Article
Medicine, Research & Experimental
Sean P. Korpela, Trista K. Hinz, Ayman Oweida, Jihye Kim, Jacob Calhoun, Robert Ferris, Raphael A. Nemenoff, Sana D. Karam, Eric T. Clambey, Lynn E. Heasley
Summary: The study found heterogeneous, tumor cell-intrinsic, EGFR/ERBB inhibitor-induced IFN pathway activation in HNSCC, suggesting that individual tumor responses to oncogene-targeted agents are a sum of direct growth inhibitory effects and variably-induced participation of host immune cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Brian J. Kwee, Johnny Lam, Adovi Akue, Mark A. KuKuruga, Kunyu Zhang, Luo Gu, Kyung E. Sung
Summary: This study evaluated the immunosuppressive capacity of IFN-gamma-licensed MSCs from multiple donors on different biomaterials, showing that specific integrin expression levels can impact the immunosuppressive capacity of MSCs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Yun Wu, Delin Chen, Yiwen Hu, Shuqing Zhang, Xinhuai Dong, Hao Liang, Minqi Liang, Yujia Zhu, Chahui Tan, Shu An, Xun Zhu, Jie Yuan, Mengfeng Li, Zhenjian He
Summary: This study identified RNF215 as a key negative regulator of type I IFNs and suggested that it plays an important role in the pathogenesis of autoimmune diseases. RNF215 inhibits the production of type I IFNs by interacting with p65, a subunit of NF-kappa B, and repressing NF-kappa B accumulation in the promoter region of IFNB1.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Yun Wu, Delin Chen, Yiwen Hu, Shuqing Zhang, Xinhuai Dong, Hao Liang, Minqi Liang, Yujia Zhu, Chahui Tan, Shu An, Xun Zhu, Jie Yuan, Mengfeng Li, Zhenjian He
Summary: This study identified ring finger protein 215 (RNF215) as a key negative regulator of type I interferons (IFNs) that inhibits their production through interaction with the NF-KB subunit p65. Additionally, the study found a negative correlation between the expression of RNF215 and type I IFNs in patients with systemic lupus erythematosus, indicating the importance of RNF215 in the pathogenesis of autoimmune diseases.
JOURNAL OF IMMUNOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Muzhda Haem Rahimi, Soizic Daniel, Fabienne Venet, Frank Bidar, Martin Cour, Sandrine Ducrot, Laurent Argaud, Anne-Claire Lukaszewicz, Franck Berthier, Guillaume Monneret
Summary: Personalized immunotherapy is being evaluated as a means of restoring immune function in severe septic shock patients. This study conducted beta testing of a fully automated interferon-γ release assay for monitoring the functionality of antigen-independent T lymphocytes in septic shock patients. The results showed promising potential for monitoring immune alterations in routine clinical conditions.
Editorial Material
Hematology
Isabelle Plo, William Vainchenker
Summary: In this study, it was reported that interferon lambda 4 (IFNL4) plays a significant role as a genetic determinant of interferon-alpha (IFN-alpha)-induced molecular response (MR) in myeloproliferative neoplasms (MPNs), leading to better patient stratification.
Article
Biochemistry & Molecular Biology
Xu-zhe Fu, Yu Wang
Summary: This study demonstrates that interferon γ promotes the Warburg effect through the PI3K/Akt/mTOR pathway to reverse the immunosuppression caused by sepsis, elucidating the potential mechanism of the immunotherapeutic effect of IFN γ in sepsis and providing a new target for sepsis treatment.
MOLECULAR MEDICINE
(2023)
Review
Immunology
Megen C. Wittling, Shannon R. Cahalan, Eric A. Levenson, Ronald L. Rabin
Summary: Type I interferons (IFN-I) were first discovered as antiviral factors, but they also modulate immunity and suppress cancer cell proliferation. There are 16 different IFN-I gene products, and investigating their shared and unique aspects is important for understanding their roles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Guy Helman, Parand Zarekiani, Samantha A. M. Tromp, Ashley Andrews, Lorenzo D. Botto, Joshua L. Bonkowsky, Anna Chassevent, Elisa Giorgio, Tommaso Pippucci, Shen Wei, Constance Smith-Hicks, Giovanna Vaula, Michel A. A. P. Willemsen, Mareike Schimmel, Kurt Vollert, Fumitaka Shimizu, Takashi Kanda, Matthew Lynch, Tony Roscioli, Ryan J. Taft, Cas Simons, Marianna Bugiani, Taco W. Kuijpers, Marjo S. van der Knaap
Summary: This study reports on 7 unrelated patients who exhibited leukoencephalopathy with calcifications and were found to have heterozygous de novo gain-of-function variants in the NOTCH1 gene. Immunologic profiling showed increased expression of CSF IP-10, a cytokine downstream of NOTCH1 signaling. Autopsy revealed extensive leukoencephalopathy and microangiopathy with vascular calcifications. These findings suggest that heterozygous gain-of-function variants in the NOTCH1 gene lead to chronic CNS inflammatory response, resulting in calcifying microangiopathy with leukoencephalopathy.
ANNALS OF NEUROLOGY
(2022)
Article
Oncology
Michael W. Knitz, Laurel B. Darragh, Thomas E. Bickett, Shilpa Bhatia, Sanjana Bukkapatnam, Jacob Gadwa, Miles Piper, Sophia Corbo, Diemmy Nguyen, Benjamin Van Court, Ayman Oweida, Sana D. Karam
Summary: The study identifies STAT1 as a mediator of radioresistance in HPV-negative HNSCC and suggests it may play a tumor-promoting role in cancer cells. Knockout of STAT1 in cancer cells resulted in decreased tumor growth and increased immune activation, indicating its potential as a biomarker for radioresistance in HNSCC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Li Pang, Oscar W. H. Yeung, Kevin T. P. Ng, Hui Liu, Jiye Zhu, Jiang Liu, Xinxiang Yang, Tao Ding, Wenqi Qiu, Yuewen Wang, T. L. Shirley Chiu, Zhiwei Chen, Chung-Mau Lo, Kwan Man
Summary: This study reveals that hepatic ischemia-reperfusion injury leads to tumor recurrence in hepatocellular carcinoma patients after surgery. The study identifies IFNa-producing plasmacytoid dendritic cells (pDCs) as the drivers of myeloid-derived suppressor cell (MDSC) recruitment, promoting tumor relapse. Targeting pDCs and the IFNa/CX3CL1/CX3CR1 axis may attenuate postoperative immunosuppression, inhibiting HCC recurrence.
Article
Biochemistry & Molecular Biology
Liam Gaziano, Claudia Giambartolomei, Alexandre C. Pereira, Anna Gaulton, Daniel C. Posner, Sonja A. Swanson, Yuk-Lam Ho, Sudha K. Iyengar, Nicole M. Kosik, Marijana Vujkovic, David R. Gagnon, A. Patricia Bento, Inigo Barrio-Hernandez, Lars Ronnblom, Niklas Hagberg, Christian Lundtoft, Claudia Langenberg, Maik Pietzner, Dennis Valentine, Stefano Gustincich, Gian Gaetano Tartaglia, Elias Allara, Praveen Surendran, Stephen Burgess, Jing Hua Zhao, James E. Peters, Bram P. Prins, Emanuele Di Angelantonio, Poornima Devineni, Yunling Shi, Kristine E. Lynch, Scott L. DuVall, Helene Garcon, Lauren O. Thomann, Jin J. Zhou, Bryan R. Gorman, Jennifer E. Huffman, Christopher J. O'Donnell, Philip S. Tsao, Jean C. Beckham, Saiju Pyarajan, Sumitra Muralidhar, Grant D. Huang, Rachel Ramoni, Pedro Beltrao, John Danesh, Adriana M. Hung, Kyong-Mi Chang, Yan V. Sun, Jacob Joseph, Andrew R. Leach, Todd L. Edwards, Kelly Cho, J. Michael Gaziano, Adam S. Butterworth, Juan P. Casas
Summary: Large-scale Mendelian randomization and colocalization analyses using gene expression and soluble protein data identified IFNAR2 and ACE2 as promising therapeutic targets for early management of COVID-19. Repurposing drugs offers a rapid solution to address the urgent need for therapeutic interventions against COVID-19.
Article
Oncology
Joris B. W. Elbers, Pascal A. Gunsch, Reno Debets, Stijn Keereweer, Esther van Meerten, Jaap Zindler, Yvette van Norden, Mischa S. Hoogeman, Gerda M. Verduijn, Michiel Kroesen, Remi A. Nout
Summary: This study aims to determine the safety of HYDRA proton- and photon radiotherapy and its impact on the immune system through two parallel phase I trials. By utilizing three innovative radiotherapy concepts, the patient's immune system can be maximally retained, providing reliable data for future hypofractionated immunoradiotherapy combination treatment.
Review
Critical Care Medicine
Xavier Wittebole, Virginie Montiel, Jean-Baptiste Mesland
Summary: The review discusses active and passive immune boosting strategies for treating severe COVID-19 patients. Active strategies such as IL-7, thymosin-alpha, interferons, and vitamin D are highlighted, with positive effects needing confirmation in large randomized controlled trials. Passive strategies like immunoglobulins and convalescent plasma do not currently have support from large RCTs.
CURRENT OPINION IN CRITICAL CARE
(2021)
Article
Biochemistry & Molecular Biology
Daniela Stadler, Martin Kaechele, Alisha N. Jones, Julia Hess, Christian Urban, Jessica Schneider, Yuchen Xia, Andreas Oswald, Firat Nebioglu, Romina Bester, Felix Lasitschka, Marc Ringelhan, Chunkyu Ko, Wen-Min Chou, Arie Geerlof, Maarten A. van de Klundert, Jochen M. Wettengel, Peter Schirmacher, Mathias Heikenwaelder, Sabrina Schreiner, Ralf Bartenschlager, Andreas Pichlmair, Michael Sattler, Kristian Unger, Ulrike Protzer
Summary: The study demonstrates that ISG20 is a nuclear protein induced by both type I and II interferons with nuclease activity, which works with APOBEC3A to degrade HBV cccDNA. ISG20 is localized in the nucleoli of interferon-stimulated hepatocytes and is expressed in acute, self-limiting hepatitis B but not in chronic infection.
Article
Cell Biology
Li Ming Zhang, Li Xin Su, Jing Zhou Hu, De Ming Wang, Hou Yu Ju, Xiao Li, Yi Feng Han, Wei Ya Xia, Wei Guo, Guo Xin Ren, Xin Dong Fan
CELL DEATH & DISEASE
(2020)
Article
Materials Science, Multidisciplinary
Taolei Wang, Chao Lin, Dan Batalu, Jingzhou Hu, Wei Lu
Summary: This study investigated the formation mechanism of enhanced hydroxyapatite (HA) coatings on ZK60 magnesium substrate by hydrothermal method, and found that the growth pattern of HA is influenced by the local pH value, leading to different morphology, corrosion resistance, and cytotoxicity. Results suggest that HA coatings prepared in neutral environment show great potential in surface modification of magnesium alloys, promoting high corrosion resistance and biocompatibility of the substrate-coating system.
Article
Metallurgy & Metallurgical Engineering
Taolei Wang, Chao Lin, Dan Batalu, Lu Zhang, Jingzhou Hu, Wei Lu
Summary: PLLA-magnesium composites have been investigated as potential biodegradable materials for bone implants. The high corrosion resistance of amorphous Mg65Zn30Ca5 prevents deteriorating mechanical strength and enhances the antibacterial property of the composite, showing promising application in bone repair and tissue regeneration.
JOURNAL OF MAGNESIUM AND ALLOYS
(2021)
Article
Oncology
Houyu Ju, Zhenrong Hu, Dongliang Wei, Jinyun Huang, Xinyi Zhang, Mengyu Rui, Zhi Li, Xiaomeng Zhang, Jingzhou Hu, Wei Guo, Guoxin Ren
Summary: This study identified a novel intronic circular RNA, circGNG7, which acts as a strong tumor suppressor in head and neck squamous cell carcinoma (HNSCC). The circGNG7/HSP27-JNK/P38 MAPK signaling pathway was found to be a novel mechanism by which HNSCC progression can be controlled.
CANCER COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Wenwen Jia, Yiyao Qi, Zhenrong Hu, Zuquan Xiong, Zhenyi Luo, Zhen Xiang, Jingzhou Hu, Wei Lu
Summary: This study successfully developed a multifunctional cancer theranostic nanoplatform with high efficiency in magneto-triggered hyperthermia, magnetic-responsive controlled drug delivery, enhanced MRI signal, and good biocompatibility.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2021)
Article
Oncology
Mingyu Li, Shufang Jin, Zhiyuan Zhang, Hailong Ma, Xi Yang
Summary: IL-6 plays a critical role in regulating xCT gene in the carcinogenesis of head and neck squamous cell carcinoma, and its upregulation is associated with ferroptosis resistance. High expression of xCT is correlated with poor prognosis.
Article
Biochemistry & Molecular Biology
Shufang Jin, Mingyu Li, Hanyue Chang, Ruijie Wang, Zhiyuan Zhang, Jianjun Zhang, Yue He, Hailong Ma
Summary: This study demonstrates that m6A status is downregulated and two demethylases are upregulated in HNSCC. Silencing the m6A demethylase ALKBH5 suppresses tumor progression. ALKBH5 downregulates the m6A modification of DDX58 mRNA, while HNRNPC binds to the m6A sites of DDX58 mRNA to promote its maturation.
Article
Chemistry, Multidisciplinary
Haishui Sun, Yiming Yang, Lei Yu, Ke Liu, Yifan Fei, Chaoyang Guo, Yuqi Zhou, Jingzhou Hu, Lei Shi, Honghai Ji
Summary: The study prepared zinc-coated titanium micro-arc oxide coating on the titanium surface using micro-arc oxidation and evaluated its physical properties, anti-inflammation, and osteogenesis. The results showed that the coating had good physical characterization, stable release of zinc ions, and good biocompatibility with BMSCs. It downregulated the expression of inflammation-related genes and promoted bone formation.
Article
Nanoscience & Nanotechnology
Xiao Wang, Yiyao Qi, Zhenrong Hu, Lijun Jiang, Fei Pan, Zhen Xiang, Zuquan Xiong, Wenwen Jia, Jingzhou Hu, Wei Lu
Summary: This study successfully developed a nanostructure for precise magnetic hyperthermia/chemo synergistic therapy, which has the functions of on-demand heating, magnetic-responsive drug release, and MRI T2 signal enhancement. Both in vitro and in vivo experiments demonstrated excellent therapeutic effects, providing a new strategy for clinical precision medicine of cancers.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Shufang Jin, Jiayi Li, Yihan Shen, Yiqun Wu, Zhiyuan Zhang, Hailong Ma
Summary: This study found that RNA, 5-methylcytosine (m5C), plays an important role in the progression of head and neck squamous cell carcinoma (HNSCC). A prognostic score (PS) model based on the expression of m5C regulator was established to predict the prognosis of HNSCC. One of the important regulators, NSUN3, was found to be upregulated and associated with poor prognosis. In vitro and in vivo experiments showed that NSUN3 knockdown inhibited tumor proliferation and growth. High PS status was negatively correlated with certain immune cell percentages. NSUN3 knockdown increased the infiltration of M1 macrophages but decreased the percentage of M2 macrophages.
Article
Dentistry, Oral Surgery & Medicine
Hailong Ma, Chaoji Shi, Shufang Jin, Surui Sheng, Mei Zhang, Ran Li, Xiaocheng Zhang, Zhiyuan Zhang, Yue He
Summary: Immediate fibular flap reconstruction was found to be a feasible and effective treatment for medication-related osteonecrosis of the jaw (MRONJ) in the mandible, providing symptom relief and improving patient quality of life.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xiangkai Zhang, Yangzi Yang, Jiaxin Li, Xinru Xie, Yongqiang Hao, Yingchun Zhu, Zhiyuan Zhang, Jingke Fu, Hailong Ma
Summary: Immunotherapy is a groundbreaking achievement in cancer treatment, but failure often occurs due to insufficient infiltration of immune cells in the tumor microenvironment (TME). In addition, hypoxia in the TME hampers immune cell function. This study demonstrates the importance of remodeling the tumor immune microenvironment and relieving hypoxia to enhance immunotherapy efficiency.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shufang Jin, Hailong Ma, Xiaowan Ling, Baoxin Tao, Feng Wang, Yiqun Wu
Summary: This study investigated the effects of zygomatic implant placement on the maxillary sinus using radiographic and clinical indicators. The results showed that the thickness of the sinus membrane significantly increased after bilateral zygomatic implant placement, which may lead to maxillary sinus mucositis and osteitis.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Materials Science, Biomaterials
Lei Yu, Yuanchen Yin, Zhaoyang Guo, Yifan Fei, Xutao Wen, Jiajia Wang, Haishui Sun, Jingzhou Hu, Shanliang Jin
Summary: In this experiment, zinc was introduced into the titanium coating to improve its pro-angiogenic ability. The physical properties, biocompatibility, pro-angiogenic function, and osteogenic effect of the zinc-containing coating were investigated. The study confirmed the pro-angiogenic effect of zinc ions and also found a mutual promotion between angiogenesis and osteogenesis in the zinc ion microenvironment.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Environmental Sciences
Xiaoting Wang, Weiguo Zhang, Jie Yin, Jun Wang, Jianping Wu, Nina S. N. Lam
Summary: This study explores the impact of spatial heterogeneity of land use on exposure assessment of land use value to erosion hazard. The results show that considering fine spatial scale heterogeneity in land use is important in carrying out exposure assessment to hazards in a dynamic deltaic coast.
ANTHROPOCENE COASTS
(2022)