期刊
MITOCHONDRION
卷 50, 期 -, 页码 35-41出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2019.10.005
关键词
Exercise; Growth and differentiation factor 15; Metabolic myopathy; Mitochondrial myopathy; Muscular dystrophy
资金
- A.P. Moller Foundation for the Advancement of Medical Science [16-373]
- LF Foghts Foundation [21.156]
Objective: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies. Methods: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls. Results and conclusions: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.
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