli-responsive drug delivery systems in eyes, summarizes their design and mechanisms, and briefly discusses their advantages and limitations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Xu Lin, Jiahe Wu, Yupeng Liu, Nengming Lin, Jian Hu, Bo Zhang
Summary: Lung cancer is the most commonly diagnosed cancer worldwide, and the development of smart carriers for drug delivery presents a promising strategy for therapy.
Article
Polymer Science
Julia Radwan-Praglowska, Lukasz Janus, Marek Piatkowski, Aleksandra Sierakowska, Ernest Szajna, Dalibor Matysek, Dariusz Bogdal
Summary: Epilepsy is a common neurological disease that can have a significant negative impact on quality of life, especially when symptoms are drug-resistant. Cannabidiol, derived from Cannabis Sativa, offers new hope for epilepsy treatment, with potential benefits in increasing bioactivity through transdermal delivery.
Review
Biotechnology & Applied Microbiology
Saba Salehi, Seyed Morteza Naghib, Hamid Reza Garshasbi, Sadegh Ghorbanzadeh, Wei Zhang
Summary: Hydrogels are widely used biomaterials for therapeutic agent delivery and tissue engineering due to their biocompatibility and similarity to natural body tissues. Some substances have injectable properties, allowing for minimally invasive administration. Gelation can be induced by stimuli, making the material stimuli-responsive. This article introduces various stimuli for gelation and investigates the mechanisms of solution-to-gel transformation, while also studying special structures such as nano gels or nanocomposite gels.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Udaykumar Vegad, Megha Patel, Dignesh Khunt, Ozbej Zupancic, Sanjay Chauhan, Amrit Paudel
Summary: In recent decades, there has been significant progress in the design and development of biomaterials based on non-cellulosic biological macromolecules. Stimuli-responsive hydrogels made from non-cellulosic biological macromolecules have gained attention due to their unique physicochemical properties, biological characteristics, and sustainability. pH-responsive hydrogels have the ability to release therapeutic substances in response to pH changes, leading to tailored drug administration, reduced side effects, and improved treatment efficacy. pH-sensitive biopolymers such as chitosan, alginate, hyaluronic acid, guar gum, and dextran have been widely used in various applications, including drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuxiang Wang, Jing Chen, Rumeng Duan, Rong Gu, Weiran Wang, Jinhui Wu, Huibo Lian, Yiqiao Hu, Ahu Yuan
Summary: In situ tumor vaccination is achieved through the integration of Phy@PLGdH nanosheets, which enhances radiation therapy-induced immunogenic cell death. The nanosheets exhibit improved radiosensitization and tumor penetrability, while Phy-mediated PPP intervention amplifies the oxidative stress and DNA damage caused by PLGdH-sensitized radiation therapy. This results in effective immunogenic cell death and enhanced immunogenicity of irradiated tumor cells. Furthermore, Phy@PLGdH-sensitized radiation therapy successfully triggers a robust CD8(+)-T-cell-dependent antitumor immune response, which enhances checkpoint blockade immunotherapies against primary and metastatic tumors.
ADVANCED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Jinbiao Li, Dandan Li, Wenjing Lu, Jinhui Wu, Hong Dong
Summary: This study proposed and verified a detailed GC method for the analysis of S-(+)-ECH impurities in (S)-oxiracetam. The method has the advantages of fast, convenience, and low cost, providing a reference method for quality control.
CURRENT PHARMACEUTICAL ANALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Huanhuan Chen, Yunfei Guo, Zhewei Zhang, Wenxuan Mao, Chenying Shen, Wei Xiong, Yingfang Yao, Xiaozhi Zhao, Yiqiao Hu, Zhigang Zou, Jinhui Wu
Summary: The hydrogen-producing hydrogel made of living Chlorella and bacteria within a cell-impermeable casing can continuously produce hydrogen for 60 hours, selectively reduce highly toxic ·OH and ONOO- species, and reduce inflammation. Studies have shown that the microbe-hydrogel dressing can promote cell proliferation and diabetic wound healing by almost 50% at day 3. This symbiotic algae-bacteria hydrogel demonstrates excellent biocompatibility and reactive oxygen species scavenging capabilities, suggesting great promise for clinical use.
Article
Engineering, Biomedical
Wenguang Wang, Haiheng Xu, Qingsong Ye, Feng Tao, Ian Wheeldon, Ahu Yuan, Yiqiao Hu, Jinhui Wu
Summary: Flagellated bacteria coated with antigen-adsorbing polymer nanoparticles and injected into tumours in mice after radiotherapy elicit systemic antitumour effects by transporting antigens to the tumour's periphery. This finding highlights the potential of leveraging bacteria to enhance dendritic cell activation and improve in situ cancer vaccination strategies.
NATURE BIOMEDICAL ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Lihong Gu, Feng Zhang, Jinhui Wu, Yuzheng Zhuge
Summary: Liver fibrosis is a reversible disease caused by various liver injuries, which can lead to severe complications. Traditional pharmacotherapy has limitations, while nanotechnology has shown great potential in liver fibrosis treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Medicine, Research & Experimental
Yuchen Wang, Chenxuan Zhao, Yang Liu, Chao Wang, Haojie Jiang, Yiqiao Hu, Jinhui Wu
Summary: This Review introduces recent advances in tumor therapy targeted on the CD47-SIRP alpha axis, including various methods such as antibodies, fusion proteins, small molecules, gene therapy, cell therapy, and drug delivery systems. Inhibition of the CD47-SIRP alpha axis can restore the phagocytic function of macrophages and exert anti-tumor effects. Additionally, the Review summarizes approaches to avoid anemia, a common side effect of CD47-SIRP alpha inhibition, and provides ideas for clinical translation.
MOLECULAR PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Haoran Wang, Honghui Liu, Yunfei Guo, Wenjing Zai, Xianghui Li, Wei Xiong, Xiaozhi Zhao, Yingfang Yao, Yiqiao Hu, Zhigang Zou, Jinhui Wu
Summary: Research has shown that using Chlorella in combination with photodynamic therapy (PDT) can enhance local tumor killing, improve the hypoxic and immunosuppressive microenvironment, increase the anti-tumor effect and immune response, and generate a stronger anti-tumor immune memory effect.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Yue Yu, Zhusheng Huang, Qian Chen, Zhicheng Zhang, Haojie Jiang, Rong Gu, Yitao Ding, Yiqiao Hu
Summary: In this study, self-assembled carrier-free nanoscale coordination polymers MFe-NCPs were constructed, which enhanced low-dose iron-induced immunogenic ferroptosis and boosted the therapeutic effect of immune checkpoint blockade therapy.
Article
Chemistry, Multidisciplinary
Qian Chen, Jing Chen, Qingqing Zhang, Peizheng Yang, Rong Gu, Hao Ren, Yue Dai, Shiqian Huang, Jinhui Wu, Xudong Wu, Yiqiao Hu, Ahu Yuan
Summary: Radiation therapy has the potential to induce immunogenic cell death in tumor cells, leading to in situ vaccination and systemic antitumor immune responses. However, there are limitations to using radiation therapy alone, such as insufficient X-ray deposition and an immunosuppressive microenvironment. To overcome these limitations, researchers developed AmGd-NPs, nanoscale coordination particles that could enhance immunogenic cell death, improve phagocytosis, and promote antigen presentation when combined with radiation therapy. AmGd-NPs also inhibited CD73 activity and promoted a proinflammatory tumor microenvironment, leading to potent in situ vaccination and boosted antitumor immune responses.
Article
Chemistry, Multidisciplinary
Haiheng Xu, Shuqin Xiong, Yiyun Chen, Qingsong Ye, Nan Guan, Yiqiao Hu, Jinhui Wu
Summary: By engineering tumor-targeting bacteria, researchers achieved precise tumor hemorrhage, leading to a change in the immunosuppressive phenotype of tumor-associated macrophages and improving the efficacy of antitumor therapy.
ADVANCED MATERIALS
(2023)
Review
Computer Science, Interdisciplinary Applications
Zhaoyi Sun, Mingquan Lin, Qingqing Zhu, Qianqian Xie, Fei Wang, Zhiyong Lu, Yifan Peng
Summary: This scoping review provides a comprehensive overview of the current state of multimodal deep learning in biomedical image and text joint learning, identifies key concepts, types of studies, and research gaps.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Review
Medicine, Research & Experimental
Qingsong Ye, Deyuan Zheng, Kaiyuan Chen, Jinhui Wu
Summary: Ischemia or hypoxia can cause pathological changes in tissue metabolism and function, leading to various diseases. Timely and effective blood resuscitation or improvement of hypoxia is crucial for disease treatment. However, the development of stable, non-toxic, and immunologically inert oxygen carriers is necessary due to limitations such as blood shortages and the risk of infections. Hemoglobin and perfluorocarbon-based oxygen carriers have been widely studied, and this paper reviews their development and applications as blood substitutes or oxygen carriers in hypoxic diseases. The design of oxygen carriers, their characteristics, and future research prospects are also discussed to provide a reference for further studies.
MOLECULAR PHARMACEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhaoyi Sun, Hanley Ong, Patrick Kennedy, Liyan Tang, Shirley Chen, Jonathan Elias, Eugene Lucas, George Shih, Yifan Peng
Article
Chemistry, Multidisciplinary
Haiheng Xu, Shuqin Xiong, Yiyun Chen, Qingsong Ye, Nan Guan, Yiqiao Hu, Jinhui Wu
Summary: This study found that inducing tumor hemorrhage using tumor-targeting bacteria can temporarily change the phenotype of macrophages, potentially improving the effectiveness of antitumor therapy.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Biomaterials
Cheng Wang, Haoran Wang, Lifeng Luo, Shaoju Gan, Yingfang Yao, Qinhua Wei, Jinhui Wu, Ahu Yuan, Yiqiao Hu, Congping Wu, Zhigang Zou
Summary: In this study, a high-energy radiation-based photocatalysis method called radiocatalysis was proposed, and a TiO2-coated lanthanide pyrosilicate scintillator (LnPS@TiO2) was prepared as the radiocatalytic material. This method can effectively kill cancer cells and cause long-term DNA damage. The research expands the application range of photocatalysis and has significant implications for tumor treatment.
BIOMATERIALS SCIENCE
(2022)
