Article
Medicine, Research & Experimental
Ying Zhang, Xiangyang Cao, Peifeng Li, Yanan Fan, Leilei Zhang, Xianghao Ma, Ruibo Sun, Youwen Liu, Wuyin Li
Summary: The study demonstrates that BMSC-exo carrying miR-935 promotes osteoblast proliferation and differentiation through targeting STAT1.
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Jingwen Zhuang, Ruiyue Hang, Ruoyue Sun, Yanshu Ding, Xiaohong Yao, Ruiqiang Hang, Hui Sun, Long Bai
Summary: Exosomes secreted by bone marrow mesenchymal stem cells have multifaceted effects on osseointegration and hold great promise as a safe, efficient, and ethically unrestricted therapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Endocrinology & Metabolism
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Ling Ma, Xiaowei Wei, Wei Ma, Yusi Liu, Yanfu Wang, Yiwen He, Shanshan Jia, Yu Wang, Wenting Luo, Dan Liu, Tianchu Huang, Jiayu Yan, Hui Gu, Yuzuo Bai, Zhengwei Yuan
Summary: This study aimed to assess the effect of neural stem cell (NSC)-derived exosomes on bone marrow mesenchymal stem cell (BMSC) neuronal differentiation and observe the therapeutic effect in an ex vivo rat spinal bifida aperta (SBA) embryo model. The results showed that NSC-derived exosomes increased the neuronal differentiation rate of BMSCs and were enriched in Netrin1, which positively regulated neuronal differentiation. Furthermore, the Netrin1-induced NSC neuronal differentiation was mediated by the Hand2/Phox2b axis. Therefore, NSC-derived exosomes are critical inducers of BMSC neuronal differentiation and have potential as a treatment agent for SBA.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Lili Chang, He Gao, Li Wang, Ning Wang, Shumei Zhang, Xiaona Zhou, Huijun Yang
Summary: The study found that miR-1228 is highly expressed in serum exosomes of gastric cancer patients, and up-regulation of miR-1228 can down-regulate MMP-14 expression, effectively hindering the development of gastric cancer.
Article
Chemistry, Physical
Chunhui Sheng, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Hao Liu, Xiao Zhang, Ping Zhang, Yunsong Liu, Wenyue Li, Yongsheng Zhou, Longwei Lv
Summary: This study investigated the potential of exosomes derived from human adipose-derived stem cells (hASCs) in promoting osteogenic differentiation for osteoporosis treatment. The study identified the key differentially expressed microRNA between two exosomes and their potential target gene. Results showed that exosomes from osteogenic induction medium had a better effect on promoting osteogenic differentiation than those from proliferation medium. Moreover, miR-335-3p inhibitor-optimized exosomes enhanced osteogenic differentiation in vitro and bone density in vivo, suggesting the potential of engineered exosomes in optimizing exosome-based therapy for osteoporosis.
Review
Cell Biology
Zhikun Wang, Yangming Wu, Zhonghan Zhao, Chengyi Liu, Lingli Zhang
Summary: Exosomes are lipid vesicles containing various bioactive substances that may improve bone microenvironment and resist bone metastasis. BMSC-Exos offer new ideas for disease prevention and rehabilitation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Min Qiu, Shuheng Zhai, Qin Fu, Da Liu
Summary: The research reveals that exosomal miR-150-3p promotes osteoblast proliferation and differentiation in osteoporosis, providing a new insight for treating patients with osteoporosis.
HUMAN GENE THERAPY
(2021)
Article
Cell & Tissue Engineering
Xinxin Zhang, Xiaorui Jiang, Shan Jiang, Xiyu Cai, Shengji Yu, Guoxian Pei
Summary: This study demonstrated that sensory nerve fibers can promote osteogenesis of tissue-engineered bone grafts (TEBGs) by influencing vascularization and provided cytological evidence for the neurotization of TEBGs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Ejaz R. Dar, Mudasir B. Gugjoo, Moien Javaid, Shahid Hussain, Mujeeb R. Fazili, Kuldeep Dhama, Taha Alqahtani, Ali M. Alqahtani, Riaz A. Shah, Talha Bin Emran
Summary: The study evaluates the influence of ambient temperature, donor physiological status, and tissue source on sheep mesenchymal stem cells. Results show that adipose tissue-derived MSCs from full term pregnant female sheep exhibit higher potential for proliferation and differentiation compared to male sheep-derived MSCs. Cryopreserved MSCs have similar characteristics to fresh cells. Therefore, it is important to consider tissue type and donor physiological status when applying MSCs in clinical settings.
Article
Cell Biology
Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, Sujin Jung, Soyeong Joung, Jihyun Kim, Jin Woo Lee
Summary: The study revealed that overexpression of USP53 can enhance osteogenic differentiation of hBMSCs by promoting the degradation of β-catenin through interaction with FBXO31, potentially promoting bone regeneration. Therefore, USP53 may be a promising target for gene therapy in bone regeneration.
CELL DEATH & DISEASE
(2021)
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Critical Care Medicine
Meng Deng, Jing He, Changfu Hao, Yonghua Guo, Huifang Si, Xuedan Deng, Chengpeng Zhang, Shiyu Li, Sanqiao Yao, Wenjie Ren, Wu Yao
Summary: This study investigates the effect of bone marrow mesenchymal stem cells (BMSCs) and exosomes derived from BMSCs (BMSCs-Exo) on blast lung injuries (BLIs) caused by gas explosion in rats. The findings demonstrate that BMSCs and BMSCs-Exo significantly reduce oxidative stress and inflammatory infiltration in the lungs. Additionally, they regulate apoptosis, autophagy, and pyroptosis, suggesting their potential in attenuating BLI.
